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Localized Ewing Sarcoma

MedGen UID:
167841
•Concept ID:
C0863029
•
Neoplastic Process
Synonyms: Ewing's Sarcoma, Localized; Localized Ewing's Sarcoma; Localized Ewing's Tumor

Definition

Ewing sarcoma that is confined to a specific site without evidence of spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Ewing Sarcoma

Professional guidelines

PubMed

The clinical prognostic factors and treatment outcomes of adult patients with Ewing sarcoma.
Jagodzińska-Mucha P, Ługowska I, Świtaj T, Koseła-Paterczyk H, Wągrodzki M, Kozak K, Falkowski S, Morysiński T, Goryń T, Dawidowska A, Rutkowski P
Int J Clin Oncol 2020 Nov;25(11):2006-2014. Epub 2020 Jul 25 doi: 10.1007/s10147-020-01741-7. PMID: 32712877
Challenges in the management of localized Ewing sarcoma in a developing country.
Totadri S, Bansal D, Rao KLN, Jain R, Saxena AK, Kapoor R, Samujh R, Trehan A
Pediatr Hematol Oncol 2020 Oct;37(7):610-619. Epub 2020 Jun 19 doi: 10.1080/08880018.2020.1772912. PMID: 32558608
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369

Recent clinical studies

Etiology

Long-Term Outcomes in Patients With Localized Ewing Sarcoma Treated With Interval-Compressed Chemotherapy on Children's Oncology Group Study AEWS0031.
Cash T, Krailo MD, Buxton AB, Pawel BR, Healey JH, Binitie O, Marcus KJ, Grier HE, Grohar PJ, Reed DR, Weiss AR, Gorlick R, Janeway KA, DuBois SG, Womer RB
J Clin Oncol 2023 Oct 20;41(30):4724-4728. Epub 2023 Aug 31 doi: 10.1200/JCO.23.00053. PMID: 37651654Free PMC Article
Ewing sarcoma: investigational mono- and combination therapies in clinical trials.
Gartrell J, Rodriguez-Galindo C
Expert Opin Investig Drugs 2021 Jun;30(6):653-663. Epub 2021 Jun 3 doi: 10.1080/13543784.2021.1919623. PMID: 33870845
Investigational therapies for Ewing sarcoma: a search without a clear finding.
Vornicova O, Bar-Sela G
Expert Opin Investig Drugs 2016 Jun;25(6):679-86. Epub 2016 Apr 7 doi: 10.1517/13543784.2016.1168398. PMID: 26988130
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
Womer RB, West DC, Krailo MD, Dickman PS, Pawel BR, Grier HE, Marcus K, Sailer S, Healey JH, Dormans JP, Weiss AR
J Clin Oncol 2012 Nov 20;30(33):4148-54. Epub 2012 Oct 22 doi: 10.1200/JCO.2011.41.5703. PMID: 23091096Free PMC Article
Ewing sarcoma: radiation dose and target volume.
Donaldson SS
Pediatr Blood Cancer 2004 May;42(5):471-6. doi: 10.1002/pbc.10472. PMID: 15049023

Diagnosis

Long-Term Outcomes in Patients With Localized Ewing Sarcoma Treated With Interval-Compressed Chemotherapy on Children's Oncology Group Study AEWS0031.
Cash T, Krailo MD, Buxton AB, Pawel BR, Healey JH, Binitie O, Marcus KJ, Grier HE, Grohar PJ, Reed DR, Weiss AR, Gorlick R, Janeway KA, DuBois SG, Womer RB
J Clin Oncol 2023 Oct 20;41(30):4724-4728. Epub 2023 Aug 31 doi: 10.1200/JCO.23.00053. PMID: 37651654Free PMC Article
Long-term follow-up results of pediatric and adolescent patients with localized Ewing sarcoma treated based on stratified modalities.
Zeng C, Chen T, Wang J, Sun F, Huang J, Lu S, Zhu J, Zhang Y, Sun X, Zhen Z
Cancer Med 2023 Apr;12(8):9409-9419. Epub 2023 Feb 21 doi: 10.1002/cam4.5703. PMID: 36808251Free PMC Article
The clinical prognostic factors and treatment outcomes of adult patients with Ewing sarcoma.
Jagodzińska-Mucha P, Ługowska I, Świtaj T, Koseła-Paterczyk H, Wągrodzki M, Kozak K, Falkowski S, Morysiński T, Goryń T, Dawidowska A, Rutkowski P
Int J Clin Oncol 2020 Nov;25(11):2006-2014. Epub 2020 Jul 25 doi: 10.1007/s10147-020-01741-7. PMID: 32712877
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
Womer RB, West DC, Krailo MD, Dickman PS, Pawel BR, Grier HE, Marcus K, Sailer S, Healey JH, Dormans JP, Weiss AR
J Clin Oncol 2012 Nov 20;30(33):4148-54. Epub 2012 Oct 22 doi: 10.1200/JCO.2011.41.5703. PMID: 23091096Free PMC Article
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369

