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Disorder of pigmentation

MedGen UID:
107500
•Concept ID:
C0549567
•
Disease or Syndrome
Synonyms: Disorder, Pigmentation; Disorders, Pigmentation; Pigmentation Disorder; Pigmentation Disorders
SNOMED CT: Pigment alteration (79644001); Disorder of pigmentation (414032001)

Definition

Diseases affecting PIGMENTATION, including SKIN PIGMENTATION. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of pigmentation

Professional guidelines

PubMed

Melasma treatment: a systematic review.
Neagu N, Conforti C, Agozzino M, Marangi GF, Morariu SH, Pellacani G, Persichetti P, Piccolo D, Segreto F, Zalaudek I, Dianzani C
J Dermatolog Treat 2022 Jun;33(4):1816-1837. Epub 2022 Mar 23 doi: 10.1080/09546634.2021.1914313. PMID: 33849384
Melasma: clinical diagnosis and management options.
Rodrigues M, Pandya AG
Australas J Dermatol 2015 Aug;56(3):151-63. Epub 2015 Mar 9 doi: 10.1111/ajd.12290. PMID: 25754098
Vitiligo: symptoms, pathogenesis and treatment.
Ghafourian A, Ghafourian S, Sadeghifard N, Mohebi R, Shokoohini Y, Nezamoleslami S, Hamat RA
Int J Immunopathol Pharmacol 2014 Oct-Dec;27(4):485-9. doi: 10.1177/039463201402700403. PMID: 25572727

Recent clinical studies

Etiology

Comparative study between efficacy of Excimer light with topical Tacrolimus 0.1% versus excimer light with topical Bimatoprost 0.01% in treatment of facial Vitiligo.
Zaky MS, Atallah RB, El Abasy NTA, Elsaie ML
Arch Dermatol Res 2024 Jun 8;316(7):350. doi: 10.1007/s00403-024-03054-5. PMID: 38850408Free PMC Article
Review of Laser Treatments for Post-Inflammatory Hyperpigmentation in Skin of Color.
Sowash M, Alster T
Am J Clin Dermatol 2023 May;24(3):381-396. Epub 2023 Feb 13 doi: 10.1007/s40257-023-00759-7. PMID: 36781686
Postinflammatory hyperpigmentation: protocol for development of a core outcome set for clinical trials.
Kang BY, Ibrahim SA, Shokeen D, Schlessinger DI, Kirkham JJ, Schmitt J, Poon E, Maher IA, Sobanko JF, Cartee TV, Alam M
Arch Dermatol Res 2022 May;314(4):357-361. Epub 2021 May 21 doi: 10.1007/s00403-021-02239-6. PMID: 34019133
Melasma treatment: a systematic review.
Neagu N, Conforti C, Agozzino M, Marangi GF, Morariu SH, Pellacani G, Persichetti P, Piccolo D, Segreto F, Zalaudek I, Dianzani C
J Dermatolog Treat 2022 Jun;33(4):1816-1837. Epub 2022 Mar 23 doi: 10.1080/09546634.2021.1914313. PMID: 33849384
The efficacy of oral vs different dilutions of intradermal tranexamic acid microinjections in melasma-A randomized clinical trial.
El Hadidi H, Mosaad R, Ragab N
Dermatol Ther 2021 May;34(3):e14924. Epub 2021 Mar 7 doi: 10.1111/dth.14924. PMID: 33651442

Diagnosis

Comparative study between efficacy of Excimer light with topical Tacrolimus 0.1% versus excimer light with topical Bimatoprost 0.01% in treatment of facial Vitiligo.
Zaky MS, Atallah RB, El Abasy NTA, Elsaie ML
Arch Dermatol Res 2024 Jun 8;316(7):350. doi: 10.1007/s00403-024-03054-5. PMID: 38850408Free PMC Article
The efficacy of oral vs different dilutions of intradermal tranexamic acid microinjections in melasma-A randomized clinical trial.
El Hadidi H, Mosaad R, Ragab N
Dermatol Ther 2021 May;34(3):e14924. Epub 2021 Mar 7 doi: 10.1111/dth.14924. PMID: 33651442
Melasma: clinical diagnosis and management options.
Rodrigues M, Pandya AG
Australas J Dermatol 2015 Aug;56(3):151-63. Epub 2015 Mar 9 doi: 10.1111/ajd.12290. PMID: 25754098
Progressive cribriform and zosteriform hyperpigmentation: a clinicopathologic study.
Cho E, Cho SH, Lee JD
Int J Dermatol 2012 Apr;51(4):399-405. doi: 10.1111/j.1365-4632.2011.04988.x. PMID: 22435426
Lymphocyte imbalance in vitiligo patients indicated by elevated CD4+/CD8+ T-cell ratio.
Pichler R, Sfetsos K, Badics B, Gutenbrunner S, Berg J, Auböck J
Wien Med Wochenschr 2009;159(13-14):337-41. doi: 10.1007/s10354-009-0699-z. PMID: 19652940

