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Myofibroma

MedGen UID:
220420
Concept ID:
C1266121
Neoplastic Process
Synonym: Myofibromas
SNOMED CT: Myofibroma (128917003); Myofibroma (1290943000)
 
Monarch Initiative: MONDO:0006312

Definition

A benign, localized, nodular and well-circumscribed neoplasm usually seen as a congenital neoplasm or in the first year of life. It is characterized by a biphasic growth pattern and is composed of small, undifferentiated mesenchymal cells associated with branching thin-walled vessels and more mature neoplastic spindle cells with abundant eosinophilic cytoplasm in a collagenous stroma. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Carruthers V, Barnett S, Rees R, Arif T, Slater O, Ramanujachar R, Johnson K, Brown S, Graham C, Burke GAA, Veal GJ
Pediatr Blood Cancer 2022 Jul;69(7):e29722. Epub 2022 Apr 20 doi: 10.1002/pbc.29722. PMID: 35441483
Goldstein JA, Cates JM
Adv Anat Pathol 2015 Jul;22(4):260-6. doi: 10.1097/PAP.0000000000000077. PMID: 26050263
Günther T, Schreiber C, Noebauer C, Eicken A, Lange R
Pediatr Cardiol 2008 Nov;29(6):1071-6. Epub 2008 Jul 4 doi: 10.1007/s00246-008-9256-6. PMID: 18600370

Recent clinical studies

Etiology

Souza LL, Fonseca FP, Cáceres CV, Soares CD, Gurgel AD, Rebelo Pontes HA, Corrêa Pontes FS, Paradela CA, Correia-Neto IJ, Kalinin Y, Lopes MA, Santos-Silva AR, Almeida OP, Vargas PA, Robinson L, van-Heerden WF
Med Oral Patol Oral Cir Bucal 2024 Nov 1;29(6):e734-e741. doi: 10.4317/medoral.26673. PMID: 39088720
Dermawan JK, Chiang S, Hensley ML, Tap WD, Antonescu CR
Mod Pathol 2023 May;36(5):100104. Epub 2023 Jan 23 doi: 10.1016/j.modpat.2023.100104. PMID: 36788091Free PMC Article
Koh SS, Kim SJ, Seghers VJ, Patel KR, Koh CJ, Lee DG
Urology 2021 Oct;156:e150-e153. Epub 2021 Mar 23 doi: 10.1016/j.urology.2021.03.006. PMID: 33766714
Mahajan P, Hicks J, Chintagumpala M, Venkatramani R
J Pediatr Hematol Oncol 2017 Apr;39(3):e136-e139. doi: 10.1097/MPH.0000000000000732. PMID: 28060105
Sargar KM, Sheybani EF, Shenoy A, Aranake-Chrisinger J, Khanna G
Radiographics 2016 Jul-Aug;36(4):1195-214. doi: 10.1148/rg.2016150191. PMID: 27399243

Diagnosis

Rastogi K, Singh L
Fetal Pediatr Pathol 2021 Apr;40(2):166-173. Epub 2019 Nov 18 doi: 10.1080/15513815.2019.1686785. PMID: 31738635
Lima LAF, Lisboa GM, Silva Filho EAD, Rabelo G
An Bras Dermatol 2018 Mar;93(2):268-270. doi: 10.1590/abd1806-4841.20186748. PMID: 29723353Free PMC Article
Goss JA, Greene AK
Otolaryngol Clin North Am 2018 Feb;51(1):89-97. doi: 10.1016/j.otc.2017.09.008. PMID: 29217070
Surabhi VR, Chua S, Patel RP, Takahashi N, Lalwani N, Prasad SR
Radiol Clin North Am 2016 May;54(3):553-63. Epub 2016 Mar 12 doi: 10.1016/j.rcl.2015.12.005. PMID: 27153788
May CJ, Compton N, Falsey RR, Knezevich S
Cutis 2014 Mar;93(3):129, 139-40. PMID: 24738101

