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Abnormality of the umbilical cord

MedGen UID:
488829
Concept ID:
C0266785
Anatomical Abnormality
Synonyms: Abnormal umbilical cord; Umbilical cord issue
SNOMED CT: Abnormal umbilical cord (90009001)
 
HPO: HP:0010881

Definition

An abnormality of the umbilical cord, which is the cord connecting the developing embryo or fetus to the placenta. [from HPO]

Professional guidelines

PubMed

Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Conde-Agudelo A, Romero R, Jung EJ, Garcia Sánchez ÁJ
Am J Obstet Gynecol 2020 Dec;223(6):848-869. Epub 2020 Sep 29 doi: 10.1016/j.ajog.2020.09.044. PMID: 33007269Free PMC Article

Recent clinical studies

Etiology

Katheria AC, Clark E, Yoder B, Schmölzer GM, Yan Law BH, El-Naggar W, Rittenberg D, Sheth S, Mohamed MA, Martin C, Vora F, Lakshminrusimha S, Underwood M, Mazela J, Kaempf J, Tomlinson M, Gollin Y, Fulford K, Goff Y, Wozniak P, Baker K, Rich W, Morales A, Varner M, Poeltler D, Vaucher Y, Mercer J, Finer N, El Ghormli L, Rice MM; of the Milking In Nonvigorous Infants group
Am J Obstet Gynecol 2023 Feb;228(2):217.e1-217.e14. Epub 2022 Aug 13 doi: 10.1016/j.ajog.2022.08.015. PMID: 35970202Free PMC Article
Pagan M, Eads L, Sward L, Manning N, Hunzicker A, Magann EF
Obstet Gynecol Surv 2020 Aug;75(8):510-518. doi: 10.1097/OGX.0000000000000818. PMID: 32856717
Hammad IA, Blue NR, Allshouse AA, Silver RM, Gibbins KJ, Page JM, Goldenberg RL, Reddy UM, Saade GR, Dudley DJ, Thorsten VR, Conway DL, Pinar H, Pysher TJ; NICHD Stillbirth Collaborative Research Network Group
Obstet Gynecol 2020 Mar;135(3):644-652. doi: 10.1097/AOG.0000000000003676. PMID: 32028503Free PMC Article
Heider A
Arch Pathol Lab Med 2017 Nov;141(11):1484-1489. doi: 10.5858/arpa.2017-0212-RA. PMID: 29072954
MCKAY RJ Jr
N Engl J Med 1964 Jun 11;270:1292-9 CONCL. doi: 10.1056/NEJM196406112702406. PMID: 14133668

Diagnosis

Pagan M, Eads L, Sward L, Manning N, Hunzicker A, Magann EF
Obstet Gynecol Surv 2020 Aug;75(8):510-518. doi: 10.1097/OGX.0000000000000818. PMID: 32856717
Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q, Zheng L, Liu Y
Drug Des Devel Ther 2019;13:4331-4340. Epub 2019 Dec 19 doi: 10.2147/DDDT.S225613. PMID: 31908418Free PMC Article
Muniraman H, Sardesai T, Sardesai S
Pediatr Rev 2018 Jul;39(7):332-341. doi: 10.1542/pir.2017-0202. PMID: 29967078
Heider A
Arch Pathol Lab Med 2017 Nov;141(11):1484-1489. doi: 10.5858/arpa.2017-0212-RA. PMID: 29072954
MCKAY RJ Jr
N Engl J Med 1964 Jun 11;270:1292-9 CONCL. doi: 10.1056/NEJM196406112702406. PMID: 14133668

Therapy

Katheria AC, Clark E, Yoder B, Schmölzer GM, Yan Law BH, El-Naggar W, Rittenberg D, Sheth S, Mohamed MA, Martin C, Vora F, Lakshminrusimha S, Underwood M, Mazela J, Kaempf J, Tomlinson M, Gollin Y, Fulford K, Goff Y, Wozniak P, Baker K, Rich W, Morales A, Varner M, Poeltler D, Vaucher Y, Mercer J, Finer N, El Ghormli L, Rice MM; of the Milking In Nonvigorous Infants group
Am J Obstet Gynecol 2023 Feb;228(2):217.e1-217.e14. Epub 2022 Aug 13 doi: 10.1016/j.ajog.2022.08.015. PMID: 35970202Free PMC Article
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q, Zheng L, Liu Y
Drug Des Devel Ther 2019;13:4331-4340. Epub 2019 Dec 19 doi: 10.2147/DDDT.S225613. PMID: 31908418Free PMC Article
Wraith JE, Jones S
Pediatr Endocrinol Rev 2014 Sep;12 Suppl 1:102-6. PMID: 25345091
Hofmeyr GJ, Gulmezoglu AM, Nikodem VC, de Jager M
Eur J Obstet Gynecol Reprod Biol 1996 Feb;64(2):159-65. doi: 10.1016/0301-2115(95)02330-5. PMID: 8819996