Therapy

A review of JAK and IL-23 inhibitors to treat vitiligo.
Lee H, Cowan TL, Daniel BS, Murrell DF
Australas J Dermatol 2023 May;64(2):204-212. Epub 2023 Feb 22 doi: 10.1111/ajd.14001. PMID: 36810815
Review of Laser Treatments for Post-Inflammatory Hyperpigmentation in Skin of Color.
Sowash M, Alster T
Am J Clin Dermatol 2023 May;24(3):381-396. Epub 2023 Feb 13 doi: 10.1007/s40257-023-00759-7. PMID: 36781686
Melasma treatment: a systematic review.
Neagu N, Conforti C, Agozzino M, Marangi GF, Morariu SH, Pellacani G, Persichetti P, Piccolo D, Segreto F, Zalaudek I, Dianzani C
J Dermatolog Treat 2022 Jun;33(4):1816-1837. Epub 2022 Mar 23 doi: 10.1080/09546634.2021.1914313. PMID: 33849384
Acquired brachial cutaneous dyschromatosis.
Rongioletti F, Atzori L, Ferreli C
Clin Dermatol 2021 Mar-Apr;39(2):199-201. Epub 2020 Oct 16 doi: 10.1016/j.clindermatol.2020.10.006. PMID: 34272009
Melasma: clinical diagnosis and management options.
Rodrigues M, Pandya AG
Australas J Dermatol 2015 Aug;56(3):151-63. Epub 2015 Mar 9 doi: 10.1111/ajd.12290. PMID: 25754098

Prognosis

Review of Laser Treatments for Post-Inflammatory Hyperpigmentation in Skin of Color.
Sowash M, Alster T
Am J Clin Dermatol 2023 May;24(3):381-396. Epub 2023 Feb 13 doi: 10.1007/s40257-023-00759-7. PMID: 36781686
Erythema dyschromicum perstans in prepubertal children.
Silverberg NB, Herz J, Wagner A, Paller AS
Pediatr Dermatol 2003 Sep-Oct;20(5):398-403. doi: 10.1046/j.1525-1470.2003.20505.x. PMID: 14521555
Mutations of the KIT (mast/stem cell growth factor receptor) proto-oncogene account for a continuous range of phenotypes in human piebaldism.
Spritz RA, Holmes SA, Ramesar R, Greenberg J, Curtis D, Beighton P
Am J Hum Genet 1992 Nov;51(5):1058-65. PMID: 1384325Free PMC Article

Clinical prediction guides

A comparative study between oral tranexamic acid versus oral tranexamic acid and Q-switched Nd-YAG laser in melasma treatment: a clinical and dermoscopic evaluation.
Agamia N, Apalla Z, Salem W, Abdallah W
J Dermatolog Treat 2021 Nov;32(7):819-826. Epub 2020 Jan 7 doi: 10.1080/09546634.2019.1708847. PMID: 31908179
Progressive cribriform and zosteriform hyperpigmentation: a clinicopathologic study.
Cho E, Cho SH, Lee JD
Int J Dermatol 2012 Apr;51(4):399-405. doi: 10.1111/j.1365-4632.2011.04988.x. PMID: 22435426
Efficacy of dioic acid compared with hydroquinone in the treatment of melasma.
Tirado-Sánchez A, Santamaría-Román A, Ponce-Olivera RM
Int J Dermatol 2009 Aug;48(8):893-5. doi: 10.1111/j.1365-4632.2009.04105.x. PMID: 19659872
Lymphocyte imbalance in vitiligo patients indicated by elevated CD4+/CD8+ T-cell ratio.
Pichler R, Sfetsos K, Badics B, Gutenbrunner S, Berg J, Auböck J
Wien Med Wochenschr 2009;159(13-14):337-41. doi: 10.1007/s10354-009-0699-z. PMID: 19652940
An histological and ultrastructural study of the 'dirty neck' appearance in atopic eczema.
Humphreys F, Spencer J, Mclaren K, Tidman MJ
Clin Exp Dermatol 1996 Jan;21(1):17-19. PMID: 8689762

Recent systematic reviews

Melasma treatment: a systematic review.
Neagu N, Conforti C, Agozzino M, Marangi GF, Morariu SH, Pellacani G, Persichetti P, Piccolo D, Segreto F, Zalaudek I, Dianzani C
J Dermatolog Treat 2022 Jun;33(4):1816-1837. Epub 2022 Mar 23 doi: 10.1080/09546634.2021.1914313. PMID: 33849384

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