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Recurrent Bone Ewing Sarcoma

MedGen UID:
233908
•Concept ID:
C1335694
•
Neoplastic Process
Synonyms: Recurrent Bone Ewing's Sarcoma; Recurrent Ewing's Sarcoma of Bone; Recurrent Ewing's Sarcoma of the Bone; Recurrent Osseous Ewing's Sarcoma; Recurrent Skeletal Ewing's Sarcoma; Relapsed Bone Ewing's Sarcoma; Relapsed Ewing's Sarcoma of Bone; Relapsed Ewing's Sarcoma of the Bone; Relapsed Osseous Ewing's Sarcoma; Relapsed Skeletal Ewing's Sarcoma

Definition

The reemergence of Ewing sarcoma of the bone after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Bone Ewing Sarcoma

Professional guidelines

PubMed

Treatment outcomes of extraskeletal Ewing sarcoma.
Houdek MT, Heidenreich MJ, Ahmed SK, Allen-Rhoades W, Siontis BL, Robinson SI, Petersen IA, Rose PS
J Surg Oncol 2023 Jul;128(1):105-110. Epub 2023 Mar 31 doi: 10.1002/jso.27250. PMID: 36999583
Potential approaches to the treatment of Ewing's sarcoma.
Yu H, Ge Y, Guo L, Huang L
Oncotarget 2017 Jan 17;8(3):5523-5539. doi: 10.18632/oncotarget.12566. PMID: 27740934Free PMC Article
Ewing Sarcoma: Current Management and Future Approaches Through Collaboration.
Gaspar N, Hawkins DS, Dirksen U, Lewis IJ, Ferrari S, Le Deley MC, Kovar H, Grimer R, Whelan J, Claude L, Delattre O, Paulussen M, Picci P, Sundby Hall K, van den Berg H, Ladenstein R, Michon J, Hjorth L, Judson I, Luksch R, Bernstein ML, Marec-Bérard P, Brennan B, Craft AW, Womer RB, Juergens H, Oberlin O
J Clin Oncol 2015 Sep 20;33(27):3036-46. Epub 2015 Aug 24 doi: 10.1200/JCO.2014.59.5256. PMID: 26304893

Recent clinical studies

Etiology

Randomized Phase III Trial of Ganitumab With Interval-Compressed Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma: A Report From the Children's Oncology Group.
DuBois SG, Krailo MD, Glade-Bender J, Buxton A, Laack N, Randall RL, Chen HX, Seibel NL, Boron M, Terezakis S, Hill-Kayser C, Hayes A, Reid JM, Teot L, Rakheja D, Womer R, Arndt C, Lessnick SL, Crompton BD, Kolb EA, Daldrup-Link H, Eutsler E, Reed DR, Janeway KA, Gorlick RG
J Clin Oncol 2023 Apr 10;41(11):2098-2107. Epub 2023 Jan 20 doi: 10.1200/JCO.22.01815. PMID: 36669140Free PMC Article
Ewing and Ewing-like sarcomas: A morphological guide through genetically-defined entities.
Yoshida A
Pathol Int 2023 Jan;73(1):12-26. Epub 2022 Dec 9 doi: 10.1111/pin.13293. PMID: 36484765Free PMC Article
Outcome of Scapular Ewing Sarcoma.
Hargiss JB, Labott JR, Broida SE, Rose PS, Barlow JD, Houdek MT
Anticancer Res 2022 Aug;42(8):3869-3872. doi: 10.21873/anticanres.15879. PMID: 35896233
Ewing's sarcoma.
Karosas AO
Am J Health Syst Pharm 2010 Oct 1;67(19):1599-605. doi: 10.2146/ajhp090526. PMID: 20852160
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383

