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Solitary fibrous tumor

MedGen UID:
224764
•Concept ID:
C1266119
•
Neoplastic Process
Synonyms: Fibrous Tumor, Solitary; Fibrous Tumors, Solitary; Solitary Fibrous Tumor; Solitary Fibrous Tumors; Tumor, Solitary Fibrous; Tumors, Solitary Fibrous
SNOMED CT: Localized fibrous tumor (128736003); Solitary fibrous tumor (128736003); Hemangiopericytoma (128736003); Solitary fibrous tumor (134335004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016238
Orphanet: ORPHA2126

Definition

A rare spindle cell neoplasm that may be benign or malignant and that most frequently arises from the pleura and peritoneum and rarely from other sites such as head and neck, liver and skeletal muscle. SFT may be clinically asymptomatic or may present with enlarging mass, compressive effects depending on the site involved and rarely with paraneoplastic manifestations (osteoarthropathy or hypoglycemia). [from ORDO]

Professional guidelines

PubMed

Toward Better Understanding and Management of Solitary Fibrous Tumor.
Kazazian K, Demicco EG, de Perrot M, Strauss D, Swallow CJ
Surg Oncol Clin N Am 2022 Jul;31(3):459-483. doi: 10.1016/j.soc.2022.03.009. PMID: 35715145
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model.
Demicco EG, Park MS, Araujo DM, Fox PS, Bassett RL, Pollock RE, Lazar AJ, Wang WL
Mod Pathol 2012 Sep;25(9):1298-306. Epub 2012 May 11 doi: 10.1038/modpathol.2012.83. PMID: 22575866

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Advances in the molecular biology of the solitary fibrous tumor and potential impact on clinical applications.
Ren C, D'Amato G, Hornicek FJ, Tao H, Duan Z
Cancer Metastasis Rev 2024 Dec;43(4):1337-1352. Epub 2024 Aug 9 doi: 10.1007/s10555-024-10204-8. PMID: 39120790Free PMC Article
Toward Better Understanding and Management of Solitary Fibrous Tumor.
Kazazian K, Demicco EG, de Perrot M, Strauss D, Swallow CJ
Surg Oncol Clin N Am 2022 Jul;31(3):459-483. doi: 10.1016/j.soc.2022.03.009. PMID: 35715145
Skull base hemangiopericytomas.
Tobias S, Jahshan S, Grober Y, Soustiel JF
Acta Neurol Belg 2022 Dec;122(6):1537-1545. Epub 2021 Sep 30 doi: 10.1007/s13760-021-01812-0. PMID: 34595730
STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology.
Karpathiou G, Papoudou-Bai A, Ferrand E, Dumollard JM, Peoc'h M
Pathol Res Pract 2021 Jul;223:153477. Epub 2021 May 11 doi: 10.1016/j.prp.2021.153477. PMID: 33991851
Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model.
Demicco EG, Park MS, Araujo DM, Fox PS, Bassett RL, Pollock RE, Lazar AJ, Wang WL
Mod Pathol 2012 Sep;25(9):1298-306. Epub 2012 May 11 doi: 10.1038/modpathol.2012.83. PMID: 22575866

Diagnosis

Orbital solitary fibrous tumor.
Paganelli B, Meney J, Nordmann JP, Bennedjaï A
J Fr Ophtalmol 2024 Nov;47(9):104297. Epub 2024 Sep 27 doi: 10.1016/j.jfo.2024.104297. PMID: 39341041
Toward Better Understanding and Management of Solitary Fibrous Tumor.
Kazazian K, Demicco EG, de Perrot M, Strauss D, Swallow CJ
Surg Oncol Clin N Am 2022 Jul;31(3):459-483. doi: 10.1016/j.soc.2022.03.009. PMID: 35715145
Dedifferentiated Solitary Fibrous Tumor: A Concise Review.
Olson NJ, Linos K
Arch Pathol Lab Med 2018 Jun;142(6):761-766. doi: 10.5858/arpa.2016-0570-RS. PMID: 29848035
The Silent Giant.
Necek M, Biskup E
Praxis (Bern 1994) 2015 Nov 25;104(24):1343-5. doi: 10.1024/1661-8157/a002197. PMID: 26602852
Solitary fibrous tumor.
Batsakis JG, Hybels RD, el-Naggar AK
Ann Otol Rhinol Laryngol 1993 Jan;102(1 Pt 1):74-6. doi: 10.1177/000348949310200114. PMID: 8420474

Therapy

Histology-tailored multidisciplinary management of primary retroperitoneal sarcomas.
Bonvalot S, Roland C, Raut C, Le Péchoux C, Tzanis D, Frezza AM, Gronchi A
Eur J Surg Oncol 2023 Jun;49(6):1061-1067. Epub 2022 May 16 doi: 10.1016/j.ejso.2022.05.010. PMID: 35599138
Solitary Fibrous Tumor With Extensive Epithelial Inclusions.
Zhao M, He H, Cao D, Fan D, Xu M, Zhang X, Ru G
Am J Clin Pathol 2022 Jul 1;158(1):35-46. doi: 10.1093/ajcp/aqab211. PMID: 34999741
Molecular pathology of tumors of the central nervous system.
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article
PAX8 Expression in Solitary Fibrous Tumor: A Potential Diagnostic Pitfall.
Ullman D, Gordetsky J, Siegal GP, Prieto-Granada CN, Wei S, Stevens TM
Appl Immunohistochem Mol Morphol 2019 Mar;27(3):195-202. doi: 10.1097/PAI.0000000000000561. PMID: 28749793
Solitary-fibrous tumor/hemangiopericytoma of the central nervous system: a population-based study.
Kinslow CJ, Bruce SS, Rae AI, Sheth SA, McKhann GM, Sisti MB, Bruce JN, Sonabend AM, Wang TJC
J Neurooncol 2018 May;138(1):173-182. Epub 2018 Feb 9 doi: 10.1007/s11060-018-2787-7. PMID: 29427152

