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Gastric Gastrointestinal Stromal Tumor

MedGen UID:
232231
•Concept ID:
C1333768
•
Neoplastic Process
Synonyms: Digestive Stromal Neoplasm of Stomach; Digestive Stromal Neoplasm of the Stomach; Digestive Stromal Tumor of Stomach; Digestive Stromal Tumor of the Stomach; Gastric Digestive Stromal Neoplasm; Gastric Digestive Stromal Tumor; Gastric GIST; Gastrointestinal Stromal Neoplasm of Stomach; Gastrointestinal Stromal Neoplasm of the Stomach; Gastrointestinal stromal tumor of stomach; Gastrointestinal Stromal Tumor of Stomach; Gastrointestinal Stromal Tumor of the Stomach; GIST of Stomach; GIST of the Stomach; Stomach Digestive Stromal Neoplasm; Stomach Digestive Stromal Tumor
SNOMED CT: Gastrointestinal stromal tumor of stomach (445736006)

Definition

A gastrointestinal stromal tumor that arises from the stomach. It covers a spectrum of benign to malignant soft tissue neoplasms and includes most gastric smooth muscle tumors, leiomyoblastomas, and tumors formerly called gastrointestinal autonomic nerve tumors. [from NCI]

Professional guidelines

PubMed

Kinase genotype analysis of gastric gastrointestinal stromal tumor cytology samples using targeted next-generation sequencing.
Gleeson FC, Kipp BR, Kerr SE, Voss JS, Graham RP, Campion MB, Minot DM, Tu ZJ, Klee EW, Lazaridis KN, Henry MR, Levy MJ
Clin Gastroenterol Hepatol 2015 Jan;13(1):202-6. Epub 2014 Jul 3 doi: 10.1016/j.cgh.2014.06.024. PMID: 24997326
Diagnosis and treatment of gastric gastrointestinal stromal tumor less than 5 cm in diameter.
Wang S, Ye YJ
Zhonghua Wei Chang Wai Ke Za Zhi 2010 Jul;13(7):477-80. PMID: 20722225

Recent clinical studies

Etiology

Is single incision laparoscopic surgery (SILS) for gastric gastrointestinal stromal tumor (GIST) dependent on the location of the tumor?
Seo JW, Park KB, Chin HM, Jun KH
BMC Surg 2023 Aug 21;23(1):247. doi: 10.1186/s12893-023-02141-0. PMID: 37605202Free PMC Article
Robotic Function-Preserving Resection of Gastric Gastrointestinal Stromal Tumor.
Lwin TM, Fong ZV, Narayan RR, Wang SJ, Wang J
J Surg Res 2023 Oct;290:164-170. Epub 2023 Jun 1 doi: 10.1016/j.jss.2023.04.021. PMID: 37269799
Clinical outcomes of laparoscopic and endoscopic cooperative surgery for gastric gastrointestinal stromal tumor.
Hanayama H, Katagata M, Sato T, Nakano H, Matsumoto T, Tada T, Watanabe Y, Hayase S, Okayama H, Momma T, Kato T, Hashimoto M, Nakamura J, Hikichi T, Saze Z, Kono K
Fukushima J Med Sci 2022;68(3):169-174. doi: 10.5387/fms.2021-25. PMID: 36543179Free PMC Article
Do microscopic surgical margins matter for primary gastric gastrointestinal stromal tumor?
Shannon AB, Song Y, Fraker DL, Roses RE, DeMatteo RP, Miura JT, Karakousis GC
Surgery 2021 Feb;169(2):419-425. Epub 2020 Aug 27 doi: 10.1016/j.surg.2020.07.018. PMID: 32863011
Short- and Long-Term Outcomes of Laparoscopic Versus Open Resection for Gastric Gastrointestinal Stromal Tumors: A Propensity Score-Matching Analysis.
Chen QF, Huang CM, Lin M, Lin JX, Lu J, Zheng CH, Li P, Xie JW, Wang JB, Chen QY, Cao LL, Tu RH
Medicine (Baltimore) 2016 Apr;95(15):e3135. doi: 10.1097/MD.0000000000003135. PMID: 27082552Free PMC Article

