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Soft tissue chondroma

MedGen UID:
266157
•Concept ID:
C1275277
•
Neoplastic Process
Synonyms: Chondroma of Soft Parts; chondroma of soft parts; Extraskeletal Chondroma; extraskeletal chondroma; Extraskeletal Osteochondroma; extraskeletal osteochondroma; Soft Tissue Chondroma; soft tissue chondroma
SNOMED CT: Soft tissue chondroma (404078000)
 
Monarch Initiative: MONDO:0006423

Definition

A benign neoplasm arising from the extraskeletal soft tissues near tendons and joints. It is a well circumscribed tumor characterized by the presence of chondrocytes, a lobulated hyaline cartilage growth pattern, and in some cases calcification. [from NCI]

Professional guidelines

PubMed

MR imaging of the forefoot: Morton neuroma and differential diagnoses.
Zanetti M, Weishaupt D
Semin Musculoskelet Radiol 2005 Sep;9(3):175-86. doi: 10.1055/s-2005-921938. PMID: 16247719

Recent clinical studies

Etiology

Comprehensive Molecular Characterization of a Large Series of Calcified Chondroid Mesenchymal Neoplasms Widening Their Morphologic Spectrum.
Benard C, Le Loarer F, Gomez-Mascard A, Azmani R, Garcia J, Perret R, de Pinieux G, Miquelestorena-Standley E, Weingertner N, Karanian M, Meurgey A, Michot A, Tirode F, Truffaux N, Macagno N, Bouvier C
Am J Surg Pathol 2024 Aug 1;48(8):991-1004. Epub 2024 Aug 15 doi: 10.1097/PAS.0000000000002260. PMID: 39016330
The distribution of chondromas: Why the hand?
Nazarova NZ, Umarova GS, Vaiman M, Abba M, Foonberg M, Mametov K, Shterenshis M
Med Hypotheses 2020 Oct;143:110132. Epub 2020 Jul 23 doi: 10.1016/j.mehy.2020.110132. PMID: 32759011
MRI Findings of Giant Cell Tumor of Tendon Sheath and Other Benign Soft Tissue Tumors in Hand.
Thammaroj P, Chowchuen P, Sumananont C, Nasang T
J Med Assoc Thai 2016 Jul;99(7):816-22. PMID: 29901913
Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group.
Tallini G, Dorfman H, Brys P, Dal Cin P, De Wever I, Fletcher CD, Jonson K, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Samson I, Sciot R, Van den Berghe H, Vanni R, Willén H
J Pathol 2002 Feb;196(2):194-203. doi: 10.1002/path.1023. PMID: 11793371
Extraskeletal chondromas.
Marcial-Seoane RA, Marcial-Seoane MA, Ramos E, Marcial-Rojas RA
Bol Asoc Med P R 1990 Sep;82(9):394-402. PMID: 2076144

Diagnosis

Calcified Chondroid Mesenchymal Neoplasms.
Kao EY, Chen EY
Surg Pathol Clin 2024 Mar;17(1):77-82. Epub 2023 Aug 1 doi: 10.1016/j.path.2023.06.006. PMID: 38278609
Soft Tissue Chondroma of the Chin.
Kim SR, An S, Lee JY
J Craniofac Surg 2023 Jul-Aug 01;34(5):e501-e503. Epub 2023 May 22 doi: 10.1097/SCS.0000000000009375. PMID: 37220670
Calcified chondroid mesenchymal neoplasms with FN1-receptor tyrosine kinase gene fusions including FGFR2, FGFR1, MERTK, NTRK1, and TEK: a molecular and clinicopathologic analysis.
Liu YJ, Wang W, Yeh J, Wu Y, Mantilla JG, Fletcher CDM, Ricciotti RW, Chen EY
Mod Pathol 2021 Jul;34(7):1373-1383. Epub 2021 Mar 16 doi: 10.1038/s41379-021-00786-x. PMID: 33727696
Soft-tissue chondroma.
Gentles C, Perin J, Berrey H, Griffiths HJ
Orthopedics 2007 Mar;30(3):180, 241-3. doi: 10.3928/01477447-20070301-13. PMID: 17375540
Extraskeletal chondromas.
Marcial-Seoane RA, Marcial-Seoane MA, Ramos E, Marcial-Rojas RA
Bol Asoc Med P R 1990 Sep;82(9):394-402. PMID: 2076144

