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Lymphocytoma cutis

MedGen UID:
81385
•Concept ID:
C0311220
•
Neoplastic Process
Synonyms: Benign cutaneous lymphoid hyperplasia; Benign lymphocytoma cutis; Cutaneous lymphoid hyperplasia; Cutaneous Pseudolymphoma; Cutaneous pseudolymphoma; cutaneous pseudolymphoma; Lymphadenosis Benigna Cutis; lymphadenosis Benigna cutis; Lymphocytoma Cutis; lymphocytoma cutis; Pseudolymphoma of Spiegler; pseudolymphoma of Spiegler; Pseudolymphoma of Spiegler-Fendt; Skin pseudolymphoma; Spiegler-Fendt sarcoid
SNOMED CT: Pseudolymphoma of Spiegler-Fendt (128862000); Lymphocytoma cutis (128862000); Cutaneous lymphoid hyperplasia (128862000); Benign lymphocytoma cutis (128862000); Benign cutaneous lymphoid hyperplasia (128862000); Cutaneous pseudolymphoma (128862000)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0031549
Monarch Initiative: MONDO:0018680
Orphanet: ORPHA451607

Definition

Lymphocytoma cutis, or Spiegler-Fendt sarcoid, is classed as one of the pseudolymphomas, referring to inflammatory disorders in which the accumulation of lymphocytes on the skin resemble, clinically and histopathologically, cutaneous lymphomas. Careful clinical evaluation, histopathological and immunohistochemical exams may be needed to make the correct diagnosis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphocytoma cutis

Professional guidelines

PubMed

Differential diagnosis of cutaneous infiltrates of B lymphocytes with follicular growth pattern.
Leinweber B, Colli C, Chott A, Kerl H, Cerroni L
Am J Dermatopathol 2004 Feb;26(1):4-13. doi: 10.1097/00000372-200402000-00002. PMID: 14726817
Effects of adequate versus inadequate treatment of cutaneous manifestations of Lyme borreliosis on the incidence of late complications and late serologic status.
Plörer A, Sepp N, Schmutzhard E, Krabichler S, Trobos S, Schauer G, Pahl C, Stöffler G, Fritsch P
J Invest Dermatol 1993 Feb;100(2):103-9. doi: 10.1111/1523-1747.ep12462773. PMID: 8429231
Immunohistochemical differential diagnosis between lymphocytoma cutis and malignant lymphoma in paraffin-embedded sections.
Toyota N, Matsuo S, Iizuka H
J Dermatol 1991 Oct;18(10):586-91. doi: 10.1111/j.1346-8138.1991.tb03137.x. PMID: 1791238

Recent clinical studies

Etiology

Lymphocytoma cutis (cutaneous B-cell pseudolymphoma): study of 102 cases with emphasis on the histological characteristics and immunohistochemistry of the miliarial type.
Villalobos-Ayala RA, Espinoza-Gurrola AA, Guevara-Gutiérrez E, Solís-Ledesma G, Ramos-Suárez M, Rodríguez-Castellanos MA, Tlacuilo-Parra A
Int J Dermatol 2022 Mar;61(3):316-323. Epub 2021 Sep 19 doi: 10.1111/ijd.15909. PMID: 34541667
Cutaneous B-Cell Pseudolymphoma (Lymphocytoma Cutis) of the Earlobe: A Poorly Recognized Complication of Ear Piercing in Children.
Slack JC, Kurek KC, Fraulin FOG, Brundler MA
Fetal Pediatr Pathol 2022 Jun;41(3):486-492. Epub 2020 Nov 5 doi: 10.1080/15513815.2020.1843573. PMID: 33150803
Borrelia burgdorferi-associated lymphocytoma cutis: clinicopathologic, immunophenotypic, and molecular study of 106 cases.
Colli C, Leinweber B, Müllegger R, Chott A, Kerl H, Cerroni L
J Cutan Pathol 2004 Mar;31(3):232-40. doi: 10.1111/j.0303-6987.2003.00167.x. PMID: 14984575
Cutaneous pseudolymphomas.
Ploysangam T, Breneman DL, Mutasim DF
J Am Acad Dermatol 1998 Jun;38(6 Pt 1):877-95; quiz 896-7. doi: 10.1016/s0190-9622(98)70154-9. PMID: 9631994
Clinicopathologic manifestations of Epstein-Barr virus-associated cutaneous lymphoproliferative disorders.
Iwatsuki K, Ohtsuka M, Harada H, Han G, Kaneko F
Arch Dermatol 1997 Sep;133(9):1081-6. PMID: 9301584

