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Syringoma

MedGen UID:
60205
Concept ID:
C0206673
Neoplastic Process
Synonym: Syringomas
SNOMED CT: Syringoma (71244007); Syringoma of skin (302828001); Syringoma (302828001)
 
Monarch Initiative: MONDO:0002191

Definition

A benign sweat gland neoplasm usually affecting the lower eyelids and upper cheeks. The lesions are papular and are usually numerous. Morphologically, there are nests, cords, and tubules of epithelial cells present, surrounded by a dense stroma in the reticular dermis. [from NCI]

Professional guidelines

PubMed

Paasch U, Zidane M, Baron JM, Bund T, Cappius HJ, Drosner M, Feise K, Fischer T, Gauglitz G, Gerber PA, Grunewald S, Herberger K, Jung A, Karsai S, Kautz G, Philipp C, Schädel D, Seitz AT, Nast A
J Dtsch Dermatol Ges 2022 Sep;20(9):1248-1267. Epub 2022 Sep 13 doi: 10.1111/ddg.14879. PMID: 36098675
Gao M, Lin Y, Wang L, Yu Y, Zhou Y, Chen S, Lu X, Shan X, Liu H
Skin Res Technol 2020 Nov;26(6):951-953. Epub 2020 Jun 14 doi: 10.1111/srt.12879. PMID: 32537748
Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654

Recent clinical studies

Etiology

Macagno N, Kervarrec T, Thanguturi S, Sohier P, Pissaloux D, Mescam L, Jullie ML, Frouin E, Osio A, Faisant M, Le Loarer F, Cribier B, Calonje E, Luna EVE, Massi D, Goto K, Nishida H, Paindavoine S, Houlier A, Tantot J, Benzerdjeb N, Tirode F, De la Fouchardière A, Battistella M
Mod Pathol 2024 Mar;37(3):100430. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100430. PMID: 38266920
Hassab-El-Naby HMM, Nouh AH
Arch Dermatol Res 2023 Aug;315(6):1649-1654. Epub 2023 Feb 13 doi: 10.1007/s00403-023-02537-1. PMID: 36781459Free PMC Article
Huang A, Taylor G, Liebman TN
Dermatol Online J 2017 Sep 15;23(9) PMID: 29469728
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378
Yiğit N, Çelik E, Yavan İ, Günal A, Kurt B, Karslıoğlu Y, Öngürü Ö, Özcan A
Ann Diagn Pathol 2016 Feb;20:44-7. Epub 2015 Oct 28 doi: 10.1016/j.anndiagpath.2015.10.005. PMID: 26616722

Diagnosis

Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Huang A, Taylor G, Liebman TN
Dermatol Online J 2017 Sep 15;23(9) PMID: 29469728
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378
Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065
Gropper CA
Clin Cornerstone 2001;4(1):1-14. doi: 10.1016/s1098-3597(01)90002-x. PMID: 12739317

Therapy

Yao B, Chen W, Wu S, Gu Q, Feng W
J Cosmet Dermatol 2023 Oct;22(10):2721-2728. Epub 2023 May 12 doi: 10.1111/jocd.15800. PMID: 37171036
Alsaidan MS
J Dermatolog Treat 2022 Dec;33(8):3127-3135. Epub 2022 Sep 27 doi: 10.1080/09546634.2022.2127307. PMID: 36125344
Zaldivar-Fujigaki JL, Achell Nava L
J Cosmet Dermatol 2021 May;20(5):1393-1395. Epub 2020 Dec 31 doi: 10.1111/jocd.13919. PMID: 33355994
Ahn GR, Jeong GJ, Kim JM, Hong JY, Li K, Lee CK, Kim BJ
Aesthet Surg J 2021 Mar 12;41(4):490-498. doi: 10.1093/asj/sjz288. PMID: 31630165
Maeda T, Natsuga K, Nishie W, Yamashita K, Shimizu H
Acta Derm Venereol 2018 Jan 12;98(1):119-120. doi: 10.2340/00015555-2814. PMID: 28971206

Prognosis

Gordon S, Fischer C, Martin A, Rosman IS, Council ML
Dermatol Surg 2017 Aug;43(8):1012-1016. doi: 10.1097/DSS.0000000000001142. PMID: 28654578
Sundling RA, So E, Logan DB
Foot Ankle Spec 2017 Apr;10(2):167-169. Epub 2016 Sep 20 doi: 10.1177/1938640016666927. PMID: 27587378
Jo VY
Surg Pathol Clin 2015 Sep;8(3):445-66. doi: 10.1016/j.path.2015.05.005. PMID: 26297065
Gropper CA
Clin Cornerstone 2001;4(1):1-14. doi: 10.1016/s1098-3597(01)90002-x. PMID: 12739317
Gregurek-Novak T, Talan-Hranilović J, Troskot N, Vucić M, Kruslin B
J Eur Acad Dermatol Venereol 2001 Mar;15(2):143-6. doi: 10.1046/j.1468-3083.2001.00210.x. PMID: 11495522

Clinical prediction guides

Macagno N, Kervarrec T, Thanguturi S, Sohier P, Pissaloux D, Mescam L, Jullie ML, Frouin E, Osio A, Faisant M, Le Loarer F, Cribier B, Calonje E, Luna EVE, Massi D, Goto K, Nishida H, Paindavoine S, Houlier A, Tantot J, Benzerdjeb N, Tirode F, De la Fouchardière A, Battistella M
Mod Pathol 2024 Mar;37(3):100430. Epub 2024 Jan 23 doi: 10.1016/j.modpat.2024.100430. PMID: 38266920
Gambichler T, Hartenstein I, Dreißigacker M, Stockfleth E, Stücker M, Schaller J, Schulze HJ, Becker JC, Käfferlein HU, Brüning T, Lang K
Clin Exp Dermatol 2021 Aug;46(6):1052-1057. Epub 2021 May 1 doi: 10.1111/ced.14634. PMID: 33714217
Lim Y, Lee J, Jang D, Abudureyimu G, Lee JH
Skin Res Technol 2021 Jan;27(1):70-73. Epub 2020 Jun 28 doi: 10.1111/srt.12910. PMID: 32596839
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Yiğit N, Çelik E, Yavan İ, Günal A, Kurt B, Karslıoğlu Y, Öngürü Ö, Özcan A
Ann Diagn Pathol 2016 Feb;20:44-7. Epub 2015 Oct 28 doi: 10.1016/j.anndiagpath.2015.10.005. PMID: 26616722

Recent systematic reviews

Williams K, Shinkai K
J Am Acad Dermatol 2016 Jun;74(6):1234-1240.e9. Epub 2016 Feb 3 doi: 10.1016/j.jaad.2015.12.006. PMID: 26850654

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