Prognosis

Chen H, Jia M, Yang S, Zou J, Xiao X
Int J Gynaecol Obstet 2024 Mar;164(3):823-829. Epub 2023 Jul 24 doi: 10.1002/ijgo.15006. PMID: 37489030
Dagdeviren G, Keles A, Yücel Celik O, Yucel A, Sahin D
J Obstet Gynaecol 2022 Apr;42(3):443-446. Epub 2021 Jun 24 doi: 10.1080/01443615.2021.1916811. PMID: 34165009
Pagan M, Eads L, Sward L, Manning N, Hunzicker A, Magann EF
Obstet Gynecol Surv 2020 Aug;75(8):510-518. doi: 10.1097/OGX.0000000000000818. PMID: 32856717
Muniraman H, Sardesai T, Sardesai S
Pediatr Rev 2018 Jul;39(7):332-341. doi: 10.1542/pir.2017-0202. PMID: 29967078
Giannubilo SR, Pasculli A, Cecchi A, Biagini A, Ciavattini A
Obstet Gynecol Surv 2017 Sep;72(9):547-552. doi: 10.1097/OGX.0000000000000476. PMID: 28905984

Clinical prediction guides

Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Katheria AC, Clark E, Yoder B, Schmölzer GM, Yan Law BH, El-Naggar W, Rittenberg D, Sheth S, Mohamed MA, Martin C, Vora F, Lakshminrusimha S, Underwood M, Mazela J, Kaempf J, Tomlinson M, Gollin Y, Fulford K, Goff Y, Wozniak P, Baker K, Rich W, Morales A, Varner M, Poeltler D, Vaucher Y, Mercer J, Finer N, El Ghormli L, Rice MM; of the Milking In Nonvigorous Infants group
Am J Obstet Gynecol 2023 Feb;228(2):217.e1-217.e14. Epub 2022 Aug 13 doi: 10.1016/j.ajog.2022.08.015. PMID: 35970202Free PMC Article
Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q, Zheng L, Liu Y
Drug Des Devel Ther 2019;13:4331-4340. Epub 2019 Dec 19 doi: 10.2147/DDDT.S225613. PMID: 31908418Free PMC Article
Kalafat E, Khalil A
Curr Opin Obstet Gynecol 2018 Dec;30(6):344-354. doi: 10.1097/GCO.0000000000000490. PMID: 30299319
Giannubilo SR, Pasculli A, Cecchi A, Biagini A, Ciavattini A
Obstet Gynecol Surv 2017 Sep;72(9):547-552. doi: 10.1097/OGX.0000000000000476. PMID: 28905984

Recent systematic reviews

Dolanc Merc M, Peterlin B, Lovrecic L
Prenat Diagn 2023 Aug;43(9):1220-1228. Epub 2023 May 11 doi: 10.1002/pd.6354. PMID: 37072878
Mirbeyk M, Saghazadeh A, Rezaei N
Arch Gynecol Obstet 2021 Jul;304(1):5-38. Epub 2021 Apr 2 doi: 10.1007/s00404-021-06049-z. PMID: 33797605Free PMC Article
Boie S, Glavind J, Velu AV, Mol BWJ, Uldbjerg N, de Graaf I, Thornton JG, Bor P, Bakker JJ
Cochrane Database Syst Rev 2018 Aug 20;8(8):CD012274. doi: 10.1002/14651858.CD012274.pub2. PMID: 30125998Free PMC Article
Ismail KI, Hannigan A, O'Donoghue K, Cotter A
Syst Rev 2017 Dec 6;6(1):242. doi: 10.1186/s13643-017-0641-1. PMID: 29208042Free PMC Article
Jessop FA, Lees CC, Pathak S, Hook CE, Sebire NJ
Virchows Arch 2014 Jan;464(1):105-12. Epub 2013 Nov 21 doi: 10.1007/s00428-013-1513-2. PMID: 24259031

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