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Askin tumor

MedGen UID:
209112
•Concept ID:
C0877849
•
Neoplastic Process
Synonym: Askin's tumor (PNET of the chest wall) (type)
SNOMED CT: Askin's tumor (128783001); Askin tumor (128783001)
 
Monarch Initiative: MONDO:0006094
OMIM®: 612219

Definition

A primitive neuroectodermal tumor (small round blue cell tumor) of the thorax which can involve the periosteum, thoracic wall and/or pleura though it spares the lung parenchyma. [from NCI]

Professional guidelines

PubMed

Outcomes after interdisciplinary management of 7 patients with Askin tumor.
Basharkhah A, Pansy J, Urban C, Höllwarth ME
Pediatr Surg Int 2013 May;29(5):431-6. Epub 2013 Feb 10 doi: 10.1007/s00383-013-3272-1. PMID: 23397588
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369
Current treatment for Ewing's sarcoma.
Thacker MM, Temple HT, Scully SP
Expert Rev Anticancer Ther 2005 Apr;5(2):319-31. doi: 10.1586/14737140.5.2.319. PMID: 15877528

Recent clinical studies

Etiology

Bad to the Bone: Emerging Approaches to Aggressive Bone Sarcomas.
Wood GE, Graves LA, Rubin EM, Reed DR, Riedel RF, Strauss SJ
Am Soc Clin Oncol Educ Book 2023 May;43:e390306. doi: 10.1200/EDBK_390306. PMID: 37220319
Survival after high-dose chemotherapy for refractory and recurrent Ewing sarcoma.
Windsor R, Hamilton A, McTiernan A, Dileo P, Michelagnoli M, Seddon B, Strauss SJ, Whelan J
Eur J Cancer 2022 Jul;170:131-139. Epub 2022 May 26 doi: 10.1016/j.ejca.2022.04.007. PMID: 35635934
Askin tumor: CT and FDG-PET/CT imaging findings and follow-up.
Xia T, Guan Y, Chen Y, Li J
Medicine (Baltimore) 2014 Jul;93(6):e42. doi: 10.1097/MD.0000000000000042. PMID: 25058144Free PMC Article
Askin's tumor: a case report and literature review.
Benbrahim Z, Arifi S, Daoudi K, Serraj M, Amara B, Benjelloun MC, Mellas N, El Mesbahi O
World J Surg Oncol 2013 Jan 22;11:10. doi: 10.1186/1477-7819-11-10. PMID: 23339634Free PMC Article
Ewing tumor: tumor biology and clinical applications.
de Alava E, Pardo J
Int J Surg Pathol 2001 Jan;9(1):7-17. doi: 10.1177/106689690100900104. PMID: 11469351

Diagnosis

Rapidly fatal Askin's tumor: a case report and literature review.
Laine M, Ghorfi IA, Lambatten D, Kettani F, Abid A
Pan Afr Med J 2014;18:104. Epub 2014 May 30 doi: 10.11604/pamj.2014.18.104.4549. PMID: 25404964Free PMC Article
Askin tumor: CT and FDG-PET/CT imaging findings and follow-up.
Xia T, Guan Y, Chen Y, Li J
Medicine (Baltimore) 2014 Jul;93(6):e42. doi: 10.1097/MD.0000000000000042. PMID: 25058144Free PMC Article
Askin's tumor: a case report and literature review.
Benbrahim Z, Arifi S, Daoudi K, Serraj M, Amara B, Benjelloun MC, Mellas N, El Mesbahi O
World J Surg Oncol 2013 Jan 22;11:10. doi: 10.1186/1477-7819-11-10. PMID: 23339634Free PMC Article
Askin tumor: four case reports and a review of the literature.
Xu Q, Xu K, Yang C, Zhang X, Meng Y, Quan Q
Cancer Imaging 2011 Nov 30;11(1):184-8. doi: 10.1102/1470-7330.2011.0025. PMID: 22138531Free PMC Article
Ewing tumor: tumor biology and clinical applications.
de Alava E, Pardo J
Int J Surg Pathol 2001 Jan;9(1):7-17. doi: 10.1177/106689690100900104. PMID: 11469351

