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Breakthrough pain

MedGen UID:
210036
Concept ID:
C1135120
Sign or Symptom
Synonyms: Breakthrough Pain; Breakthrough Pains; Pain, Breakthrough; Pains, Breakthrough
SNOMED CT: Breakthrough pain (879969009)
 
HPO: HP:0032149

Definition

A episode of severe pain that breaks through (i.e., temporarily exacerbates) a period of persistent pain. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreakthrough pain

Professional guidelines

PubMed

Kang RA, Ko JS
Curr Opin Organ Transplant 2023 Dec 1;28(6):391-396. Epub 2023 Sep 7 doi: 10.1097/MOT.0000000000001099. PMID: 37678396
Virgen CG, Kelkar N, Tran A, Rosa CM, Cruz-Topete D, Amatya S, Cornett EM, Urits I, Viswanath O, Kaye AD
Biomed Pharmacother 2022 Dec;156:113871. Epub 2022 Oct 19 doi: 10.1016/j.biopha.2022.113871. PMID: 36272265
De Giorgio R, Zucco FM, Chiarioni G, Mercadante S, Corazziari ES, Caraceni A, Odetti P, Giusti R, Marinangeli F, Pinto C
Adv Ther 2021 Jul;38(7):3589-3621. Epub 2021 Jun 4 doi: 10.1007/s12325-021-01766-y. PMID: 34086265Free PMC Article

Recent clinical studies

Etiology

Virgen CG, Kelkar N, Tran A, Rosa CM, Cruz-Topete D, Amatya S, Cornett EM, Urits I, Viswanath O, Kaye AD
Biomed Pharmacother 2022 Dec;156:113871. Epub 2022 Oct 19 doi: 10.1016/j.biopha.2022.113871. PMID: 36272265
De Giorgio R, Zucco FM, Chiarioni G, Mercadante S, Corazziari ES, Caraceni A, Odetti P, Giusti R, Marinangeli F, Pinto C
Adv Ther 2021 Jul;38(7):3589-3621. Epub 2021 Jun 4 doi: 10.1007/s12325-021-01766-y. PMID: 34086265Free PMC Article
Shatil B, Landau R
Clin Perinatol 2020 Dec;47(4):769-777. doi: 10.1016/j.clp.2020.08.004. PMID: 33153661
Davies AN
Curr Pain Headache Rep 2014 Jun;18(6):420. doi: 10.1007/s11916-014-0420-9. PMID: 24760489
Farrar JT, Portenoy RK, Berlin JA, Kinman JL, Strom BL
Pain 2000 Dec 1;88(3):287-294. doi: 10.1016/S0304-3959(00)00339-0. PMID: 11068116

Diagnosis

Kang RA, Ko JS
Curr Opin Organ Transplant 2023 Dec 1;28(6):391-396. Epub 2023 Sep 7 doi: 10.1097/MOT.0000000000001099. PMID: 37678396
Virgen CG, Kelkar N, Tran A, Rosa CM, Cruz-Topete D, Amatya S, Cornett EM, Urits I, Viswanath O, Kaye AD
Biomed Pharmacother 2022 Dec;156:113871. Epub 2022 Oct 19 doi: 10.1016/j.biopha.2022.113871. PMID: 36272265
Fink RM, Gallagher E
Semin Oncol Nurs 2019 Jun;35(3):229-234. Epub 2019 Apr 26 doi: 10.1016/j.soncn.2019.04.003. PMID: 31036386
Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, Ripamonti CI; ESMO Guidelines Committee
Ann Oncol 2018 Oct 1;29(Suppl 4):iv166-iv191. doi: 10.1093/annonc/mdy152. PMID: 30052758
Farrar JT, Portenoy RK, Berlin JA, Kinman JL, Strom BL
Pain 2000 Dec 1;88(3):287-294. doi: 10.1016/S0304-3959(00)00339-0. PMID: 11068116

