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Recurrent Adult Acute Lymphoblastic Leukemia

MedGen UID:
124510
•Concept ID:
C0278785
•
Neoplastic Process
Synonyms: Recurrent Adult Acute Lymphoid Leukemia; Recurrent Adult ALL; Recurrent Adult Precursor Lymphoblastic Leukemia; Relapsed Adult Acute Lymphoblastic Leukemia; Relapsed Adult Acute Lymphoid Leukemia; Relapsed Adult ALL

Definition

The reemergence of acute lymphoblastic leukemia in adults after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Adult Acute Lymphoblastic Leukemia

Professional guidelines

PubMed

Nelarabine: when and how to use in the treatment of T-cell acute lymphoblastic leukemia.
Shimony S, DeAngelo DJ, Luskin MR
Blood Adv 2024 Jan 9;8(1):23-36. doi: 10.1182/bloodadvances.2023010303. PMID: 37389830Free PMC Article
Genetic alterations and MRD refine risk assessment for KMT2A-rearranged B-cell precursor ALL in adults: a GRAALL study.
Kim R, Bergugnat H, Pastoret C, Pasquier F, Raffoux E, Larcher L, Passet M, Grardel N, Delabesse E, Kubetzko S, Caye-Eude A, Meyer C, Marschalek R, Lafage-Pochitaloff M, Thiebaut-Bertrand A, Balsat M, Escoffre-Barbe M, Blum S, Baumann M, Banos A, Straetmans N, Gallego-Hernanz MP, Chalandon Y, Graux C, Soulier J, Leguay T, Hunault M, Huguet F, Lhéritier V, Dombret H, Boissel N, Clappier E
Blood 2023 Nov 23;142(21):1806-1817. doi: 10.1182/blood.2023021501. PMID: 37595275
Central Nervous System Involvement in Adults with Acute Leukemia: Diagnosis, Prevention, and Management.
Paul S, Short NJ
Curr Oncol Rep 2022 Apr;24(4):427-436. Epub 2022 Feb 10 doi: 10.1007/s11912-022-01220-4. PMID: 35141858

Recent clinical studies

Etiology

How I treat newly diagnosed and refractory T-cell acute lymphoblastic lymphoma in children and young adults.
Si Lim SJ, Ford JB, Hermiston ML
Blood 2023 Jun 22;141(25):3019-3030. doi: 10.1182/blood.2022016503. PMID: 37018730
How I prevent and treat central nervous system disease in adults with acute lymphoblastic leukemia.
Kopmar NE, Cassaday RD
Blood 2023 Mar 23;141(12):1379-1388. doi: 10.1182/blood.2022017035. PMID: 36548957Free PMC Article
Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Brown PA, Ji L, Xu X, Devidas M, Hogan LE, Borowitz MJ, Raetz EA, Zugmaier G, Sharon E, Bernhardt MB, Terezakis SA, Gore L, Whitlock JA, Pulsipher MA, Hunger SP, Loh ML
JAMA 2021 Mar 2;325(9):833-842. doi: 10.1001/jama.2021.0669. PMID: 33651090Free PMC Article
Recent Advances in Managing Acute Lymphoblastic Leukemia.
DeAngelo DJ, Jabbour E, Advani A
Am Soc Clin Oncol Educ Book 2020 May;40:330-342. doi: 10.1200/EDBK_280175. PMID: 32421447
Acute lymphoblastic leukaemia.
Inaba H, Greaves M, Mullighan CG
Lancet 2013 Jun 1;381(9881):1943-55. Epub 2013 Mar 22 doi: 10.1016/S0140-6736(12)62187-4. PMID: 23523389Free PMC Article

Diagnosis

How I treat newly diagnosed and refractory T-cell acute lymphoblastic lymphoma in children and young adults.
Si Lim SJ, Ford JB, Hermiston ML
Blood 2023 Jun 22;141(25):3019-3030. doi: 10.1182/blood.2022016503. PMID: 37018730
How I prevent and treat central nervous system disease in adults with acute lymphoblastic leukemia.
Kopmar NE, Cassaday RD
Blood 2023 Mar 23;141(12):1379-1388. doi: 10.1182/blood.2022017035. PMID: 36548957Free PMC Article
T-Cell Acute Lymphoblastic Leukemia: Biomarkers and Their Clinical Usefulness.
Bardelli V, Arniani S, Pierini V, Di Giacomo D, Pierini T, Gorello P, Mecucci C, La Starza R
Genes (Basel) 2021 Jul 23;12(8) doi: 10.3390/genes12081118. PMID: 34440292Free PMC Article
Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
Acute Lymphoblastic Leukemia in the Older Adult.
Aldoss I, Forman SJ, Pullarkat V
J Oncol Pract 2019 Feb;15(2):67-75. doi: 10.1200/JOP.18.00271. PMID: 30763199

