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Metastatic Malignant Neoplasm in the Liver

MedGen UID:
141667
•Concept ID:
C0494165
•
Neoplastic Process
Synonyms: Cancer metastatic to liver; Hepatic metastasis; Liver Metastases; Liver Metastasis; Liver secondaries; Liver secondary cancer; Metastasis to liver; Metastatic malignant neoplasm of liver; Metastatic malignant neoplasm to liver; Metastatic Malignant Neoplasm to the Liver; Metastatic Neoplasm to the Liver; Metastatic Tumor to the Liver; Secondary malignancy of liver; Secondary malignant neoplasm of liver
SNOMED CT: Secondary malignant neoplasm of liver (94381002); Metastatic malignant neoplasm to liver (94381002); Cancer metastatic to liver (94381002); Metastatic malignant neoplasm of liver (94381002); Liver secondary cancer (94381002); Metastasis to liver (94381002); Liver secondaries (94381002); Secondary malignancy of liver (94381002); Hepatic metastasis (94381002)

Definition

A malignant neoplasm that has spread to the liver from another (primary) anatomic site. Representative examples include carcinomas, lymphomas, melanomas, or sarcomas. [from NCI]

Professional guidelines

PubMed

Advances in the clinical management of uveal melanoma.
Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S
Nat Rev Clin Oncol 2023 Feb;20(2):99-115. Epub 2023 Jan 4 doi: 10.1038/s41571-022-00714-1. PMID: 36600005
Radiomics Improves Cancer Screening and Early Detection.
Gillies RJ, Schabath MB
Cancer Epidemiol Biomarkers Prev 2020 Dec;29(12):2556-2567. Epub 2020 Sep 11 doi: 10.1158/1055-9965.EPI-20-0075. PMID: 32917666
Testicular Cancer: Diagnosis and Treatment.
Baird DC, Meyers GJ, Hu JS
Am Fam Physician 2018 Feb 15;97(4):261-268. PMID: 29671528

Recent clinical studies

Etiology

Evolving Role of Liver Resection in Selected Patients With Metastatic Breast Cancer.
Millen JA, Hofmann A, Mesquita-Neto JW, Rose J, Macedo FI
J Surg Res 2021 Mar;259:363-371. Epub 2020 Nov 11 doi: 10.1016/j.jss.2020.09.022. PMID: 33189360
Percutaneous Laser Ablation of Liver Metastases from Neuroendocrine Neoplasm. A Retrospective Study for Safety and Effectiveness.
Sartori S, Tombesi P, Di Vece F, Bianchi L, Ambrosio R
Cardiovasc Intervent Radiol 2019 Nov;42(11):1571-1578. Epub 2019 Aug 13 doi: 10.1007/s00270-019-02308-4. PMID: 31410534
Long-term survival and cure model following liver resection for breast cancer metastases.
Ruiz A, Sebagh M, Wicherts DA, Castro-Benitez C, van Hillegersberg R, Paule B, Castaing D, Vibert E, Cunha AS, Cherqui D, Morère JF, Adam R
Breast Cancer Res Treat 2018 Jul;170(1):89-100. Epub 2018 Feb 20 doi: 10.1007/s10549-018-4714-1. PMID: 29464535Free PMC Article
Treatment sequence of synchronously (liver) metastasized colon cancer.
Gruenberger T, Beets G, Van Laethem JL, Rougier P, Cervantes A, Douillard JY, Figueras J, Gruenberger B, Haller DG, Labianca R, Maleux G, Roth A, Ducreux M, Schmiegel W, Seufferlein T, Van Cutsem E
Dig Liver Dis 2016 Oct;48(10):1119-23. Epub 2016 Jun 17 doi: 10.1016/j.dld.2016.06.009. PMID: 27375207
Metastatic melanoma to the liver: a contemporary and comprehensive review of surgical, systemic, and regional therapeutic options.
Agarwala SS, Eggermont AM, O'Day S, Zager JS
Cancer 2014 Mar 15;120(6):781-9. Epub 2013 Dec 2 doi: 10.1002/cncr.28480. PMID: 24301420

