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Metastatic Pancreatic Adenocarcinoma

MedGen UID:
163663
Concept ID:
C0861727
Neoplastic Process

Definition

An adenocarcinoma that arises from the exocrine pancreatic tissue and has metastasized to other anatomic sites. [from NCI]

Professional guidelines

PubMed

Cheema AR, O'Reilly EM
Surg Clin North Am 2016 Dec;96(6):1391-1414. doi: 10.1016/j.suc.2016.07.011. PMID: 27865284
Varghese AM, Lowery MA, Yu KH, O'Reilly EM
Cancer 2016 Dec 15;122(24):3765-3775. Epub 2016 Sep 20 doi: 10.1002/cncr.30342. PMID: 27649047Free PMC Article
Thota R, Pauff JM, Berlin JD
Oncology (Williston Park) 2014 Jan;28(1):70-4. PMID: 24683721

Recent clinical studies

Etiology

Huffman BM, Feng H, Parmar K, Wang J, Kapner KS, Kochupurakkal B, Martignetti DB, Sadatrezaei G, Abrams TA, Biller LH, Giannakis M, Ng K, Patel AK, Perez KJ, Singh H, Rubinson DA, Schlechter BL, Andrews E, Hannigan AM, Dunwell S, Getchell Z, Raghavan S, Wolpin BM, Fortier C, D'Andrea AD, Aguirre AJ, Shapiro GI, Cleary JM
Clin Cancer Res 2023 Dec 15;29(24):5047-5056. doi: 10.1158/1078-0432.CCR-23-2005. PMID: 37819936Free PMC Article
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
O'Hara MH, O'Reilly EM, Varadhachary G, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Mick R, Gherardini PF, Kitch LJ, Xu J, Samuel T, Karakunnel J, Fairchild J, Bucktrout S, LaVallee TM, Selinsky C, Till JE, Carpenter EL, Alanio C, Byrne KT, Chen RO, Trifan OC, Dugan U, Horak C, Hubbard-Lucey VM, Wherry EJ, Ibrahim R, Vonderheide RH
Lancet Oncol 2021 Jan;22(1):118-131. doi: 10.1016/S1470-2045(20)30532-5. PMID: 33387490
Lamb YN, Scott LJ
Drugs 2017 May;77(7):785-792. doi: 10.1007/s40265-017-0741-1. PMID: 28401446
Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, Harris M, Reni M, Dowden S, Laheru D, Bahary N, Ramanathan RK, Tabernero J, Hidalgo M, Goldstein D, Van Cutsem E, Wei X, Iglesias J, Renschler MF
N Engl J Med 2013 Oct 31;369(18):1691-703. Epub 2013 Oct 16 doi: 10.1056/NEJMoa1304369. PMID: 24131140Free PMC Article

Diagnosis

Huffman BM, Feng H, Parmar K, Wang J, Kapner KS, Kochupurakkal B, Martignetti DB, Sadatrezaei G, Abrams TA, Biller LH, Giannakis M, Ng K, Patel AK, Perez KJ, Singh H, Rubinson DA, Schlechter BL, Andrews E, Hannigan AM, Dunwell S, Getchell Z, Raghavan S, Wolpin BM, Fortier C, D'Andrea AD, Aguirre AJ, Shapiro GI, Cleary JM
Clin Cancer Res 2023 Dec 15;29(24):5047-5056. doi: 10.1158/1078-0432.CCR-23-2005. PMID: 37819936Free PMC Article
Ebrahimi A, Cham J, Puglisi L, De Shadarevian M, Hermel DJ, Spierling Bagsic SR, Sigal D
Cancer Med 2023 May;12(9):10243-10253. Epub 2023 Mar 14 doi: 10.1002/cam4.5751. PMID: 36916531Free PMC Article
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Taieb J, Pointet AL, Van Laethem JL, Laquente B, Pernot S, Lordick F, Reni M
Ann Oncol 2017 Jul 1;28(7):1473-1483. doi: 10.1093/annonc/mdx174. PMID: 28459988
Varghese AM, Lowery MA, Yu KH, O'Reilly EM
Cancer 2016 Dec 15;122(24):3765-3775. Epub 2016 Sep 20 doi: 10.1002/cncr.30342. PMID: 27649047Free PMC Article

