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Hypolipidemia

MedGen UID:
575275
•Concept ID:
C0342892
•
Finding; Pathologic Function
SNOMED CT: Hypolipidemia (238090007)
 
HPO: HP:0045014

Definition

abnormally decreased amount of fat in the blood. [from CRISP]

Conditions with this feature

Congenital bile acid synthesis defect 6
MedGen UID:
934591
•Concept ID:
C4310624
•
Disease or Syndrome
Congenital bile acid synthesis defect-6 (CBAS6) is characterized by persistent hypertransaminasemia and accumulation of C27 bile acids (summary by Alonso-Pena et al., 2022). For a general phenotypic description and a discussion of genetic heterogeneity of congenital bile acid synthesis defects, see CBAS1 (607765).
See: Condition Record
Congenital bile acid synthesis defect 6

Professional guidelines

PubMed

Current Diagnosis and Management of Familial Hypobetalipoproteinemia 1.
Wakabayashi T, Takahashi M, Okazaki H, Okazaki S, Yokote K, Tada H, Ogura M, Ishigaki Y, Yamashita S, Harada-Shiba M; Committee on Primary Dyslipidemia under the Research Program on Rare and Intractable Disease of the Ministry of Health, Labour and Welfare of Japan
J Atheroscler Thromb 2024 Jul 1;31(7):1005-1023. Epub 2024 May 3 doi: 10.5551/jat.RV22018. PMID: 38710625Free PMC Article
Guidance for the diagnosis and treatment of hypolipidemia disorders.
Bredefeld C, Hussain MM, Averna M, Black DD, Brin MF, Burnett JR, Charrière S, Cuerq C, Davidson NO, Deckelbaum RJ, Goldberg IJ, Granot E, Hegele RA, Ishibashi S, Karmally W, Levy E, Moulin P, Okazaki H, Poinsot P, Rader DJ, Takahashi M, Tarugi P, Traber MG, Di Filippo M, Peretti N
J Clin Lipidol 2022 Nov-Dec;16(6):797-812. Epub 2022 Sep 29 doi: 10.1016/j.jacl.2022.08.009. PMID: 36243606
Current Diagnosis and Management of Abetalipoproteinemia.
Takahashi M, Okazaki H, Ohashi K, Ogura M, Ishibashi S, Okazaki S, Hirayama S, Hori M, Matsuki K, Yokoyama S, Harada-Shiba M
J Atheroscler Thromb 2021 Oct 1;28(10):1009-1019. Epub 2021 May 16 doi: 10.5551/jat.RV17056. PMID: 33994405Free PMC Article

Recent clinical studies

Etiology

Hypotriglyceridemias/hypolipidemias.
Martínez-Hervás S, Real-Collado JT, Ascaso-Gimilio JF
Clin Investig Arterioscler 2021 May;33 Suppl 2:63-68. doi: 10.1016/j.arteri.2020.12.011. PMID: 34006356
Healthy Uses for Garlic.
White D
Nurs Clin North Am 2021 Mar;56(1):153-156. doi: 10.1016/j.cnur.2020.12.001. PMID: 33549282
Evinacumab for Homozygous Familial Hypercholesterolemia.
Raal FJ, Rosenson RS, Reeskamp LF, Hovingh GK, Kastelein JJP, Rubba P, Ali S, Banerjee P, Chan KC, Gipe DA, Khilla N, Pordy R, Weinreich DM, Yancopoulos GD, Zhang Y, Gaudet D; ELIPSE HoFH Investigators
N Engl J Med 2020 Aug 20;383(8):711-720. doi: 10.1056/NEJMoa2004215. PMID: 32813947
Familial combined hypolipidemia: angiopoietin-like protein-3 deficiency.
Arca M, D'Erasmo L, Minicocci I
Curr Opin Lipidol 2020 Apr;31(2):41-48. doi: 10.1097/MOL.0000000000000668. PMID: 32022755
Hypobetalipoproteinemia and abetalipoproteinemia.
Welty FK
Curr Opin Lipidol 2014 Jun;25(3):161-8. doi: 10.1097/MOL.0000000000000072. PMID: 24751931Free PMC Article

Diagnosis

Guidance for the diagnosis and treatment of hypolipidemia disorders.
Bredefeld C, Hussain MM, Averna M, Black DD, Brin MF, Burnett JR, Charrière S, Cuerq C, Davidson NO, Deckelbaum RJ, Goldberg IJ, Granot E, Hegele RA, Ishibashi S, Karmally W, Levy E, Moulin P, Okazaki H, Poinsot P, Rader DJ, Takahashi M, Tarugi P, Traber MG, Di Filippo M, Peretti N
J Clin Lipidol 2022 Nov-Dec;16(6):797-812. Epub 2022 Sep 29 doi: 10.1016/j.jacl.2022.08.009. PMID: 36243606
Hypotriglyceridemias/hypolipidemias.
Martínez-Hervás S, Real-Collado JT, Ascaso-Gimilio JF
Clin Investig Arterioscler 2021 May;33 Suppl 2:63-68. doi: 10.1016/j.arteri.2020.12.011. PMID: 34006356
Current Diagnosis and Management of Abetalipoproteinemia.
Takahashi M, Okazaki H, Ohashi K, Ogura M, Ishibashi S, Okazaki S, Hirayama S, Hori M, Matsuki K, Yokoyama S, Harada-Shiba M
J Atheroscler Thromb 2021 Oct 1;28(10):1009-1019. Epub 2021 May 16 doi: 10.5551/jat.RV17056. PMID: 33994405Free PMC Article
Familial combined hypolipidemia: angiopoietin-like protein-3 deficiency.
Arca M, D'Erasmo L, Minicocci I
Curr Opin Lipidol 2020 Apr;31(2):41-48. doi: 10.1097/MOL.0000000000000668. PMID: 32022755
Hypobetalipoproteinemia and abetalipoproteinemia.
Welty FK
Curr Opin Lipidol 2014 Jun;25(3):161-8. doi: 10.1097/MOL.0000000000000072. PMID: 24751931Free PMC Article