Therapy

Long-Term Outcomes in Patients With Localized Ewing Sarcoma Treated With Interval-Compressed Chemotherapy on Children's Oncology Group Study AEWS0031.
Cash T, Krailo MD, Buxton AB, Pawel BR, Healey JH, Binitie O, Marcus KJ, Grier HE, Grohar PJ, Reed DR, Weiss AR, Gorlick R, Janeway KA, DuBois SG, Womer RB
J Clin Oncol 2023 Oct 20;41(30):4724-4728. Epub 2023 Aug 31 doi: 10.1200/JCO.23.00053. PMID: 37651654Free PMC Article
Ewing sarcoma: investigational mono- and combination therapies in clinical trials.
Gartrell J, Rodriguez-Galindo C
Expert Opin Investig Drugs 2021 Jun;30(6):653-663. Epub 2021 Jun 3 doi: 10.1080/13543784.2021.1919623. PMID: 33870845
Investigational therapies for Ewing sarcoma: a search without a clear finding.
Vornicova O, Bar-Sela G
Expert Opin Investig Drugs 2016 Jun;25(6):679-86. Epub 2016 Apr 7 doi: 10.1517/13543784.2016.1168398. PMID: 26988130
Prospects and challenges for the development of new therapies for Ewing sarcoma.
Grohar PJ, Helman LJ
Pharmacol Ther 2013 Feb;137(2):216-24. Epub 2012 Oct 18 doi: 10.1016/j.pharmthera.2012.10.004. PMID: 23085431Free PMC Article
Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
Womer RB, West DC, Krailo MD, Dickman PS, Pawel BR, Grier HE, Marcus K, Sailer S, Healey JH, Dormans JP, Weiss AR
J Clin Oncol 2012 Nov 20;30(33):4148-54. Epub 2012 Oct 22 doi: 10.1200/JCO.2011.41.5703. PMID: 23091096Free PMC Article

Prognosis

Long-term follow-up results of pediatric and adolescent patients with localized Ewing sarcoma treated based on stratified modalities.
Zeng C, Chen T, Wang J, Sun F, Huang J, Lu S, Zhu J, Zhang Y, Sun X, Zhen Z
Cancer Med 2023 Apr;12(8):9409-9419. Epub 2023 Feb 21 doi: 10.1002/cam4.5703. PMID: 36808251Free PMC Article
Investigational therapies for Ewing sarcoma: a search without a clear finding.
Vornicova O, Bar-Sela G
Expert Opin Investig Drugs 2016 Jun;25(6):679-86. Epub 2016 Apr 7 doi: 10.1517/13543784.2016.1168398. PMID: 26988130
Prospects and challenges for the development of new therapies for Ewing sarcoma.
Grohar PJ, Helman LJ
Pharmacol Ther 2013 Feb;137(2):216-24. Epub 2012 Oct 18 doi: 10.1016/j.pharmthera.2012.10.004. PMID: 23085431Free PMC Article
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369
Ewing sarcoma: radiation dose and target volume.
Donaldson SS
Pediatr Blood Cancer 2004 May;42(5):471-6. doi: 10.1002/pbc.10472. PMID: 15049023

Clinical prediction guides

Histological response to neoadjuvant chemotherapy in localized Ewing sarcoma of the bone: A retrospective analysis of available scoring tools.
Righi A, Pacheco M, Palmerini E, Carretta E, Gambarotti M, Longhi A, Magagnoli G, Sbaraglia M, Manfrini M, Picci P, Dei Tos AP
Eur J Surg Oncol 2021 Jul;47(7):1778-1783. Epub 2021 Feb 16 doi: 10.1016/j.ejso.2021.02.009. PMID: 33622576
Challenges in the management of localized Ewing sarcoma in a developing country.
Totadri S, Bansal D, Rao KLN, Jain R, Saxena AK, Kapoor R, Samujh R, Trehan A
Pediatr Hematol Oncol 2020 Oct;37(7):610-619. Epub 2020 Jun 19 doi: 10.1080/08880018.2020.1772912. PMID: 32558608
Risk stratification by somatic mutation burden in Ewing sarcoma.
Liu KX, Lamba N, Hwang WL, Niemierko A, DuBois SG, Haas-Kogan DA
Cancer 2019 Apr 15;125(8):1357-1364. Epub 2019 Jan 2 doi: 10.1002/cncr.31919. PMID: 30602061
Localized Adult Ewing Sarcoma: Favorable Outcomes with Alternating Vincristine, Doxorubicin, Cyclophosphamide, and Ifosfamide, Etoposide (VDC/IE)-Based Multimodality Therapy.
Pretz JL, Barysauskas CM, George S, Hornick JL, Raut CP, Chen YE, Marcus KJ, Choy E, Hornicek F, Ready JE, DeLaney TF, Baldini EH
Oncologist 2017 Oct;22(10):1265-1270. Epub 2017 May 26 doi: 10.1634/theoncologist.2016-0463. PMID: 28550026Free PMC Article
Ewing's sarcoma: standard and experimental treatment options.
Subbiah V, Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA
Curr Treat Options Oncol 2009 Apr;10(1-2):126-40. Epub 2009 Jun 17 doi: 10.1007/s11864-009-0104-6. PMID: 19533369

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