Therapy

De La Fouchardière C, Malka D, Cropet C, Chabaud S, Raimbourg J, Botsen D, Launay S, Evesque L, Vienot A, Perrier H, Jary M, Rinaldi Y, Coutzac C, Bachet JB, Neuzillet C, Williet N, Desgrippes R, Grainville T, Aparicio T, Peytier A, Lecomte T, Roth GS, Thirot-Bidault A, Lachaux N, Bouché O, Ghiringhelli F
J Clin Oncol 2024 Mar 20;42(9):1055-1066. Epub 2024 Jan 17 doi: 10.1200/JCO.23.00795. PMID: 38232341
Kindler HL, Hammel P, Reni M, Van Cutsem E, Macarulla T, Hall MJ, Park JO, Hochhauser D, Arnold D, Oh DY, Reinacher-Schick A, Tortora G, Algül H, O'Reilly EM, Bordia S, McGuinness D, Cui K, Locker GY, Golan T
J Clin Oncol 2022 Dec 1;40(34):3929-3939. Epub 2022 Jul 14 doi: 10.1200/JCO.21.01604. PMID: 35834777Free PMC Article
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
Varghese AM, Lowery MA, Yu KH, O'Reilly EM
Cancer 2016 Dec 15;122(24):3765-3775. Epub 2016 Sep 20 doi: 10.1002/cncr.30342. PMID: 27649047Free PMC Article
Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, Harris M, Reni M, Dowden S, Laheru D, Bahary N, Ramanathan RK, Tabernero J, Hidalgo M, Goldstein D, Van Cutsem E, Wei X, Iglesias J, Renschler MF
N Engl J Med 2013 Oct 31;369(18):1691-703. Epub 2013 Oct 16 doi: 10.1056/NEJMoa1304369. PMID: 24131140Free PMC Article

Prognosis

Huffman BM, Feng H, Parmar K, Wang J, Kapner KS, Kochupurakkal B, Martignetti DB, Sadatrezaei G, Abrams TA, Biller LH, Giannakis M, Ng K, Patel AK, Perez KJ, Singh H, Rubinson DA, Schlechter BL, Andrews E, Hannigan AM, Dunwell S, Getchell Z, Raghavan S, Wolpin BM, Fortier C, D'Andrea AD, Aguirre AJ, Shapiro GI, Cleary JM
Clin Cancer Res 2023 Dec 15;29(24):5047-5056. doi: 10.1158/1078-0432.CCR-23-2005. PMID: 37819936Free PMC Article
Tang H, Ge Y, You T, Li X, Wang Y, Cheng Y, Bai C
BMC Cancer 2023 Oct 10;23(1):958. doi: 10.1186/s12885-023-11464-3. PMID: 37817078Free PMC Article
Ebrahimi A, Cham J, Puglisi L, De Shadarevian M, Hermel DJ, Spierling Bagsic SR, Sigal D
Cancer Med 2023 May;12(9):10243-10253. Epub 2023 Mar 14 doi: 10.1002/cam4.5751. PMID: 36916531Free PMC Article
Rémond MS, Pellat A, Brezault C, Dhooge M, Coriat R
ESMO Open 2022 Dec;7(6):100638. Epub 2022 Nov 16 doi: 10.1016/j.esmoop.2022.100638. PMID: 36399952Free PMC Article
Weinberg BA, Yabar CS, Brody JR, Pishvaian MJ
Oncology (Williston Park) 2015 Nov;29(11):809-20, 886. PMID: 26573060

Clinical prediction guides

Kindler HL, Hammel P, Reni M, Van Cutsem E, Macarulla T, Hall MJ, Park JO, Hochhauser D, Arnold D, Oh DY, Reinacher-Schick A, Tortora G, Algül H, O'Reilly EM, Bordia S, McGuinness D, Cui K, Locker GY, Golan T
J Clin Oncol 2022 Dec 1;40(34):3929-3939. Epub 2022 Jul 14 doi: 10.1200/JCO.21.01604. PMID: 35834777Free PMC Article
Wainberg ZA, Bekaii-Saab T, Boland PM, Dayyani F, Macarulla T, Mody K, Belanger B, Maxwell F, Moore Y, Thiagalingam A, Wang T, Zhang B, Dean A
Eur J Cancer 2021 Jul;151:14-24. Epub 2021 May 4 doi: 10.1016/j.ejca.2021.03.028. PMID: 33957442
O'Hara MH, O'Reilly EM, Varadhachary G, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Mick R, Gherardini PF, Kitch LJ, Xu J, Samuel T, Karakunnel J, Fairchild J, Bucktrout S, LaVallee TM, Selinsky C, Till JE, Carpenter EL, Alanio C, Byrne KT, Chen RO, Trifan OC, Dugan U, Horak C, Hubbard-Lucey VM, Wherry EJ, Ibrahim R, Vonderheide RH
Lancet Oncol 2021 Jan;22(1):118-131. doi: 10.1016/S1470-2045(20)30532-5. PMID: 33387490
Frampton JE
Drugs 2020 Jul;80(10):1007-1018. doi: 10.1007/s40265-020-01336-6. PMID: 32557396Free PMC Article
Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, Seay T, Tjulandin SA, Ma WW, Saleh MN, Harris M, Reni M, Dowden S, Laheru D, Bahary N, Ramanathan RK, Tabernero J, Hidalgo M, Goldstein D, Van Cutsem E, Wei X, Iglesias J, Renschler MF
N Engl J Med 2013 Oct 31;369(18):1691-703. Epub 2013 Oct 16 doi: 10.1056/NEJMoa1304369. PMID: 24131140Free PMC Article

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