U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Advanced Cervical Adenosquamous Carcinoma

MedGen UID:
1765965
•Concept ID:
C5420536
•
Neoplastic Process

Definition

Cervical adenosquamous carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Cervical Adenosquamous Carcinoma

Professional guidelines

PubMed

Influence of treatment center and hospital volume on survival for locally advanced cervical cancer.
Wright JD, Huang Y, Ananth CV, Tergas AI, Duffy C, Deutsch I, Burke WM, Hou JY, Neugut AI, Hershman DL
Gynecol Oncol 2015 Dec;139(3):506-12. Epub 2015 Jul 12 doi: 10.1016/j.ygyno.2015.07.015. PMID: 26177552Free PMC Article
Cervical cancer: prevention and treatment.
Denny L
Discov Med 2012 Aug;14(75):125-31. PMID: 22935209
Multimodal treatment of locally advanced cervical cancer.
Dueñas-González A, Cetina-Pérez L, Oñate-Ocaña LF, Rivera L, Lopez-Graniel C, González-Enciso A, Candelaria M, Mohar A
Arch Med Res 2005 Mar-Apr;36(2):129-35. doi: 10.1016/j.arcmed.2004.12.008. PMID: 15847945

Recent clinical studies

Etiology

Atezolizumab plus bevacizumab and chemotherapy for metastatic, persistent, or recurrent cervical cancer (BEATcc): a randomised, open-label, phase 3 trial.
Oaknin A, Gladieff L, Martínez-García J, Villacampa G, Takekuma M, De Giorgi U, Lindemann K, Woelber L, Colombo N, Duska L, Leary A, Godoy-Ortiz A, Nishio S, Angelergues A, Rubio MJ, Fariñas-Madrid L, Yamaguchi S, Lorusso D, Ray-Coquard I, Manso L, Joly F, Alarcón J, Follana P, Romero I, Lebreton C, Pérez-Fidalgo JA, Yunokawa M, Dahlstrand H, D'Hondt V, Randall LM; ENGOT-Cx10–GEICO 68-C–JGOG1084–GOG-3030 Investigators
Lancet 2024 Jan 6;403(10421):31-43. Epub 2023 Dec 1 doi: 10.1016/S0140-6736(23)02405-4. PMID: 38048793
Adjuvant chemotherapy following chemoradiotherapy as primary treatment for locally advanced cervical cancer versus chemoradiotherapy alone (OUTBACK): an international, open-label, randomised, phase 3 trial.
Mileshkin LR, Moore KN, Barnes EH, Gebski V, Narayan K, King MT, Bradshaw N, Lee YC, Diamante K, Fyles AW, Small W Jr, Gaffney DK, Khaw P, Brooks S, Thompson JS, Huh WK, Mathews CA, Buck M, Suder A, Lad TE, Barani IJ, Holschneider CH, Van Dyk S, Quinn M, Rischin D, Monk BJ, Stockler MR
Lancet Oncol 2023 May;24(5):468-482. Epub 2023 Apr 17 doi: 10.1016/S1470-2045(23)00147-X. PMID: 37080223Free PMC Article
Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.
Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group
Lancet Oncol 2021 Apr;22(4):538-547. doi: 10.1016/S1470-2045(20)30753-1. PMID: 33794207
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer.
Rose PG, Bundy BN, Watkins EB, Thigpen JT, Deppe G, Maiman MA, Clarke-Pearson DL, Insalaco S
N Engl J Med 1999 Apr 15;340(15):1144-53. doi: 10.1056/NEJM199904153401502. PMID: 10202165