Prognosis

STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology.
Karpathiou G, Papoudou-Bai A, Ferrand E, Dumollard JM, Peoc'h M
Pathol Res Pract 2021 Jul;223:153477. Epub 2021 May 11 doi: 10.1016/j.prp.2021.153477. PMID: 33991851
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
The 2020 WHO Classification: What's New in Soft Tissue Tumor Pathology?
Kallen ME, Hornick JL
Am J Surg Pathol 2021 Jan;45(1):e1-e23. doi: 10.1097/PAS.0000000000001552. PMID: 32796172
Molecular pathology of tumors of the central nervous system.
Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P
Ann Oncol 2019 Aug 1;30(8):1265-1278. doi: 10.1093/annonc/mdz164. PMID: 31124566Free PMC Article
Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model.
Demicco EG, Park MS, Araujo DM, Fox PS, Bassett RL, Pollock RE, Lazar AJ, Wang WL
Mod Pathol 2012 Sep;25(9):1298-306. Epub 2012 May 11 doi: 10.1038/modpathol.2012.83. PMID: 22575866

Clinical prediction guides

Advances in the molecular biology of the solitary fibrous tumor and potential impact on clinical applications.
Ren C, D'Amato G, Hornicek FJ, Tao H, Duan Z
Cancer Metastasis Rev 2024 Dec;43(4):1337-1352. Epub 2024 Aug 9 doi: 10.1007/s10555-024-10204-8. PMID: 39120790Free PMC Article
Sarcoma care in the era of precision medicine.
Wallander K, Öfverholm I, Boye K, Tsagkozis P, Papakonstantinou A, Lin Y, Haglund de Flon F
J Intern Med 2023 Dec;294(6):690-707. Epub 2023 Sep 7 doi: 10.1111/joim.13717. PMID: 37643281
STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology.
Karpathiou G, Papoudou-Bai A, Ferrand E, Dumollard JM, Peoc'h M
Pathol Res Pract 2021 Jul;223:153477. Epub 2021 May 11 doi: 10.1016/j.prp.2021.153477. PMID: 33991851
The many faces of solitary fibrous tumor; diversity of histological features, differential diagnosis and role of molecular studies and surrogate markers in avoiding misdiagnosis and predicting the behavior.
Tariq MU, Din NU, Abdul-Ghafar J, Park YK
Diagn Pathol 2021 Apr 20;16(1):32. doi: 10.1186/s13000-021-01095-2. PMID: 33879215Free PMC Article
Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model.
Demicco EG, Park MS, Araujo DM, Fox PS, Bassett RL, Pollock RE, Lazar AJ, Wang WL
Mod Pathol 2012 Sep;25(9):1298-306. Epub 2012 May 11 doi: 10.1038/modpathol.2012.83. PMID: 22575866

Recent systematic reviews

Postoperative stereotactic radiosurgery for intracranial solitary fibrous tumors: systematic review and pooled quantitative analysis.
Golub D, McBriar JD, Donaldson H, Wong T, Unadkat P, White TG, Quach ET, Haddock S, Chitti B, Ziemba Y, Goenka A, Singer S, Schulder M, Dehdashti AR
J Neurooncol 2023 Nov;165(2):229-239. Epub 2023 Nov 13 doi: 10.1007/s11060-023-04499-w. PMID: 37955760
Radiological Differentiation Between Intracranial Meningioma and Solitary Fibrous Tumor/Hemangiopericytoma: A Systematic Literature Review.
El-Abtah ME, Murayi R, Lee J, Recinos PF, Kshettry VR
World Neurosurg 2023 Feb;170:68-83. Epub 2022 Nov 18 doi: 10.1016/j.wneu.2022.11.062. PMID: 36403933
Skull base hemangiopericytomas.
Tobias S, Jahshan S, Grober Y, Soustiel JF
Acta Neurol Belg 2022 Dec;122(6):1537-1545. Epub 2021 Sep 30 doi: 10.1007/s13760-021-01812-0. PMID: 34595730
Solitary Fibrous Tumor of the Seminal Vesicle: A Systematic Literature Review and Case Presentation.
Crocetti D, Sapienza P, Lamazza A, DE Felice F, Brachini G, Desiato E, Mingoli A, Fiori E, DE Cesare A
In Vivo 2021 Jul-Aug;35(4):1945-1950. doi: 10.21873/invivo.12461. PMID: 34182467Free PMC Article
Characteristics and prognosis of glomangiopericytomas: A systematic review.
Park ES, Kim J, Jun SY
Head Neck 2017 Sep;39(9):1897-1909. Epub 2017 May 12 doi: 10.1002/hed.24818. PMID: 28497509

Supplemental Content

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    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

    Reviews

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