U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Adult acute lymphoblastic leukemia

MedGen UID:
199693
Concept ID:
C0751606
Neoplastic Process
Synonyms: Adult Acute Lymphoblastic Leukemia; adult acute lymphoblastic leukemia; adult acute lymphocytic leukaemia; adult acute lymphocytic leukemia; adult acute lymphogenous leukaemia; adult acute lymphogenous leukemia; adult acute lymphoid leukaemia; Adult Acute Lymphoid Leukemia; adult acute lymphoid leukemia; Adult ALL; adult ALL; adult precursor lymphoblastic leukaemia; Adult Precursor Lymphoblastic Leukemia; adult precursor lymphoblastic leukemia
 
Monarch Initiative: MONDO:0003541

Definition

An acute lymphoblastic leukemia occurring during adulthood. [from NCI]

Professional guidelines

PubMed

Gökbuget N, Boissel N, Chiaretti S, Dombret H, Doubek M, Fielding A, Foà R, Giebel S, Hoelzer D, Hunault M, Marks DI, Martinelli G, Ottmann O, Rijneveld A, Rousselot P, Ribera J, Bassan R
Blood 2024 May 9;143(19):1903-1930. doi: 10.1182/blood.2023023568. PMID: 38306595
Samra B, Jabbour E, Ravandi F, Kantarjian H, Short NJ
J Hematol Oncol 2020 Jun 5;13(1):70. doi: 10.1186/s13045-020-00905-2. PMID: 32503572Free PMC Article
Gregory S
Semin Oncol Nurs 2019 Dec;35(6):150951. Epub 2019 Nov 20 doi: 10.1016/j.soncn.2019.150951. PMID: 31759820

Recent clinical studies

Etiology

Gökbuget N, Boissel N, Chiaretti S, Dombret H, Doubek M, Fielding A, Foà R, Giebel S, Hoelzer D, Hunault M, Marks DI, Martinelli G, Ottmann O, Rijneveld A, Rousselot P, Ribera J, Bassan R
Blood 2024 May 9;143(19):1903-1930. doi: 10.1182/blood.2023023568. PMID: 38306595
Bassan R, Chiaretti S, Della Starza I, Spinelli O, Santoro A, Paoloni F, Messina M, Elia L, De Propris MS, Scattolin AM, Audisio E, Marbello L, Borlenghi E, Zappasodi P, Mauro E, Martinelli G, Mattei D, Fracchiolla N, Bocchia M, De Fabritiis P, Bonifacio M, Candoni A, Cassibba V, Di Bartolomeo P, Latte G, Trappolini S, Guarini A, Vitale A, Fazi P, Piciocchi A, Rambaldi A, Foà R
Blood Adv 2023 Aug 22;7(16):4448-4461. doi: 10.1182/bloodadvances.2022009596. PMID: 37276451Free PMC Article
Jabbour E, Short NJ, Jain N, Haddad FG, Welch MA, Ravandi F, Kantarjian H
J Hematol Oncol 2023 Mar 16;16(1):22. doi: 10.1186/s13045-023-01409-5. PMID: 36927623Free PMC Article
Huguet F, Chevret S, Leguay T, Thomas X, Boissel N, Escoffre-Barbe M, Chevallier P, Hunault M, Vey N, Bonmati C, Lepretre S, Marolleau JP, Pabst T, Rousselot P, Buzyn A, Cahn JY, Lhéritier V, Béné MC, Asnafi V, Delabesse E, Macintyre E, Chalandon Y, Ifrah N, Dombret H; Group of Research on Adult ALL (GRAALL)
J Clin Oncol 2018 Aug 20;36(24):2514-2523. Epub 2018 Jun 4 doi: 10.1200/JCO.2017.76.8192. PMID: 29863974
Maury S, Chevret S, Thomas X, Heim D, Leguay T, Huguet F, Chevallier P, Hunault M, Boissel N, Escoffre-Barbe M, Hess U, Vey N, Pignon JM, Braun T, Marolleau JP, Cahn JY, Chalandon Y, Lhéritier V, Beldjord K, Béné MC, Ifrah N, Dombret H; for GRAALL
N Engl J Med 2016 Sep 15;375(11):1044-53. doi: 10.1056/NEJMoa1605085. PMID: 27626518