Diagnosis

Pembrolizumab or placebo with chemoradiotherapy followed by pembrolizumab or placebo for newly diagnosed, high-risk, locally advanced cervical cancer (ENGOT-cx11/GOG-3047/KEYNOTE-A18): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 trial.
Lorusso D, Xiang Y, Hasegawa K, Scambia G, Leiva M, Ramos-Elias P, Acevedo A, Cvek J, Randall L, Pereira de Santana Gomes AJ, Contreras Mejía F, Helpman L, Akıllı H, Lee JY, Saevets V, Zagouri F, Gilbert L, Sehouli J, Tharavichitkul E, Lindemann K, Colombo N, Chang CL, Bednarikova M, Zhu H, Oaknin A, Christiaens M, Petru E, Usami T, Liu P, Yamada K, Toker S, Keefe SM, Pignata S, Duska LR; ENGOT-cx11/GOG-3047/KEYNOTE-A18 investigators
Lancet 2024 Oct 5;404(10460):1321-1332. Epub 2024 Sep 14 doi: 10.1016/S0140-6736(24)01808-7. PMID: 39288779
Prevalence and prognostic value of PD-L1 expression and tumor mutational burden in persistent, recurrent, or metastatic cervical cancer.
Baek MH, Chen L, Tekin C, Cristescu R, Jin XY, Shao C, Ihm SY, Jelinic P, Park JY
J Gynecol Oncol 2024 Nov;35(6):e105. Epub 2024 May 23 doi: 10.3802/jgo.2024.35.e105. PMID: 38857910Free PMC Article
Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
Hypercalcemia-Leukocytosis syndrome and adenosquamous lung carcinoma: An overlooked conjugation.
Oliveira Pereira J, Gama J, Ferreira D, Santos A
Oncol Res 2021;29(2):81-85. Epub 2022 Jul 13 doi: 10.32604/or.2022.023450. PMID: 37305400Free PMC Article
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903

Therapy

Atezolizumab plus bevacizumab and chemotherapy for metastatic, persistent, or recurrent cervical cancer (BEATcc): a randomised, open-label, phase 3 trial.
Oaknin A, Gladieff L, Martínez-García J, Villacampa G, Takekuma M, De Giorgi U, Lindemann K, Woelber L, Colombo N, Duska L, Leary A, Godoy-Ortiz A, Nishio S, Angelergues A, Rubio MJ, Fariñas-Madrid L, Yamaguchi S, Lorusso D, Ray-Coquard I, Manso L, Joly F, Alarcón J, Follana P, Romero I, Lebreton C, Pérez-Fidalgo JA, Yunokawa M, Dahlstrand H, D'Hondt V, Randall LM; ENGOT-Cx10–GEICO 68-C–JGOG1084–GOG-3030 Investigators
Lancet 2024 Jan 6;403(10421):31-43. Epub 2023 Dec 1 doi: 10.1016/S0140-6736(23)02405-4. PMID: 38048793
Adjuvant chemotherapy following chemoradiotherapy as primary treatment for locally advanced cervical cancer versus chemoradiotherapy alone (OUTBACK): an international, open-label, randomised, phase 3 trial.
Mileshkin LR, Moore KN, Barnes EH, Gebski V, Narayan K, King MT, Bradshaw N, Lee YC, Diamante K, Fyles AW, Small W Jr, Gaffney DK, Khaw P, Brooks S, Thompson JS, Huh WK, Mathews CA, Buck M, Suder A, Lad TE, Barani IJ, Holschneider CH, Van Dyk S, Quinn M, Rischin D, Monk BJ, Stockler MR
Lancet Oncol 2023 May;24(5):468-482. Epub 2023 Apr 17 doi: 10.1016/S1470-2045(23)00147-X. PMID: 37080223Free PMC Article
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.
Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group
Lancet Oncol 2021 Apr;22(4):538-547. doi: 10.1016/S1470-2045(20)30753-1. PMID: 33794207
CALLA: Efficacy and safety of concurrent and adjuvant durvalumab with chemoradiotherapy versus chemoradiotherapy alone in women with locally advanced cervical cancer: a phase III, randomized, double-blind, multicenter study.
Mayadev J, Nunes AT, Li M, Marcovitz M, Lanasa MC, Monk BJ
Int J Gynecol Cancer 2020 Jul;30(7):1065-1070. Epub 2020 May 23 doi: 10.1136/ijgc-2019-001135. PMID: 32447296Free PMC Article
Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer.
Rose PG, Bundy BN, Watkins EB, Thigpen JT, Deppe G, Maiman MA, Clarke-Pearson DL, Insalaco S
N Engl J Med 1999 Apr 15;340(15):1144-53. doi: 10.1056/NEJM199904153401502. PMID: 10202165

