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Syringoma

MedGen UID:
60205
•Concept ID:
C0206673
•
Neoplastic Process
Synonym: Syringomas
SNOMED CT: Syringoma (71244007); Syringoma of skin (302828001); Syringoma (302828001)
 
Monarch Initiative: MONDO:0002191

Definition

A benign sweat gland neoplasm usually affecting the lower eyelids and upper cheeks. The lesions are papular and are usually numerous. Morphologically, there are nests, cords, and tubules of epithelial cells present, surrounded by a dense stroma in the reticular dermis. [from NCI]

Professional guidelines

PubMed

S2k guideline: Laser therapy of the skin.
Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Evaluation and management of the patient with multiple syringomas: A systematic review of the literature.
Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654
Commentary: treatment of syringoma using an ablative 10,600-nm carbon dioxide fractional laser.
Brightman L, Geronemus R
Dermatol Surg 2011 Apr;37(4):439-40. doi: 10.1111/j.1524-4725.2011.01936.x. PMID: 21481062

Recent clinical studies

Etiology

Eccrine duct dilatation in neutrophilic scarring alopecias.
Tababa E, Gonzalez M, Chung HJ
J Cutan Pathol 2020 Aug;47(8):686-690. Epub 2020 Jun 8 doi: 10.1111/cup.13693. PMID: 32222989
Chondroid Syringoma.
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378
Will MAC be back?
Salerno S, Terrill P
ANZ J Surg 2003 Oct;73(10):830-2. doi: 10.1046/j.1445-2197.2003.02780.x. PMID: 14525576
Syringoid eccrine carcinoma.
Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, Kruslin B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):143-6. doi: 10.1046/j.1468-3083.2001.00210.x. PMID: 11495522
Acral syringoma.
Hughes PS, Apisarnthanarax P
Arch Dermatol 1977 Oct;113(10):1435-6. PMID: 911173

Diagnosis

Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Chondroid Syringoma.
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378
Chondroid syringoma.
Agrawal A, Kumar A, Sinha AK, Kumar B, Sabira KC
Singapore Med J 2008 Feb;49(2):e33-4. PMID: 18301822
An approach to clinical dermatologic diagnosis based on morphologic reaction patterns.
Gropper CA
Clin Cornerstone 2001;4(1):1-14. doi: 10.1016/s1098-3597(01)90002-x. PMID: 12739317
Eruptive syringoma.
Pruzan DL, Esterly NB, Prose NS
Arch Dermatol 1989 Aug;125(8):1119-20. PMID: 2547344

Therapy

Botulinum toxin A as monotherapy for syringoma.
Zaldivar-Fujigaki JL, Achell Nava L
J Cosmet Dermatol 2021 May;20(5):1393-1395. Epub 2020 Dec 31 doi: 10.1111/jocd.13919. PMID: 33355994
Intralesional Electrocoagulation With Insulated Microneedle for the Treatment of Periorbital Syringomas: A Retrospective Analysis.
Ahn GR, Jeong GJ, Kim JM, Hong JY, Li K, Lee CK, Kim BJ
Aesthet Surg J 2021 Mar 12;41(4):490-498. doi: 10.1093/asj/sjz288. PMID: 31630165
Extensive Eruptive Syringoma After Liver Transplantation.
Maeda T, Natsuga K, Nishie W, Yamashita K, Shimizu H
Acta Derm Venereol 2018 Jan 12;98(1):119-120. doi: 10.2340/00015555-2814. PMID: 28971206
Carbon dioxide laser combined with botulinum toxin A for patients with periorbital syringomas.
Seo HM, Choi JY, Min J, Kim WS
J Cosmet Laser Ther 2016 Jun;18(3):149-53. Epub 2016 Mar 31 doi: 10.3109/14764172.2015.1052517. PMID: 26073121
Eruptive syringomas in the groin.
Litvinov IV, Jafarian F
CMAJ 2014 May 13;186(8):612. Epub 2013 Nov 18 doi: 10.1503/cmaj.130793. PMID: 24246582Free PMC Article

Prognosis

Atypical Chondroid Syringoma of the Toe.
Ge C, Gu J, Deng A, Joshi G, Most M, Tai R
J Am Podiatr Med Assoc 2023 May-Jun;113(3) doi: 10.7547/22-094. PMID: 37463189
Chondroid Syringoma.
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378
Unusual eyelid, periocular, and periorbital cutaneous malignancies.
Kim JW, Lee DK
Int Ophthalmol Clin 2009 Fall;49(4):77-96. doi: 10.1097/IIO.0b013e3181b7f3f7. PMID: 20348859
An approach to clinical dermatologic diagnosis based on morphologic reaction patterns.
Gropper CA
Clin Cornerstone 2001;4(1):1-14. doi: 10.1016/s1098-3597(01)90002-x. PMID: 12739317
Syringoid eccrine carcinoma.
Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, Kruslin B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):143-6. doi: 10.1046/j.1468-3083.2001.00210.x. PMID: 11495522

Clinical prediction guides

Treatment of a case wıth gıant eyelıd syrıngomas.
Iritas I, Iritas SY, Ozer PA, Umudum H
Niger J Clin Pract 2020 Feb;23(2):273-274. doi: 10.4103/njcp.njcp_115_19. PMID: 32031106
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Late-onset of eruptive syringomas: a diagnostic challenge.
Resende C, Araújo C, Santos R, Pereira T, Brito C
An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):239-41. doi: 10.1590/abd1806-4841.20153899. PMID: 26312728Free PMC Article
Fibroblast-activation protein: valuable marker of cutaneous epithelial malignancy.
El Khoury J, Kurban M, Kibbi AG, Abbas O
Arch Dermatol Res 2014 May;306(4):359-65. Epub 2014 Mar 5 doi: 10.1007/s00403-014-1456-8. PMID: 24595644
Familial eruptive syringomas: case report and review of the literature.
Lau J, Haber RM
J Cutan Med Surg 2013 Mar-Apr;17(2):84-8. doi: 10.2310/7750.2012.12027. PMID: 23582162

Recent systematic reviews

Evaluation and management of the patient with multiple syringomas: A systematic review of the literature.
Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654

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