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Distal Esophagus Adenocarcinoma

MedGen UID:
1650160
•Concept ID:
C4726620
•
Neoplastic Process
Synonym: Adenocarcinoma of the Lower Third of the Esophagus

Definition

An adenocarcinoma arising from the lower third of the esophagus. The vast majority of esophageal adenocarcinomas involve the lower third of the esophagus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDistal Esophagus Adenocarcinoma

Professional guidelines

PubMed

Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
AGA Clinical Practice Update on New Technology and Innovation for Surveillance and Screening in Barrett's Esophagus: Expert Review.
Muthusamy VR, Wani S, Gyawali CP, Komanduri S; CGIT Barrett’s Esophagus Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 Dec;20(12):2696-2706.e1. Epub 2022 Jul 3 doi: 10.1016/j.cgh.2022.06.003. PMID: 35788412Free PMC Article
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766

Recent clinical studies

Etiology

Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
AGA Clinical Practice Update on New Technology and Innovation for Surveillance and Screening in Barrett's Esophagus: Expert Review.
Muthusamy VR, Wani S, Gyawali CP, Komanduri S; CGIT Barrett’s Esophagus Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 Dec;20(12):2696-2706.e1. Epub 2022 Jul 3 doi: 10.1016/j.cgh.2022.06.003. PMID: 35788412Free PMC Article
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Barrett's esophagus: What do we need to know?
Mohy-Ud-Din N, Krill TS, Shah AR, Chatila AT, Singh S, Bilal M, Parupudi S
Dis Mon 2020 Jan;66(1):100850. Epub 2019 Feb 23 doi: 10.1016/j.disamonth.2019.02.003. PMID: 30808502
Barrett's esophagus.
Spechler SJ
Semin Gastrointest Dis 1996 Apr;7(2):51-60. PMID: 8705259

Diagnosis

Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
Claudin-18.
Wong MT, Singhi AD, Larson BK, Huynh CAT, Balzer BL, Burch M, Dhall D, Gangi A, Gong J, Guindi M, Hendifar AE, Kim SA, de Peralta-Venturina M, Waters KM
Arch Pathol Lab Med 2022 May 1;147(5):559-567. doi: 10.5858/arpa.2021-0428-OA. PMID: 35976638
AGA Clinical Practice Update on New Technology and Innovation for Surveillance and Screening in Barrett's Esophagus: Expert Review.
Muthusamy VR, Wani S, Gyawali CP, Komanduri S; CGIT Barrett’s Esophagus Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 Dec;20(12):2696-2706.e1. Epub 2022 Jul 3 doi: 10.1016/j.cgh.2022.06.003. PMID: 35788412Free PMC Article
Barrett Esophagus.
Iyer PG, Kaul V
Mayo Clin Proc 2019 Sep;94(9):1888-1901. doi: 10.1016/j.mayocp.2019.01.032. PMID: 31486383
Barrett's esophagus.
Spechler SJ
Semin Gastrointest Dis 1996 Apr;7(2):51-60. PMID: 8705259

Therapy

Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
Claudin-18.
Wong MT, Singhi AD, Larson BK, Huynh CAT, Balzer BL, Burch M, Dhall D, Gangi A, Gong J, Guindi M, Hendifar AE, Kim SA, de Peralta-Venturina M, Waters KM
Arch Pathol Lab Med 2022 May 1;147(5):559-567. doi: 10.5858/arpa.2021-0428-OA. PMID: 35976638
AGA Clinical Practice Update on New Technology and Innovation for Surveillance and Screening in Barrett's Esophagus: Expert Review.
Muthusamy VR, Wani S, Gyawali CP, Komanduri S; CGIT Barrett’s Esophagus Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 Dec;20(12):2696-2706.e1. Epub 2022 Jul 3 doi: 10.1016/j.cgh.2022.06.003. PMID: 35788412Free PMC Article
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Barrett's esophagus: What do we need to know?
Mohy-Ud-Din N, Krill TS, Shah AR, Chatila AT, Singh S, Bilal M, Parupudi S
Dis Mon 2020 Jan;66(1):100850. Epub 2019 Feb 23 doi: 10.1016/j.disamonth.2019.02.003. PMID: 30808502