Diagnosis

Emerging therapies in Ewing sarcoma.
Strauss SJ, Berlanga P, McCabe MG
Curr Opin Oncol 2024 Jul 1;36(4):297-304. Epub 2024 May 22 doi: 10.1097/CCO.0000000000001048. PMID: 38775200Free PMC Article
Artificial intelligence-based radiomics in bone tumors: Technical advances and clinical application.
Meng Y, Yang Y, Hu M, Zhang Z, Zhou X
Semin Cancer Biol 2023 Oct;95:75-87. Epub 2023 Jul 26 doi: 10.1016/j.semcancer.2023.07.003. PMID: 37499847
Ewing Sarcoma Drug Therapy: Current Standard of Care and Emerging Agents.
Setty BA, Gikandi A, DuBois SG
Paediatr Drugs 2023 Jul;25(4):389-397. Epub 2023 Apr 4 doi: 10.1007/s40272-023-00568-9. PMID: 37014523
Randomized Phase III Trial of Ganitumab With Interval-Compressed Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma: A Report From the Children's Oncology Group.
DuBois SG, Krailo MD, Glade-Bender J, Buxton A, Laack N, Randall RL, Chen HX, Seibel NL, Boron M, Terezakis S, Hill-Kayser C, Hayes A, Reid JM, Teot L, Rakheja D, Womer R, Arndt C, Lessnick SL, Crompton BD, Kolb EA, Daldrup-Link H, Eutsler E, Reed DR, Janeway KA, Gorlick RG
J Clin Oncol 2023 Apr 10;41(11):2098-2107. Epub 2023 Jan 20 doi: 10.1200/JCO.22.01815. PMID: 36669140Free PMC Article
Ewing's sarcoma.
Meyers PA, Levy AS
Curr Treat Options Oncol 2000 Aug;1(3):247-57. doi: 10.1007/s11864-000-0036-7. PMID: 12057167

Therapy

AURKA inhibition induces Ewing's sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis.
Chen H, Hu J, Xiong X, Chen H, Lin B, Chen Y, Li Y, Cheng D, Li Z
Cell Death Dis 2024 Jan 29;15(1):99. doi: 10.1038/s41419-024-06485-0. PMID: 38287009Free PMC Article
Randomized Phase III Trial of Ganitumab With Interval-Compressed Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma: A Report From the Children's Oncology Group.
DuBois SG, Krailo MD, Glade-Bender J, Buxton A, Laack N, Randall RL, Chen HX, Seibel NL, Boron M, Terezakis S, Hill-Kayser C, Hayes A, Reid JM, Teot L, Rakheja D, Womer R, Arndt C, Lessnick SL, Crompton BD, Kolb EA, Daldrup-Link H, Eutsler E, Reed DR, Janeway KA, Gorlick RG
J Clin Oncol 2023 Apr 10;41(11):2098-2107. Epub 2023 Jan 20 doi: 10.1200/JCO.22.01815. PMID: 36669140Free PMC Article
Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma.
Ahmed N, Brawley VS, Hegde M, Robertson C, Ghazi A, Gerken C, Liu E, Dakhova O, Ashoori A, Corder A, Gray T, Wu MF, Liu H, Hicks J, Rainusso N, Dotti G, Mei Z, Grilley B, Gee A, Rooney CM, Brenner MK, Heslop HE, Wels WS, Wang LL, Anderson P, Gottschalk S
J Clin Oncol 2015 May 20;33(15):1688-96. Epub 2015 Mar 23 doi: 10.1200/JCO.2014.58.0225. PMID: 25800760Free PMC Article
Ewing's sarcoma.
Karosas AO
Am J Health Syst Pharm 2010 Oct 1;67(19):1599-605. doi: 10.2146/ajhp090526. PMID: 20852160
Ewing's sarcoma.
Meyers PA, Levy AS
Curr Treat Options Oncol 2000 Aug;1(3):247-57. doi: 10.1007/s11864-000-0036-7. PMID: 12057167

Prognosis

Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks.
Cillo AR, Mukherjee E, Bailey NG, Onkar S, Daley J, Salgado C, Li X, Liu D, Ranganathan S, Burgess M, Sembrat J, Weiss K, Watters R, Bruno TC, Vignali DAA, Bailey KM
Clin Cancer Res 2022 Nov 14;28(22):4968-4982. doi: 10.1158/1078-0432.CCR-22-1471. PMID: 36074145Free PMC Article
BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas.
Kao YC, Owosho AA, Sung YS, Zhang L, Fujisawa Y, Lee JC, Wexler L, Argani P, Swanson D, Dickson BC, Fletcher CDM, Antonescu CR
Am J Surg Pathol 2018 May;42(5):604-615. doi: 10.1097/PAS.0000000000000965. PMID: 29300189Free PMC Article
Ewing's sarcoma.
Karosas AO
Am J Health Syst Pharm 2010 Oct 1;67(19):1599-605. doi: 10.2146/ajhp090526. PMID: 20852160
The epidemiology of osteosarcoma.
Ottaviani G, Jaffe N
Cancer Treat Res 2009;152:3-13. doi: 10.1007/978-1-4419-0284-9_1. PMID: 20213383
Ewing's sarcoma.
Meyers PA, Levy AS
Curr Treat Options Oncol 2000 Aug;1(3):247-57. doi: 10.1007/s11864-000-0036-7. PMID: 12057167

