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Febrile neutropenia

MedGen UID:
152883
Concept ID:
C0746883
Disease or Syndrome
Synonyms: Febrile Neutropenia; Febrile Neutropenias; Neutropenia, Febrile; Neutropenias, Febrile
SNOMED CT: Febrile neutropenia (409089005); Neutropenic fever (409089005)

Definition

Neutropenia associated with fever, the latter indicating the presence of an infection. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Escrihuela-Vidal F, Laporte J, Albasanz-Puig A, Gudiol C
Rev Esp Quimioter 2019 Sep;32 Suppl 2(Suppl 2):55-58. PMID: 31475812Free PMC Article
DiNardo CD, Pratz K, Pullarkat V, Jonas BA, Arellano M, Becker PS, Frankfurt O, Konopleva M, Wei AH, Kantarjian HM, Xu T, Hong WJ, Chyla B, Potluri J, Pollyea DA, Letai A
Blood 2019 Jan 3;133(1):7-17. Epub 2018 Oct 25 doi: 10.1182/blood-2018-08-868752. PMID: 30361262Free PMC Article
Taplitz RA, Kennedy EB, Bow EJ, Crews J, Gleason C, Hawley DK, Langston AA, Nastoupil LJ, Rajotte M, Rolston K, Strasfeld L, Flowers CR
J Clin Oncol 2018 May 10;36(14):1443-1453. Epub 2018 Feb 20 doi: 10.1200/JCO.2017.77.6211. PMID: 29461916

Recent clinical studies

Etiology

Boccia R, Glaspy J, Crawford J, Aapro M
Oncologist 2022 Aug 5;27(8):625-636. doi: 10.1093/oncolo/oyac074. PMID: 35552754Free PMC Article
Escrihuela-Vidal F, Laporte J, Albasanz-Puig A, Gudiol C
Rev Esp Quimioter 2019 Sep;32 Suppl 2(Suppl 2):55-58. PMID: 31475812Free PMC Article
Patel K, West HJ
JAMA Oncol 2017 Dec 1;3(12):1751. doi: 10.1001/jamaoncol.2017.1114. PMID: 28750112
Smith TJ, Bohlke K, Lyman GH, Carson KR, Crawford J, Cross SJ, Goldberg JM, Khatcheressian JL, Leighl NB, Perkins CL, Somlo G, Wade JL, Wozniak AJ, Armitage JO; American Society of Clinical Oncology
J Clin Oncol 2015 Oct 1;33(28):3199-212. Epub 2015 Jul 13 doi: 10.1200/JCO.2015.62.3488. PMID: 26169616
Lyman GH, Abella E, Pettengell R
Crit Rev Oncol Hematol 2014 Jun;90(3):190-9. Epub 2013 Dec 12 doi: 10.1016/j.critrevonc.2013.12.006. PMID: 24434034

Diagnosis

Feng S, Rao G, Wei X, Fu R, Hou M, Song Y, Xu C, Han P, Gong B, Chen X, Wang Y, Dong X, Jiang Z, Wang J
Clin Microbiol Infect 2024 Jan;30(1):107-113. Epub 2023 Jun 2 doi: 10.1016/j.cmi.2023.05.034. PMID: 37271194
Peseski AM, McClean M, Green SD, Beeler C, Konig H
Expert Rev Anti Infect Ther 2021 Mar;19(3):359-378. Epub 2020 Oct 5 doi: 10.1080/14787210.2020.1820863. PMID: 32892669
Curtis BR
Hematology Am Soc Hematol Educ Program 2017 Dec 8;2017(1):187-193. doi: 10.1182/asheducation-2017.1.187. PMID: 29222255Free PMC Article
Aguilar-Guisado M, Espigado I, Martín-Peña A, Gudiol C, Royo-Cebrecos C, Falantes J, Vázquez-López L, Montero MI, Rosso-Fernández C, de la Luz Martino M, Parody R, González-Campos J, Garzón-López S, Calderón-Cabrera C, Barba P, Rodríguez N, Rovira M, Montero-Mateos E, Carratalá J, Pérez-Simón JA, Cisneros JM
Lancet Haematol 2017 Dec;4(12):e573-e583. Epub 2017 Nov 15 doi: 10.1016/S2352-3026(17)30211-9. PMID: 29153975
Smith TJ, Bohlke K, Lyman GH, Carson KR, Crawford J, Cross SJ, Goldberg JM, Khatcheressian JL, Leighl NB, Perkins CL, Somlo G, Wade JL, Wozniak AJ, Armitage JO; American Society of Clinical Oncology
J Clin Oncol 2015 Oct 1;33(28):3199-212. Epub 2015 Jul 13 doi: 10.1200/JCO.2015.62.3488. PMID: 26169616