Diagnosis

Gökbuget N, Boissel N, Chiaretti S, Dombret H, Doubek M, Fielding A, Foà R, Giebel S, Hoelzer D, Hunault M, Marks DI, Martinelli G, Ottmann O, Rijneveld A, Rousselot P, Ribera J, Bassan R
Blood 2024 May 9;143(19):1903-1930. doi: 10.1182/blood.2023023568. PMID: 38306595
Bardelli V, Arniani S, Pierini V, Di Giacomo D, Pierini T, Gorello P, Mecucci C, La Starza R
Genes (Basel) 2021 Jul 23;12(8) doi: 10.3390/genes12081118. PMID: 34440292Free PMC Article
Huguet F, Chevret S, Leguay T, Thomas X, Boissel N, Escoffre-Barbe M, Chevallier P, Hunault M, Vey N, Bonmati C, Lepretre S, Marolleau JP, Pabst T, Rousselot P, Buzyn A, Cahn JY, Lhéritier V, Béné MC, Asnafi V, Delabesse E, Macintyre E, Chalandon Y, Ifrah N, Dombret H; Group of Research on Adult ALL (GRAALL)
J Clin Oncol 2018 Aug 20;36(24):2514-2523. Epub 2018 Jun 4 doi: 10.1200/JCO.2017.76.8192. PMID: 29863974
Salmoiraghi S, Rambaldi A, Spinelli O
Leuk Lymphoma 2018 Apr;59(4):778-789. Epub 2017 Jul 6 doi: 10.1080/10428194.2017.1344839. PMID: 28679301
Paul S, Kantarjian H, Jabbour EJ
Mayo Clin Proc 2016 Nov;91(11):1645-1666. doi: 10.1016/j.mayocp.2016.09.010. PMID: 27814839

Therapy

Jabbour E, Short NJ, Jain N, Haddad FG, Welch MA, Ravandi F, Kantarjian H
J Hematol Oncol 2023 Mar 16;16(1):22. doi: 10.1186/s13045-023-01409-5. PMID: 36927623Free PMC Article
Samra B, Jabbour E, Ravandi F, Kantarjian H, Short NJ
J Hematol Oncol 2020 Jun 5;13(1):70. doi: 10.1186/s13045-020-00905-2. PMID: 32503572Free PMC Article
Gregory S
Semin Oncol Nurs 2019 Dec;35(6):150951. Epub 2019 Nov 20 doi: 10.1016/j.soncn.2019.150951. PMID: 31759820
DeFilipp Z, Advani AS, Bachanova V, Cassaday RD, Deangelo DJ, Kebriaei P, Rowe JM, Seftel MD, Stock W, Tallman MS, Fanning S, Inamoto Y, Kansagra A, Johnston L, Nagler A, Sauter CS, Savani BN, Perales MA, Carpenter PA, Larson RA, Weisdorf D
Biol Blood Marrow Transplant 2019 Nov;25(11):2113-2123. Epub 2019 Aug 22 doi: 10.1016/j.bbmt.2019.08.014. PMID: 31446198
Maury S, Chevret S, Thomas X, Heim D, Leguay T, Huguet F, Chevallier P, Hunault M, Boissel N, Escoffre-Barbe M, Hess U, Vey N, Pignon JM, Braun T, Marolleau JP, Cahn JY, Chalandon Y, Lhéritier V, Beldjord K, Béné MC, Ifrah N, Dombret H; for GRAALL
N Engl J Med 2016 Sep 15;375(11):1044-53. doi: 10.1056/NEJMoa1605085. PMID: 27626518

Prognosis

Gökbuget N, Boissel N, Chiaretti S, Dombret H, Doubek M, Fielding A, Foà R, Giebel S, Hoelzer D, Hunault M, Marks DI, Martinelli G, Ottmann O, Rijneveld A, Rousselot P, Ribera J, Bassan R
Blood 2024 May 9;143(19):1903-1930. doi: 10.1182/blood.2023023568. PMID: 38306595
Bassan R, Chiaretti S, Della Starza I, Spinelli O, Santoro A, Paoloni F, Messina M, Elia L, De Propris MS, Scattolin AM, Audisio E, Marbello L, Borlenghi E, Zappasodi P, Mauro E, Martinelli G, Mattei D, Fracchiolla N, Bocchia M, De Fabritiis P, Bonifacio M, Candoni A, Cassibba V, Di Bartolomeo P, Latte G, Trappolini S, Guarini A, Vitale A, Fazi P, Piciocchi A, Rambaldi A, Foà R
Blood Adv 2023 Aug 22;7(16):4448-4461. doi: 10.1182/bloodadvances.2022009596. PMID: 37276451Free PMC Article
Samra B, Jabbour E, Ravandi F, Kantarjian H, Short NJ
J Hematol Oncol 2020 Jun 5;13(1):70. doi: 10.1186/s13045-020-00905-2. PMID: 32503572Free PMC Article
Berry DA, Zhou S, Higley H, Mukundan L, Fu S, Reaman GH, Wood BL, Kelloff GJ, Jessup JM, Radich JP
JAMA Oncol 2017 Jul 13;3(7):e170580. doi: 10.1001/jamaoncol.2017.0580. PMID: 28494052Free PMC Article
Maury S, Chevret S, Thomas X, Heim D, Leguay T, Huguet F, Chevallier P, Hunault M, Boissel N, Escoffre-Barbe M, Hess U, Vey N, Pignon JM, Braun T, Marolleau JP, Cahn JY, Chalandon Y, Lhéritier V, Beldjord K, Béné MC, Ifrah N, Dombret H; for GRAALL
N Engl J Med 2016 Sep 15;375(11):1044-53. doi: 10.1056/NEJMoa1605085. PMID: 27626518

