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Myxoid/round cell liposarcoma

MedGen UID:
107784
Concept ID:
C0545074
Neoplastic Process
Synonyms: MRCLS; Myxoid Liposarcoma; Myxoid/Round Cell Liposarcoma; myxoid/round cell liposarcoma; myxoid/round-cell liposarcoma
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0020561
Orphanet: ORPHA99967

Definition

Myxoid/round cell liposarcoma (MRCLS) is a type of liposarcoma (LS; see this term) mostly located in the limbs, with a variable behavior depending on the histological subtype. Both myxoid and round cell are distinct histological subtypes of LS. [from ORDO]

Professional guidelines

PubMed

Nassif EF, Keung EZ, Thirasastr P, Somaiah N
Curr Treat Options Oncol 2023 Apr;24(4):274-291. Epub 2023 Feb 28 doi: 10.1007/s11864-023-01057-4. PMID: 36853469
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Hatina J, Kripnerova M, Houfkova K, Pesta M, Kuncova J, Sana J, Slaby O, Rodríguez R
Adv Exp Med Biol 2019;1123:95-118. doi: 10.1007/978-3-030-11096-3_7. PMID: 31016597
Oda Y, Yamamoto H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, Bekki H
Pathol Int 2017 Sep;67(9):435-446. Epub 2017 Jul 31 doi: 10.1111/pin.12565. PMID: 28759137
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Hoffman A, Ghadimi MP, Demicco EG, Creighton CJ, Torres K, Colombo C, Peng T, Lusby K, Ingram D, Hornick JL, Wang WL, Ravi V, Lazar AJ, Lev D, Pollock RE
Cancer 2013 May 15;119(10):1868-77. Epub 2013 Feb 7 doi: 10.1002/cncr.27847. PMID: 23401071
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Diagnosis

Dermawan JK
Surg Pathol Clin 2024 Mar;17(1):25-29. Epub 2023 Aug 1 doi: 10.1016/j.path.2023.06.005. PMID: 38278605
Nassif EF, Keung EZ, Thirasastr P, Somaiah N
Curr Treat Options Oncol 2023 Apr;24(4):274-291. Epub 2023 Feb 28 doi: 10.1007/s11864-023-01057-4. PMID: 36853469
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Manji GA, Schwartz GK
J Oncol Pract 2016 Mar;12(3):221-7. doi: 10.1200/JOP.2015.009860. PMID: 26962163
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Therapy

D'Angelo SP, Araujo DM, Abdul Razak AR, Agulnik M, Attia S, Blay JY, Carrasco Garcia I, Charlson JA, Choy E, Demetri GD, Druta M, Forcade E, Ganjoo KN, Glod J, Keedy VL, Le Cesne A, Liebner DA, Moreno V, Pollack SM, Schuetze SM, Schwartz GK, Strauss SJ, Tap WD, Thistlethwaite F, Valverde Morales CM, Wagner MJ, Wilky BA, McAlpine C, Hudson L, Navenot JM, Wang T, Bai J, Rafail S, Wang R, Sun A, Fernandes L, Van Winkle E, Elefant E, Lunt C, Norry E, Williams D, Biswas S, Van Tine BA
Lancet 2024 Apr 13;403(10435):1460-1471. Epub 2024 Mar 27 doi: 10.1016/S0140-6736(24)00319-2. PMID: 38554725Free PMC Article
Nassif EF, Keung EZ, Thirasastr P, Somaiah N
Curr Treat Options Oncol 2023 Apr;24(4):274-291. Epub 2023 Feb 28 doi: 10.1007/s11864-023-01057-4. PMID: 36853469
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Manji GA, Schwartz GK
J Oncol Pract 2016 Mar;12(3):221-7. doi: 10.1200/JOP.2015.009860. PMID: 26962163

Prognosis

Pollack SM
Expert Rev Vaccines 2018 Feb;17(2):107-114. Epub 2017 Dec 27 doi: 10.1080/14760584.2018.1419068. PMID: 29280411Free PMC Article
Oda Y, Yamamoto H, Kohashi K, Yamada Y, Iura K, Ishii T, Maekawa A, Bekki H
Pathol Int 2017 Sep;67(9):435-446. Epub 2017 Jul 31 doi: 10.1111/pin.12565. PMID: 28759137
Hoffman A, Ghadimi MP, Demicco EG, Creighton CJ, Torres K, Colombo C, Peng T, Lusby K, Ingram D, Hornick JL, Wang WL, Ravi V, Lazar AJ, Lev D, Pollock RE
Cancer 2013 May 15;119(10):1868-77. Epub 2013 Feb 7 doi: 10.1002/cncr.27847. PMID: 23401071
Orvieto E, Furlanetto A, Laurino L, Dei Tos AP
Semin Diagn Pathol 2001 Nov;18(4):267-73. PMID: 11757867
Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

Clinical prediction guides

Mahalingam P, Julve M, Huang P, Furness AJS, Pollack SM, Jones RL
Curr Opin Oncol 2022 Jul 1;34(4):362-370. doi: 10.1097/CCO.0000000000000843. PMID: 35837706
Yen CC, Chen TW
Chin Clin Oncol 2018 Aug;7(4):43. doi: 10.21037/cco.2018.08.04. PMID: 30173533
Ståhlberg A, Kåbjörn Gustafsson C, Engtröm K, Thomsen C, Dolatabadi S, Jonasson E, Li CY, Ruff D, Chen SM, Åman P
PLoS One 2014;9(11):e113110. Epub 2014 Nov 13 doi: 10.1371/journal.pone.0113110. PMID: 25393000Free PMC Article
Hoffman A, Ghadimi MP, Demicco EG, Creighton CJ, Torres K, Colombo C, Peng T, Lusby K, Ingram D, Hornick JL, Wang WL, Ravi V, Lazar AJ, Lev D, Pollock RE
Cancer 2013 May 15;119(10):1868-77. Epub 2013 Feb 7 doi: 10.1002/cncr.27847. PMID: 23401071
Orvieto E, Furlanetto A, Laurino L, Dei Tos AP
Semin Diagn Pathol 2001 Nov;18(4):267-73. PMID: 11757867

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

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