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Testicular Germ Cell Neoplasia In Situ

MedGen UID:
690124
•Concept ID:
C1266157
•
Neoplastic Process
Synonyms: Gonocytoma In Situ; Intratubular germ cell neoplasia; Intratubular malignant germ cells; Testicular Intraepithelial Neoplasia; Testicular Intratubular Germ Cell Neoplasia; Testicular Intratubular Germ Cell Neoplasia of the Unclassified Type; Testicular Intratubular Germ Cell Neoplasia of Unclassified Type
SNOMED CT: Intratubular germ cell neoplasia (128902002); Intratubular malignant germ cells (128902002)

Definition

A non-invasive lesion of the testis, characterized by the presence of malignant large germ cells with abundant cytoplasm in the seminiferous tubules. It may be associated with undescended or atrophic testis and infertility. The vast majority of cases progress to invasive germ cell tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Germ Cell Neoplasia In Situ

Professional guidelines

PubMed

Diagnosis and Management of Intratubular Germ Cell Neoplasia In Situ: A Systematic Review.
Gupta M, Cheaib JG, Patel HD, Sharma R, Zhang A, Bass EB, Pierorazio PM
J Urol 2020 Jul;204(1):33-41. Epub 2020 Jan 22 doi: 10.1097/JU.0000000000000758. PMID: 31967523

Recent clinical studies

Etiology

The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM
Eur Urol 2016 Jul;70(1):93-105. Epub 2016 Feb 28 doi: 10.1016/j.eururo.2016.02.029. PMID: 26935559
Testicular germ cell tumors.
Looijenga LH
Pediatr Endocrinol Rev 2014 Feb;11 Suppl 2:251-62. PMID: 24683949

Diagnosis

Spermatocytic Tumor: A Review.
Secondino S, Viglio A, Neri G, Galli G, Faverio C, Mascaro F, Naspro R, Rosti G, Pedrazzoli P
Int J Mol Sci 2023 May 31;24(11) doi: 10.3390/ijms24119529. PMID: 37298487Free PMC Article
The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
An introduction to the WHO 5th edition 2022 classification of testicular tumours.
Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251

Therapy

Subsets of preoperative sex hormones in testicular germ cell cancer: a retrospective multicenter study.
Törzsök P, Oswald D, Dieckmann KP, Angerer M, Scherer LC, Tymoszuk P, Kunz Y, Pinggera GM, Lusuardi L, Horninger W, Pichler R
Sci Rep 2023 Sep 5;13(1):14604. doi: 10.1038/s41598-023-41915-7. PMID: 37669975Free PMC Article
The relationship between testicular tumour characteristics and azoospermia: a systematic review.
Pang KH, Osman NI, Muneer A, Alnajjar HM
Int J Impot Res 2022 Sep;34(6):543-551. Epub 2021 Nov 6 doi: 10.1038/s41443-021-00492-x. PMID: 34743192
Current knowledge of risk factors for testicular germ cell tumors.
Fukawa T, Kanayama HO
Int J Urol 2018 Apr;25(4):337-344. Epub 2018 Jan 17 doi: 10.1111/iju.13519. PMID: 29345008
Biomarkers of chemotherapy-induced testicular damage.
Dere E, Anderson LM, Hwang K, Boekelheide K
Fertil Steril 2013 Nov;100(5):1192-202. doi: 10.1016/j.fertnstert.2013.09.017. PMID: 24182554Free PMC Article
Germ cell cancer.
Oliver RT
Curr Opin Oncol 1999 May;11(3):236-41. doi: 10.1097/00001622-199905000-00017. PMID: 10328600

Prognosis

Spermatocytic Tumor: A Review.
Secondino S, Viglio A, Neri G, Galli G, Faverio C, Mascaro F, Naspro R, Rosti G, Pedrazzoli P
Int J Mol Sci 2023 May 31;24(11) doi: 10.3390/ijms24119529. PMID: 37298487Free PMC Article
An introduction to the WHO 5th edition 2022 classification of testicular tumours.
Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Testicular germ cell tumors.
Looijenga LH
Pediatr Endocrinol Rev 2014 Feb;11 Suppl 2:251-62. PMID: 24683949

Clinical prediction guides

The Role of miRNA in Testicular Cancer: Current Insights and Future Perspectives.
Ditonno F, Franco A, Manfredi C, Fasanella D, Abate M, La Rocca R, Crocerossa F, Iossa V, Falagario UG, Cirillo L, Altieri VM, Di Mauro E, Crocetto F, Barone B, Cilio S, Pandolfo SD, Aveta A, Mirone V, Franzese CA, Arcaniolo D, Napolitano L
Medicina (Kaunas) 2023 Nov 17;59(11) doi: 10.3390/medicina59112033. PMID: 38004082Free PMC Article
Testicular cancer in mice: interplay between stem cells and endocrine insults.
Kaushik A, Bhartiya D
Stem Cell Res Ther 2022 Jun 8;13(1):243. doi: 10.1186/s13287-022-02784-5. PMID: 35676718Free PMC Article
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Biomarkers of chemotherapy-induced testicular damage.
Dere E, Anderson LM, Hwang K, Boekelheide K
Fertil Steril 2013 Nov;100(5):1192-202. doi: 10.1016/j.fertnstert.2013.09.017. PMID: 24182554Free PMC Article
Testicular cancer.
Oliver T, Mead G
Curr Opin Oncol 1993 May;5(3):559-67. doi: 10.1097/00001622-199305000-00018. PMID: 8388258

Recent systematic reviews

Steroidogenic acute regulatory protein (STAR) deficiency: Our experience and systematic review for phenotype-genotype correlation.
Phadte A, Dhole C, Hegishte S, Sarathi V, Lila A, Gada JV, Memon SS, Arya S, Karlekar M, Patil V, Varthakavi PK, Shah N, Bhagwat NM, Bandgar T
Clin Endocrinol (Oxf) 2024 May;100(5):431-440. Epub 2024 Feb 18 doi: 10.1111/cen.15032. PMID: 38368602
Testis-sparing Surgery in Adult Patients with Germ Cell Tumors: Systematic Search of the Literature and Focused Review.
Heidenreich A, Seelemeyer F, Altay B, Laguna MP
Eur Urol Focus 2023 Mar;9(2):244-247. Epub 2022 Nov 21 doi: 10.1016/j.euf.2022.11.001. PMID: 36418210
Oncological and functional outcomes after testis-sparing surgery in patients with germ cell tumors: a systematic review of 285 cases.
Grogg JB, Dursun ZH, Beyer J, Eberli D, Poyet C, Hermanns T, Fankhauser CD
World J Urol 2022 Sep;40(9):2293-2303. Epub 2022 Jul 12 doi: 10.1007/s00345-022-04048-6. PMID: 35821265Free PMC Article
The relationship between testicular tumour characteristics and azoospermia: a systematic review.
Pang KH, Osman NI, Muneer A, Alnajjar HM
Int J Impot Res 2022 Sep;34(6):543-551. Epub 2021 Nov 6 doi: 10.1038/s41443-021-00492-x. PMID: 34743192
Diagnosis and Management of Intratubular Germ Cell Neoplasia In Situ: A Systematic Review.
Gupta M, Cheaib JG, Patel HD, Sharma R, Zhang A, Bass EB, Pierorazio PM
J Urol 2020 Jul;204(1):33-41. Epub 2020 Jan 22 doi: 10.1097/JU.0000000000000758. PMID: 31967523

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