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Lemierre syndrome

MedGen UID:
83364
•Concept ID:
C0343525
•
Disease or Syndrome
Synonyms: Disease, Lemierre; Disease, Lemierre's; Lemierre Disease; Lemierre Syndrome; Lemierre's Disease; Lemierre's Syndrome; Lemierres Disease; Lemierres Syndrome; Postanginal Sepses; Postanginal Sepsis; Sepses, Postanginal; Sepsis, Postanginal; Syndrome, Lemierre; Syndrome, Lemierre's
SNOMED CT: Septic phlebitis of internal jugular vein (1231140009); Lemierre syndrome (1231140009); Postanginal sepsis secondary to oropharyngeal infection (1231140009); Lemierre postanginal sepsis (1231140009)

Definition

A rare potentially lethal oropharyngeal infectious disease occurring in immunocompetent adolescents and young adults that is mainly due to Fusobacterium necrophorum and with characteristics of septic thrombophlebitis of the internal jugular vein that leads to septic usually pulmonary embolism, associated with ENT (ear, nose, and throat) infection that manifests with fever, neck pain and tonsillopharyngitis. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLemierre syndrome
Follow this link to review classifications for Lemierre syndrome in Orphanet.

Professional guidelines

PubMed

Management of Lemierre Syndrome.
Valerio L, Pleming W, Pecci A, Barco S
Minerva Med 2021 Dec;112(6):726-739. Epub 2021 May 14 doi: 10.23736/S0026-4806.21.07497-8. PMID: 33988011
Anaerobic bacteria in upper respiratory tract and head and neck infections: microbiology and treatment.
Brook I
Anaerobe 2012 Apr;18(2):214-20. Epub 2011 Dec 20 doi: 10.1016/j.anaerobe.2011.12.014. PMID: 22197951
Current management of upper respiratory tract and head and neck infections.
Brook I
Eur Arch Otorhinolaryngol 2009 Mar;266(3):315-23. Epub 2008 Nov 5 doi: 10.1007/s00405-008-0849-8. PMID: 18985371

Recent clinical studies

Etiology

High risk and low prevalence diseases: Lemierre's syndrome.
Carius BM, Koyfman A, Long B
Am J Emerg Med 2022 Nov;61:98-104. Epub 2022 Aug 30 doi: 10.1016/j.ajem.2022.08.050. PMID: 36058204
Fusobacterium necrophorum oral infections - A need for guidance.
Centor RM, Atkinson TP, Xiao L
Anaerobe 2022 Jun;75:102532. Epub 2022 Feb 2 doi: 10.1016/j.anaerobe.2022.102532. PMID: 35122953
Head, Neck, and Abdominopelvic Septic Thrombophlebitis: Current Evidence and Challenges in Diagnosis and Treatment.
Valerio L, Riva N
Hamostaseologie 2020 Aug;40(3):301-310. Epub 2020 Jul 29 doi: 10.1055/a-1177-5127. PMID: 32726825
Invasive infections with Fusobacterium necrophorum including Lemierre's syndrome: an 8-year Swedish nationwide retrospective study.
Nygren D, Holm K
Clin Microbiol Infect 2020 Aug;26(8):1089.e7-1089.e12. Epub 2019 Dec 14 doi: 10.1016/j.cmi.2019.12.002. PMID: 31843654
Lemierre Syndrome: A Retrospective Study of the Role of Anticoagulation and Thrombosis Outcomes.
Cupit-Link MC, Nageswara Rao A, Warad DM, Rodriguez V
Acta Haematol 2017;137(2):59-65. Epub 2016 Dec 23 doi: 10.1159/000452855. PMID: 28006761

Diagnosis

Lemierre's syndrome.
Foo EC, Tanti M, Cliffe H, Randall M
Pract Neurol 2021 Oct;21(5):442-444. Epub 2021 May 7 doi: 10.1136/practneurol-2021-002928. PMID: 33963085
Lemierre's syndrome: A forgotten and re-emerging infection.
Lee WS, Jean SS, Chen FL, Hsieh SM, Hsueh PR
J Microbiol Immunol Infect 2020 Aug;53(4):513-517. Epub 2020 Apr 4 doi: 10.1016/j.jmii.2020.03.027. PMID: 32303484
Lemierre's Syndrome.
Walkty A, Embil J
N Engl J Med 2019 Mar 21;380(12):e16. doi: 10.1056/NEJMicm1808378. PMID: 30893539
Lemierre's syndrome due to Fusobacterium necrophorum.
Kuppalli K, Livorsi D, Talati NJ, Osborn M
Lancet Infect Dis 2012 Oct;12(10):808-15. Epub 2012 May 25 doi: 10.1016/S1473-3099(12)70089-0. PMID: 22633566
Necrobacillosis in humans.
Dahlén G, Ebenfelt A
Expert Rev Anti Infect Ther 2011 Feb;9(2):227-36. doi: 10.1586/eri.10.172. PMID: 21342070

Therapy

Hard to Swallow.
Litt MJ, Gaffney R, Vaidya A, Montgomery MW
N Engl J Med 2021 Sep 30;385(14):e47. doi: 10.1056/NEJMimc2103214. PMID: 34587389
Lemierre's syndrome: A forgotten and re-emerging infection.
Lee WS, Jean SS, Chen FL, Hsieh SM, Hsueh PR
J Microbiol Immunol Infect 2020 Aug;53(4):513-517. Epub 2020 Apr 4 doi: 10.1016/j.jmii.2020.03.027. PMID: 32303484
Photoclinic.
Mirfazaelian H, Akhgar A, Farajidaneshgar F, Daneshbod Y
Arch Iran Med 2018 Aug 1;21(8):378-379. PMID: 30113861
Lemierre's syndrome due to Fusobacterium necrophorum.
Kuppalli K, Livorsi D, Talati NJ, Osborn M
Lancet Infect Dis 2012 Oct;12(10):808-15. Epub 2012 May 25 doi: 10.1016/S1473-3099(12)70089-0. PMID: 22633566
Necrobacillosis in humans.
Dahlén G, Ebenfelt A
Expert Rev Anti Infect Ther 2011 Feb;9(2):227-36. doi: 10.1586/eri.10.172. PMID: 21342070

