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Dedifferentiated chondrosarcoma

MedGen UID:
209021
Concept ID:
C0862878
Neoplastic Process
Synonyms: DDCHS; Dedifferentiated Chondrosarcoma; dedifferentiated chondrosarcoma
SNOMED CT: Dedifferentiated chondrosarcoma (128776008); Dedifferentiated chondrosarcoma (1290897001)
 
Monarch Initiative: MONDO:0005013

Definition

An aggressive morphologic variant of chondrosarcoma. It is composed of a low grade chondrosarcoma and a high grade non-cartilagenous sarcomatous component. Due to the aggressive nature of the disease, its prognosis is poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDedifferentiated chondrosarcoma

Professional guidelines

PubMed

Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Kozawa E, Nishida Y, Kawai A, Hayakawa K, Setsu N, Kawashima H, Iwata S, Tsuchiya H, Tsukushi S, Takenaka S, Imanishi J, Baba I, Nagano A, Morii T, Shirai T, Shimizu K, Kawano H
Cancer Sci 2022 Jul;113(7):2397-2408. Epub 2022 May 18 doi: 10.1111/cas.15382. PMID: 35485870Free PMC Article
Sharma S, Sharma AK, Tapia N, Blumenthal D
J Clin Rheumatol 2021 Dec 1;27(8S):S690-S691. doi: 10.1097/RHU.0000000000001605. PMID: 33136693

Recent clinical studies

Etiology

Denu RA, Yang RK, Lazar AJ, Patel SS, Lewis VO, Roszik J, Livingston JA, Wang WL, Shaw KR, Ratan R, Zarzour MA, Bird J, Raza S, Akdemir KC, Rodon Ahnert J, Subbiah V, Patel S, Conley AP
Clin Cancer Res 2023 Dec 1;29(23):4844-4852. doi: 10.1158/1078-0432.CCR-23-1703. PMID: 37747813Free PMC Article
Kozawa E, Nishida Y, Kawai A, Hayakawa K, Setsu N, Kawashima H, Iwata S, Tsuchiya H, Tsukushi S, Takenaka S, Imanishi J, Baba I, Nagano A, Morii T, Shirai T, Shimizu K, Kawano H
Cancer Sci 2022 Jul;113(7):2397-2408. Epub 2022 May 18 doi: 10.1111/cas.15382. PMID: 35485870Free PMC Article
Dhinsa BS, DeLisa M, Pollock R, Flanagan AM, Whelan J, Gregory J
Oncol Res Treat 2018;41(7-8):456-460. Epub 2018 Jun 15 doi: 10.1159/000487803. PMID: 29902785
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896
Capanna R, Bertoni F, Bettelli G, Picci P, Bacchini P, Present D, Giunti A, Campanacci M
J Bone Joint Surg Am 1988 Jan;70(1):60-9. PMID: 3335575

Diagnosis

Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Kattepur AK, Jones RL, Gulia A
Future Oncol 2021 Dec;17(35):4983-4991. Epub 2021 Nov 4 doi: 10.2217/fon-2021-0830. PMID: 34734747
Baraban E, Cooper K
Semin Diagn Pathol 2021 Nov;38(6):119-126. Epub 2020 Sep 5 doi: 10.1053/j.semdp.2020.09.002. PMID: 32948384
Mavrogenis AF, Ruggieri P, Mercuri M, Papagelopoulos PJ
J Surg Orthop Adv 2011 Summer;20(2):106-11. PMID: 21838071
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Therapy