Therapy

Three-Year Update of Tisagenlecleucel in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia in the ELIANA Trial.
Laetsch TW, Maude SL, Rives S, Hiramatsu H, Bittencourt H, Bader P, Baruchel A, Boyer M, De Moerloose B, Qayed M, Buechner J, Pulsipher MA, Myers GD, Stefanski HE, Martin PL, Nemecek E, Peters C, Yanik G, Khaw SL, Davis KL, Krueger J, Balduzzi A, Boissel N, Tiwari R, O'Donovan D, Grupp SA
J Clin Oncol 2023 Mar 20;41(9):1664-1669. Epub 2022 Nov 18 doi: 10.1200/JCO.22.00642. PMID: 36399695Free PMC Article
Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial.
Brown PA, Ji L, Xu X, Devidas M, Hogan LE, Borowitz MJ, Raetz EA, Zugmaier G, Sharon E, Bernhardt MB, Terezakis SA, Gore L, Whitlock JA, Pulsipher MA, Hunger SP, Loh ML
JAMA 2021 Mar 2;325(9):833-842. doi: 10.1001/jama.2021.0669. PMID: 33651090Free PMC Article
Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia.
Park JH, Rivière I, Gonen M, Wang X, Sénéchal B, Curran KJ, Sauter C, Wang Y, Santomasso B, Mead E, Roshal M, Maslak P, Davila M, Brentjens RJ, Sadelain M
N Engl J Med 2018 Feb 1;378(5):449-459. doi: 10.1056/NEJMoa1709919. PMID: 29385376Free PMC Article
Chimeric antigen receptor T cells for sustained remissions in leukemia.
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, Chew A, Gonzalez VE, Zheng Z, Lacey SF, Mahnke YD, Melenhorst JJ, Rheingold SR, Shen A, Teachey DT, Levine BL, June CH, Porter DL, Grupp SA
N Engl J Med 2014 Oct 16;371(16):1507-17. doi: 10.1056/NEJMoa1407222. PMID: 25317870Free PMC Article
Acute lymphoblastic leukaemia.
Inaba H, Greaves M, Mullighan CG
Lancet 2013 Jun 1;381(9881):1943-55. Epub 2013 Mar 22 doi: 10.1016/S0140-6736(12)62187-4. PMID: 23523389Free PMC Article

Prognosis

How I treat newly diagnosed and refractory T-cell acute lymphoblastic lymphoma in children and young adults.
Si Lim SJ, Ford JB, Hermiston ML
Blood 2023 Jun 22;141(25):3019-3030. doi: 10.1182/blood.2022016503. PMID: 37018730
Inotuzumab ozogamicin versus standard of care in relapsed or refractory acute lymphoblastic leukemia: Final report and long-term survival follow-up from the randomized, phase 3 INO-VATE study.
Kantarjian HM, DeAngelo DJ, Stelljes M, Liedtke M, Stock W, Gökbuget N, O'Brien SM, Jabbour E, Wang T, Liang White J, Sleight B, Vandendries E, Advani AS
Cancer 2019 Jul 15;125(14):2474-2487. Epub 2019 Mar 28 doi: 10.1002/cncr.32116. PMID: 30920645Free PMC Article
Acute Lymphoblastic Leukemia in the Older Adult.
Aldoss I, Forman SJ, Pullarkat V
J Oncol Pract 2019 Feb;15(2):67-75. doi: 10.1200/JOP.18.00271. PMID: 30763199
Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Dombret H, Bonifacio M, Reichle A, Graux C, Faul C, Diedrich H, Topp MS, Brüggemann M, Horst HA, Havelange V, Stieglmaier J, Wessels H, Haddad V, Benjamin JE, Zugmaier G, Nagorsen D, Bargou RC
Blood 2018 Apr 5;131(14):1522-1531. Epub 2018 Jan 22 doi: 10.1182/blood-2017-08-798322. PMID: 29358182Free PMC Article
Acute lymphoblastic leukaemia.
Inaba H, Greaves M, Mullighan CG
Lancet 2013 Jun 1;381(9881):1943-55. Epub 2013 Mar 22 doi: 10.1016/S0140-6736(12)62187-4. PMID: 23523389Free PMC Article

