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Odontogenic Fibroma

MedGen UID:
266049
•Concept ID:
C1260966
•
Neoplastic Process
Synonyms: Central odontogenic fibroma; Central Odontogenic Fibroma; Odontogenic fibroma
SNOMED CT: Central odontogenic fibroma (88686005); Odontogenic fibroma (88686005)

Definition

A rare, benign, intraosseous neoplasm arising from tooth-forming tissues in the mandible and maxilla. It is characterized by the presence of odontogenic epithelium which is embedded in a fibrous stroma. Local enucleation of the tumor is curative. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOdontogenic Fibroma

Professional guidelines

PubMed

Histopathological analysis of the differential diagnosis of peripheral odontogenic fibroma from fibrous epulis.
Manabe K, Yakeishi M, Sakaguchi W, Saruta J, Tsukinoki K
J Oral Biosci 2019 Dec;61(4):221-225. Epub 2019 Oct 25 doi: 10.1016/j.job.2019.10.003. PMID: 31669716
Peripheral odontogenic tumours--differential diagnosis in gingival lesions.
Manor Y, Mardinger O, Katz J, Taicher S, Hirshberg A
Int J Oral Maxillofac Surg 2004 Apr;33(3):268-73. doi: 10.1006/ijom.2003.0508. PMID: 15287310

Recent clinical studies

Therapy

Periodontal plastic surgery associated with treatment for the removal of gingival overgrowth.
Bosco AF, Bonfante S, Luize DS, Bosco JM, Garcia VG
J Periodontol 2006 May;77(5):922-8. doi: 10.1902/jop.2006.050248. PMID: 16671888
Dental findings associated with the malformations of CHARGE.
Al ST, Cottrell DA, Hughes CV
Pediatr Dent 2002 Jan-Feb;24(1):43-6. PMID: 11874058

Prognosis

Odontogenic Cysts and Neoplasms.
Bilodeau EA, Collins BM
Surg Pathol Clin 2017 Mar;10(1):177-222. Epub 2016 Dec 29 doi: 10.1016/j.path.2016.10.006. PMID: 28153133
Odontogenic fibroma, including amyloid and ossifying variants.
Eversole LR
Head Neck Pathol 2011 Dec;5(4):335-43. Epub 2011 Jul 13 doi: 10.1007/s12105-011-0279-6. PMID: 21751042Free PMC Article
Peripheral odontogenic fibroma: a clinicopathologic study of 151 cases and review of the literature with special emphasis on recurrence.
Ritwik P, Brannon RB
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Sep;110(3):357-63. Epub 2010 Jul 31 doi: 10.1016/j.tripleo.2010.04.018. PMID: 20674403
Odontogenic cysts, odontogenic tumors, fibroosseous, and giant cell lesions of the jaws.
Regezi JA
Mod Pathol 2002 Mar;15(3):331-41. doi: 10.1038/modpathol.3880527. PMID: 11904346
Odontogenic fibroma.
Dunlap CL
Semin Diagn Pathol 1999 Nov;16(4):293-6. PMID: 10587271

Clinical prediction guides

Central odontogenic fibroma: report of 29 cases in a Korean population with tooth management.
Kim H, Chang E, Han SY, Han D, Sil Kim H, Nam W
Br J Oral Maxillofac Surg 2024 Apr;62(3):247-251. Epub 2023 Dec 15 doi: 10.1016/j.bjoms.2023.12.008. PMID: 38311535
Hybrid odontogenic lesions: A systematic review of 203 cases reported in the literature.
Pontes FSC, Mosqueda-Taylor A, de Souza LL, de Paula LP, Batista LAL, Rodrigues-Fernandes CI, Paiva E Costa AM, de Abreu MC, Gomez RS, de Oliveira EM, Fonseca FP, Rahimi S, Brennan PA, Pontes HAR
J Oral Pathol Med 2022 Jan;51(1):5-12. Epub 2021 Sep 20 doi: 10.1111/jop.13238. PMID: 34469012
SATB2 Immunoexpression in Peripheral Ossifying Fibroma and Peripheral Odontogenic Fibroma.
Shahrabi-Farahani S, Pencarinha DM, Anderson M
Head Neck Pathol 2022 Jun;16(2):339-343. Epub 2021 Jul 5 doi: 10.1007/s12105-021-01355-z. PMID: 34224081Free PMC Article
External tooth resorption associated with a peripheral odontogenic fibroma: review and case report.
Heithersay GS, Musu D, Cotti E
Aust Dent J 2017 Dec;62(4):516-522. Epub 2017 Sep 8 doi: 10.1111/adj.12544. PMID: 28665047
Peripheral odontogenic fibroma: a clinicopathologic study of 151 cases and review of the literature with special emphasis on recurrence.
Ritwik P, Brannon RB
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010 Sep;110(3):357-63. Epub 2010 Jul 31 doi: 10.1016/j.tripleo.2010.04.018. PMID: 20674403

Recent systematic reviews

A Systematic Review of the Granular Cell Odontogenic Fibroma and Report of a New Case.
Severino Lazo RJG, Martins-de-Barros AV, da Silva Cunha J, de Paiva Macedo RA, Borges MA, Islam MN, Vasconcelos BCDE, Carvalho MV
Head Neck Pathol 2023 Sep;17(3):793-802. Epub 2023 Apr 28 doi: 10.1007/s12105-023-01553-x. PMID: 37118351Free PMC Article
Hybrid odontogenic lesions: A systematic review of 203 cases reported in the literature.
Pontes FSC, Mosqueda-Taylor A, de Souza LL, de Paula LP, Batista LAL, Rodrigues-Fernandes CI, Paiva E Costa AM, de Abreu MC, Gomez RS, de Oliveira EM, Fonseca FP, Rahimi S, Brennan PA, Pontes HAR
J Oral Pathol Med 2022 Jan;51(1):5-12. Epub 2021 Sep 20 doi: 10.1111/jop.13238. PMID: 34469012
A systematic review of the clinical and radiographic features of hybrid central giant cell granuloma lesions of the jaws.
Alsufyani NA, Aldosary RM, Alrasheed RS, Alsaif RF
Acta Odontol Scand 2021 Mar;79(2):124-131. Epub 2020 Jul 30 doi: 10.1080/00016357.2020.1797160. PMID: 32730731
Central odontogenic fibroma: An updated systematic review of cases reported in the literature with emphasis on recurrence influencing factors.
Correa Pontes FS, Lacerda de Souza L, Paula de Paula L, de Melo Galvão Neto E, Silva Gonçalves PF, Rebelo Pontes HA
J Craniomaxillofac Surg 2018 Oct;46(10):1753-1757. Epub 2018 Aug 7 doi: 10.1016/j.jcms.2018.07.025. PMID: 30143268
Central granular cell odontogenic tumor: a systematic review.
Sarode SC, Sarode GS, Vaidya K
J Oral Pathol Med 2014 Mar;43(3):167-76. Epub 2013 May 13 doi: 10.1111/jop.12085. PMID: 23668324

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