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Childhood Chronic Myeloid Leukemia, BCR-ABL1 Positive

MedGen UID:
233004
•Concept ID:
C1327920
•
Neoplastic Process
Synonyms: Childhood Chronic Myelogenous Leukemia; Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Childhood Chronic Myelogenous Leukemia, BCR::ABL1 Positive; Childhood Chronic Myeloid Leukemia; Childhood Chronic Myeloid Leukemia, BCR::ABL1 Positive; Childhood CML

Definition

A chronic myeloid leukemia, BCR-ABL1 positive occurring during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood Chronic Myeloid Leukemia, BCR-ABL1 Positive

Professional guidelines

PubMed

Optimal management for pediatric chronic myeloid leukemia.
Tanizawa A
Pediatr Int 2016 Mar;58(3):171-179. doi: 10.1111/ped.12876. PMID: 26646444
Treatment-free remission after imatinib discontinuation is possible in paediatric patients with chronic myeloid leukaemia.
Giona F, Saglio G, Moleti ML, Piciocchi A, Rea M, Nanni M, Marzella D, Testi AM, Mariani S, Laurino M, Diverio D, Gottardi E, Foà R
Br J Haematol 2015 Jan;168(2):305-8. Epub 2014 Aug 27 doi: 10.1111/bjh.13103. PMID: 25160793
Managing children with chronic myeloid leukaemia (CML): recommendations for the management of CML in children and young people up to the age of 18 years.
de la Fuente J, Baruchel A, Biondi A, de Bont E, Dresse MF, Suttorp M, Millot F; International BFM Group (iBFM) Study Group Chronic Myeloid Leukaemia Committee
Br J Haematol 2014 Oct;167(1):33-47. Epub 2014 Jun 30 doi: 10.1111/bjh.12977. PMID: 24976289

Recent clinical studies

Etiology

Chronic Myeloid Leukemia in Children and Adolescents.
Gotesman M, Raheel S, Panosyan EH
Adv Pediatr 2023 Aug;70(1):145-155. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.002. PMID: 37422292
Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease.
Zuna J, Hovorkova L, Krotka J, Koehrmann A, Bardini M, Winkowska L, Fronkova E, Alten J, Koehler R, Eckert C, Brizzolara L, Trkova M, Stuchly J, Zimmermann M, De Lorenzo P, Valsecchi MG, Conter V, Stary J, Schrappe M, Biondi A, Trka J, Zaliova M, Cazzaniga G, Cario G
Leukemia 2022 Dec;36(12):2793-2801. Epub 2022 Aug 6 doi: 10.1038/s41375-022-01668-0. PMID: 35933523
Genetic Heterogeneity in Chronic Myeloid Leukemia: How Clonal Hematopoiesis and Clonal Evolution May Influence Prognosis, Treatment Outcome, and Risk of Cardiovascular Events.
Sant'Antonio E, Camerini C, Rizzo V, Musolino C, Allegra A
Clin Lymphoma Myeloma Leuk 2021 Sep;21(9):573-579. Epub 2021 Apr 29 doi: 10.1016/j.clml.2021.04.014. PMID: 34078586
Prospective assessment of NGS-detectable mutations in CML patients with nonoptimal response: the NEXT-in-CML study.
Soverini S, Bavaro L, De Benedittis C, Martelli M, Iurlo A, Orofino N, Sica S, Sorà F, Lunghi F, Ciceri F, Galimberti S, Baratè C, Bonifacio M, Scaffidi L, Castagnetti F, Gugliotta G, Albano F, Russo Rossi AV, Stagno F, di Raimondo F, D'Adda M, di Bona E, Abruzzese E, Binotto G, Sancetta R, Salvucci M, Capodanno I, Girasoli M, Coluzzi S, Attolico I, Musolino C, Calistri E, Annunziata M, Bocchia M, Stella S, Serra A, Errichiello S, Saglio G, Pane F, Vigneri P, Mignone F, Laginestra MA, Pileri SA, Percesepe A, Tenti E, Rosti G, Baccarani M, Cavo M, Martinelli G
Blood 2020 Feb 20;135(8):534-541. doi: 10.1182/blood.2019002969. PMID: 31877211
Managing children with chronic myeloid leukaemia (CML): recommendations for the management of CML in children and young people up to the age of 18 years.
de la Fuente J, Baruchel A, Biondi A, de Bont E, Dresse MF, Suttorp M, Millot F; International BFM Group (iBFM) Study Group Chronic Myeloid Leukaemia Committee
Br J Haematol 2014 Oct;167(1):33-47. Epub 2014 Jun 30 doi: 10.1111/bjh.12977. PMID: 24976289

