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Barrett adenocarcinoma

MedGen UID:
272350
•Concept ID:
C1332460
•
Neoplastic Process
Synonyms: Adenocarcinoma Arising in Barrett's Mucosa; adenocarcinoma arising in Barrett's mucosa; Barrett Adenocarcinoma; Barrett's Adenocarcinoma; Barrett's adenocarcinoma
 
Monarch Initiative: MONDO:0004405

Definition

An adenocarcinoma arising from Barrett metaplastic epithelium in the esophagus. There is evidence supporting the idea that the Barrett adenocarcinomas develop through a stepwise progression through intestinal metaplastic epithelium to epithelial dysplasia to malignancy. Adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular. In terms of grading, they are well or moderately differentiated adenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBarrett adenocarcinoma

Professional guidelines

PubMed

The utility of a genetic progression risk test for Barrett esophagus.
Gong D, Lunz D, Stover JS, Meltzer SJ
Medicine (Baltimore) 2022 Sep 16;101(37):e30503. doi: 10.1097/MD.0000000000030503. PMID: 36123898Free PMC Article
Endoscopic Management of Early Esophageal Cancer.
Barnes JA, Willingham FF
J Clin Gastroenterol 2015 Sep;49(8):638-46. doi: 10.1097/MCG.0000000000000353. PMID: 26125458

Recent clinical studies

Etiology

Sex steroid hormones in relation to Barrett's esophagus: an analysis of the FINBAR Study.
Cook MB, Wood S, Hyland PL, Caron P, Drahos J, Falk RT, Pfeiffer RM, Dawsey SM, Abnet CC, Taylor PR, Guillemette C, Murray LJ, Anderson LA
Andrology 2017 Mar;5(2):240-247. Epub 2017 Feb 27 doi: 10.1111/andr.12314. PMID: 28241109Free PMC Article
Anterior gradient 2 profiling in Barrett columnar epithelia and adenocarcinoma.
Pizzi M, Fassan M, Realdon S, Balistreri M, Battaglia G, Giacometti C, Zaninotto G, Zagonel V, De Boni M, Rugge M
Hum Pathol 2012 Nov;43(11):1839-44. Epub 2012 Apr 20 doi: 10.1016/j.humpath.2012.01.004. PMID: 22521076
Effect of adiponectin and ghrelin on apoptosis of Barrett adenocarcinoma cell line.
Konturek PC, Burnat G, Rau T, Hahn EG, Konturek S
Dig Dis Sci 2008 Mar;53(3):597-605. Epub 2007 Sep 1 doi: 10.1007/s10620-007-9922-1. PMID: 17763959
Adenocarcinoma of the esophagus with and without Barrett mucosa.
Sabel MS, Pastore K, Toon H, Smith JL
Arch Surg 2000 Jul;135(7):831-5; discussion 836. doi: 10.1001/archsurg.135.7.831. PMID: 10896378
Prevalence and characteristics of Barrett esophagus in patients with adenocarcinoma of the esophagus or esophagogastric junction.
Hamilton SR, Smith RR, Cameron JL
Hum Pathol 1988 Aug;19(8):942-8. doi: 10.1016/s0046-8177(88)80010-8. PMID: 3402983

Diagnosis

Molecular abnormalities in pediatric barrett esophagus: can we test for potential of neoplastic progression?
Maltby EL, Dyson MJ, Wheeler MR, Thomson M, Sethuraman C, Cohen MC
Pediatr Dev Pathol 2010 Jul-Aug;13(4):310-7. doi: 10.2350/09-08-0700-OA.1. PMID: 20053129
Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma.
Takubo K, Aida J, Naomoto Y, Sawabe M, Arai T, Shiraishi H, Matsuura M, Ell C, May A, Pech O, Stolte M, Vieth M
Hum Pathol 2009 Jan;40(1):65-74. Epub 2008 Aug 27 doi: 10.1016/j.humpath.2008.06.008. PMID: 18755496
Cytokeratin expression patterns in noncardia, intestinal metaplasia-associated gastric adenocarcinoma: implication for the evaluation of intestinal metaplasia and tumors at the esophagogastric junction.
Shen B, Ormsby AH, Shen C, Dumot JA, Shao YW, Bevins CL, Gramlich TL
Cancer 2002 Feb 1;94(3):820-31. doi: 10.1002/cncr.10215. PMID: 11857318
Adenocarcinoma of the esophagus with and without Barrett mucosa.
Sabel MS, Pastore K, Toon H, Smith JL
Arch Surg 2000 Jul;135(7):831-5; discussion 836. doi: 10.1001/archsurg.135.7.831. PMID: 10896378