Prognosis

Ophthalmic complications of Lemierre syndrome.
Kreuzpointner R, Valerio L, Corsi G, Zane F, Sacco C, Holm K, Righini C, Pecci A, Zweifel S, Barco S
Acta Ophthalmol 2022 Feb;100(1):e314-e320. Epub 2021 Apr 8 doi: 10.1111/aos.14871. PMID: 33829646
Lemierre's syndrome.
Foo EC, Tanti M, Cliffe H, Randall M
Pract Neurol 2021 Oct;21(5):442-444. Epub 2021 May 7 doi: 10.1136/practneurol-2021-002928. PMID: 33963085
Head, Neck, and Abdominopelvic Septic Thrombophlebitis: Current Evidence and Challenges in Diagnosis and Treatment.
Valerio L, Riva N
Hamostaseologie 2020 Aug;40(3):301-310. Epub 2020 Jul 29 doi: 10.1055/a-1177-5127. PMID: 32726825
Lemierre's syndrome due to Fusobacterium necrophorum.
Kuppalli K, Livorsi D, Talati NJ, Osborn M
Lancet Infect Dis 2012 Oct;12(10):808-15. Epub 2012 May 25 doi: 10.1016/S1473-3099(12)70089-0. PMID: 22633566
Lemierre syndrome: a pediatric case series and review of literature.
Ridgway JM, Parikh DA, Wright R, Holden P, Armstrong W, Camilon F, Wong BJ
Am J Otolaryngol 2010 Jan-Feb;31(1):38-45. Epub 2009 Mar 26 doi: 10.1016/j.amjoto.2008.09.006. PMID: 19944898

Clinical prediction guides

The Clinical Value of Cranial CT Venography for Predicting Fusobacterium necrophorum as the Causative Agent in Children with Complicated Acute Mastoiditis.
Shiran SI, Pratt LT, DeRowe A, Matot S, Neiderman NC, Wasserzug O
AJNR Am J Neuroradiol 2024 Jun 7;45(6):761-768. doi: 10.3174/ajnr.A8217. PMID: 38724201
Management of Lemierre Syndrome.
Valerio L, Pleming W, Pecci A, Barco S
Minerva Med 2021 Dec;112(6):726-739. Epub 2021 May 14 doi: 10.23736/S0026-4806.21.07497-8. PMID: 33988011
Head, Neck, and Abdominopelvic Septic Thrombophlebitis: Current Evidence and Challenges in Diagnosis and Treatment.
Valerio L, Riva N
Hamostaseologie 2020 Aug;40(3):301-310. Epub 2020 Jul 29 doi: 10.1055/a-1177-5127. PMID: 32726825
Lemierre's Syndrome Associated with Periodontal Injury-derived Odontogenic Infection that Did Not Respond to Meropenem.
Oya M, Tanimoto T, Yamamoto T, Hakozaki Y
Intern Med 2015;54(14):1803-8. Epub 2015 Jul 15 doi: 10.2169/internalmedicine.54.4126. PMID: 26179541
Lemierre syndrome: a pediatric case series and review of literature.
Ridgway JM, Parikh DA, Wright R, Holden P, Armstrong W, Camilon F, Wong BJ
Am J Otolaryngol 2010 Jan-Feb;31(1):38-45. Epub 2009 Mar 26 doi: 10.1016/j.amjoto.2008.09.006. PMID: 19944898

Recent systematic reviews

Cardiac and Cerebral Arterial Complications of Lemierre Syndrome: Results from a Systematic Review and Individual Patient Data Meta-analysis.
Pleming W, Barco S, Voci D, Sacco C, Zane F, Granziera S, Corsi G, Konstantinides SV, Kucher N, Pecci A, Valerio L
Hamostaseologie 2022 Aug;42(4):261-267. Epub 2022 Mar 7 doi: 10.1055/a-1694-8723. PMID: 35255510Free PMC Article
Anticoagulation Strategies in the Management of Lemierre Syndrome: A Systematic Review of the Literature.
Adedeji A, Chukwura O, Obafemi T, McNulty SB, Reinert JP
Ann Pharmacother 2021 May;55(5):658-665. Epub 2020 Sep 10 doi: 10.1177/1060028020957620. PMID: 32909436
Lemierre's syndrome in adulthood, a case report and systematic review.
Moretti M, De Geyter D, Goethal L, Allard SD
Acta Clin Belg 2021 Aug;76(4):324-334. Epub 2020 Feb 29 doi: 10.1080/17843286.2020.1731661. PMID: 32116143
Lemierre Syndrome: Clinical Update and Protocol for a Systematic Review and Individual Patient Data Meta-analysis.
Sacco C, Zane F, Granziera S, Holm K, Creemers-Schild D, Hotz MA, Turpini E, Valentini A, Righini C, Karkos PD, Verhamme P, Di Nisio M, Konstantinides S, Pecci A, Barco S; Lemierre Study Group
Hamostaseologie 2019 Feb;39(1):76-86. Epub 2018 Aug 2 doi: 10.1055/s-0038-1654720. PMID: 30071559

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