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Malignant Granulosa Cell Tumor

MedGen UID:
87235
•Concept ID:
C0334401
•
Neoplastic Process
Synonyms: Cancer of Granulosa Cells; Cancer, Granulosa Cell; Cancers, Granulosa Cell; Cell Cancer, Granulosa; Cell Cancers, Granulosa; Cells Cancer, Granulosa; Cells Cancers, Granulosa; Granulosa Cell Cancer; Granulosa Cell Cancers; Granulosa Cells Cancer; Granulosa Cells Cancers
SNOMED CT: Malignant granulosa cell tumor (18861007); Granulosa cell tumor, sarcomatoid (18861007); Granulosa cell tumor, malignant (18861007); Malignant adult granulosa cell tumor (18861007)

Definition

A granulosa cell tumor which has an aggressive clinical course and metastasizes to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Granulosa Cell Tumor

Professional guidelines

PubMed

Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment.
Melnik BC
Cells 2023 Nov 10;12(22) doi: 10.3390/cells12222600. PMID: 37998335Free PMC Article
Nanocomposites based on nanoceria regulate the immune microenvironment for the treatment of polycystic ovary syndrome.
Yan S, Gao Z, Ding J, Chen S, Wang Z, Jin W, Qu B, Zhang Y, Yang L, Guo D, Yin T, Yang Y, Zhang Y, Yang J
J Nanobiotechnology 2023 Nov 7;21(1):412. doi: 10.1186/s12951-023-02182-w. PMID: 37936120Free PMC Article
DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792

Recent clinical studies

Diagnosis

Malignant granulosa cell tumor of testis with metastasis to liver: Case report and review of literature.
Bordiya S, Priyanka K, Garg D
Indian J Pathol Microbiol 2020 Jul-Sep;63(3):470-471. doi: 10.4103/IJPM.IJPM_436_18. PMID: 32769343
Staging ovarian cancer: role of imaging.
Coakley FV
Radiol Clin North Am 2002 May;40(3):609-36. doi: 10.1016/s0033-8389(01)00012-4. PMID: 12117196
Malignant granulosa cell tumor of the testis associated with gynecomastia and long survival.
Matoska J, Ondrus D, Talerman A
Cancer 1992 Apr 1;69(7):1769-72. doi: 10.1002/1097-0142(19920401)69:7<1769::aid-cncr2820690719>3.0.co;2-v. PMID: 1551061
Human granulosa cell tumor: stimulation of steroidogenesis by gonadotropins in vitro.
Hahlin M, Crona N, Knutsson F, Janson PO
Gynecol Oncol 1991 Mar;40(3):201-6. doi: 10.1016/0090-8258(90)90278-s. PMID: 1849499
Malignant ovarian tumors in children and adolescents.
Raney RB Jr, Sinclair L, Uri A, Schnaufer L, Cooper A, Littman P
Cancer 1987 Mar 15;59(6):1214-20. doi: 10.1002/1097-0142(19870315)59:6<1214::aid-cncr2820590631>3.0.co;2-z. PMID: 3815296

Therapy

Malignant ovarian tumors in children and adolescents.
Raney RB Jr, Sinclair L, Uri A, Schnaufer L, Cooper A, Littman P
Cancer 1987 Mar 15;59(6):1214-20. doi: 10.1002/1097-0142(19870315)59:6<1214::aid-cncr2820590631>3.0.co;2-z. PMID: 3815296

Prognosis

Malignant granulosa cell tumor of the testis associated with gynecomastia and long survival.
Matoska J, Ondrus D, Talerman A
Cancer 1992 Apr 1;69(7):1769-72. doi: 10.1002/1097-0142(19920401)69:7<1769::aid-cncr2820690719>3.0.co;2-v. PMID: 1551061

Clinical prediction guides

Trisomy 12 in pediatric granulosa-stromal cell tumors. Demonstration by a modified method of fluorescence in situ hybridization on paraffin-embedded material.
Schofield DE, Fletcher JA
Am J Pathol 1992 Dec;141(6):1265-9. PMID: 1466394Free PMC Article

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