Prognosis

AGA Clinical Practice Update on New Technology and Innovation for Surveillance and Screening in Barrett's Esophagus: Expert Review.
Muthusamy VR, Wani S, Gyawali CP, Komanduri S; CGIT Barrett’s Esophagus Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 Dec;20(12):2696-2706.e1. Epub 2022 Jul 3 doi: 10.1016/j.cgh.2022.06.003. PMID: 35788412Free PMC Article
Barrett Esophagus.
Iyer PG, Kaul V
Mayo Clin Proc 2019 Sep;94(9):1888-1901. doi: 10.1016/j.mayocp.2019.01.032. PMID: 31486383
Barrett's Esophagus and Esophageal Adenocarcinoma: How Common Are They Really?
Thrift AP
Dig Dis Sci 2018 Aug;63(8):1988-1996. doi: 10.1007/s10620-018-5068-6. PMID: 29671158
Siewert III adenocarcinoma: treatment update.
Di Leo A, Zanoni A
Updates Surg 2017 Sep;69(3):319-325. Epub 2017 Mar 16 doi: 10.1007/s13304-017-0429-9. PMID: 28303519
Transthoracically or transabdominally: how to approach adenocarcinoma of the distal esophagus and cardia. A meta-analysis.
Aurello P, Magistri P, Berardi G, Petrucciani N, Sirimarco D, Antolino L, Nigri G, D'Angelo F, Ramacciato G
Tumori 2016 Aug 3;102(4):352-60. Epub 2016 May 20 doi: 10.5301/tj.5000517. PMID: 27230277

Clinical prediction guides

Facing adenocarcinoma of distal esophagus and esophagogastric junction: a CROSS versus FLOT propensity score-matched analysis of oncological outcomes in a high-volume institution.
Lombardi PM, Pansa A, Basato S, Giorgi L, Perano V, Marano S, Castoro C
Updates Surg 2023 Jun;75(4):921-930. Epub 2023 Mar 29 doi: 10.1007/s13304-023-01497-5. PMID: 36991302
AGA Clinical Practice Update on New Technology and Innovation for Surveillance and Screening in Barrett's Esophagus: Expert Review.
Muthusamy VR, Wani S, Gyawali CP, Komanduri S; CGIT Barrett’s Esophagus Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 Dec;20(12):2696-2706.e1. Epub 2022 Jul 3 doi: 10.1016/j.cgh.2022.06.003. PMID: 35788412Free PMC Article
Stomach cancer.
Bailey C
BMJ Clin Evid 2011 Mar 28;2011 PMID: 21439098Free PMC Article
Stomach cancer.
Bailey C
BMJ Clin Evid 2008 Sep 3;2008 PMID: 19445803Free PMC Article
Surgical techniques.
Lerut T, Coosemans W, Decker G, De Leyn P, Moons J, Nafteux P, Van Raemdonck D
J Surg Oncol 2005 Dec 1;92(3):218-29. doi: 10.1002/jso.20363. PMID: 16299783

Recent systematic reviews

Longitudinal and circumferential resection margin in adenocarcinoma of distal esophagus and cardia.
Migliore M, Rassl D, Criscione A
Future Oncol 2014 Apr;10(5):891-901. doi: 10.2217/fon.13.241. PMID: 24799068
Obesity, metabolic syndrome and esophageal adenocarcinoma: epidemiology, etiology and new targets.
Ryan AM, Duong M, Healy L, Ryan SA, Parekh N, Reynolds JV, Power DG
Cancer Epidemiol 2011 Aug;35(4):309-19. Epub 2011 Apr 5 doi: 10.1016/j.canep.2011.03.001. PMID: 21470937
Stomach cancer.
Bailey C
BMJ Clin Evid 2011 Mar 28;2011 PMID: 21439098Free PMC Article
Helicobacter pylori infection and Barrett's esophagus: a systematic review and meta-analysis.
Wang C, Yuan Y, Hunt RH
Am J Gastroenterol 2009 Feb;104(2):492-500; quiz 491, 501. Epub 2009 Jan 6 doi: 10.1038/ajg.2008.37. PMID: 19174811
Stomach cancer.
Bailey C
BMJ Clin Evid 2008 Sep 3;2008 PMID: 19445803Free PMC Article

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