Therapy

Black Garlic and Its Bioactive Compounds on Human Health Diseases: A Review.
Ahmed T, Wang CK
Molecules 2021 Aug 19;26(16) doi: 10.3390/molecules26165028. PMID: 34443625Free PMC Article
Healthy Uses for Garlic.
White D
Nurs Clin North Am 2021 Mar;56(1):153-156. doi: 10.1016/j.cnur.2020.12.001. PMID: 33549282
Evinacumab for Homozygous Familial Hypercholesterolemia.
Raal FJ, Rosenson RS, Reeskamp LF, Hovingh GK, Kastelein JJP, Rubba P, Ali S, Banerjee P, Chan KC, Gipe DA, Khilla N, Pordy R, Weinreich DM, Yancopoulos GD, Zhang Y, Gaudet D; ELIPSE HoFH Investigators
N Engl J Med 2020 Aug 20;383(8):711-720. doi: 10.1056/NEJMoa2004215. PMID: 32813947
Familial combined hypolipidemia: angiopoietin-like protein-3 deficiency.
Arca M, D'Erasmo L, Minicocci I
Curr Opin Lipidol 2020 Apr;31(2):41-48. doi: 10.1097/MOL.0000000000000668. PMID: 32022755
Update on primary hypobetalipoproteinemia.
Hooper AJ, Burnett JR
Curr Atheroscler Rep 2014 Jul;16(7):423. doi: 10.1007/s11883-014-0423-3. PMID: 24781598

Prognosis

Current Diagnosis and Management of Abetalipoproteinemia.
Takahashi M, Okazaki H, Ohashi K, Ogura M, Ishibashi S, Okazaki S, Hirayama S, Hori M, Matsuki K, Yokoyama S, Harada-Shiba M
J Atheroscler Thromb 2021 Oct 1;28(10):1009-1019. Epub 2021 May 16 doi: 10.5551/jat.RV17056. PMID: 33994405Free PMC Article
ANGPTL3 gene variants in subjects with familial combined hyperlipidemia.
Bea AM, Franco-Marín E, Marco-Benedí V, Jarauta E, Gracia-Rubio I, Cenarro A, Civeira F, Lamiquiz-Moneo I
Sci Rep 2021 Mar 26;11(1):7002. doi: 10.1038/s41598-021-86384-y. PMID: 33772079Free PMC Article
Abnormalities of Lipoprotein Levels in Liver Cirrhosis: Clinical Relevance.
Privitera G, Spadaro L, Marchisello S, Fede G, Purrello F
Dig Dis Sci 2018 Jan;63(1):16-26. Epub 2017 Nov 25 doi: 10.1007/s10620-017-4862-x. PMID: 29177578
Energy balance, glucose and lipid metabolism, cardiovascular risk and liver disease burden in adult patients with type 1 Gaucher disease.
Nascimbeni F, Dalla Salda A, Carubbi F
Blood Cells Mol Dis 2018 Feb;68:74-80. Epub 2016 Oct 20 doi: 10.1016/j.bcmd.2016.10.012. PMID: 27839982
Evaluation of serum lipids and lipoproteins as prognosticators in leukoplakia.
Ganavi BS, Patil S, Rao RS
J Contemp Dent Pract 2014 May 1;15(3):294-9. doi: 10.5005/jp-journals-10024-1531. PMID: 25307809

Clinical prediction guides

MANF/EWSR1/ANXA6 pathway might as the bridge between hypolipidemia and major depressive disorder.
Xu K, Zheng P, Zhao S, Wang M, Tu D, Wei Q, Feng J, Wang H, Chen J, Xie P
Transl Psychiatry 2022 Dec 30;12(1):527. doi: 10.1038/s41398-022-02287-0. PMID: 36585419Free PMC Article
Multi-Trait Genetic Analysis Reveals Clinically Interpretable Hypertension Subtypes.
Vaura F, Kim H, Udler MS; FinnGen*, Salomaa V, Lahti L, Niiranen T
Circ Genom Precis Med 2022 Aug;15(4):e003583. Epub 2022 May 23 doi: 10.1161/CIRCGEN.121.003583. PMID: 35604428Free PMC Article
Abnormalities of Lipoprotein Levels in Liver Cirrhosis: Clinical Relevance.
Privitera G, Spadaro L, Marchisello S, Fede G, Purrello F
Dig Dis Sci 2018 Jan;63(1):16-26. Epub 2017 Nov 25 doi: 10.1007/s10620-017-4862-x. PMID: 29177578
Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization.
Minicocci I, Montali A, Robciuc MR, Quagliarini F, Censi V, Labbadia G, Gabiati C, Pigna G, Sepe ML, Pannozzo F, Lütjohann D, Fazio S, Jauhiainen M, Ehnholm C, Arca M
J Clin Endocrinol Metab 2012 Jul;97(7):E1266-75. Epub 2012 Jun 1 doi: 10.1210/jc.2012-1298. PMID: 22659251Free PMC Article
PPARalpha: energy combustion, hypolipidemia, inflammation and cancer.
Pyper SR, Viswakarma N, Yu S, Reddy JK
Nucl Recept Signal 2010 Apr 16;8:e002. doi: 10.1621/nrs.08002. PMID: 20414453Free PMC Article

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