Clinical prediction guides

Chalandon Y, Rousselot P, Chevret S, Cayuela JM, Kim R, Huguet F, Chevallier P, Graux C, Thiebaut-Bertrand A, Chantepie S, Thomas X, Vincent L, Berthon C, Hicheri Y, Raffoux E, Escoffre-Barbe M, Plantier I, Joris M, Turlure P, Pasquier F, Belhabri A, Guepin GR, Blum S, Gregor M, Lafage-Pochitaloff M, Quessada J, Lhéritier V, Clappier E, Boissel N, Dombret H
Blood 2024 Jun 6;143(23):2363-2372. doi: 10.1182/blood.2023023502. PMID: 38452207
Bassan R, Chiaretti S, Della Starza I, Spinelli O, Santoro A, Paoloni F, Messina M, Elia L, De Propris MS, Scattolin AM, Audisio E, Marbello L, Borlenghi E, Zappasodi P, Mauro E, Martinelli G, Mattei D, Fracchiolla N, Bocchia M, De Fabritiis P, Bonifacio M, Candoni A, Cassibba V, Di Bartolomeo P, Latte G, Trappolini S, Guarini A, Vitale A, Fazi P, Piciocchi A, Rambaldi A, Foà R
Blood Adv 2023 Aug 22;7(16):4448-4461. doi: 10.1182/bloodadvances.2022009596. PMID: 37276451Free PMC Article
Huguet F, Chevret S, Leguay T, Thomas X, Boissel N, Escoffre-Barbe M, Chevallier P, Hunault M, Vey N, Bonmati C, Lepretre S, Marolleau JP, Pabst T, Rousselot P, Buzyn A, Cahn JY, Lhéritier V, Béné MC, Asnafi V, Delabesse E, Macintyre E, Chalandon Y, Ifrah N, Dombret H; Group of Research on Adult ALL (GRAALL)
J Clin Oncol 2018 Aug 20;36(24):2514-2523. Epub 2018 Jun 4 doi: 10.1200/JCO.2017.76.8192. PMID: 29863974
Salmoiraghi S, Rambaldi A, Spinelli O
Leuk Lymphoma 2018 Apr;59(4):778-789. Epub 2017 Jul 6 doi: 10.1080/10428194.2017.1344839. PMID: 28679301
Maury S, Chevret S, Thomas X, Heim D, Leguay T, Huguet F, Chevallier P, Hunault M, Boissel N, Escoffre-Barbe M, Hess U, Vey N, Pignon JM, Braun T, Marolleau JP, Cahn JY, Chalandon Y, Lhéritier V, Beldjord K, Béné MC, Ifrah N, Dombret H; for GRAALL
N Engl J Med 2016 Sep 15;375(11):1044-53. doi: 10.1056/NEJMoa1605085. PMID: 27626518

Recent systematic reviews

Soliman R, Heneghan C, Bolous NS, Sidhom I, Ahmed S, Roberts N, Oke J, Elhaddad A
Expert Rev Hematol 2022 Apr;15(4):345-357. Epub 2022 May 4 doi: 10.1080/17474086.2022.2069096. PMID: 35485262
Radhakrishnan VS, Agrawal N, Bagal B, Patel I
Clin Lymphoma Myeloma Leuk 2021 Jan;21(1):e85-e98. Epub 2020 Sep 18 doi: 10.1016/j.clml.2020.08.023. PMID: 33189603
Pidala J, Djulbegovic B, Anasetti C, Kharfan-Dabaja M, Kumar A
Cochrane Database Syst Rev 2011 Oct 5;2011(10):CD008818. doi: 10.1002/14651858.CD008818.pub2. PMID: 21975786Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...