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Composite lymphoma

MedGen UID:
107468
•Concept ID:
C0545080
•
Neoplastic Process
Synonyms: Composite Lymphoma; Composite Lymphomas; Lymphoma, Composite; Lymphomas, Composite
SNOMED CT: Composite Hodgkin and non-Hodgkin lymphoma (128798004); Composite Hodgkin and non-Hodgkin lymphoma (1156403002); Composite lymphoma (1156403002)
 
Monarch Initiative: MONDO:0005710
Orphanet: ORPHA168966

Definition

A rare lymphoma with concurrent occurrence of two or more histologic types of lymphoma involving the same anatomic site. Composite lymphomas can be combinations of two non-Hodgkin lymphomas or of a non-Hodgkin and a Hodgkin lymphoma. In many cases, the neoplasms are clonally related. Clinical presentation and treatment are determined by the more aggressive component. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVComposite lymphoma

Professional guidelines

PubMed

Peripheral lymphadenopathy: role of excisional biopsy in differential diagnosis based on a five-year experience.
Campanelli M, Cabry F, Marasca R, Gelmini R
Minerva Chir 2019 Jun;74(3):218-223. Epub 2018 Oct 9 doi: 10.23736/S0026-4733.18.07752-0. PMID: 30306770
Pathogenesis, diagnosis, and treatment of composite lymphomas.
Küppers R, Dührsen U, Hansmann ML
Lancet Oncol 2014 Sep;15(10):e435-46. doi: 10.1016/S1470-2045(14)70153-6. PMID: 25186047

Recent clinical studies

Etiology

Clinicopathological features of splenic tumours of lymphoid tissue.
Chen DB, Shen DH, Yang SM, Fang XZ
Pathol Res Pract 2018 Dec;214(12):1952-1958. Epub 2018 Jul 27 doi: 10.1016/j.prp.2018.07.021. PMID: 30087035
Clinicopathological analysis of a composite lymphoma containing both T- and B-cell lymphomas.
Suefuji N, Niino D, Arakawa F, Karube K, Kimura Y, Kiyasu J, Takeuchi M, Miyoshi H, Yoshida M, Ichikawa A, Sugita Y, Ohshima K
Pathol Int 2012 Oct;62(10):690-8. doi: 10.1111/j.1440-1827.2012.02858.x. PMID: 23005596
Pathology of lymphoma progression.
Müller-Hermelink HK, Zettl A, Pfeifer W, Ott G
Histopathology 2001 Apr;38(4):285-306. doi: 10.1046/j.1365-2559.2001.01120.x. PMID: 11318894
Limited stage I and II follicular non-Hodgkin's lymphoma: the Nebraska Lymphoma Study Group experience.
Tezcan H, Vose JM, Bast M, Bierman PJ, Kessinger A, Armitage JO
Leuk Lymphoma 1999 Jul;34(3-4):273-85. doi: 10.3109/10428199909050952. PMID: 10439364
The interrelationship between Hodgkin's disease and non-Hodgkin's lymphomas.
Jaffe ES, Zarate-Osorno A, Kingma DW, Raffeld M, Medeiros LJ
Ann Oncol 1994;5 Suppl 1:7-11. doi: 10.1093/annonc/5.suppl_1.s7. PMID: 8172822

Diagnosis

From the archives of MD Anderson Cancer Center: Composite mantle cell lymphoma and lymphoplasmacytic lymphoma involving bone marrow at presentation.
Dimopoulos YP, Thakral B, Lin P, Toruner G, Zuo Z, Medeiros LJ, Leventaki V
Ann Diagn Pathol 2024 Dec;73:152372. Epub 2024 Aug 22 doi: 10.1016/j.anndiagpath.2024.152372. PMID: 39208652
Composite B-cell and T-cell lymphomas: clinical, pathological, and molecular features of three cases and literature review.
Jin X, Liu H, Li J, Xiao X, Yuan X, Chen P, Chen B, Liang Y, Huang F
J Zhejiang Univ Sci B 2023 Aug 15;24(8):711-722. doi: 10.1631/jzus.B2300181. PMID: 37551557Free PMC Article
Mediastinal large B cell lymphoma and surrounding gray areas: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology.
Gibson SE, Dojcinov S, Dotlic S, Hartmann S, Hsi ED, Klimkowska M, Melle F, Pileri SA, Ramsower CA, Rech K, Rimsza LM, Rodriguez-Pinilla SM, Tousseyn TA, de Jong D, Sabattini E
Virchows Arch 2023 Dec;483(6):733-749. Epub 2023 Aug 2 doi: 10.1007/s00428-023-03550-5. PMID: 37530791Free PMC Article
Pathogenesis, diagnosis, and treatment of composite lymphomas.
Küppers R, Dührsen U, Hansmann ML
Lancet Oncol 2014 Sep;15(10):e435-46. doi: 10.1016/S1470-2045(14)70153-6. PMID: 25186047
Composite lymphoma.
Kim H, Hendrickson R, Dorfman RF
Cancer 1977 Sep;40(3):959-76. doi: 10.1002/1097-0142(197709)40:3<959::aid-cncr2820400302>3.0.co;2-3. PMID: 332325