Diagnosis

Chronic Myeloid Leukemia in Children and Adolescents.
Gotesman M, Raheel S, Panosyan EH
Adv Pediatr 2023 Aug;70(1):145-155. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.002. PMID: 37422292
Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease.
Zuna J, Hovorkova L, Krotka J, Koehrmann A, Bardini M, Winkowska L, Fronkova E, Alten J, Koehler R, Eckert C, Brizzolara L, Trkova M, Stuchly J, Zimmermann M, De Lorenzo P, Valsecchi MG, Conter V, Stary J, Schrappe M, Biondi A, Trka J, Zaliova M, Cazzaniga G, Cario G
Leukemia 2022 Dec;36(12):2793-2801. Epub 2022 Aug 6 doi: 10.1038/s41375-022-01668-0. PMID: 35933523
Characterization of leukemias with ETV6-ABL1 fusion.
Zaliova M, Moorman AV, Cazzaniga G, Stanulla M, Harvey RC, Roberts KG, Heatley SL, Loh ML, Konopleva M, Chen IM, Zimmermannova O, Schwab C, Smith O, Mozziconacci MJ, Chabannon C, Kim M, Frederik Falkenburg JH, Norton A, Marshall K, Haas OA, Starkova J, Stuchly J, Hunger SP, White D, Mullighan CG, Willman CL, Stary J, Trka J, Zuna J
Haematologica 2016 Sep;101(9):1082-93. Epub 2016 May 26 doi: 10.3324/haematol.2016.144345. PMID: 27229714Free PMC Article
Optimal management for pediatric chronic myeloid leukemia.
Tanizawa A
Pediatr Int 2016 Mar;58(3):171-179. doi: 10.1111/ped.12876. PMID: 26646444
Genes and childhood leukemia.
Kęsy J, Januszkiewicz-Lewandowska D
Postepy Hig Med Dosw (Online) 2015 Mar 5;69:302-8. doi: 10.5604/17322693.1142719. PMID: 25748621

Therapy

Chronic Myeloid Leukemia in Children and Adolescents.
Gotesman M, Raheel S, Panosyan EH
Adv Pediatr 2023 Aug;70(1):145-155. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.002. PMID: 37422292
Prospective assessment of NGS-detectable mutations in CML patients with nonoptimal response: the NEXT-in-CML study.
Soverini S, Bavaro L, De Benedittis C, Martelli M, Iurlo A, Orofino N, Sica S, Sorà F, Lunghi F, Ciceri F, Galimberti S, Baratè C, Bonifacio M, Scaffidi L, Castagnetti F, Gugliotta G, Albano F, Russo Rossi AV, Stagno F, di Raimondo F, D'Adda M, di Bona E, Abruzzese E, Binotto G, Sancetta R, Salvucci M, Capodanno I, Girasoli M, Coluzzi S, Attolico I, Musolino C, Calistri E, Annunziata M, Bocchia M, Stella S, Serra A, Errichiello S, Saglio G, Pane F, Vigneri P, Mignone F, Laginestra MA, Pileri SA, Percesepe A, Tenti E, Rosti G, Baccarani M, Cavo M, Martinelli G
Blood 2020 Feb 20;135(8):534-541. doi: 10.1182/blood.2019002969. PMID: 31877211
Pharmacology and pharmacokinetics of imatinib in pediatric patients.
Suttorp M, Bornhäuser M, Metzler M, Millot F, Schleyer E
Expert Rev Clin Pharmacol 2018 Mar;11(3):219-231. Epub 2017 Nov 6 doi: 10.1080/17512433.2018.1398644. PMID: 29076384
Long-term results of high-dose imatinib in children and adolescents with chronic myeloid leukaemia in chronic phase: the Italian experience.
Giona F, Putti MC, Micalizzi C, Menna G, Moleti ML, Santoro N, Iaria G, Ladogana S, Burnelli R, Consarino C, Varotto S, Tucci F, Messina C, Nanni M, Diverio D, Biondi A, Pession A, Locatelli F, Piciocchi A, Gottardi E, Saglio G, Foà R
Br J Haematol 2015 Aug;170(3):398-407. Epub 2015 Apr 20 doi: 10.1111/bjh.13453. PMID: 25891192
Sustained complete molecular remission after imatinib discontinuation in children with chronic myeloid leukemia.
Moser O, Krumbholz M, Thiede C, Tauer JT, Janz I, Lauten M, Dilloo D, Metzler M, Suttorp M
Pediatr Blood Cancer 2014 Nov;61(11):2080-2. Epub 2014 May 9 doi: 10.1002/pbc.25090. PMID: 24810322

