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Mediastinal malignant lymphoma

MedGen UID:
235311
•Concept ID:
C1334665
•
Neoplastic Process
Synonyms: Lymphoma of Mediastinum; lymphoma of mediastinum; Lymphoma of the Mediastinum; lymphoma of the mediastinum; Mediastinal Lymphoma; mediastinal lymphoma; Mediastinal Malignant Lymphoma; mediastinal malignant lymphoma; mediastinum lymphoma; Primary Mediastinal Lymphoma; primary mediastinal lymphoma
 
Monarch Initiative: MONDO:0004021

Definition

A lymphoma that arises from the mediastinum. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma. [from NCI]

Professional guidelines

PubMed

Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Primary Mediastinal B-Cell Lymphoma: A 2021 Update on Genetics, Diagnosis, and Novel Therapeutics.
Ahmed Z, Afridi SS, Shahid Z, Zamani Z, Rehman S, Aiman W, Khan M, Mir MA, Awan FT, Anwer F, Iftikhar R
Clin Lymphoma Myeloma Leuk 2021 Nov;21(11):e865-e875. Epub 2021 Jun 24 doi: 10.1016/j.clml.2021.06.012. PMID: 34330673
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616

Recent clinical studies

Etiology

Endosonography for the diagnosis of malignant lymphoma presenting with mediastinal lymphadenopathy.
Talebian Yazdi M, von Bartheld MB, Waaijenborg FG, Nabers J, Venmans BJ, Veselic-Charvat M, Jansen PM, Marijt EW, Annema JT
J Bronchology Interv Pulmonol 2014 Oct;21(4):298-305. doi: 10.1097/LBR.0000000000000093. PMID: 25321448
The importance of CT scan in the clinical-morphological and anatomical assessment of mediastinal lymphomas.
Motoc A, Brad S, Brad V, Bolintineanu S
Rom J Morphol Embryol 2005;46(4):295-9. PMID: 16688366
Magnetic resonance imaging and 67Ga scan versus computed tomography in the staging and in the monitoring of mediastinal malignant lymphoma: a prospective pilot study.
Bendini M, Zuiani C, Bazzocchi M, Dalpiaz G, Zaja F, Englaro E
MAGMA 1996 Sep-Dec;4(3-4):213-24. doi: 10.1007/BF01772009. PMID: 9220410
Magnetic resonance imaging and 67gallium scan in mediastinal malignant lymphoma: a prospective pilot study.
Abrahamsen AF, Lien HH, Aas M, Winderen M, Hager B, Kvaløy S, Elgjo RF, Nome O
Ann Oncol 1994 May;5(5):433-6. doi: 10.1093/oxfordjournals.annonc.a058875. PMID: 8075050

Diagnosis

Endosonography for the diagnosis of malignant lymphoma presenting with mediastinal lymphadenopathy.
Talebian Yazdi M, von Bartheld MB, Waaijenborg FG, Nabers J, Venmans BJ, Veselic-Charvat M, Jansen PM, Marijt EW, Annema JT
J Bronchology Interv Pulmonol 2014 Oct;21(4):298-305. doi: 10.1097/LBR.0000000000000093. PMID: 25321448
Posterior mediastinal malignant lymphoma mimicking a neurogenic tumor.
Ohtaki Y, Shimizu K, Nagashima T, Nakano T, Takeyoshi I
Ann Thorac Surg 2013 Feb;95(2):e49. doi: 10.1016/j.athoracsur.2012.09.027. PMID: 23336918
Magnetic resonance imaging and 67gallium scan in mediastinal malignant lymphoma: a prospective pilot study.
Abrahamsen AF, Lien HH, Aas M, Winderen M, Hager B, Kvaløy S, Elgjo RF, Nome O
Ann Oncol 1994 May;5(5):433-6. doi: 10.1093/oxfordjournals.annonc.a058875. PMID: 8075050
Primary mediastinal malignant lymphoma.
Sutcliffe SB
Semin Thorac Cardiovasc Surg 1992 Jan;4(1):55-67. PMID: 1550890
Acute myeloblastic leukemia developing in patients with mediastinal lymphoblastic lymphoma.
Kjeldsberg CR, Nathwani BN, Rappaport H
Cancer 1979 Dec;44(6):2316-23. doi: 10.1002/1097-0142(197912)44:6<2316::aid-cncr2820440647>3.0.co;2-6. PMID: 389413

