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Esophageal Gastrointestinal Stromal Tumor

MedGen UID:
232159
•Concept ID:
C1333446
•
Neoplastic Process
Synonym: Esophageal GIST

Definition

A gastrointestinal stromal tumor that arises from the esophagus. The majority are spindle cell tumors that exhibit high mitotic activity and affect the distal esophagus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal Gastrointestinal Stromal Tumor

Professional guidelines

PubMed

Endoscopic treatment can be a viable therapeutic option for esophageal gastrointestinal stromal tumors.
Du H, Ning L, Chen H, Hu F, Shan G, Chen W, Xu G
Scand J Gastroenterol 2022 Mar;57(3):371-376. Epub 2021 Nov 28 doi: 10.1080/00365521.2021.2009024. PMID: 34839764

Recent clinical studies

Etiology

Endoscopic treatment can be a viable therapeutic option for esophageal gastrointestinal stromal tumors.
Du H, Ning L, Chen H, Hu F, Shan G, Chen W, Xu G
Scand J Gastroenterol 2022 Mar;57(3):371-376. Epub 2021 Nov 28 doi: 10.1080/00365521.2021.2009024. PMID: 34839764
A large national comparative study of clinicopathological features and long-term survivals between esophageal gastrointestinal stromal tumor and leiomyosarcoma.
Azab B, Macedo FI, Cass SH, Ripat C, Razi SS, Picado O, Franceschi D, Livingstone AS, Yakoub D
Am J Surg 2019 Aug;218(2):323-328. Epub 2018 Nov 16 doi: 10.1016/j.amjsurg.2018.10.046. PMID: 30471808
Clinicopathologic Features and Clinical Outcomes of Esophageal Gastrointestinal Stromal Tumor: Evaluation of a Pooled Case Series.
Feng F, Tian Y, Liu Z, Xu G, Liu S, Guo M, Lian X, Fan D, Zhang H
Medicine (Baltimore) 2016 Jan;95(2):e2446. doi: 10.1097/MD.0000000000002446. PMID: 26765432Free PMC Article
Esophageal gastrointestinal stromal tumor: is tumoral enucleation a viable therapeutic option?
Robb WB, Bruyere E, Amielh D, Vinatier E, Mabrut JY, Perniceni T, Piessen G, Mariette C; FREGAT Working Group--FRENCH
Ann Surg 2015 Jan;261(1):117-24. doi: 10.1097/SLA.0000000000000505. PMID: 25062398
Esophageal gastrointestinal stromal tumor: report of 7 patients.
Shinagare AB, Zukotynski KA, Krajewski KM, Jagannathan JP, Butrynski J, Hornick JL, Ramaiya NH
Cancer Imaging 2012 Apr 27;12(1):100-8. doi: 10.1102/1470-7330.2012.0017. PMID: 22542728Free PMC Article

Diagnosis

Endoscopic treatment can be a viable therapeutic option for esophageal gastrointestinal stromal tumors.
Du H, Ning L, Chen H, Hu F, Shan G, Chen W, Xu G
Scand J Gastroenterol 2022 Mar;57(3):371-376. Epub 2021 Nov 28 doi: 10.1080/00365521.2021.2009024. PMID: 34839764
A large national comparative study of clinicopathological features and long-term survivals between esophageal gastrointestinal stromal tumor and leiomyosarcoma.
Azab B, Macedo FI, Cass SH, Ripat C, Razi SS, Picado O, Franceschi D, Livingstone AS, Yakoub D
Am J Surg 2019 Aug;218(2):323-328. Epub 2018 Nov 16 doi: 10.1016/j.amjsurg.2018.10.046. PMID: 30471808
Giant esophageal gastrointestinal stromal tumor: report of a case.
Nakano A, Akutsu Y, Shuto K, Uesato M, Kono T, Hoshino I, Akanuma N, Maruyama T, Isozaki Y, Matsubara H
Surg Today 2015 Feb;45(2):247-52. Epub 2014 Jun 4 doi: 10.1007/s00595-014-0929-x. PMID: 24890800
Esophageal gastrointestinal stromal tumor: report of 7 patients.
Shinagare AB, Zukotynski KA, Krajewski KM, Jagannathan JP, Butrynski J, Hornick JL, Ramaiya NH
Cancer Imaging 2012 Apr 27;12(1):100-8. doi: 10.1102/1470-7330.2012.0017. PMID: 22542728Free PMC Article
Bleeding esophageal GIST.
Manu N, Richard P, Howard S
Dis Esophagus 2005;18(4):281-2. doi: 10.1111/j.1442-2050.2005.00480.x. PMID: 16128787

