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Prostatic acinar adenocarcinoma

MedGen UID:
231350
•Concept ID:
C1332139
•
Neoplastic Process
Synonyms: Acinar Adenocarcinoma of Prostate; acinar adenocarcinoma of prostate; Acinar Adenocarcinoma of the Prostate; acinar adenocarcinoma of the prostate; Acinar Prostate Adenocarcinoma; acinar prostate adenocarcinoma; Prostate Acinar Adenocarcinoma; prostate acinar adenocarcinoma; Prostatic Acinar Adenocarcinoma; prostatic acinar adenocarcinoma
 
Monarch Initiative: MONDO:0002493

Definition

An invasive adenocarcinoma of the prostate gland composed of secretory cells. It is the most common histologic type of prostate adenocarcinoma. Several morphologic variants exist, including atrophic, pseudohyperplastic, foamy gland, and oncocytic variants. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstatic acinar adenocarcinoma

Professional guidelines

PubMed

Ductal, intraductal, and cribriform carcinoma of the prostate: Molecular characteristics and clinical management.
Shi Y, Wang H, Golijanin B, Amin A, Lee J, Sikov M, Hyams E, Pareek G, Carneiro BA, Mega AE, Lagos GG, Wang L, Wang Z, Cheng L
Urol Oncol 2024 May;42(5):144-154. Epub 2024 Mar 13 doi: 10.1016/j.urolonc.2024.01.037. PMID: 38485644
Defining Diagnostic Criteria for Prostatic Ductal Adenocarcinoma at Multiparametric MRI.
Ranasinghe WKB, Troncoso P, Surasi DS, Ibarra Rovira JJ, Bhosale P, Szklaruk J, Kokorovic A, Wang X, Elsheshtawi M, Zhang M, Aparicio A, Chapin BF, Bathala TK
Radiology 2022 Apr;303(1):110-118. Epub 2022 Jan 25 doi: 10.1148/radiol.204732. PMID: 35076303
Optimizing the diagnosis and management of ductal prostate cancer.
Ranasinghe W, Shapiro DD, Zhang M, Bathala T, Navone N, Thompson TC, Broom B, Aparicio A, Tu SM, Tang C, Davis JW, Pisters L, Chapin BF
Nat Rev Urol 2021 Jun;18(6):337-358. Epub 2021 Apr 6 doi: 10.1038/s41585-021-00447-3. PMID: 33824525

Recent clinical studies

Etiology

Emerging Insights in Small-Cell Carcinoma of the Genitourinary Tract: From Diagnosis to Novel Therapeutic Horizons.
Liao RS, Ruan HT, Jang A, Huynh M, Nadal Rios R, Hoffman-Censits JH, Wei S, Mian OY, Barata PC
Am Soc Clin Oncol Educ Book 2024 Jan;44:e430336. doi: 10.1200/EDBK_430336. PMID: 38176691
Prostatic Ductal Adenocarcinoma Controlled for Tumor Grade, Stage, and Margin Status Does Not Independently Influence the Likelihood of Biochemical Recurrence in Localized Prostate Cancer After Radical Prostatectomy.
Kryvenko ON, Iakymenko OA, De Lima Guido LP, Bhattu AS, Merhe A, Mouzannar A, Briski LM, Oymagil I, Lugo I, Nemov I, Ritch CR, Kava BR, Punnen S, Jorda M, Parekh DJ, Gonzalgo ML
Arch Pathol Lab Med 2022 Aug 1;146(8):1012-1017. doi: 10.5858/arpa.2021-0048-OA. PMID: 34739539
Optimizing the diagnosis and management of ductal prostate cancer.
Ranasinghe W, Shapiro DD, Zhang M, Bathala T, Navone N, Thompson TC, Broom B, Aparicio A, Tu SM, Tang C, Davis JW, Pisters L, Chapin BF
Nat Rev Urol 2021 Jun;18(6):337-358. Epub 2021 Apr 6 doi: 10.1038/s41585-021-00447-3. PMID: 33824525
ERG oncoprotein expression in prostatic acinar adenocarcinoma; clinicopathologic significance.
Hashmi AA, Khan EY, Irfan M, Ali R, Asif H, Naeem M, Nisar L, Faridi N, Khan A, Edhi MM
BMC Res Notes 2019 Jan 18;12(1):35. doi: 10.1186/s13104-019-4090-x. PMID: 30658688Free PMC Article
Updates on Grading and Staging of Prostate Cancer.
Braunhut BL, Punnen S, Kryvenko ON
Surg Pathol Clin 2018 Dec;11(4):759-774. doi: 10.1016/j.path.2018.07.003. PMID: 30447840