Hompland I, Ferrari S, Bielack S, Palmerini E, Hall KS, Picci P, Hecker-Nolting S, Donati DM, Blattmann C, Bjerkehagen B, Staals E, Kager L, Gambarotti M, Kühne T, Eriksson M, Ferraresi V, Kevric M, Biagini R, Baumhoer D, Brosjø O, Comandone A, Schwarz R, Bertulli R, Kessler T, Hansson L, Apice G, Heydrich BN, Setola E, Flörcken A, Ruggieri P, Krasniqi F, Hofmann-Wackersreuther G, Casali P, Reichardt P, Smeland S
Eur J Cancer 2021 Jul;151:150-158. Epub 2021 May 11 doi: 10.1016/j.ejca.2021.04.017. PMID: 33990016
Dhinsa BS, DeLisa M, Pollock R, Flanagan AM, Whelan J, Gregory J
Oncol Res Treat 2018;41(7-8):456-460. Epub 2018 Jun 15 doi: 10.1159/000487803. PMID: 29902785
Davies BW, Prescott CR, Said SA, Campana J, Attié-Castro FA, Velasco E Cruz AA, Durairaj VD
Ophthalmic Plast Reconstr Surg 2014 May-Jun;30(3):205-8. doi: 10.1097/IOP.0000000000000168. PMID: 24807535
Kawaguchi S, Sun T, Lin PP, Deavers M, Harun N, Lewis VO
Clin Orthop Relat Res 2014 Mar;472(3):983-9. Epub 2013 Nov 7 doi: 10.1007/s11999-013-3360-5. PMID: 24197392Free PMC Article
Randall RL, Gowski W
J Natl Compr Canc Netw 2005 Mar;3(2):149-56. doi: 10.6004/jnccn.2005.0011. PMID: 19817027

Prognosis

Tlemsani C, Larousserie F, De Percin S, Audard V, Hadjadj D, Chen J, Biau D, Anract P, Terris B, Goldwasser F, Pasmant E, Boudou-Rouquette P
Int J Mol Sci 2023 Jan 10;24(2) doi: 10.3390/ijms24021361. PMID: 36674874Free PMC Article
Dehner CA, Maloney N, Amini B, Jennings JW, McDonald DJ, Wang WL, Chrisinger JSA
Mod Pathol 2022 Jul;35(7):922-928. Epub 2022 Feb 3 doi: 10.1038/s41379-022-01008-8. PMID: 35115636
Kattepur AK, Jones RL, Gulia A
Future Oncol 2021 Dec;17(35):4983-4991. Epub 2021 Nov 4 doi: 10.2217/fon-2021-0830. PMID: 34734747
Mavrogenis AF, Ruggieri P, Mercuri M, Papagelopoulos PJ
J Surg Orthop Adv 2011 Summer;20(2):106-11. PMID: 21838071
Mercuri M, Picci P, Campanacci L, Rulli E
Skeletal Radiol 1995 Aug;24(6):409-16. doi: 10.1007/BF00941235. PMID: 7481896

Clinical prediction guides

Hung YP, Chebib I, Bredella MA, Berner EA, Taylor-Black Q, Choy E, Cote GM, Chen YL, MacDonald SM, Schwab JH, Raskin KA, Newman ET, Selig MK, Deshpande V, Hornick JL, Lozano-Calderón SA, Nielsen GP
Mod Pathol 2023 Mar;36(3):100069. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100069. PMID: 36788104
Tilden W, Andrei V, O'Donnell P, Saifuddin A
Skeletal Radiol 2022 Jun;51(6):1189-1199. Epub 2021 Oct 29 doi: 10.1007/s00256-021-03947-w. PMID: 34714386
Cao L, Wu Y, Han SM, Sun T, Yu BH, Gao F, Wu WJ, Gao BL
BMC Musculoskelet Disord 2021 Feb 15;22(1):189. doi: 10.1186/s12891-021-04053-7. PMID: 33588810Free PMC Article
Lucas CG, Grenert JP, Horvai A
Arch Pathol Lab Med 2021 Aug 1;145(8):1009-1017. doi: 10.5858/arpa.2020-0379-OA. PMID: 33147331
Sambri A, Tuzzato G, Donati DM, De Paolis M, Bianchi G
J Orthop Sci 2021 May;26(3):473-477. Epub 2020 Jun 18 doi: 10.1016/j.jos.2020.04.013. PMID: 32564907

Recent systematic reviews

Tsukamoto S, Mavrogenis AF, Nitta Y, Righi A, Masunaga T, Honoki K, Fujii H, Kido A, Tanaka Y, Tanaka Y, Errani C
Curr Oncol 2024 Jan 19;31(1):566-578. doi: 10.3390/curroncol31010040. PMID: 38275833Free PMC Article

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