Therapy

Giant esophageal gastrointestinal stromal tumor: report of a case.
Nakano A, Akutsu Y, Shuto K, Uesato M, Kono T, Hoshino I, Akanuma N, Maruyama T, Isozaki Y, Matsubara H
Surg Today 2015 Feb;45(2):247-52. Epub 2014 Jun 4 doi: 10.1007/s00595-014-0929-x. PMID: 24890800
A large esophageal gastrointestinal stromal tumor that was successfully resected after neoadjuvant imatinib treatment: case report.
Yanagawa S, Tanabe K, Suzuki T, Tokumoto N, Arihiro K, Ohdan H
World J Surg Oncol 2014 Feb 27;12:47. doi: 10.1186/1477-7819-12-47. PMID: 24575748Free PMC Article
Long-term survival after excision of a giant esophageal gastrointestinal stromal tumor with imatinib mesylate resistance: report of a case.
Takeno S, Kamei M, Takahashi Y, Ono K, Moroga T, Kawahara K, Yamana I, Maki K, Shiroshita T, Yamashita Y
Surg Today 2014 Sep;44(9):1764-7. Epub 2013 Oct 24 doi: 10.1007/s00595-013-0770-7. PMID: 24154923
Esophageal gastrointestinal stromal tumor: report of 7 patients.
Shinagare AB, Zukotynski KA, Krajewski KM, Jagannathan JP, Butrynski J, Hornick JL, Ramaiya NH
Cancer Imaging 2012 Apr 27;12(1):100-8. doi: 10.1102/1470-7330.2012.0017. PMID: 22542728Free PMC Article
Esophageal gastrointestinal stromal tumor with pulmonary and bone metastases.
Ozan E, Oztekin O, Alacacioğlu A, Aykaş A, Postaci H, Adibelli Z
Diagn Interv Radiol 2010 Sep;16(3):217-20. Epub 2009 Oct 19 doi: 10.4261/1305-3825.DIR.1861-08.2. PMID: 19838991

Prognosis

Endoscopic treatment can be a viable therapeutic option for esophageal gastrointestinal stromal tumors.
Du H, Ning L, Chen H, Hu F, Shan G, Chen W, Xu G
Scand J Gastroenterol 2022 Mar;57(3):371-376. Epub 2021 Nov 28 doi: 10.1080/00365521.2021.2009024. PMID: 34839764
Management of esophageal gastrointestinal stromal tumor: review of one hundred seven patients.
Pence K, Correa AM, Chan E, Khaitan P, Hofstetter W, Kim MP
Dis Esophagus 2017 Dec 1;30(12):1-5. doi: 10.1093/dote/dox064. PMID: 28881878
Clinicopathologic Features and Clinical Outcomes of Esophageal Gastrointestinal Stromal Tumor: Evaluation of a Pooled Case Series.
Feng F, Tian Y, Liu Z, Xu G, Liu S, Guo M, Lian X, Fan D, Zhang H
Medicine (Baltimore) 2016 Jan;95(2):e2446. doi: 10.1097/MD.0000000000002446. PMID: 26765432Free PMC Article
Giant esophageal gastrointestinal stromal tumor: report of a case.
Nakano A, Akutsu Y, Shuto K, Uesato M, Kono T, Hoshino I, Akanuma N, Maruyama T, Isozaki Y, Matsubara H
Surg Today 2015 Feb;45(2):247-52. Epub 2014 Jun 4 doi: 10.1007/s00595-014-0929-x. PMID: 24890800
Esophageal gastrointestinal stromal tumor: report of 7 patients.
Shinagare AB, Zukotynski KA, Krajewski KM, Jagannathan JP, Butrynski J, Hornick JL, Ramaiya NH
Cancer Imaging 2012 Apr 27;12(1):100-8. doi: 10.1102/1470-7330.2012.0017. PMID: 22542728Free PMC Article

Clinical prediction guides

A large national comparative study of clinicopathological features and long-term survivals between esophageal gastrointestinal stromal tumor and leiomyosarcoma.
Azab B, Macedo FI, Cass SH, Ripat C, Razi SS, Picado O, Franceschi D, Livingstone AS, Yakoub D
Am J Surg 2019 Aug;218(2):323-328. Epub 2018 Nov 16 doi: 10.1016/j.amjsurg.2018.10.046. PMID: 30471808
Clinicopathologic Features and Clinical Outcomes of Esophageal Gastrointestinal Stromal Tumor: Evaluation of a Pooled Case Series.
Feng F, Tian Y, Liu Z, Xu G, Liu S, Guo M, Lian X, Fan D, Zhang H
Medicine (Baltimore) 2016 Jan;95(2):e2446. doi: 10.1097/MD.0000000000002446. PMID: 26765432Free PMC Article
Esophageal gastrointestinal stromal tumor: is tumoral enucleation a viable therapeutic option?
Robb WB, Bruyere E, Amielh D, Vinatier E, Mabrut JY, Perniceni T, Piessen G, Mariette C; FREGAT Working Group--FRENCH
Ann Surg 2015 Jan;261(1):117-24. doi: 10.1097/SLA.0000000000000505. PMID: 25062398
Long-term survival after enucleation of a giant esophageal gastrointestinal stromal tumor.
Mu ZM, Xie YC, Peng XX, Zhang H, Hui G, Wu H, Liu JX, Chen BK, Wu D, Ye YW
World J Gastroenterol 2014 Oct 7;20(37):13632-6. doi: 10.3748/wjg.v20.i37.13632. PMID: 25309096Free PMC Article
Thoracoscopic enucleation of esophageal gastrointestinal stromal tumor using prone positioning in a patient with severe chronic obstructive lung disease.
Yamada H, Shinohara T, Yokoyama K, Takasu K, Fujimori Y, Yamagishi K
J Laparoendosc Adv Surg Tech A 2011 Sep;21(7):635-9. Epub 2011 Jul 20 doi: 10.1089/lap.2011.0264. PMID: 21774702

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