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Functioning pituitary gland neoplasm

MedGen UID:
163414
•Concept ID:
C0851693
•
Neoplastic Process
Synonyms: functioning endocrine neoplasm of pituitary gland; functioning pituitary gland neoplasm; functioning pituitary neoplasm; functioning pituitary tumor; functioning pituitary tumour; growth hormone producing pituitary tumour; hormone producing pituitary cancer; hormone producing pituitary neoplasm; pituitary gland functioning endocrine neoplasm; pituitary neoplasms, hormone producing; pituitary tumors, hormone producing; secretory pituitary tumor; secretory pituitary tumour; somatotropinoma
 
Monarch Initiative: MONDO:0003604

Definition

A hormone producing pituitary gland tumor, associated with a hormonal syndrome. [from MONDO]

Professional guidelines

PubMed

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Diagnosis and Treatment of Acromegaly: An Update.
Ershadinia N, Tritos NA
Mayo Clin Proc 2022 Feb;97(2):333-346. doi: 10.1016/j.mayocp.2021.11.007. PMID: 35120696
A Pituitary Society update to acromegaly management guidelines.
Fleseriu M, Biller BMK, Freda PU, Gadelha MR, Giustina A, Katznelson L, Molitch ME, Samson SL, Strasburger CJ, van der Lely AJ, Melmed S
Pituitary 2021 Feb;24(1):1-13. Epub 2020 Oct 20 doi: 10.1007/s11102-020-01091-7. PMID: 33079318Free PMC Article

Recent clinical studies

Etiology

ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy.
Luger A, Broersen LHA, Biermasz NR, Biller BMK, Buchfelder M, Chanson P, Jorgensen JOL, Kelestimur F, Llahana S, Maiter D, Mintziori G, Petraglia F, Verkauskiene R, Webb SM, Dekkers OM
Eur J Endocrinol 2021 Aug 23;185(3):G1-G33. doi: 10.1530/EJE-21-0462. PMID: 34425558
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Treatment of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline.
Nieman LK, Biller BM, Findling JW, Murad MH, Newell-Price J, Savage MO, Tabarin A; Endocrine Society
J Clin Endocrinol Metab 2015 Aug;100(8):2807-31. Epub 2015 Jul 29 doi: 10.1210/jc.2015-1818. PMID: 26222757Free PMC Article
Management of clinically non-functioning pituitary adenoma.
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284
Pituitary incidentaloma: an endocrine society clinical practice guideline.
Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, Vance ML; Endocrine Society
J Clin Endocrinol Metab 2011 Apr;96(4):894-904. doi: 10.1210/jc.2010-1048. PMID: 21474686Free PMC Article

Diagnosis

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
The Diagnosis and Treatment of Craniopharyngioma.
Müller HL
Neuroendocrinology 2020;110(9-10):753-766. Epub 2019 Nov 4 doi: 10.1159/000504512. PMID: 31678973
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Management of clinically non-functioning pituitary adenoma.
Chanson P, Raverot G, Castinetti F, Cortet-Rudelli C, Galland F, Salenave S; French Endocrinology Society non-functioning pituitary adenoma work-group
Ann Endocrinol (Paris) 2015 Jul;76(3):239-47. Epub 2015 Jun 10 doi: 10.1016/j.ando.2015.04.002. PMID: 26072284
Pituitary adenomas: an overview.
Lake MG, Krook LS, Cruz SV
Am Fam Physician 2013 Sep 1;88(5):319-27. PMID: 24010395

Therapy

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Pediatric pituitary adenomas.
Walz PC, Drapeau A, Shaikhouni A, Eide J, Rugino AJ, Mohyeldin A, Carrau R, Prevedello D
Childs Nerv Syst 2019 Nov;35(11):2107-2118. Epub 2019 Jul 13 doi: 10.1007/s00381-019-04293-y. PMID: 31302729
Craniopharyngioma.
Müller HL
Handb Clin Neurol 2014;124:235-53. doi: 10.1016/B978-0-444-59602-4.00016-2. PMID: 25248591
Craniopharyngioma.
Müller HL
Endocr Rev 2014 Jun;35(3):513-43. Epub 2014 Jan 27 doi: 10.1210/er.2013-1115. PMID: 24467716
Antipsychotic-induced hyperprolactinemia.
Bostwick JR, Guthrie SK, Ellingrod VL
Pharmacotherapy 2009 Jan;29(1):64-73. doi: 10.1592/phco.29.1.64. PMID: 19113797