Diagnosis

Prostate Pathology: What is New in the 2022 WHO Classification of Urinary and Male Genital Tumors?
Surintrspanont J, Zhou M
Pathologica 2022 Feb;115(1):41-56. Epub 2023 Jan 16 doi: 10.32074/1591-951X-822. PMID: 36645399Free PMC Article
Defining Diagnostic Criteria for Prostatic Ductal Adenocarcinoma at Multiparametric MRI.
Ranasinghe WKB, Troncoso P, Surasi DS, Ibarra Rovira JJ, Bhosale P, Szklaruk J, Kokorovic A, Wang X, Elsheshtawi M, Zhang M, Aparicio A, Chapin BF, Bathala TK
Radiology 2022 Apr;303(1):110-118. Epub 2022 Jan 25 doi: 10.1148/radiol.204732. PMID: 35076303
Optimizing the diagnosis and management of ductal prostate cancer.
Ranasinghe W, Shapiro DD, Zhang M, Bathala T, Navone N, Thompson TC, Broom B, Aparicio A, Tu SM, Tang C, Davis JW, Pisters L, Chapin BF
Nat Rev Urol 2021 Jun;18(6):337-358. Epub 2021 Apr 6 doi: 10.1038/s41585-021-00447-3. PMID: 33824525
Prostate Ductal Adenocarcinoma.
Amin A
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):514-521. doi: 10.1097/PAI.0000000000000508. PMID: 28362706
Models of neuroendocrine prostate cancer.
Berman-Booty LD, Knudsen KE
Endocr Relat Cancer 2015 Feb;22(1):R33-49. Epub 2014 Oct 27 doi: 10.1530/ERC-14-0393. PMID: 25349195Free PMC Article

Therapy

Feasibility study of ADCs targeting TROP-2, HER2, and CD46 in Ductal Adenocarcinoma and Intraductal Carcinoma of the prostate.
Wang X, Qi L, Chen M, Zhang Y, Gao X, Cai Y
World J Urol 2024 Jul 11;42(1):404. doi: 10.1007/s00345-024-05109-8. PMID: 38990246
Emerging Insights in Small-Cell Carcinoma of the Genitourinary Tract: From Diagnosis to Novel Therapeutic Horizons.
Liao RS, Ruan HT, Jang A, Huynh M, Nadal Rios R, Hoffman-Censits JH, Wei S, Mian OY, Barata PC
Am Soc Clin Oncol Educ Book 2024 Jan;44:e430336. doi: 10.1200/EDBK_430336. PMID: 38176691
Prostatic ductal adenocarcinoma variant predicts worse pathological and oncological outcomes: Insight from over 1000 consecutive patients from a large prospective uro-oncology registry.
Tan YG, Khalid F, Huang HH, Chen K, Tay KJ, Lau WKO, Cheng CWS, Ngo NT, Yuen JSP
Prostate 2021 Mar;81(4):242-251. Epub 2021 Jan 11 doi: 10.1002/pros.24100. PMID: 33428259
Pigs in a blanket: an unusual presentation of malignant ascites in prostatic adenocarcinoma.
Samankan S, Taherian M, Aghighi M, Crossland D
BMJ Case Rep 2019 Nov 14;12(11) doi: 10.1136/bcr-2019-230899. PMID: 31732542Free PMC Article