Therapy

Phase 2 trial of palbociclib and ganitumab in patients with relapsed Ewing sarcoma.
Shulman DS, Merriam P, Choy E, Guenther LM, Cavanaugh KL, Kao PC, Posner A, Bhushan K, Fairchild G, Barker E, Klega K, Stegmaier K, Crompton BD, London WB, DuBois SG
Cancer Med 2023 Jul;12(14):15207-15216. Epub 2023 Jun 12 doi: 10.1002/cam4.6208. PMID: 37306107Free PMC Article
Bad to the Bone: Emerging Approaches to Aggressive Bone Sarcomas.
Wood GE, Graves LA, Rubin EM, Reed DR, Riedel RF, Strauss SJ
Am Soc Clin Oncol Educ Book 2023 May;43:e390306. doi: 10.1200/EDBK_390306. PMID: 37220319
Askin's tumor: a case report and literature review.
Benbrahim Z, Arifi S, Daoudi K, Serraj M, Amara B, Benjelloun MC, Mellas N, El Mesbahi O
World J Surg Oncol 2013 Jan 22;11:10. doi: 10.1186/1477-7819-11-10. PMID: 23339634Free PMC Article
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369
Current treatment for Ewing's sarcoma.
Thacker MM, Temple HT, Scully SP
Expert Rev Anticancer Ther 2005 Apr;5(2):319-31. doi: 10.1586/14737140.5.2.319. PMID: 15877528

Prognosis

Rapidly fatal Askin's tumor: a case report and literature review.
Laine M, Ghorfi IA, Lambatten D, Kettani F, Abid A
Pan Afr Med J 2014;18:104. Epub 2014 May 30 doi: 10.11604/pamj.2014.18.104.4549. PMID: 25404964Free PMC Article
Askin tumor: CT and FDG-PET/CT imaging findings and follow-up.
Xia T, Guan Y, Chen Y, Li J
Medicine (Baltimore) 2014 Jul;93(6):e42. doi: 10.1097/MD.0000000000000042. PMID: 25058144Free PMC Article
Askin's tumor: a case report and literature review.
Benbrahim Z, Arifi S, Daoudi K, Serraj M, Amara B, Benjelloun MC, Mellas N, El Mesbahi O
World J Surg Oncol 2013 Jan 22;11:10. doi: 10.1186/1477-7819-11-10. PMID: 23339634Free PMC Article
Askin tumor: four case reports and a review of the literature.
Xu Q, Xu K, Yang C, Zhang X, Meng Y, Quan Q
Cancer Imaging 2011 Nov 30;11(1):184-8. doi: 10.1102/1470-7330.2011.0025. PMID: 22138531Free PMC Article
Ewing tumor: tumor biology and clinical applications.
de Alava E, Pardo J
Int J Surg Pathol 2001 Jan;9(1):7-17. doi: 10.1177/106689690100900104. PMID: 11469351

Clinical prediction guides

Survival after high-dose chemotherapy for refractory and recurrent Ewing sarcoma.
Windsor R, Hamilton A, McTiernan A, Dileo P, Michelagnoli M, Seddon B, Strauss SJ, Whelan J
Eur J Cancer 2022 Jul;170:131-139. Epub 2022 May 26 doi: 10.1016/j.ejca.2022.04.007. PMID: 35635934
Eponyms in cardiothoracic radiology: Part I. Neoplasms.
Mohammed TL, Saettele MR, Saettele T, Patel V, Kanne JP
Curr Probl Diagn Radiol 2014 Mar-Apr;43(2):91-8. doi: 10.1067/j.cpradiol.2013.12.003. PMID: 24629662
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369
Activation of trkA induces differentiation and inhibits the growth of JK-GMS Askin tumor cells.
Kim GJ, Kim CJ, Cho SY, Chung IP, Park SH, Lee MJ, Chi JG
Lab Invest 2002 Feb;82(2):221-9. doi: 10.1038/labinvest.3780414. PMID: 11850535
Neurogenic tumors of the thorax.
Shields TW, Reynolds M
Surg Clin North Am 1988 Jun;68(3):645-68. doi: 10.1016/s0039-6109(16)44538-x. PMID: 3375959

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