Diagnosis

A nomogram for predicting liver metastasis in patients with gastric gastrointestinal stromal tumor.
Ruan J, He Y, Li Q, Jiang Z, Liu S, Ai J, Mao K, Dong X, Zhang D, Yang G, Gao D, Li Z
J Gastrointest Surg 2024 May;28(5):710-718. Epub 2024 Feb 20 doi: 10.1016/j.gassur.2024.02.025. PMID: 38462423
Gastric gastrointestinal stromal tumor abscess.
Velilla Vico D, Carbonell Morote S, Ruiz de la Cuesta Tapia E, Ramia Ángel JM
Rev Esp Enferm Dig 2023 Jan;115(1):35-36. doi: 10.17235/reed.2022.8580/2022. PMID: 35255697
Do microscopic surgical margins matter for primary gastric gastrointestinal stromal tumor?
Shannon AB, Song Y, Fraker DL, Roses RE, DeMatteo RP, Miura JT, Karakousis GC
Surgery 2021 Feb;169(2):419-425. Epub 2020 Aug 27 doi: 10.1016/j.surg.2020.07.018. PMID: 32863011
Somatic SDHA mutations in paragangliomas in siblings: Case report of 2 cases.
Huang YC, Chang HH, Chen MH, Huang KH, Li AF, Lin CH, Shyr YM, Fang WL
Medicine (Baltimore) 2020 Oct 9;99(41):e22497. doi: 10.1097/MD.0000000000022497. PMID: 33031286Free PMC Article
Clinicopathologic Features of Gastric Schwannoma: 8-Year Experience at a Single Institution in China.
Tao K, Chang W, Zhao E, Deng R, Gao J, Cai K, Wang G, Zhang P
Medicine (Baltimore) 2015 Nov;94(45):e1970. doi: 10.1097/MD.0000000000001970. PMID: 26559271Free PMC Article

Therapy

A nomogram for predicting liver metastasis in patients with gastric gastrointestinal stromal tumor.
Ruan J, He Y, Li Q, Jiang Z, Liu S, Ai J, Mao K, Dong X, Zhang D, Yang G, Gao D, Li Z
J Gastrointest Surg 2024 May;28(5):710-718. Epub 2024 Feb 20 doi: 10.1016/j.gassur.2024.02.025. PMID: 38462423
Robotic Function-Preserving Resection of Gastric Gastrointestinal Stromal Tumor.
Lwin TM, Fong ZV, Narayan RR, Wang SJ, Wang J
J Surg Res 2023 Oct;290:164-170. Epub 2023 Jun 1 doi: 10.1016/j.jss.2023.04.021. PMID: 37269799
Clinical outcomes of laparoscopic and endoscopic cooperative surgery for gastric gastrointestinal stromal tumor.
Hanayama H, Katagata M, Sato T, Nakano H, Matsumoto T, Tada T, Watanabe Y, Hayase S, Okayama H, Momma T, Kato T, Hashimoto M, Nakamura J, Hikichi T, Saze Z, Kono K
Fukushima J Med Sci 2022;68(3):169-174. doi: 10.5387/fms.2021-25. PMID: 36543179Free PMC Article
A Huge Malignant Gastric Gastrointestinal Stromal Tumor in a Young Patient.
Jeong YJ, Hwang HS, Park YE, Nam KH, Oh SJ
Korean J Gastroenterol 2022 Apr 25;79(4):177-181. doi: 10.4166/kjg.2022.006. PMID: 35473776
Differentiation of Gastric Schwannoma From Gastric Gastrointestinal Stromal Tumor With Dual-Phase Contrast-Enhanced Computed Tomography.
Li R, Gan H, Ni S, Fu Y, Zhu H, Peng W
J Comput Assist Tomogr 2019 Sep/Oct;43(5):741-746. doi: 10.1097/RCT.0000000000000902. PMID: 31356524