Diagnosis

Evolving Role of Liver Resection in Selected Patients With Metastatic Breast Cancer.
Millen JA, Hofmann A, Mesquita-Neto JW, Rose J, Macedo FI
J Surg Res 2021 Mar;259:363-371. Epub 2020 Nov 11 doi: 10.1016/j.jss.2020.09.022. PMID: 33189360
Cancers Metastatic to the Liver.
Rashidian N, Alseidi A, Kirks RC
Surg Clin North Am 2020 Jun;100(3):551-563. Epub 2020 Apr 3 doi: 10.1016/j.suc.2020.02.005. PMID: 32402300
Nonbacterial Thrombotic Endocarditis.
Fournier JB, Testa EJ
N Engl J Med 2019 Jun 20;380(25):e48. doi: 10.1056/NEJMicm1804137. PMID: 31216402
Frozen Sections of the Liver.
Pittman ME, Yantiss RK
Surg Pathol Clin 2018 Jun;11(2):453-466. Epub 2018 Mar 26 doi: 10.1016/j.path.2018.02.012. PMID: 29751885
Hepatic resection for liver metastasis of sigmoid colon cancer after incomplete percutaneous microwave coagulation therapy.
Idani H, Narusue M, Kin H, Uda K, Muro M, Kaneko A, Sasaki H, Watanabe K, Takahashi K
Hepatogastroenterology 2001 Jan-Feb;48(37):244-6. PMID: 11268974

Therapy

Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer.
Taraborrelli L, Şenbabaoğlu Y, Wang L, Lim J, Blake K, Kljavin N, Gierke S, Scherl A, Ziai J, McNamara E, Owyong M, Rao S, Calviello AK, Oreper D, Jhunjhunwala S, Argiles G, Bendell J, Kim TW, Ciardiello F, Wongchenko MJ, de Sauvage FJ, de Sousa E Melo F, Yan Y, West NR, Murthy A
Nat Commun 2023 Sep 23;14(1):5945. doi: 10.1038/s41467-023-41618-7. PMID: 37741832Free PMC Article
Metastatic uveal melanoma: The final frontier.
Rantala ES, Hernberg MM, Piperno-Neumann S, Grossniklaus HE, Kivelä TT
Prog Retin Eye Res 2022 Sep;90:101041. Epub 2022 Jan 6 doi: 10.1016/j.preteyeres.2022.101041. PMID: 34999237
Colorectal liver metastases: surgery versus thermal ablation (COLLISION) - a phase III single-blind prospective randomized controlled trial.
Puijk RS, Ruarus AH, Vroomen LGPH, van Tilborg AAJM, Scheffer HJ, Nielsen K, de Jong MC, de Vries JJJ, Zonderhuis BM, Eker HH, Kazemier G, Verheul H, van der Meijs BB, van Dam L, Sorgedrager N, Coupé VMH, van den Tol PMP, Meijerink MR; COLLISION Trial Group
BMC Cancer 2018 Aug 15;18(1):821. doi: 10.1186/s12885-018-4716-8. PMID: 30111304Free PMC Article
Management of disappearing colorectal liver metastases.
Kuhlmann K, van Hilst J, Fisher S, Poston G
Eur J Surg Oncol 2016 Dec;42(12):1798-1805. Epub 2016 May 24 doi: 10.1016/j.ejso.2016.05.005. PMID: 27260846
Role of surgery in colorectal cancer liver metastases.
Akgül Ö, Çetinkaya E, Ersöz Ş, Tez M
World J Gastroenterol 2014 May 28;20(20):6113-22. doi: 10.3748/wjg.v20.i20.6113. PMID: 24876733Free PMC Article

Prognosis

Evolving Role of Liver Resection in Selected Patients With Metastatic Breast Cancer.
Millen JA, Hofmann A, Mesquita-Neto JW, Rose J, Macedo FI
J Surg Res 2021 Mar;259:363-371. Epub 2020 Nov 11 doi: 10.1016/j.jss.2020.09.022. PMID: 33189360
Cancers Metastatic to the Liver.
Rashidian N, Alseidi A, Kirks RC
Surg Clin North Am 2020 Jun;100(3):551-563. Epub 2020 Apr 3 doi: 10.1016/j.suc.2020.02.005. PMID: 32402300
Nonbacterial Thrombotic Endocarditis.
Fournier JB, Testa EJ
N Engl J Med 2019 Jun 20;380(25):e48. doi: 10.1056/NEJMicm1804137. PMID: 31216402
Relevance of liver-limited disease in metastatic colorectal cancer: Subgroup findings of the FIRE-3/AIO KRK0306 trial.
Holch JW, Ricard I, Stintzing S, Fischer von Weikersthal L, Decker T, Kiani A, Vehling-Kaiser U, Al-Batran SE, Heintges T, Lerchenmüller C, Kahl C, Kullmann F, Scheithauer W, Scholz M, Müller S, Link H, Rost A, Höffkes HG, Moehler M, Lindig RU, Miller-Phillips L, Kirchner T, Jung A, von Einem JC, Modest DP, Heinemann V
Int J Cancer 2018 Mar 1;142(5):1047-1055. Epub 2017 Nov 7 doi: 10.1002/ijc.31114. PMID: 29047142
Role of surgery in colorectal cancer liver metastases.
Akgül Ö, Çetinkaya E, Ersöz Ş, Tez M
World J Gastroenterol 2014 May 28;20(20):6113-22. doi: 10.3748/wjg.v20.i20.6113. PMID: 24876733Free PMC Article