Therapy

Rare case of bladder chondroma causing lower urinary tract symptoms.
Ngweso S, Mukhtar S, Forrest C, Mander J
BMJ Case Rep 2019 Jan 18;12(1) doi: 10.1136/bcr-2018-227006. PMID: 30661043Free PMC Article
Cytogenetic findings in 14 benign cartilaginous neoplasms.
Sakai Junior N, Abe KT, Formigli LM, Pereira MF, de Oliveira MD, Cornelio DA, de La Roque Ferreira A, Kalil RK
Cancer Genet 2011 Apr;204(4):180-6. doi: 10.1016/j.cancergen.2011.02.004. PMID: 21536235
Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group.
Tallini G, Dorfman H, Brys P, Dal Cin P, De Wever I, Fletcher CD, Jonson K, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Samson I, Sciot R, Van den Berghe H, Vanni R, Willén H
J Pathol 2002 Feb;196(2):194-203. doi: 10.1002/path.1023. PMID: 11793371

Prognosis

ERG expression in chondrogenic bone and soft tissue tumours.
Shon W, Folpe AL, Fritchie KJ
J Clin Pathol 2015 Feb;68(2):125-9. Epub 2014 Nov 5 doi: 10.1136/jclinpath-2014-202601. PMID: 25378537
A case of congenital soft tissue chondroma.
Ryu JH, Park EJ, Kim KH, Kim KJ
J Dermatol 2005 Mar;32(3):214-6. doi: 10.1111/j.1346-8138.2005.tb00748.x. PMID: 15863870
Correlation between clinicopathological features and karyotype in 100 cartilaginous and chordoid tumours. A report from the Chromosomes and Morphology (CHAMP) Collaborative Study Group.
Tallini G, Dorfman H, Brys P, Dal Cin P, De Wever I, Fletcher CD, Jonson K, Mandahl N, Mertens F, Mitelman F, Rosai J, Rydholm A, Samson I, Sciot R, Van den Berghe H, Vanni R, Willén H
J Pathol 2002 Feb;196(2):194-203. doi: 10.1002/path.1023. PMID: 11793371

Clinical prediction guides

Imaging characteristics of slow-growing soft tissue chondroma of the tongue: A case report.
Park Y, Kim HY, Yu IK, Jang DS, Kim JH
Medicine (Baltimore) 2022 May 13;101(19):e29276. doi: 10.1097/MD.0000000000029276. PMID: 35583538Free PMC Article
Soft-Tissue Chondroma in the Right Hallux: A Case Report.
Hao X, Yim J, Qi C, Mirkin G
J Am Podiatr Med Assoc 2019 Nov;109(6):451-454. doi: 10.7547/18-047. PMID: 31755773
Synovial chondromatosis and soft tissue chondroma: extraosseous cartilaginous tumor defined by FN1 gene rearrangement.
Amary F, Perez-Casanova L, Ye H, Cottone L, Strobl AC, Cool P, Miranda E, Berisha F, Aston W, Rocha M, O'Donnell P, Pillay N, Tirabosco R, Baumhoer D, Hookway ES, Flanagan AM
Mod Pathol 2019 Dec;32(12):1762-1771. Epub 2019 Jul 4 doi: 10.1038/s41379-019-0315-8. PMID: 31273315Free PMC Article
Soft Tissue Chondroma of the Eyelid.
Aseem F, Pace ST, Onajin O, Sangueza OP, Yeatts RP
Ophthalmic Plast Reconstr Surg 2018 Sep/Oct;34(5):e168-e170. doi: 10.1097/IOP.0000000000001199. PMID: 30124612
ERG expression in chondrogenic bone and soft tissue tumours.
Shon W, Folpe AL, Fritchie KJ
J Clin Pathol 2015 Feb;68(2):125-9. Epub 2014 Nov 5 doi: 10.1136/jclinpath-2014-202601. PMID: 25378537

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