Prognosis

A nomogram for predicting liver metastasis in patients with gastric gastrointestinal stromal tumor.
Ruan J, He Y, Li Q, Jiang Z, Liu S, Ai J, Mao K, Dong X, Zhang D, Yang G, Gao D, Li Z
J Gastrointest Surg 2024 May;28(5):710-718. Epub 2024 Feb 20 doi: 10.1016/j.gassur.2024.02.025. PMID: 38462423
Predictors of the difficulty for endoscopic resection of gastric gastrointestinal stromal tumor and follow-up data.
Su W, Wang M, Zhang D, Zhu Y, Lv M, Zhu L, He J, Hu H, Zhou P
J Gastroenterol Hepatol 2022 Jan;37(1):48-55. Epub 2021 Aug 16 doi: 10.1111/jgh.15650. PMID: 34368989
Do microscopic surgical margins matter for primary gastric gastrointestinal stromal tumor?
Shannon AB, Song Y, Fraker DL, Roses RE, DeMatteo RP, Miura JT, Karakousis GC
Surgery 2021 Feb;169(2):419-425. Epub 2020 Aug 27 doi: 10.1016/j.surg.2020.07.018. PMID: 32863011
Clinicopathological feature and prognosis of primary hepatic gastrointestinal stromal tumor.
Liu Z, Tian Y, Liu S, Xu G, Guo M, Lian X, Fan D, Zhang H, Feng F
Cancer Med 2016 Sep;5(9):2268-75. Epub 2016 Aug 3 doi: 10.1002/cam4.808. PMID: 27484851Free PMC Article
Laparoscopic resection for large gastric gastrointestinal stromal tumor (GIST): intermediate follow-up results.
Hsiao CY, Yang CY, Lai IR, Chen CN, Lin MT
Surg Endosc 2015 Apr;29(4):868-73. Epub 2014 Jul 23 doi: 10.1007/s00464-014-3742-0. PMID: 25052129

Clinical prediction guides

A nomogram for predicting liver metastasis in patients with gastric gastrointestinal stromal tumor.
Ruan J, He Y, Li Q, Jiang Z, Liu S, Ai J, Mao K, Dong X, Zhang D, Yang G, Gao D, Li Z
J Gastrointest Surg 2024 May;28(5):710-718. Epub 2024 Feb 20 doi: 10.1016/j.gassur.2024.02.025. PMID: 38462423
A Huge Malignant Gastric Gastrointestinal Stromal Tumor in a Young Patient.
Jeong YJ, Hwang HS, Park YE, Nam KH, Oh SJ
Korean J Gastroenterol 2022 Apr 25;79(4):177-181. doi: 10.4166/kjg.2022.006. PMID: 35473776
Predictors of the difficulty for endoscopic resection of gastric gastrointestinal stromal tumor and follow-up data.
Su W, Wang M, Zhang D, Zhu Y, Lv M, Zhu L, He J, Hu H, Zhou P
J Gastroenterol Hepatol 2022 Jan;37(1):48-55. Epub 2021 Aug 16 doi: 10.1111/jgh.15650. PMID: 34368989
Short- and Long-Term Outcomes of Laparoscopic Versus Open Resection for Gastric Gastrointestinal Stromal Tumors: A Propensity Score-Matching Analysis.
Chen QF, Huang CM, Lin M, Lin JX, Lu J, Zheng CH, Li P, Xie JW, Wang JB, Chen QY, Cao LL, Tu RH
Medicine (Baltimore) 2016 Apr;95(15):e3135. doi: 10.1097/MD.0000000000003135. PMID: 27082552Free PMC Article
Prognostic analysis of gastric gastrointestinal stromal tumor with synchronous gastric cancer.
Lin M, Lin JX, Huang CM, Zheng CH, Li P, Xie JW, Wang JB, Lu J
World J Surg Oncol 2014 Jan 31;12:25. doi: 10.1186/1477-7819-12-25. PMID: 24479763Free PMC Article

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