Prognosis

Outcomes and prognostic factors in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy.
Liu J, Tang G, Zhou Q, Kuang W
Radiat Oncol 2022 Aug 17;17(1):142. doi: 10.1186/s13014-022-02115-1. PMID: 35978412Free PMC Article
Hypercalcemia-Leukocytosis syndrome and adenosquamous lung carcinoma: An overlooked conjugation.
Oliveira Pereira J, Gama J, Ferreira D, Santos A
Oncol Res 2021;29(2):81-85. Epub 2022 Jul 13 doi: 10.32604/or.2022.023450. PMID: 37305400Free PMC Article
Surgical versus clinical staging prior to primary chemoradiation in patients with cervical cancer FIGO stages IIB-IVA: oncologic results of a prospective randomized international multicenter (Uterus-11) intergroup study.
Marnitz S, Tsunoda AT, Martus P, Vieira M, Affonso Junior RJ, Nunes J, Budach V, Hertel H, Mustea A, Sehouli J, Scharf JP, Ulrich U, Ebert A, Piwonski I, Kohler C
Int J Gynecol Cancer 2020 Dec;30(12):1855-1861. doi: 10.1136/ijgc-2020-001973. PMID: 33293284Free PMC Article
Adenosquamous carcinoma of the head and neck: report of 20 cases and review of the literature.
Schick U, Pusztaszeri M, Betz M, Ghadjar P, Demiroz C, Kaanders JH, Ozsahin M
Oral Surg Oral Med Oral Pathol Oral Radiol 2013 Sep;116(3):313-20. Epub 2013 Jul 10 doi: 10.1016/j.oooo.2013.05.003. PMID: 23850369
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Clinical prediction guides

Prevalence and prognostic value of PD-L1 expression and tumor mutational burden in persistent, recurrent, or metastatic cervical cancer.
Baek MH, Chen L, Tekin C, Cristescu R, Jin XY, Shao C, Ihm SY, Jelinic P, Park JY
J Gynecol Oncol 2024 Nov;35(6):e105. Epub 2024 May 23 doi: 10.3802/jgo.2024.35.e105. PMID: 38857910Free PMC Article
TPP1 is associated with risk of advanced precursors and cervical cancer survival.
Wang QL, Gong C, Meng XY, Fu M, Yang H, Zhou F, Wu Q, Zhou Y
PLoS One 2024;19(5):e0298118. Epub 2024 May 9 doi: 10.1371/journal.pone.0298118. PMID: 38722833Free PMC Article
Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
Locally advanced cervical carcinoma patients treated with chemoradiation followed by radical surgery: clinical response and oncological outcomes according to histotype after propensity score analysis.
Legge F, Bizzarri N, Gallotta V, Pedone Anchora L, Cosentino F, Turco LC, Certelli C, Macchia G, Valentini V, Scambia G, Ferrandina G
Eur J Surg Oncol 2022 Sep;48(9):2045-2052. Epub 2022 Apr 12 doi: 10.1016/j.ejso.2022.04.004. PMID: 35450757
MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study.
Pötter R, Tanderup K, Schmid MP, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza AE, Hoskin P, Mahantshetty U, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Tan LT, Nout RA, De Leeuw AAC, Ristl R, Petric P, Nesvacil N, Kirchheiner K, Kirisits C, Lindegaard JC; EMBRACE Collaborative Group
Lancet Oncol 2021 Apr;22(4):538-547. doi: 10.1016/S1470-2045(20)30753-1. PMID: 33794207

Recent systematic reviews

Adjuvant chemotherapy after concurrent chemoradiation for locally advanced cervical cancer.
Tangjitgamol S, Katanyoo K, Laopaiboon M, Lumbiganon P, Manusirivithaya S, Supawattanabodee B
Cochrane Database Syst Rev 2014 Dec 3;2014(12):CD010401. doi: 10.1002/14651858.CD010401.pub2. PMID: 25470408Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...