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Cervical adenosquamous carcinoma

MedGen UID:
91091
•Concept ID:
C0346202
•
Neoplastic Process
Synonyms: Adenosquamous carcinoma of cervix; adenosquamous carcinoma of cervix; Adenosquamous Cell Carcinoma of Cervix; adenosquamous cell carcinoma of cervix; Adenosquamous Cell Carcinoma of Cervix Uteri; adenosquamous cell carcinoma of cervix uteri; Adenosquamous Cell Carcinoma of the Cervix; adenosquamous cell carcinoma of the cervix; Adenosquamous Cell Carcinoma of the Cervix Uteri; adenosquamous cell carcinoma of the cervix uteri; Adenosquamous Cell Carcinoma of the Uterine Cervix; adenosquamous cell carcinoma of the uterine cervix; Adenosquamous Cell Carcinoma of Uterine Cervix; adenosquamous cell carcinoma of uterine cervix; cervical adenosquamous cancer; Cervical Adenosquamous Carcinoma; cervical adenosquamous carcinoma; Cervical Adenosquamous Cell Carcinoma; cervical adenosquamous cell carcinoma; Cervix Adenosquamous Cell Carcinoma; cervix adenosquamous cell carcinoma; Cervix Uteri Adenosquamous Cell Carcinoma; cervix uteri adenosquamous cell carcinoma; Uterine Cervix Adenosquamous Cell Carcinoma; uterine cervix adenosquamous cell carcinoma
SNOMED CT: Adenosquamous carcinoma of cervix (254888007)
 
Monarch Initiative: MONDO:0006134

Definition

An uncommon carcinoma arising from the cervix. It is composed of malignant glandular epithelial cells and malignant squamous epithelial cells. [from NCI]

Professional guidelines

PubMed

Cervical screening test results associated with 265 histopathologic diagnoses of cervical glandular neoplasia.
Zhao C, Li Z, Austin RM
Am J Clin Pathol 2013 Jul;140(1):47-54. doi: 10.1309/AJCPIP9M8HPVBSSC. PMID: 23765533
Clinical utility of adjunctive high-risk human papillomavirus DNA testing in women with Papanicolaou test findings of atypical glandular cells.
Zhao C, Florea A, Austin RM
Arch Pathol Lab Med 2010 Jan;134(1):103-8. doi: 10.5858/2008-0755-OAR1.1. PMID: 20073612

Recent clinical studies

Etiology

Comparison between laparoscopic and abdominal radical hysterectomy for cervical adenosquamous carcinoma at stage IA2 to IIA2: A multicenter retrospective study.
Teng X, Kang S, Li W, Ding H, Ling B, Zhu L, Wang D, Lang J, Liu P, Chen C
J Obstet Gynaecol Res 2023 Jun;49(6):1592-1610. Epub 2023 Mar 14 doi: 10.1111/jog.15633. PMID: 36919234
Cervical Adenosquamous Carcinoma: Detailed Analysis of Morphology, Immunohistochemical Profile, and Outcome in 59 Cases.
Stolnicu S, Hoang L, Zhou Q, Iasonos A, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Oliva E, Park KJ, Soslow RA
Int J Gynecol Pathol 2023 May 1;42(3):259-269. Epub 2022 Aug 31 doi: 10.1097/PGP.0000000000000921. PMID: 36044310Free PMC Article
The best postoperative adjuvant therapy for patients with early stage cervical adenosquamous carcinoma.
Liu Y, Tu H, Zhang L, Zhong M, Wang Y, Li L, Xiang X
BMC Womens Health 2022 Apr 12;22(1):112. doi: 10.1186/s12905-021-01588-8. PMID: 35410240Free PMC Article
Analysis of clinical characteristics and prognosis with cervical adenosquamous carcinoma: a large population-based study.
Ma Y, Zhao A, Zhang J, Wang S, Zhang J
Future Oncol 2021 May;17(13):1637-1652. Epub 2021 Jan 22 doi: 10.2217/fon-2020-1156. PMID: 33478265
RETRACTED ARTICLE: Cervical adenosquamous carcinoma: detailed analysis of morphology, immunohistochemical profile, and clinical outcomes in 59 cases.
Stolnicu S, Hoang L, Hanko-Bauer O, Barsan I, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Oliva E, Park KJ, Soslow RA
Mod Pathol 2019 Feb;32(2):269-279. Epub 2018 Sep 26 doi: 10.1038/s41379-018-0123-6. PMID: 30258209Free PMC Article

Diagnosis

Comparison between laparoscopic and abdominal radical hysterectomy for cervical adenosquamous carcinoma at stage IA2 to IIA2: A multicenter retrospective study.
Teng X, Kang S, Li W, Ding H, Ling B, Zhu L, Wang D, Lang J, Liu P, Chen C
J Obstet Gynaecol Res 2023 Jun;49(6):1592-1610. Epub 2023 Mar 14 doi: 10.1111/jog.15633. PMID: 36919234
Cervical Adenosquamous Carcinoma: Detailed Analysis of Morphology, Immunohistochemical Profile, and Outcome in 59 Cases.
Stolnicu S, Hoang L, Zhou Q, Iasonos A, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Oliva E, Park KJ, Soslow RA
Int J Gynecol Pathol 2023 May 1;42(3):259-269. Epub 2022 Aug 31 doi: 10.1097/PGP.0000000000000921. PMID: 36044310Free PMC Article
The best postoperative adjuvant therapy for patients with early stage cervical adenosquamous carcinoma.
Liu Y, Tu H, Zhang L, Zhong M, Wang Y, Li L, Xiang X
BMC Womens Health 2022 Apr 12;22(1):112. doi: 10.1186/s12905-021-01588-8. PMID: 35410240Free PMC Article
Analysis of clinical characteristics and prognosis with cervical adenosquamous carcinoma: a large population-based study.
Ma Y, Zhao A, Zhang J, Wang S, Zhang J
Future Oncol 2021 May;17(13):1637-1652. Epub 2021 Jan 22 doi: 10.2217/fon-2020-1156. PMID: 33478265
RETRACTED ARTICLE: Cervical adenosquamous carcinoma: detailed analysis of morphology, immunohistochemical profile, and clinical outcomes in 59 cases.
Stolnicu S, Hoang L, Hanko-Bauer O, Barsan I, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Oliva E, Park KJ, Soslow RA
Mod Pathol 2019 Feb;32(2):269-279. Epub 2018 Sep 26 doi: 10.1038/s41379-018-0123-6. PMID: 30258209Free PMC Article

