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Colorectal Traditional Serrated Adenoma

MedGen UID:
232384
•Concept ID:
C1333116
•
Neoplastic Process
Synonyms: Colorectal Serrated Adenoma; Colorectal Serrated Adenoma Type II; Colorectal TSA; Large Bowel Traditional Serrated Adenoma; Traditional Serrated Adenoma of Large Bowel; Traditional Serrated Adenoma of the Large Bowel

Definition

An adenoma that arises from the colon or rectum. It is characterized by prominent serration of the glands. [from NCI]

Professional guidelines

PubMed

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article
Serrated polyps of the colon and rectum (hyperplastic polyps, sessile serrated adenomas, traditional serrated adenomas, and mixed polyps)-proposal for diagnostic criteria.
Aust DE, Baretton GB; Members of the Working Group GI-Pathology of the German Society of Pathology
Virchows Arch 2010 Sep;457(3):291-7. Epub 2010 Jul 9 doi: 10.1007/s00428-010-0945-1. PMID: 20617338

Recent clinical studies

Etiology

The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas.
Pai RK, Bettington M, Srivastava A, Rosty C
Mod Pathol 2019 Oct;32(10):1390-1415. Epub 2019 Apr 25 doi: 10.1038/s41379-019-0280-2. PMID: 31028362
Serrated adenomas.
De Jesus-Monge WE, Gonzalez-Keelan C, Cruz-Correa M
Curr Gastroenterol Rep 2009 Oct;11(5):420-7. doi: 10.1007/s11894-009-0063-x. PMID: 19765371

Diagnosis

The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Serrated polyps of the colon and rectum: Remove or not?
Sano W, Hirata D, Teramoto A, Iwatate M, Hattori S, Fujita M, Sano Y
World J Gastroenterol 2020 May 21;26(19):2276-2285. doi: 10.3748/wjg.v26.i19.2276. PMID: 32476792Free PMC Article
Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas.
Pai RK, Bettington M, Srivastava A, Rosty C
Mod Pathol 2019 Oct;32(10):1390-1415. Epub 2019 Apr 25 doi: 10.1038/s41379-019-0280-2. PMID: 31028362
Serrated adenomas.
De Jesus-Monge WE, Gonzalez-Keelan C, Cruz-Correa M
Curr Gastroenterol Rep 2009 Oct;11(5):420-7. doi: 10.1007/s11894-009-0063-x. PMID: 19765371

Therapy

Efficacy and safety of Shenbai Granules for recurrent colorectal adenoma: A multicenter randomized controlled trial.
Ni M, Zhang Y, Sun Z, Zhou Q, Xiao J, Zhang B, Lin J, Gong B, Liu F, Meng F, Zheng G, Wang Y, Gu L, Li L, Shen W, Chen Y, Liu Y, Li L, Ling T, Cheng H
Phytomedicine 2024 May;127:155496. Epub 2024 Feb 27 doi: 10.1016/j.phymed.2024.155496. PMID: 38471368
Predicting Risk of Colorectal Cancer After Adenoma Removal in a Large Community-Based Setting.
Lee JK, Jensen CD, Udaltsova N, Zheng Y, Levin TR, Chubak J, Kamineni A, Halm EA, Skinner CS, Schottinger JE, Ghai NR, Burnett-Hartman A, Issaka R, Corley DA
Am J Gastroenterol 2024 Aug 1;119(8):1590-1599. Epub 2024 Feb 14 doi: 10.14309/ajg.0000000000002721. PMID: 38354214Free PMC Article
Colorectal dysplasia in chronic inflammatory bowel disease: a contemporary consensus classification and interobserver study.
Harpaz N, Goldblum JR, Shepherd NA, Riddell RH, Rubio CA, Vieth M, Wang HH, Odze RD
Hum Pathol 2023 Aug;138:49-61. Epub 2023 May 27 doi: 10.1016/j.humpath.2023.05.008. PMID: 37247824
British Society of Gastroenterology position statement on serrated polyps in the colon and rectum.
East JE, Atkin WS, Bateman AC, Clark SK, Dolwani S, Ket SN, Leedham SJ, Phull PS, Rutter MD, Shepherd NA, Tomlinson I, Rees CJ
Gut 2017 Jul;66(7):1181-1196. Epub 2017 Apr 27 doi: 10.1136/gutjnl-2017-314005. PMID: 28450390Free PMC Article
Histological overlap between colorectal villous/tubulovillous and traditional serrated adenomas.
Hafezi-Bakhtiari S, Wang LM, Colling R, Serra S, Chetty R
Histopathology 2015 Jan;66(2):308-13. Epub 2014 Nov 13 doi: 10.1111/his.12555. PMID: 25257227