Therapy

Mediastinal malignant lymphoma complicated with esophagobronchial fistula: successfully treated case.
Tachimori Y, Kato H, Watanabe H, Iizuka T, Minato K, Yamaguchi H, Mukai K
Jpn J Clin Oncol 1987 Dec;17(4):363-70. PMID: 3694829

Prognosis

Endosonography for the diagnosis of malignant lymphoma presenting with mediastinal lymphadenopathy.
Talebian Yazdi M, von Bartheld MB, Waaijenborg FG, Nabers J, Venmans BJ, Veselic-Charvat M, Jansen PM, Marijt EW, Annema JT
J Bronchology Interv Pulmonol 2014 Oct;21(4):298-305. doi: 10.1097/LBR.0000000000000093. PMID: 25321448
B-cell-type malignant lymphoma with placental involvement.
Nishi Y, Suzuki S, Otsubo Y, Ishikawa G, Ichikawa M, Takei R, Sawa R, Yoneyama K, Yoneyama Y, Araki T
J Obstet Gynaecol Res 2000 Feb;26(1):39-43. doi: 10.1111/j.1447-0756.2000.tb01199.x. PMID: 10761330
Magnetic resonance imaging and 67Ga scan versus computed tomography in the staging and in the monitoring of mediastinal malignant lymphoma: a prospective pilot study.
Bendini M, Zuiani C, Bazzocchi M, Dalpiaz G, Zaja F, Englaro E
MAGMA 1996 Sep-Dec;4(3-4):213-24. doi: 10.1007/BF01772009. PMID: 9220410
Magnetic resonance imaging and 67gallium scan in mediastinal malignant lymphoma: a prospective pilot study.
Abrahamsen AF, Lien HH, Aas M, Winderen M, Hager B, Kvaløy S, Elgjo RF, Nome O
Ann Oncol 1994 May;5(5):433-6. doi: 10.1093/oxfordjournals.annonc.a058875. PMID: 8075050
Mediastinal malignant lymphoma.
Van Heerden JA, Harrison EG Jr, Bernatz PE, Kiely JM
Chest 1970 Jun;57(6):518-29. doi: 10.1378/chest.57.6.518. PMID: 5537415

Clinical prediction guides

Endosonography for the diagnosis of malignant lymphoma presenting with mediastinal lymphadenopathy.
Talebian Yazdi M, von Bartheld MB, Waaijenborg FG, Nabers J, Venmans BJ, Veselic-Charvat M, Jansen PM, Marijt EW, Annema JT
J Bronchology Interv Pulmonol 2014 Oct;21(4):298-305. doi: 10.1097/LBR.0000000000000093. PMID: 25321448
Magnetic resonance imaging and 67Ga scan versus computed tomography in the staging and in the monitoring of mediastinal malignant lymphoma: a prospective pilot study.
Bendini M, Zuiani C, Bazzocchi M, Dalpiaz G, Zaja F, Englaro E
MAGMA 1996 Sep-Dec;4(3-4):213-24. doi: 10.1007/BF01772009. PMID: 9220410
Magnetic resonance imaging and 67gallium scan in mediastinal malignant lymphoma: a prospective pilot study.
Abrahamsen AF, Lien HH, Aas M, Winderen M, Hager B, Kvaløy S, Elgjo RF, Nome O
Ann Oncol 1994 May;5(5):433-6. doi: 10.1093/oxfordjournals.annonc.a058875. PMID: 8075050

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