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Functioning pituitary gland adenoma

MedGen UID:
163135
•Concept ID:
C0854486
•
Neoplastic Process
Synonyms: Endocrine active pituitary adenoma; endocrine active pituitary adenoma; Functioning Adenoma of Pituitary; functioning adenoma of pituitary; Functioning Adenoma of Pituitary Gland; functioning adenoma of pituitary gland; Functioning Adenoma of the Pituitary; functioning adenoma of the pituitary; Functioning Adenoma of the Pituitary Gland; functioning adenoma of the pituitary gland; Functioning PitNET/Adenoma; Functioning Pituitary Adenoma; functioning pituitary adenoma; Functioning pituitary adenoma; Functioning Pituitary Gland Adenoma; functioning pituitary gland adenoma; functioning pituitary gland adenoma (benign); Functioning Pituitary Neuroendocrine Tumor; Functioning Pituitary Neuroendocrine Tumor/Adenoma; Secreting pituitary adenoma; secreting pituitary adenoma; Secretory Adenoma of Pituitary; secretory adenoma of pituitary; Secretory Adenoma of Pituitary Gland; secretory adenoma of pituitary gland; Secretory Adenoma of the Pituitary; secretory adenoma of the pituitary; Secretory Adenoma of the Pituitary Gland; secretory adenoma of the pituitary gland; Secretory Pituitary Adenoma; secretory pituitary adenoma; Secretory Pituitary Gland Adenoma; secretory pituitary gland adenoma
 
Monarch Initiative: MONDO:0003429
Orphanet: ORPHA314753

Definition

A hormone producing pituitary neuroendocrine tumor associated with a hormonal syndrome. [from NCI]

Professional guidelines

PubMed

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
A Pituitary Society update to acromegaly management guidelines.
Fleseriu M, Biller BMK, Freda PU, Gadelha MR, Giustina A, Katznelson L, Molitch ME, Samson SL, Strasburger CJ, van der Lely AJ, Melmed S
Pituitary 2021 Feb;24(1):1-13. Epub 2020 Oct 20 doi: 10.1007/s11102-020-01091-7. PMID: 33079318Free PMC Article

Recent clinical studies

Etiology

The World Health Organization classifications of pituitary neuroendocrine tumours: a clinico-pathological appraisal.
Villa C, Baussart B, Assié G, Raverot G, Roncaroli F
Endocr Relat Cancer 2023 Aug 1;30(8) Epub 2023 Jun 22 doi: 10.1530/ERC-23-0021. PMID: 37068095
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline.
Nieman LK, Biller BM, Findling JW, Murad MH, Newell-Price J, Savage MO, Tabarin A; Endocrine Society
J Clin Endocrinol Metab 2015 Aug;100(8):2807-31. Epub 2015 Jul 29 doi: 10.1210/jc.2015-1818. PMID: 26222757Free PMC Article
Pituitary incidentaloma: an endocrine society clinical practice guideline.
Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, Vance ML; Endocrine Society
J Clin Endocrinol Metab 2011 Apr;96(4):894-904. doi: 10.1210/jc.2010-1048. PMID: 21474686Free PMC Article

Diagnosis

ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy.
Luger A, Broersen LHA, Biermasz NR, Biller BMK, Buchfelder M, Chanson P, Jorgensen JOL, Kelestimur F, Llahana S, Maiter D, Mintziori G, Petraglia F, Verkauskiene R, Webb SM, Dekkers OM
Eur J Endocrinol 2021 Aug 23;185(3):G1-G33. doi: 10.1530/EJE-21-0462. PMID: 34425558
Pituitary in the Spotlight.
Reincke M, Honegger J
Exp Clin Endocrinol Diabetes 2021 Mar;129(3):143-145. Epub 2021 Mar 9 doi: 10.1055/a-1369-8898. PMID: 33690869
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Pituitary adenomas: an overview.
Lake MG, Krook LS, Cruz SV
Am Fam Physician 2013 Sep 1;88(5):319-27. PMID: 24010395
Pituitary incidentaloma: an endocrine society clinical practice guideline.
Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, Vance ML; Endocrine Society
J Clin Endocrinol Metab 2011 Apr;96(4):894-904. doi: 10.1210/jc.2010-1048. PMID: 21474686Free PMC Article