Prognosis

Prostate Pathology: What is New in the 2022 WHO Classification of Urinary and Male Genital Tumors?
Surintrspanont J, Zhou M
Pathologica 2022 Feb;115(1):41-56. Epub 2023 Jan 16 doi: 10.32074/1591-951X-822. PMID: 36645399Free PMC Article
Optimizing the diagnosis and management of ductal prostate cancer.
Ranasinghe W, Shapiro DD, Zhang M, Bathala T, Navone N, Thompson TC, Broom B, Aparicio A, Tu SM, Tang C, Davis JW, Pisters L, Chapin BF
Nat Rev Urol 2021 Jun;18(6):337-358. Epub 2021 Apr 6 doi: 10.1038/s41585-021-00447-3. PMID: 33824525
ERG oncoprotein expression in prostatic acinar adenocarcinoma; clinicopathologic significance.
Hashmi AA, Khan EY, Irfan M, Ali R, Asif H, Naeem M, Nisar L, Faridi N, Khan A, Edhi MM
BMC Res Notes 2019 Jan 18;12(1):35. doi: 10.1186/s13104-019-4090-x. PMID: 30658688Free PMC Article
Updates on Grading and Staging of Prostate Cancer.
Braunhut BL, Punnen S, Kryvenko ON
Surg Pathol Clin 2018 Dec;11(4):759-774. doi: 10.1016/j.path.2018.07.003. PMID: 30447840
Prostate Ductal Adenocarcinoma.
Amin A
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):514-521. doi: 10.1097/PAI.0000000000000508. PMID: 28362706

Clinical prediction guides

Defining Diagnostic Criteria for Prostatic Ductal Adenocarcinoma at Multiparametric MRI.
Ranasinghe WKB, Troncoso P, Surasi DS, Ibarra Rovira JJ, Bhosale P, Szklaruk J, Kokorovic A, Wang X, Elsheshtawi M, Zhang M, Aparicio A, Chapin BF, Bathala TK
Radiology 2022 Apr;303(1):110-118. Epub 2022 Jan 25 doi: 10.1148/radiol.204732. PMID: 35076303
Prostatic Ductal Adenocarcinoma Controlled for Tumor Grade, Stage, and Margin Status Does Not Independently Influence the Likelihood of Biochemical Recurrence in Localized Prostate Cancer After Radical Prostatectomy.
Kryvenko ON, Iakymenko OA, De Lima Guido LP, Bhattu AS, Merhe A, Mouzannar A, Briski LM, Oymagil I, Lugo I, Nemov I, Ritch CR, Kava BR, Punnen S, Jorda M, Parekh DJ, Gonzalgo ML
Arch Pathol Lab Med 2022 Aug 1;146(8):1012-1017. doi: 10.5858/arpa.2021-0048-OA. PMID: 34739539
Multiple Origin and Tumor Heterogeneity of Prostatic Ductal Adenocarcinoma in the Han Chinese Population.
Zhang W, Su F, Wang M, Hou H, Liu M, Liu D, Liu H
Genet Test Mol Biomarkers 2021 Nov;25(11):727-732. doi: 10.1089/gtmb.2021.0126. PMID: 34788144
ERG oncoprotein expression in prostatic acinar adenocarcinoma; clinicopathologic significance.
Hashmi AA, Khan EY, Irfan M, Ali R, Asif H, Naeem M, Nisar L, Faridi N, Khan A, Edhi MM
BMC Res Notes 2019 Jan 18;12(1):35. doi: 10.1186/s13104-019-4090-x. PMID: 30658688Free PMC Article
Models of neuroendocrine prostate cancer.
Berman-Booty LD, Knudsen KE
Endocr Relat Cancer 2015 Feb;22(1):R33-49. Epub 2014 Oct 27 doi: 10.1530/ERC-14-0393. PMID: 25349195Free PMC Article

Recent systematic reviews

The Association of Invasive Cribriform Lesions With Adverse Prostatic Adenocarcinoma Outcomes: An Institutional Experience, Systematic Review, and Meta-analysis.
Luo X, Khurana JS, Jhala N, Zhao H, Wang H
Arch Pathol Lab Med 2019 Aug;143(8):1012-1021. Epub 2019 Feb 1 doi: 10.5858/arpa.2017-0582-RA. PMID: 30702333

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