Clinical prediction guides

Evolving Role of Liver Resection in Selected Patients With Metastatic Breast Cancer.
Millen JA, Hofmann A, Mesquita-Neto JW, Rose J, Macedo FI
J Surg Res 2021 Mar;259:363-371. Epub 2020 Nov 11 doi: 10.1016/j.jss.2020.09.022. PMID: 33189360
DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25.
Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, Huang D, Li J, Li H, Chen F, Liu J, Xing Y, Chen X, Su S, Song E
Nature 2020 Jul;583(7814):133-138. Epub 2020 Jun 11 doi: 10.1038/s41586-020-2394-6. PMID: 32528174
Robotic ALPPS.
Machado MAC, Surjan RC, Makdissi F
Ann Surg Oncol 2020 Apr;27(4):1174-1179. Epub 2019 Nov 4 doi: 10.1245/s10434-019-08027-x. PMID: 31686346
Radiation-Induced Liver Toxicity.
Munoz-Schuffenegger P, Ng S, Dawson LA
Semin Radiat Oncol 2017 Oct;27(4):350-357. doi: 10.1016/j.semradonc.2017.04.002. PMID: 28865518
Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases.
Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH
Ann Surg 1999 Sep;230(3):309-18; discussion 318-21. doi: 10.1097/00000658-199909000-00004. PMID: 10493478Free PMC Article

Recent systematic reviews

Treatment of Metastatic Colorectal Cancer: ASCO Guideline.
Morris VK, Kennedy EB, Baxter NN, Benson AB 3rd, Cercek A, Cho M, Ciombor KK, Cremolini C, Davis A, Deming DA, Fakih MG, Gholami S, Hong TS, Jaiyesimi I, Klute K, Lieu C, Sanoff H, Strickler JH, White S, Willis JA, Eng C
J Clin Oncol 2023 Jan 20;41(3):678-700. Epub 2022 Oct 17 doi: 10.1200/JCO.22.01690. PMID: 36252154Free PMC Article
Clinical characteristics, surveillance, treatment allocation, and outcomes of non-alcoholic fatty liver disease-related hepatocellular carcinoma: a systematic review and meta-analysis.
Tan DJH, Ng CH, Lin SY, Pan XH, Tay P, Lim WH, Teng M, Syn N, Lim G, Yong JN, Quek J, Xiao J, Dan YY, Siddiqui MS, Sanyal AJ, Muthiah MD, Loomba R, Huang DQ
Lancet Oncol 2022 Apr;23(4):521-530. Epub 2022 Mar 4 doi: 10.1016/S1470-2045(22)00078-X. PMID: 35255263Free PMC Article
Intra-Arterial Therapies for Liver Metastatic Breast Cancer: A Systematic Review and Meta-Analysis.
Aarts BM, Muñoz FMG, Wildiers H, Dezentjé VO, Baetens TR, Schats W, Lopez-Yurda M, Dresen RC, Wit-van der Veen BJ, Deroose CM, Maleux G, Beets-Tan RGH, Klompenhouwer EG
Cardiovasc Intervent Radiol 2021 Dec;44(12):1868-1882. Epub 2021 Jul 28 doi: 10.1007/s00270-021-02906-1. PMID: 34322751
Liver Resection Versus Local Ablation Therapies for Hepatocellular Carcinoma Within the Milan Criteria: A Systematic Review and Meta-analysis.
Shin SW, Ahn KS, Kim SW, Kim TS, Kim YH, Kang KJ
Ann Surg 2021 Apr 1;273(4):656-666. doi: 10.1097/SLA.0000000000004350. PMID: 33074898
A systematic review of the role of hepatectomy in the management of metastatic renal cell carcinoma.
Grimes NG, Devlin JM, Dunne DF, Jones RP, Poston GJ, Fenwick SW, Malik HZ
Eur J Surg Oncol 2014 Dec;40(12):1622-8. Epub 2014 Aug 27 doi: 10.1016/j.ejso.2014.08.472. PMID: 25228053

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