Therapy

Montesinos P, Recher C, Vives S, Zarzycka E, Wang J, Bertani G, Heuser M, Calado RT, Schuh AC, Yeh SP, Daigle SR, Hui J, Pandya SS, Gianolio DA, de Botton S, Döhner H
N Engl J Med 2022 Apr 21;386(16):1519-1531. doi: 10.1056/NEJMoa2117344. PMID: 35443108
DiNardo CD, Jonas BA, Pullarkat V, Thirman MJ, Garcia JS, Wei AH, Konopleva M, Döhner H, Letai A, Fenaux P, Koller E, Havelange V, Leber B, Esteve J, Wang J, Pejsa V, Hájek R, Porkka K, Illés Á, Lavie D, Lemoli RM, Yamamoto K, Yoon SS, Jang JH, Yeh SP, Turgut M, Hong WJ, Zhou Y, Potluri J, Pratz KW
N Engl J Med 2020 Aug 13;383(7):617-629. doi: 10.1056/NEJMoa2012971. PMID: 32786187
Horwitz S, O'Connor OA, Pro B, Illidge T, Fanale M, Advani R, Bartlett NL, Christensen JH, Morschhauser F, Domingo-Domenech E, Rossi G, Kim WS, Feldman T, Lennard A, Belada D, Illés Á, Tobinai K, Tsukasaki K, Yeh SP, Shustov A, Hüttmann A, Savage KJ, Yuen S, Iyer S, Zinzani PL, Hua Z, Little M, Rao S, Woolery J, Manley T, Trümper L; ECHELON-2 Study Group
Lancet 2019 Jan 19;393(10168):229-240. Epub 2018 Dec 4 doi: 10.1016/S0140-6736(18)32984-2. PMID: 30522922Free PMC Article
Aguilar-Guisado M, Espigado I, Martín-Peña A, Gudiol C, Royo-Cebrecos C, Falantes J, Vázquez-López L, Montero MI, Rosso-Fernández C, de la Luz Martino M, Parody R, González-Campos J, Garzón-López S, Calderón-Cabrera C, Barba P, Rodríguez N, Rovira M, Montero-Mateos E, Carratalá J, Pérez-Simón JA, Cisneros JM
Lancet Haematol 2017 Dec;4(12):e573-e583. Epub 2017 Nov 15 doi: 10.1016/S2352-3026(17)30211-9. PMID: 29153975
Smith TJ, Bohlke K, Lyman GH, Carson KR, Crawford J, Cross SJ, Goldberg JM, Khatcheressian JL, Leighl NB, Perkins CL, Somlo G, Wade JL, Wozniak AJ, Armitage JO; American Society of Clinical Oncology
J Clin Oncol 2015 Oct 1;33(28):3199-212. Epub 2015 Jul 13 doi: 10.1200/JCO.2015.62.3488. PMID: 26169616

Prognosis

DiNardo CD, Lachowiez CA, Takahashi K, Loghavi S, Xiao L, Kadia T, Daver N, Adeoti M, Short NJ, Sasaki K, Wang S, Borthakur G, Issa G, Maiti A, Alvarado Y, Pemmaraju N, Montalban Bravo G, Masarova L, Yilmaz M, Jain N, Andreeff M, Jabbour E, Garcia-Manero G, Kornblau S, Ravandi F, Konopleva MY, Kantarjian HM
J Clin Oncol 2021 Sep 1;39(25):2768-2778. Epub 2021 May 27 doi: 10.1200/JCO.20.03736. PMID: 34043428Free PMC Article
Salles G, Duell J, González Barca E, Tournilhac O, Jurczak W, Liberati AM, Nagy Z, Obr A, Gaidano G, André M, Kalakonda N, Dreyling M, Weirather J, Dirnberger-Hertweck M, Ambarkhane S, Fingerle-Rowson G, Maddocks K
Lancet Oncol 2020 Jul;21(7):978-988. Epub 2020 Jun 5 doi: 10.1016/S1470-2045(20)30225-4. PMID: 32511983
Roschewski M, Dunleavy K, Abramson JS, Powell BL, Link BK, Patel P, Bierman PJ, Jagadeesh D, Mitsuyasu RT, Peace D, Watson PR, Hanna WT, Melani C, Lucas AN, Steinberg SM, Pittaluga S, Jaffe ES, Friedberg JW, Kahl BS, Little RF, Bartlett NL, Fanale MA, Noy A, Wilson WH
J Clin Oncol 2020 Aug 1;38(22):2519-2529. Epub 2020 May 26 doi: 10.1200/JCO.20.00303. PMID: 32453640Free PMC Article
DiNardo CD, Pratz K, Pullarkat V, Jonas BA, Arellano M, Becker PS, Frankfurt O, Konopleva M, Wei AH, Kantarjian HM, Xu T, Hong WJ, Chyla B, Potluri J, Pollyea DA, Letai A
Blood 2019 Jan 3;133(1):7-17. Epub 2018 Oct 25 doi: 10.1182/blood-2018-08-868752. PMID: 30361262Free PMC Article
DiNardo CD, Stein EM, de Botton S, Roboz GJ, Altman JK, Mims AS, Swords R, Collins RH, Mannis GN, Pollyea DA, Donnellan W, Fathi AT, Pigneux A, Erba HP, Prince GT, Stein AS, Uy GL, Foran JM, Traer E, Stuart RK, Arellano ML, Slack JL, Sekeres MA, Willekens C, Choe S, Wang H, Zhang V, Yen KE, Kapsalis SM, Yang H, Dai D, Fan B, Goldwasser M, Liu H, Agresta S, Wu B, Attar EC, Tallman MS, Stone RM, Kantarjian HM
N Engl J Med 2018 Jun 21;378(25):2386-2398. Epub 2018 Jun 2 doi: 10.1056/NEJMoa1716984. PMID: 29860938