Therapy

Gaucher Disease Types I and III Responded Well to Substrate Reduction Therapy Using Eliglustat.
Harai N, Ichijo M, Uchinuma H, Hanihara M, Kawaguchi Y, Ichikawa D, Tsuchiya K
Intern Med 2023 Oct 15;62(20):3005-3011. Epub 2023 Mar 8 doi: 10.2169/internalmedicine.1425-22. PMID: 36889706Free PMC Article
Bile acids down-regulate caveolin-1 in esophageal epithelial cells through sterol responsive element-binding protein.
Prade E, Tobiasch M, Hitkova I, Schäffer I, Lian F, Xing X, Tänzer M, Rauser S, Walch A, Feith M, Post S, Röcken C, Schmid RM, Ebert MP, Burgermeister E
Mol Endocrinol 2012 May;26(5):819-32. Epub 2012 Apr 3 doi: 10.1210/me.2011-1140. PMID: 22474125Free PMC Article
Bile acids are multifunctional modulators of the Barrett's carcinogenesis.
Burnat G, Majka J, Konturek PC
J Physiol Pharmacol 2010 Apr;61(2):185-92. PMID: 20436219
Genetic polymorphisms of microsomal epoxide hydroxylase and glutathione S-transferases M1, T1 and P1, interactions with smoking, and risk for esophageal (Barrett) adenocarcinoma.
Casson AG, Zheng Z, Porter GA, Guernsey DL
Cancer Detect Prev 2006;30(5):423-31. Epub 2006 Oct 24 doi: 10.1016/j.cdp.2006.09.005. PMID: 17064856
Exclusive radical surgery for esophageal adenocarcinoma.
Collard JM
Cancer 2001 Mar 15;91(6):1098-104. PMID: 11267954

Prognosis

Molecular abnormalities in pediatric barrett esophagus: can we test for potential of neoplastic progression?
Maltby EL, Dyson MJ, Wheeler MR, Thomson M, Sethuraman C, Cohen MC
Pediatr Dev Pathol 2010 Jul-Aug;13(4):310-7. doi: 10.2350/09-08-0700-OA.1. PMID: 20053129
Genetic polymorphisms of microsomal epoxide hydroxylase and glutathione S-transferases M1, T1 and P1, interactions with smoking, and risk for esophageal (Barrett) adenocarcinoma.
Casson AG, Zheng Z, Porter GA, Guernsey DL
Cancer Detect Prev 2006;30(5):423-31. Epub 2006 Oct 24 doi: 10.1016/j.cdp.2006.09.005. PMID: 17064856
Intratumoral genetic heterogeneity in Barrett adenocarcinoma.
Owonikoko T, Rees M, Gabbert HE, Sarbia M
Am J Clin Pathol 2002 Apr;117(4):558-66. doi: 10.1309/6XY8-FMM5-VVCJ-T3N0. PMID: 11939730
Exclusive radical surgery for esophageal adenocarcinoma.
Collard JM
Cancer 2001 Mar 15;91(6):1098-104. PMID: 11267954
Adenocarcinoma of the esophagus with and without Barrett mucosa.
Sabel MS, Pastore K, Toon H, Smith JL
Arch Surg 2000 Jul;135(7):831-5; discussion 836. doi: 10.1001/archsurg.135.7.831. PMID: 10896378

Clinical prediction guides

Sex steroid hormones in relation to Barrett's esophagus: an analysis of the FINBAR Study.
Cook MB, Wood S, Hyland PL, Caron P, Drahos J, Falk RT, Pfeiffer RM, Dawsey SM, Abnet CC, Taylor PR, Guillemette C, Murray LJ, Anderson LA
Andrology 2017 Mar;5(2):240-247. Epub 2017 Feb 27 doi: 10.1111/andr.12314. PMID: 28241109Free PMC Article
Her-2 Expression in Gastroesophageal Intestinal Metaplasia, Dysplasia, and Adenocarcinoma.
Almhanna K, Rosa M, Henderson-Jackson E, Jiang K, Shamekh R, Sayegh Z, Malafa MP, Coppola D
Appl Immunohistochem Mol Morphol 2016 Oct;24(9):633-638. doi: 10.1097/PAI.0000000000000243. PMID: 26186253Free PMC Article
Molecular abnormalities in pediatric barrett esophagus: can we test for potential of neoplastic progression?
Maltby EL, Dyson MJ, Wheeler MR, Thomson M, Sethuraman C, Cohen MC
Pediatr Dev Pathol 2010 Jul-Aug;13(4):310-7. doi: 10.2350/09-08-0700-OA.1. PMID: 20053129
Cardiac rather than intestinal-type background in endoscopic resection specimens of minute Barrett adenocarcinoma.
Takubo K, Aida J, Naomoto Y, Sawabe M, Arai T, Shiraishi H, Matsuura M, Ell C, May A, Pech O, Stolte M, Vieth M
Hum Pathol 2009 Jan;40(1):65-74. Epub 2008 Aug 27 doi: 10.1016/j.humpath.2008.06.008. PMID: 18755496
DNA copy number profiling in esophageal Barrett adenocarcinoma: comparison with gastric adenocarcinoma and esophageal squamous cell carcinoma.
Varis A, Puolakkainen P, Savolainen H, Kokkola A, Salo J, Nieminen O, Nordling S, Knuutila S
Cancer Genet Cytogenet 2001 May;127(1):53-8. doi: 10.1016/s0165-4608(00)00423-4. PMID: 11408066

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