Therapy

Evaluation of p16INK4a in cervical lesion of premenopausal and postmenopausal women.
Bolanca IK, Ciglar S
Coll Antropol 2007 Apr;31 Suppl 2:107-11. PMID: 17600938
Port-site metastasis following laparoscopic lymphadenectomy for adenosquamous carcinoma of the cervix.
Lane G, Tay J
Gynecol Oncol 1999 Jul;74(1):130-3. doi: 10.1006/gyno.1999.5379. PMID: 10385565

Prognosis

Comparison between laparoscopic and abdominal radical hysterectomy for cervical adenosquamous carcinoma at stage IA2 to IIA2: A multicenter retrospective study.
Teng X, Kang S, Li W, Ding H, Ling B, Zhu L, Wang D, Lang J, Liu P, Chen C
J Obstet Gynaecol Res 2023 Jun;49(6):1592-1610. Epub 2023 Mar 14 doi: 10.1111/jog.15633. PMID: 36919234
Verification of HPV16 as a good prognostic factor for cervical adeno-adenosquamous carcinoma via an international collaborative study.
Chen WC, Ngan HY, Yang LY, Chang WY, Wu RC, Chen CY, Lin H, Cheng YM, Kan YY, Tseng CJ, Chang CC, Jung SM, Tung HJ, Tang YH, Lin CT, Chao A, Lai CH
Taiwan J Obstet Gynecol 2022 May;61(3):494-500. doi: 10.1016/j.tjog.2022.03.036. PMID: 35595444
The best postoperative adjuvant therapy for patients with early stage cervical adenosquamous carcinoma.
Liu Y, Tu H, Zhang L, Zhong M, Wang Y, Li L, Xiang X
BMC Womens Health 2022 Apr 12;22(1):112. doi: 10.1186/s12905-021-01588-8. PMID: 35410240Free PMC Article
Analysis of clinical characteristics and prognosis with cervical adenosquamous carcinoma: a large population-based study.
Ma Y, Zhao A, Zhang J, Wang S, Zhang J
Future Oncol 2021 May;17(13):1637-1652. Epub 2021 Jan 22 doi: 10.2217/fon-2020-1156. PMID: 33478265
Outcome analysis of cervical adenosquamous carcinoma compared with adenocarcinoma.
Chen JL, Cheng JC, Kuo SH, Chen CA, Lin MC, Huang CY
Acta Obstet Gynecol Scand 2012 Oct;91(10):1158-66. Epub 2012 Aug 13 doi: 10.1111/j.1600-0412.2012.01420.x. PMID: 22497449

Clinical prediction guides

Gene Expression Analysis for Uterine Cervix and Corpus Cancer Characterization.
Almorox L, Antequera L, Rojas I, Herrera LJ, Ortuño FM
Genes (Basel) 2024 Feb 28;15(3) doi: 10.3390/genes15030312. PMID: 38540371Free PMC Article
Comparison between laparoscopic and abdominal radical hysterectomy for cervical adenosquamous carcinoma at stage IA2 to IIA2: A multicenter retrospective study.
Teng X, Kang S, Li W, Ding H, Ling B, Zhu L, Wang D, Lang J, Liu P, Chen C
J Obstet Gynaecol Res 2023 Jun;49(6):1592-1610. Epub 2023 Mar 14 doi: 10.1111/jog.15633. PMID: 36919234
Verification of HPV16 as a good prognostic factor for cervical adeno-adenosquamous carcinoma via an international collaborative study.
Chen WC, Ngan HY, Yang LY, Chang WY, Wu RC, Chen CY, Lin H, Cheng YM, Kan YY, Tseng CJ, Chang CC, Jung SM, Tung HJ, Tang YH, Lin CT, Chao A, Lai CH
Taiwan J Obstet Gynecol 2022 May;61(3):494-500. doi: 10.1016/j.tjog.2022.03.036. PMID: 35595444
Analysis of clinical characteristics and prognosis with cervical adenosquamous carcinoma: a large population-based study.
Ma Y, Zhao A, Zhang J, Wang S, Zhang J
Future Oncol 2021 May;17(13):1637-1652. Epub 2021 Jan 22 doi: 10.2217/fon-2020-1156. PMID: 33478265
Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma.
Longatto-Filho A, Pinheiro C, Martinho O, Moreira MA, Ribeiro LF, Queiroz GS, Schmitt FC, Baltazar F, Reis RM
BMC Cancer 2009 Jun 29;9:212. doi: 10.1186/1471-2407-9-212. PMID: 19563658Free PMC Article

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