Prognosis

Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
Pangenomic Classification of Pituitary Neuroendocrine Tumors.
Neou M, Villa C, Armignacco R, Jouinot A, Raffin-Sanson ML, Septier A, Letourneur F, Diry S, Diedisheim M, Izac B, Gaspar C, Perlemoine K, Verjus V, Bernier M, Boulin A, Emile JF, Bertagna X, Jaffrezic F, Laloe D, Baussart B, Bertherat J, Gaillard S, Assié G
Cancer Cell 2020 Jan 13;37(1):123-134.e5. Epub 2019 Dec 26 doi: 10.1016/j.ccell.2019.11.002. PMID: 31883967
The epidemiology, diagnosis and treatment of Prolactinomas: The old and the new.
Chanson P, Maiter D
Best Pract Res Clin Endocrinol Metab 2019 Apr;33(2):101290. Epub 2019 Jul 10 doi: 10.1016/j.beem.2019.101290. PMID: 31326373
Clinical and Pathological Aspects of Silent Pituitary Adenomas.
Drummond J, Roncaroli F, Grossman AB, Korbonits M
J Clin Endocrinol Metab 2019 Jul 1;104(7):2473-2489. doi: 10.1210/jc.2018-00688. PMID: 30020466Free PMC Article
Pituitary incidentaloma: an endocrine society clinical practice guideline.
Freda PU, Beckers AM, Katznelson L, Molitch ME, Montori VM, Post KD, Vance ML; Endocrine Society
J Clin Endocrinol Metab 2011 Apr;96(4):894-904. doi: 10.1210/jc.2010-1048. PMID: 21474686Free PMC Article

Clinical prediction guides

Diagnosis and Management of Pituitary Adenomas: A Review.
Tritos NA, Miller KK
JAMA 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444. PMID: 37097352
Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET.
Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, Yao S, Wang Y, Cheng H, Chen H, Ye H, Wang Y, Li Y, Chen J, Zhang Z, Guo F, Zhao Y
Cell Rep Med 2023 Feb 21;4(2):100934. Epub 2023 Feb 7 doi: 10.1016/j.xcrm.2023.100934. PMID: 36754052Free PMC Article
Clinically non-functioning pituitary adenomas.
Chanson P, Wolf P
Presse Med 2021 Dec;50(4):104086. Epub 2021 Oct 28 doi: 10.1016/j.lpm.2021.104086. PMID: 34718111
Childhood-onset Craniopharyngioma.
Otte A, Müller HL
J Clin Endocrinol Metab 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397. PMID: 34086900
Pituitary adenomas: an overview.
Lake MG, Krook LS, Cruz SV
Am Fam Physician 2013 Sep 1;88(5):319-27. PMID: 24010395

Recent systematic reviews

Aggressive PitNETs and Potential Target Therapies: A Systematic Review of Molecular and Genetic Pathways.
Serioli S, Agostini L, Pietrantoni A, Valeri F, Costanza F, Chiloiro S, Buffoli B, Piazza A, Poliani PL, Peris-Celda M, Iavarone F, Gaudino S, Gessi M, Schinzari G, Mattogno PP, Giampietro A, De Marinis L, Pontecorvi A, Fontanella MM, Lauretti L, Rindi G, Olivi A, Bianchi A, Doglietto F
Int J Mol Sci 2023 Oct 29;24(21) doi: 10.3390/ijms242115719. PMID: 37958702Free PMC Article
Natural History of Non-Functioning Pituitary Adenomas: A Systematic Review and Meta-Analysis.
Rikvold SD, Pedersen MB, Andreassen M, Krogh J
Horm Metab Res 2023 Jul;55(7):443-451. Epub 2023 Jul 10 doi: 10.1055/a-2096-1340. PMID: 37494058
Metabolomics in acromegaly: a systematic review.
Pînzariu O, Georgescu CE
J Investig Med 2023 Aug;71(6):634-645. Epub 2023 May 4 doi: 10.1177/10815589231169452. PMID: 37139720
Immune-checkpoint inhibitors in pituitary malignancies.
Di Nunno V, Franceschi E, Tosoni A, Gatto L, Maggio I, Lodi R, Bartolini S, Brandes AA
Anticancer Drugs 2022 Jan 1;33(1):e28-e35. doi: 10.1097/CAD.0000000000001157. PMID: 34348358
Headache and pituitary disease: a systematic review.
Kreitschmann-Andermahr I, Siegel S, Weber Carneiro R, Maubach JM, Harbeck B, Brabant G
Clin Endocrinol (Oxf) 2013 Dec;79(6):760-9. Epub 2013 Sep 20 doi: 10.1111/cen.12314. PMID: 23941570

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