Clinical prediction guides

De Oliveira Brandao C, Lewis S, Sandschafer D, Crawford J
Curr Med Res Opin 2023 May;39(5):707-718. Epub 2023 Apr 8 doi: 10.1080/03007995.2023.2196197. PMID: 36976784
Bochennek K, Hogardt M, Lehrnbecher T
Expert Rev Clin Immunol 2023 Mar;19(3):267-277. Epub 2023 Jan 18 doi: 10.1080/1744666X.2023.2168646. PMID: 36635981
Van Belle H, Hurvitz SA, Gilbar PJ, Wildiers H
Breast Cancer Res Treat 2021 Dec;190(3):357-372. Epub 2021 Sep 17 doi: 10.1007/s10549-021-06387-1. PMID: 34533681
Guarana M, Nucci M, Nouér SA
Antimicrob Agents Chemother 2019 Nov;63(11) Epub 2019 Oct 22 doi: 10.1128/AAC.01250-19. PMID: 31405857Free PMC Article
Klastersky J, Paesmans M, Rubenstein EB, Boyer M, Elting L, Feld R, Gallagher J, Herrstedt J, Rapoport B, Rolston K, Talcott J
J Clin Oncol 2000 Aug;18(16):3038-51. doi: 10.1200/JCO.2000.18.16.3038. PMID: 10944139

Recent systematic reviews

Taplitz RA, Kennedy EB, Bow EJ, Crews J, Gleason C, Hawley DK, Langston AA, Nastoupil LJ, Rajotte M, Rolston K, Strasfeld L, Flowers CR
J Clin Oncol 2018 May 10;36(14):1443-1453. Epub 2018 Feb 20 doi: 10.1200/JCO.2017.77.6211. PMID: 29461916
Dale DC, Crawford J, Klippel Z, Reiner M, Osslund T, Fan E, Morrow PK, Allcott K, Lyman GH
Support Care Cancer 2018 Jan;26(1):7-20. Epub 2017 Sep 22 doi: 10.1007/s00520-017-3854-x. PMID: 28939926Free PMC Article
Lehrnbecher T, Robinson P, Fisher B, Alexander S, Ammann RA, Beauchemin M, Carlesse F, Groll AH, Haeusler GM, Santolaya M, Steinbach WJ, Castagnola E, Davis BL, Dupuis LL, Gaur AH, Tissing WJE, Zaoutis T, Phillips R, Sung L
J Clin Oncol 2017 Jun 20;35(18):2082-2094. Epub 2017 May 1 doi: 10.1200/JCO.2016.71.7017. PMID: 28459614
Smith TJ, Bohlke K, Lyman GH, Carson KR, Crawford J, Cross SJ, Goldberg JM, Khatcheressian JL, Leighl NB, Perkins CL, Somlo G, Wade JL, Wozniak AJ, Armitage JO; American Society of Clinical Oncology
J Clin Oncol 2015 Oct 1;33(28):3199-212. Epub 2015 Jul 13 doi: 10.1200/JCO.2015.62.3488. PMID: 26169616
Lyman GH, Abella E, Pettengell R
Crit Rev Oncol Hematol 2014 Jun;90(3):190-9. Epub 2013 Dec 12 doi: 10.1016/j.critrevonc.2013.12.006. PMID: 24434034

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