Therapy

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Pediatric pituitary adenomas.
Walz PC, Drapeau A, Shaikhouni A, Eide J, Rugino AJ, Mohyeldin A, Carrau R, Prevedello D
Childs Nerv Syst 2019 Nov;35(11):2107-2118. Epub 2019 Jul 13 doi: 10.1007/s00381-019-04293-y. PMID: 31302729
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Craniopharyngioma.
Müller HL
Endocr Rev 2014 Jun;35(3):513-43. Epub 2014 Jan 27 doi: 10.1210/er.2013-1115. PMID: 24467716

Prognosis

The World Health Organization classifications of pituitary neuroendocrine tumours: a clinico-pathological appraisal.
Villa C, Baussart B, Assié G, Raverot G, Roncaroli F
Endocr Relat Cancer 2023 Aug 1;30(8) Epub 2023 Jun 22 doi: 10.1530/ERC-23-0021. PMID: 37068095
Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Silent corticotroph adenomas.
Ben-Shlomo A, Cooper O
Pituitary 2018 Apr;21(2):183-193. doi: 10.1007/s11102-018-0864-8. PMID: 29344907
Pituitary incidentaloma: an endocrine society clinical practice guideline.
Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, Vance ML; Endocrine Society
J Clin Endocrinol Metab 2011 Apr;96(4):894-904. doi: 10.1210/jc.2010-1048. PMID: 21474686Free PMC Article

Clinical prediction guides

The World Health Organization classifications of pituitary neuroendocrine tumours: a clinico-pathological appraisal.
Villa C, Baussart B, Assié G, Raverot G, Roncaroli F
Endocr Relat Cancer 2023 Aug 1;30(8) Epub 2023 Jun 22 doi: 10.1530/ERC-23-0021. PMID: 37068095
Clinically non-functioning pituitary adenomas.
Chanson P, Wolf P
Presse Med 2021 Dec;50(4):104086. Epub 2021 Oct 28 doi: 10.1016/j.lpm.2021.104086. PMID: 34718111
Aggressive Pituitary Adenomas and Carcinomas.
Ilie MD, Jouanneau E, Raverot G
Endocrinol Metab Clin North Am 2020 Sep;49(3):505-515. Epub 2020 Jul 8 doi: 10.1016/j.ecl.2020.05.008. PMID: 32741485
Hypopituitarism.
Higham CE, Johannsson G, Shalet SM
Lancet 2016 Nov 12;388(10058):2403-2415. Epub 2016 Mar 31 doi: 10.1016/S0140-6736(16)30053-8. PMID: 27041067
Pituitary adenomas: an overview.
Lake MG, Krook LS, Cruz SV
Am Fam Physician 2013 Sep 1;88(5):319-27. PMID: 24010395

Recent systematic reviews

Aggressive PitNETs and Potential Target Therapies: A Systematic Review of Molecular and Genetic Pathways.
Serioli S, Agostini L, Pietrantoni A, Valeri F, Costanza F, Chiloiro S, Buffoli B, Piazza A, Poliani PL, Peris-Celda M, Iavarone F, Gaudino S, Gessi M, Schinzari G, Mattogno PP, Giampietro A, De Marinis L, Pontecorvi A, Fontanella MM, Lauretti L, Rindi G, Olivi A, Bianchi A, Doglietto F
Int J Mol Sci 2023 Oct 29;24(21) doi: 10.3390/ijms242115719. PMID: 37958702Free PMC Article
Natural History of Non-Functioning Pituitary Adenomas: A Systematic Review and Meta-Analysis.
Rikvold SD, Pedersen MB, Andreassen M, Krogh J
Horm Metab Res 2023 Jul;55(7):443-451. Epub 2023 Jul 10 doi: 10.1055/a-2096-1340. PMID: 37494058
Metabolomics in acromegaly: a systematic review.
Pînzariu O, Georgescu CE
J Investig Med 2023 Aug;71(6):634-645. Epub 2023 May 4 doi: 10.1177/10815589231169452. PMID: 37139720
Treatment of non-functioning pituitary adenoma with cabergoline: a systematic review and meta-analysis.
Botelho MS, Franzini ÍA, Nunes-Nogueira VDS, Boguszewski CL
Pituitary 2022 Dec;25(6):810-818. Epub 2022 Jul 28 doi: 10.1007/s11102-022-01257-5. PMID: 35902444
Headache and pituitary disease: a systematic review.
Kreitschmann-Andermahr I, Siegel S, Weber Carneiro R, Maubach JM, Harbeck B, Brabant G
Clin Endocrinol (Oxf) 2013 Dec;79(6):760-9. Epub 2013 Sep 20 doi: 10.1111/cen.12314. PMID: 23941570

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