Clinical prediction guides

Blinatumomab for MRD-Negative Acute Lymphoblastic Leukemia in Adults.
Litzow MR, Sun Z, Mattison RJ, Paietta EM, Roberts KG, Zhang Y, Racevskis J, Lazarus HM, Rowe JM, Arber DA, Wieduwilt MJ, Liedtke M, Bergeron J, Wood BL, Zhao Y, Wu G, Chang TC, Zhang W, Pratz KW, Dinner SN, Frey N, Gore SD, Bhatnagar B, Atallah EL, Uy GL, Jeyakumar D, Lin TL, Willman CL, DeAngelo DJ, Patel SB, Elliott MA, Advani AS, Tzachanis D, Vachhani P, Bhave RR, Sharon E, Little RF, Erba HP, Stone RM, Luger SM, Mullighan CG, Tallman MS
N Engl J Med 2024 Jul 25;391(4):320-333. doi: 10.1056/NEJMoa2312948. PMID: 39047240Free PMC Article
CRISPR/Cas9-Engineered Universal CD19/CD22 Dual-Targeted CAR-T Cell Therapy for Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia.
Hu Y, Zhou Y, Zhang M, Ge W, Li Y, Yang L, Wei G, Han L, Wang H, Yu S, Chen Y, Wang Y, He X, Zhang X, Gao M, Yang J, Li X, Ren J, Huang H
Clin Cancer Res 2021 May 15;27(10):2764-2772. Epub 2021 Feb 24 doi: 10.1158/1078-0432.CCR-20-3863. PMID: 33627493
Inotuzumab ozogamicin versus standard of care in relapsed or refractory acute lymphoblastic leukemia: Final report and long-term survival follow-up from the randomized, phase 3 INO-VATE study.
Kantarjian HM, DeAngelo DJ, Stelljes M, Liedtke M, Stock W, Gökbuget N, O'Brien SM, Jabbour E, Wang T, Liang White J, Sleight B, Vandendries E, Advani AS
Cancer 2019 Jul 15;125(14):2474-2487. Epub 2019 Mar 28 doi: 10.1002/cncr.32116. PMID: 30920645Free PMC Article
Acute Lymphoblastic Leukemia in the Older Adult.
Aldoss I, Forman SJ, Pullarkat V
J Oncol Pract 2019 Feb;15(2):67-75. doi: 10.1200/JOP.18.00271. PMID: 30763199
Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia.
Gökbuget N, Dombret H, Bonifacio M, Reichle A, Graux C, Faul C, Diedrich H, Topp MS, Brüggemann M, Horst HA, Havelange V, Stieglmaier J, Wessels H, Haddad V, Benjamin JE, Zugmaier G, Nagorsen D, Bargou RC
Blood 2018 Apr 5;131(14):1522-1531. Epub 2018 Jan 22 doi: 10.1182/blood-2017-08-798322. PMID: 29358182Free PMC Article

Recent systematic reviews

Late relapse after CAR-T cell therapy for adult patients with hematologic malignancies: A definite evidence from systematic review and meta-analysis on individual data.
Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592
Adherence to Oral Chemotherapy in Acute Lymphoblastic Leukemia during Maintenance Therapy in Children, Adolescents, and Young Adults: A Systematic Review.
Zeng XL, Heneghan MB, Badawy SM
Curr Oncol 2023 Jan 5;30(1):720-748. doi: 10.3390/curroncol30010056. PMID: 36661705Free PMC Article
Systematic Review and Meta-analysis of CD19-Specific CAR-T Cell Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia in the Pediatric and Young Adult Population: Safety and Efficacy Outcomes.
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Philadelphia-Like Acute Lymphoblastic Leukemia: A Systematic Review.
Yadav V, Ganesan P, Veeramani R, Kumar V D
Clin Lymphoma Myeloma Leuk 2021 Jan;21(1):e57-e65. Epub 2020 Aug 18 doi: 10.1016/j.clml.2020.08.011. PMID: 33485429
Allogeneic hematopoietic cell transplantation for adult acute lymphoblastic leukemia (ALL) in first complete remission.
Pidala J, Djulbegovic B, Anasetti C, Kharfan-Dabaja M, Kumar A
Cochrane Database Syst Rev 2011 Oct 5;2011(10):CD008818. doi: 10.1002/14651858.CD008818.pub2. PMID: 21975786Free PMC Article

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