Clinical prediction guides

Artificial intelligence-based radiomics in bone tumors: Technical advances and clinical application.
Meng Y, Yang Y, Hu M, Zhang Z, Zhou X
Semin Cancer Biol 2023 Oct;95:75-87. Epub 2023 Jul 26 doi: 10.1016/j.semcancer.2023.07.003. PMID: 37499847
Outcome of Scapular Ewing Sarcoma.
Hargiss JB, Labott JR, Broida SE, Rose PS, Barlow JD, Houdek MT
Anticancer Res 2022 Aug;42(8):3869-3872. doi: 10.21873/anticanres.15879. PMID: 35896233
Unraveling Ewing Sarcoma Tumorigenesis Originating from Patient-Derived Mesenchymal Stem Cells.
Sole A, Grossetête S, Heintzé M, Babin L, Zaïdi S, Revy P, Renouf B, De Cian A, Giovannangeli C, Pierre-Eugène C, Janoueix-Lerosey I, Couronné L, Kaltenbach S, Tomishima M, Jasin M, Grünewald TGP, Delattre O, Surdez D, Brunet E
Cancer Res 2021 Oct 1;81(19):4994-5006. Epub 2021 Aug 2 doi: 10.1158/0008-5472.CAN-20-3837. PMID: 34341072Free PMC Article
STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma.
Adane B, Alexe G, Seong BKA, Lu D, Hwang EE, Hnisz D, Lareau CA, Ross L, Lin S, Dela Cruz FS, Richardson M, Weintraub AS, Wang S, Iniguez AB, Dharia NV, Conway AS, Robichaud AL, Tanenbaum B, Krill-Burger JM, Vazquez F, Schenone M, Berman JN, Kung AL, Carr SA, Aryee MJ, Young RA, Crompton BD, Stegmaier K
Cancer Cell 2021 Jun 14;39(6):827-844.e10. doi: 10.1016/j.ccell.2021.05.007. PMID: 34129824Free PMC Article
BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas.
Kao YC, Owosho AA, Sung YS, Zhang L, Fujisawa Y, Lee JC, Wexler L, Argani P, Swanson D, Dickson BC, Fletcher CDM, Antonescu CR
Am J Surg Pathol 2018 May;42(5):604-615. doi: 10.1097/PAS.0000000000000965. PMID: 29300189Free PMC Article

Recent systematic reviews

Primary Sarcomas of the Spine: A Systematic Review and Pooled Data Analysis.
Kooner P, Bozzo I, Rizkallah M, Hassani M, Turcotte RE, Aoude A
Clin Spine Surg 2023 Aug 1;36(7):280-286. Epub 2023 Feb 20 doi: 10.1097/BSD.0000000000001432. PMID: 36823708
(18) F-FDG PET and PET/CT as a diagnostic method for Ewing sarcoma: A systematic review and meta-analysis.
Seth N, Seth I, Bulloch G, Siu AHY, Guo A, Chatterjee R, MacManus M, Donnan L
Pediatr Blood Cancer 2022 Mar;69(3):e29415. Epub 2021 Oct 28 doi: 10.1002/pbc.29415. PMID: 34709700
Ewing Sarcoma of the Craniofacial Bones: A Qualitative Systematic Review.
Rehman R, Osto M, Parry N, Awada N, Agemy J, Arianpour K, Folbe AJ
Otolaryngol Head Neck Surg 2022 Apr;166(4):608-614. Epub 2021 Jul 13 doi: 10.1177/01945998211022228. PMID: 34255595
High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with first recurrence of Ewing sarcoma.
Haveman LM, van Ewijk R, van Dalen EC, Breunis WB, Kremer LC, van den Berg H, Dirksen U, Merks JH
Cochrane Database Syst Rev 2021 Sep 2;9(9):CD011406. doi: 10.1002/14651858.CD011406.pub2. PMID: 34472084Free PMC Article
Systematic review of phase-I/II trials enrolling refractory and recurrent Ewing sarcoma: Actual knowledge and future directions to optimize the research.
Felix A, Berlanga P, Toulmonde M, Landman-Parker J, Dumont S, Vassal G, Le Deley MC, Gaspar N
Cancer Med 2021 Mar;10(5):1589-1604. Epub 2021 Jan 15 doi: 10.1002/cam4.3712. PMID: 33452711Free PMC Article

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