Prognosis

The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.
He X, Hang D, Wu K, Nayor J, Drew DA, Giovannucci EL, Ogino S, Chan AT, Song M
Gastroenterology 2020 Mar;158(4):852-861.e4. Epub 2019 Jul 11 doi: 10.1053/j.gastro.2019.06.039. PMID: 31302144Free PMC Article
Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
Traditional serrated adenoma (TSA): morphological questions, queries and quandaries.
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333

Clinical prediction guides

Single-cell Transcriptomics Reveals Early Molecular and Immune Alterations Underlying the Serrated Neoplasia Pathway Toward Colorectal Cancer.
Zhou YJ, Lu XF, Chen H, Wang XY, Cheng W, Zhang QW, Chen JN, Wang XY, Jin JZ, Yan FR, Chen H, Li XB
Cell Mol Gastroenterol Hepatol 2023;15(2):393-424. Epub 2022 Oct 8 doi: 10.1016/j.jcmgh.2022.10.001. PMID: 36216310Free PMC Article
The Frontiers of Serrated Polyps.
Bell PD, Anderson JC, Srivastava A
Am J Surg Pathol 2022 Jan 1;46(1):e64-e70. doi: 10.1097/PAS.0000000000001806. PMID: 34545859
Serrated lesions: A challenging enemy.
Trovato A, Turshudzhyan A, Tadros M
World J Gastroenterol 2021 Sep 14;27(34):5625-5629. doi: 10.3748/wjg.v27.i34.5625. PMID: 34629791Free PMC Article
Traditional serrated adenoma (TSA): morphological questions, queries and quandaries.
Chetty R
J Clin Pathol 2016 Jan;69(1):6-11. Epub 2015 Nov 9 doi: 10.1136/jclinpath-2015-203452. PMID: 26553935
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333

Recent systematic reviews

Effect of computer-aided colonoscopy on adenoma miss rates and polyp detection: A systematic review and meta-analysis.
Shah S, Park N, Chehade NEH, Chahine A, Monachese M, Tiritilli A, Moosvi Z, Ortizo R, Samarasena J
J Gastroenterol Hepatol 2023 Feb;38(2):162-176. Epub 2022 Dec 11 doi: 10.1111/jgh.16059. PMID: 36350048
Site-specific risk of colorectal neoplasms in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis.
Lin X, You F, Liu H, Fang Y, Jin S, Wang Q
PLoS One 2021;16(1):e0245921. Epub 2021 Jan 25 doi: 10.1371/journal.pone.0245921. PMID: 33493235Free PMC Article
Comparing endoscopic interventions to improve serrated adenoma detection rates during colonoscopy: a systematic review and network meta-analysis of randomized controlled trials.
Aziz M, Fatima R, Lee-Smith W, Khuder S, Nawras A
Eur J Gastroenterol Hepatol 2020 Oct;32(10):1284-1292. doi: 10.1097/MEG.0000000000001844. PMID: 32773510
Clinicopathological factors associated with BRAF-V600E mutation in colorectal serrated adenomas.
Travaglino A, D'Armiento FP, Cassese G, Campanino MR, Borrelli G, Pignatiello S, Luglio G, Maione F, De Palma GD, D'Armiento M
Histopathology 2019 Aug;75(2):160-173. Epub 2019 May 16 doi: 10.1111/his.13846. PMID: 30815911

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