Therapy

Composite B-cell and T-cell lymphomas: clinical, pathological, and molecular features of three cases and literature review.
Jin X, Liu H, Li J, Xiao X, Yuan X, Chen P, Chen B, Liang Y, Huang F
J Zhejiang Univ Sci B 2023 Aug 15;24(8):711-722. doi: 10.1631/jzus.B2300181. PMID: 37551557Free PMC Article
Composite lymphoma in the anterior mediastinum: a case report and review of the literature.
Yu G, Kong L, Qu G, Zhang Q, Wang W, Jiang L
Diagn Pathol 2011 Jul 6;6:60. doi: 10.1186/1746-1596-6-60. PMID: 21733146Free PMC Article
Composite T lymphoblastic leukemia/lymphoma and diffuse large B-cell lymphoma: case report.
Niino D, Ohsaki K, Arakawa F, Watanabe J, Kimura Y, Kiyasu J, Takeuchi M, Miyoshi H, Yoshida M, Sugita Y, Ohshima K, Okamura T
Pathol Int 2011 Jun;61(6):363-8. Epub 2011 Mar 13 doi: 10.1111/j.1440-1827.2011.02662.x. PMID: 21615612
Limited stage I and II follicular non-Hodgkin's lymphoma: the Nebraska Lymphoma Study Group experience.
Tezcan H, Vose JM, Bast M, Bierman PJ, Kessinger A, Armitage JO
Leuk Lymphoma 1999 Jul;34(3-4):273-85. doi: 10.3109/10428199909050952. PMID: 10439364
Composite lymphoma.
Toner GC, Sinclair RA, Sutherland RC, Schwarz MA
Am J Clin Pathol 1986 Sep;86(3):375-8. doi: 10.1093/ajcp/86.3.375. PMID: 3755861

Prognosis

Composite B-cell and T-cell lymphomas: clinical, pathological, and molecular features of three cases and literature review.
Jin X, Liu H, Li J, Xiao X, Yuan X, Chen P, Chen B, Liang Y, Huang F
J Zhejiang Univ Sci B 2023 Aug 15;24(8):711-722. doi: 10.1631/jzus.B2300181. PMID: 37551557Free PMC Article
Composite Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia and Follicular Lymphoma: A Clinicopathological Study of Six Cases.
Jelloul FZ, Chen QH, Yang T, Haghi N, Brody J, Zhang X, Sheikh-Fayyaz S
Int J Surg Pathol 2018 Apr;26(2):135-144. Epub 2017 Oct 26 doi: 10.1177/1066896917737161. PMID: 29069998
Pathogenesis, diagnosis, and treatment of composite lymphomas.
Küppers R, Dührsen U, Hansmann ML
Lancet Oncol 2014 Sep;15(10):e435-46. doi: 10.1016/S1470-2045(14)70153-6. PMID: 25186047
Pathology of lymphoma progression.
Müller-Hermelink HK, Zettl A, Pfeifer W, Ott G
Histopathology 2001 Apr;38(4):285-306. doi: 10.1046/j.1365-2559.2001.01120.x. PMID: 11318894
Composite lymphoma.
Kim H, Hendrickson R, Dorfman RF
Cancer 1977 Sep;40(3):959-76. doi: 10.1002/1097-0142(197709)40:3<959::aid-cncr2820400302>3.0.co;2-3. PMID: 332325

Clinical prediction guides

Survival among patients with composite and sequential lymphoma between primary mediastinal lymphoma/diffuse large B-cell lymphoma and classical Hodgkin lymphoma: A population-based study.
Tao Y, Chen H, Liu D, Dai X
Leuk Res 2021 Dec;111:106669. Epub 2021 Jul 16 doi: 10.1016/j.leukres.2021.106669. PMID: 34333276
Composite lymphoma with diffuse large B-cell lymphoma and classical Hodgkin lymphoma components: A case report and review of the literature.
Goyal G, Nguyen AH, Kendric K, Caponetti GC
Pathol Res Pract 2016 Dec;212(12):1179-1190. Epub 2016 Nov 5 doi: 10.1016/j.prp.2016.11.002. PMID: 27887763
Gray zone lymphoma: chromosomal aberrations with immunophenotypic and clinical correlations.
Eberle FC, Salaverria I, Steidl C, Summers TA Jr, Pittaluga S, Neriah SB, Rodriguez-Canales J, Xi L, Ylaya K, Liewehr D, Dunleavy K, Wilson WH, Hewitt SM, Raffeld M, Gascoyne RD, Siebert R, Jaffe ES
Mod Pathol 2011 Dec;24(12):1586-97. Epub 2011 Aug 5 doi: 10.1038/modpathol.2011.116. PMID: 21822207Free PMC Article
Composite marginal zone B-cell lymphoma and classical Hodgkin's lymphoma: a clinicopathological study of 12 cases.
Zettl A, Rüdiger T, Marx A, Müller-Hermelink HK, Ott G
Histopathology 2005 Feb;46(2):217-28. doi: 10.1111/j.1365-2559.2005.02046.x. PMID: 15693895
The interrelationship between Hodgkin's disease and non-Hodgkin's lymphomas.
Jaffe ES, Zarate-Osorno A, Kingma DW, Raffeld M, Medeiros LJ
Ann Oncol 1994;5 Suppl 1:7-11. doi: 10.1093/annonc/5.suppl_1.s7. PMID: 8172822

Recent systematic reviews

The Conundrum of Diagnosing Cutaneous Composite Lymphoma in the Molecular Age.
Ahmed A, Aragao AP, Mudaliar K, Wilcox R, Vardiman J, Anastasi J, Mirza K
Am J Dermatopathol 2019 Oct;41(10):757-766. doi: 10.1097/DAD.0000000000001424. PMID: 30973519

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