Prognosis

Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease.
Zuna J, Hovorkova L, Krotka J, Koehrmann A, Bardini M, Winkowska L, Fronkova E, Alten J, Koehler R, Eckert C, Brizzolara L, Trkova M, Stuchly J, Zimmermann M, De Lorenzo P, Valsecchi MG, Conter V, Stary J, Schrappe M, Biondi A, Trka J, Zaliova M, Cazzaniga G, Cario G
Leukemia 2022 Dec;36(12):2793-2801. Epub 2022 Aug 6 doi: 10.1038/s41375-022-01668-0. PMID: 35933523
Genetic Heterogeneity in Chronic Myeloid Leukemia: How Clonal Hematopoiesis and Clonal Evolution May Influence Prognosis, Treatment Outcome, and Risk of Cardiovascular Events.
Sant'Antonio E, Camerini C, Rizzo V, Musolino C, Allegra A
Clin Lymphoma Myeloma Leuk 2021 Sep;21(9):573-579. Epub 2021 Apr 29 doi: 10.1016/j.clml.2021.04.014. PMID: 34078586
Characterization of leukemias with ETV6-ABL1 fusion.
Zaliova M, Moorman AV, Cazzaniga G, Stanulla M, Harvey RC, Roberts KG, Heatley SL, Loh ML, Konopleva M, Chen IM, Zimmermannova O, Schwab C, Smith O, Mozziconacci MJ, Chabannon C, Kim M, Frederik Falkenburg JH, Norton A, Marshall K, Haas OA, Starkova J, Stuchly J, Hunger SP, White D, Mullighan CG, Willman CL, Stary J, Trka J, Zuna J
Haematologica 2016 Sep;101(9):1082-93. Epub 2016 May 26 doi: 10.3324/haematol.2016.144345. PMID: 27229714Free PMC Article
Genes and childhood leukemia.
Kęsy J, Januszkiewicz-Lewandowska D
Postepy Hig Med Dosw (Online) 2015 Mar 5;69:302-8. doi: 10.5604/17322693.1142719. PMID: 25748621
Managing children with chronic myeloid leukaemia (CML): recommendations for the management of CML in children and young people up to the age of 18 years.
de la Fuente J, Baruchel A, Biondi A, de Bont E, Dresse MF, Suttorp M, Millot F; International BFM Group (iBFM) Study Group Chronic Myeloid Leukaemia Committee
Br J Haematol 2014 Oct;167(1):33-47. Epub 2014 Jun 30 doi: 10.1111/bjh.12977. PMID: 24976289

Clinical prediction guides

Minimal residual disease in BCR::ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease.
Zuna J, Hovorkova L, Krotka J, Koehrmann A, Bardini M, Winkowska L, Fronkova E, Alten J, Koehler R, Eckert C, Brizzolara L, Trkova M, Stuchly J, Zimmermann M, De Lorenzo P, Valsecchi MG, Conter V, Stary J, Schrappe M, Biondi A, Trka J, Zaliova M, Cazzaniga G, Cario G
Leukemia 2022 Dec;36(12):2793-2801. Epub 2022 Aug 6 doi: 10.1038/s41375-022-01668-0. PMID: 35933523
Genetic Heterogeneity in Chronic Myeloid Leukemia: How Clonal Hematopoiesis and Clonal Evolution May Influence Prognosis, Treatment Outcome, and Risk of Cardiovascular Events.
Sant'Antonio E, Camerini C, Rizzo V, Musolino C, Allegra A
Clin Lymphoma Myeloma Leuk 2021 Sep;21(9):573-579. Epub 2021 Apr 29 doi: 10.1016/j.clml.2021.04.014. PMID: 34078586
Monitoring of childhood ALL using BCR-ABL1 genomic breakpoints identifies a subgroup with CML-like biology.
Hovorkova L, Zaliova M, Venn NC, Bleckmann K, Trkova M, Potuckova E, Vaskova M, Linhartova J, Machova Polakova K, Fronkova E, Muskovic W, Giles JE, Shaw PJ, Cario G, Sutton R, Stary J, Trka J, Zuna J
Blood 2017 May 18;129(20):2771-2781. Epub 2017 Mar 22 doi: 10.1182/blood-2016-11-749978. PMID: 28331056

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