Diagnosis

Lymphocytoma cutis (cutaneous B-cell pseudolymphoma): study of 102 cases with emphasis on the histological characteristics and immunohistochemistry of the miliarial type.
Villalobos-Ayala RA, Espinoza-Gurrola AA, Guevara-Gutiérrez E, Solís-Ledesma G, Ramos-Suárez M, Rodríguez-Castellanos MA, Tlacuilo-Parra A
Int J Dermatol 2022 Mar;61(3):316-323. Epub 2021 Sep 19 doi: 10.1111/ijd.15909. PMID: 34541667
Drug induced pseudolymphoma.
Magro CM, Daniels BH, Crowson AN
Semin Diagn Pathol 2018 Jul;35(4):247-259. Epub 2018 Feb 1 doi: 10.1053/j.semdp.2017.11.003. PMID: 29361381
The many faces of lymphocytoma cutis.
van Vloten WA, Willemze R
J Eur Acad Dermatol Venereol 2003 Jan;17(1):3-6. doi: 10.1046/j.1468-3083.2003.00482.x. PMID: 12602958
Cutaneous pseudolymphomas.
Ploysangam T, Breneman DL, Mutasim DF
J Am Acad Dermatol 1998 Jun;38(6 Pt 1):877-95; quiz 896-7. doi: 10.1016/s0190-9622(98)70154-9. PMID: 9631994
Lymphomas.
Patterson JW
Dermatol Clin 1992 Jan;10(1):235-51. PMID: 1730170

Therapy

Lymphocytoma cutis--case report.
Oliveira EV, Badiale GB, Moraes MM
An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):128-31. doi: 10.1590/abd1806-4841.20132320. PMID: 24346899Free PMC Article
Miliarial-type perifollicular B-cell pseudolymphoma (lymphocytoma cutis): a misleading eruption in two women.
Moulonguet I, Ghnassia M, Molina T, Fraitag S
J Cutan Pathol 2012 Nov;39(11):1016-21. Epub 2012 Sep 23 doi: 10.1111/cup.12010. PMID: 22998442
Drugs with antihistaminic properties as a cause of atypical cutaneous lymphoid hyperplasia.
Magro CM, Crowson AN
J Am Acad Dermatol 1995 Mar;32(3):419-28. doi: 10.1016/0190-9622(95)90063-2. PMID: 7868710
Antidepressant therapy. A possible cause of atypical cutaneous lymphoid hyperplasia.
Crowson AN, Magro CM
Arch Dermatol 1995 Aug;131(8):925-9. doi: 10.1001/archderm.131.8.925. PMID: 7632065
Lymphocytoma cutis.
Roenigk HH Jr, Lesowitz SA
Arch Dermatol 1970 Feb;101(2):248. PMID: 5467061

Prognosis

The application of a PCR technique for the detection of immunoglobulin heavy chain gene rearrangements in fresh or paraffin-embedded skin tissue.
Hughes J, Weston S, Bennetts B, Prasad M, Angulo R, Jaworskit R, Jolles S, Kossard S, Fox S, Benson E
Pathology 2001 May;33(2):222-5. PMID: 11358058
Drug-induced immune dysregulation as a cause of atypical cutaneous lymphoid infiltrates: a hypothesis.
Magro CM, Crowson AN
Hum Pathol 1996 Feb;27(2):125-32. doi: 10.1016/s0046-8177(96)90365-2. PMID: 8617453
Drugs with antihistaminic properties as a cause of atypical cutaneous lymphoid hyperplasia.
Magro CM, Crowson AN
J Am Acad Dermatol 1995 Mar;32(3):419-28. doi: 10.1016/0190-9622(95)90063-2. PMID: 7868710
Effects of adequate versus inadequate treatment of cutaneous manifestations of Lyme borreliosis on the incidence of late complications and late serologic status.
Plörer A, Sepp N, Schmutzhard E, Krabichler S, Trobos S, Schauer G, Pahl C, Stöffler G, Fritsch P
J Invest Dermatol 1993 Feb;100(2):103-9. doi: 10.1111/1523-1747.ep12462773. PMID: 8429231
Characterization of benign cutaneous lymphocytic infiltrates by monoclonal antibodies.
Ralfkiaer E, Lange Wantzin G, Mason DY, Stein H, Thomsen K
Br J Dermatol 1984 Dec;111(6):635-45. doi: 10.1111/j.1365-2133.1984.tb14146.x. PMID: 6391533

Clinical prediction guides

Lymphocytoma cutis--case report.
Oliveira EV, Badiale GB, Moraes MM
An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):128-31. doi: 10.1590/abd1806-4841.20132320. PMID: 24346899Free PMC Article
Cutaneous B-cell pseudolymphoma at the site of vaccination.
Cerroni L, Borroni RG, Massone C, Chott A, Kerl H
Am J Dermatopathol 2007 Dec;29(6):538-42. doi: 10.1097/DAD.0b013e3181591bea. PMID: 18032948
Borrelia burgdorferi-associated lymphocytoma cutis: clinicopathologic, immunophenotypic, and molecular study of 106 cases.
Colli C, Leinweber B, Müllegger R, Chott A, Kerl H, Cerroni L
J Cutan Pathol 2004 Mar;31(3):232-40. doi: 10.1111/j.0303-6987.2003.00167.x. PMID: 14984575
Drugs with antihistaminic properties as a cause of atypical cutaneous lymphoid hyperplasia.
Magro CM, Crowson AN
J Am Acad Dermatol 1995 Mar;32(3):419-28. doi: 10.1016/0190-9622(95)90063-2. PMID: 7868710
Antidepressant therapy. A possible cause of atypical cutaneous lymphoid hyperplasia.
Crowson AN, Magro CM
Arch Dermatol 1995 Aug;131(8):925-9. doi: 10.1001/archderm.131.8.925. PMID: 7632065

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