Therapy

Polites SF, Heaton TE, LaQuaglia MP, Kim ES, Barry WE, Goodhue CJ, Murphy AJ, Davidoff AM, Langham MR, Meyers RL, Short SS, Lautz TB, Glick RD, Vasudevan SA, Bence CM, Lal DR, Baertschiger RM, Emr B, Malek MM, Dasgupta R
Ann Surg 2021 Dec 1;274(6):e605-e609. doi: 10.1097/SLA.0000000000003795. PMID: 32209902
Maistry N, Durell J, Wilson S, Lakhoo K
Ann R Coll Surg Engl 2020 May;102(5):335-339. Epub 2020 Mar 11 doi: 10.1308/rcsann.2020.0025. PMID: 32159373Free PMC Article
Mai S, Xiong G, Diao D, Wang W, Zhou Y, Cai R
Lung Cancer 2019 Feb;128:101-104. Epub 2018 Dec 17 doi: 10.1016/j.lungcan.2018.12.016. PMID: 30642440
Schöffski P, Sufliarsky J, Gelderblom H, Blay JY, Strauss SJ, Stacchiotti S, Rutkowski P, Lindner LH, Leahy MG, Italiano A, Isambert N, Debiec-Rychter M, Sciot R, Van Cann T, Marréaud S, Nzokirantevye A, Collette S, Wozniak A
Lancet Respir Med 2018 Jun;6(6):431-441. Epub 2018 Apr 15 doi: 10.1016/S2213-2600(18)30116-4. PMID: 29669701
Mahajan P, Hicks J, Chintagumpala M, Venkatramani R
J Pediatr Hematol Oncol 2017 Apr;39(3):e136-e139. doi: 10.1097/MPH.0000000000000732. PMID: 28060105

Prognosis

Dermawan JK, Chiang S, Hensley ML, Tap WD, Antonescu CR
Mod Pathol 2023 May;36(5):100104. Epub 2023 Jan 23 doi: 10.1016/j.modpat.2023.100104. PMID: 36788091Free PMC Article
Alerasool N, Leng H, Lin ZY, Gingras AC, Taipale M
Mol Cell 2022 Feb 3;82(3):677-695.e7. Epub 2022 Jan 10 doi: 10.1016/j.molcel.2021.12.008. PMID: 35016035
Dachy G, Fraitag S, Boulouadnine B, Cordi S, Demoulin JB
J Cell Mol Med 2021 May;25(9):4387-4394. Epub 2021 Apr 8 doi: 10.1111/jcmm.16502. PMID: 33830670Free PMC Article
Moghimi M, Joukar F, Salehi-Abargouei A, Mozayan MR, Aryanfar A
Adv Anat Pathol 2017 Mar;24(2):88-98. doi: 10.1097/PAP.0000000000000143. PMID: 28181952
Gopal M, Chahal G, Al-Rifai Z, Eradi B, Ninan G, Nour S
Pediatr Surg Int 2008 Mar;24(3):287-91. Epub 2007 Dec 12 doi: 10.1007/s00383-007-2091-7. PMID: 18074145

Clinical prediction guides

Souza LL, Fonseca FP, Cáceres CV, Soares CD, Gurgel AD, Rebelo Pontes HA, Corrêa Pontes FS, Paradela CA, Correia-Neto IJ, Kalinin Y, Lopes MA, Santos-Silva AR, Almeida OP, Vargas PA, Robinson L, van-Heerden WF
Med Oral Patol Oral Cir Bucal 2024 Nov 1;29(6):e734-e741. doi: 10.4317/medoral.26673. PMID: 39088720
Alerasool N, Leng H, Lin ZY, Gingras AC, Taipale M
Mol Cell 2022 Feb 3;82(3):677-695.e7. Epub 2022 Jan 10 doi: 10.1016/j.molcel.2021.12.008. PMID: 35016035
Dachy G, Fraitag S, Boulouadnine B, Cordi S, Demoulin JB
J Cell Mol Med 2021 May;25(9):4387-4394. Epub 2021 Apr 8 doi: 10.1111/jcmm.16502. PMID: 33830670Free PMC Article
Davis JL, Rudzinski ER
Surg Pathol Clin 2020 Dec;13(4):739-762. doi: 10.1016/j.path.2020.08.009. PMID: 33183731
Smith KJ, Skelton HG, Barrett TL, Lupton GP, Graham JH
Mod Pathol 1989 Nov;2(6):603-9. PMID: 2587567

Recent systematic reviews

Silveira FM, Kirschnick LB, Só BB, Schuch LF, Pereira Prado V, Sicco E, Lima RR, Bologna-Molina RE, Mosqueda-Taylor A, Vasconcelos ACU, Martins MD
J Oral Pathol Med 2024 Jul;53(6):334-340. Epub 2024 May 6 doi: 10.1111/jop.13537. PMID: 38711183

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