Therapy

Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, Ripamonti CI; ESMO Guidelines Committee
Ann Oncol 2018 Oct 1;29(Suppl 4):iv166-iv191. doi: 10.1093/annonc/mdy152. PMID: 30052758
Mercadante S
Expert Rev Anticancer Ther 2018 May;18(5):445-449. Epub 2018 Mar 16 doi: 10.1080/14737140.2018.1443813. PMID: 29478355
Davies AN
Curr Pain Headache Rep 2014 Jun;18(6):420. doi: 10.1007/s11916-014-0420-9. PMID: 24760489
Randive S, Mehta V
Curr Clin Pharmacol 2012 May;7(2):116-20. doi: 10.2174/157488412800228893. PMID: 22432841
Farrar JT, Portenoy RK, Berlin JA, Kinman JL, Strom BL
Pain 2000 Dec 1;88(3):287-294. doi: 10.1016/S0304-3959(00)00339-0. PMID: 11068116

Prognosis

Virgen CG, Kelkar N, Tran A, Rosa CM, Cruz-Topete D, Amatya S, Cornett EM, Urits I, Viswanath O, Kaye AD
Biomed Pharmacother 2022 Dec;156:113871. Epub 2022 Oct 19 doi: 10.1016/j.biopha.2022.113871. PMID: 36272265
Løhre ET, Thronæs M, Klepstad P
Curr Opin Support Palliat Care 2020 Jun;14(2):94-99. doi: 10.1097/SPC.0000000000000494. PMID: 32332210
Zeppetella G
Clin Oncol (R Coll Radiol) 2011 Aug;23(6):393-8. Epub 2011 Jan 11 doi: 10.1016/j.clon.2010.12.002. PMID: 21227666
Farrar JT, Portenoy RK, Berlin JA, Kinman JL, Strom BL
Pain 2000 Dec 1;88(3):287-294. doi: 10.1016/S0304-3959(00)00339-0. PMID: 11068116
Portenoy RK, Hagen NA
Oncology (Williston Park) 1989 Aug;3(8 Suppl):25-9. PMID: 2484297

Clinical prediction guides

Løhre ET, Thronæs M, Klepstad P
Curr Opin Support Palliat Care 2020 Jun;14(2):94-99. doi: 10.1097/SPC.0000000000000494. PMID: 32332210
Schug SA, Ting S
Drugs 2017 May;77(7):747-763. doi: 10.1007/s40265-017-0727-z. PMID: 28337672
Zeppetella G
Clin Oncol (R Coll Radiol) 2011 Aug;23(6):393-8. Epub 2011 Jan 11 doi: 10.1016/j.clon.2010.12.002. PMID: 21227666
Farrar JT, Portenoy RK, Berlin JA, Kinman JL, Strom BL
Pain 2000 Dec 1;88(3):287-294. doi: 10.1016/S0304-3959(00)00339-0. PMID: 11068116
Portenoy RK, Hagen NA
Oncology (Williston Park) 1989 Aug;3(8 Suppl):25-9. PMID: 2484297

Recent systematic reviews

Liossi C, Greenfield K, Schoth DE, Mott C, Jassal S, Fraser LK, Rajapakse D, Howard RF, Johnson M, Anderson AK, Harrop E
J Pain Symptom Manage 2021 Nov;62(5):1041-1064. Epub 2021 Apr 30 doi: 10.1016/j.jpainsymman.2021.04.018. PMID: 33933619
Brant JM, Rodgers BB, Gallagher E, Sundaramurthi T
Clin J Oncol Nurs 2017 Jun 1;21(3 Suppl):71-80. doi: 10.1188/17.CJON.S3.71-80. PMID: 28524907
Davies AN
Curr Pain Headache Rep 2014 Jun;18(6):420. doi: 10.1007/s11916-014-0420-9. PMID: 24760489
Deandrea S, Corli O, Consonni D, Villani W, Greco MT, Apolone G
J Pain Symptom Manage 2014 Jan;47(1):57-76. Epub 2013 Jun 21 doi: 10.1016/j.jpainsymman.2013.02.015. PMID: 23796584
Haugen DF, Hjermstad MJ, Hagen N, Caraceni A, Kaasa S; European Palliative Care Research Collaborative (EPCRC)
Pain 2010 Jun;149(3):476-482. Epub 2010 Mar 16 doi: 10.1016/j.pain.2010.02.035. PMID: 20236762

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