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Anaplastic large cell lymphoma

MedGen UID:
61533
•Concept ID:
C0206180
•
Neoplastic Process
Synonyms: Anaplastic Large Cell Lymphoma; Anaplastic Large-Cell Lymphoma; Anaplastic Large-Cell Lymphomas; CD30 Positive Anaplastic Large Cell Lymphoma; CD30+ Anaplastic Large Cell Lymphoma; CD30+ Anaplastic Large-Cell Lymphoma; CD30-Positive Anaplastic Large-Cell Lymphoma; Ki 1 Lymphoma; Ki-1 Lymphoma; Ki-1 Lymphomas; Large-Cell Lymphoma, Anaplastic; Large-Cell Lymphomas, Anaplastic; Lymphoma, Anaplastic Large-Cell; Lymphoma, Ki-1; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Large-Cell, Ki-1; Lymphomas, Anaplastic Large-Cell; Lymphomas, Ki-1; Systemic Anaplastic Large Cell Lymphoma; Systemic Anaplastic Large-Cell Lymphoma
SNOMED CT: Anaplastic large cell lymphoma, CD30+ (53237008); Anaplastic large cell lymphoma, T cell and Null cell type (53237008); Large cell anaplastic lymphoma T cell and Null cell type (702785000); Large cell (Ki-1 positive) lymphoma (702785000); Large cell (Ki-1 positive) lymphoma (53237008); Anaplastic large cell lymphoma CD30 positive (53237008); Anaplastic large cell lymphoma CD30 positive (702785000); Anaplastic large cell lymphoma (ALCL) CD30+ (53237008)
 
HPO: HP:0012193
Monarch Initiative: MONDO:0020325

Definition

A type of T-cell lymphoma that is characterized by so-called hallmark cells with a pleomorphic appearance that express the CD30 antigen, are lobulated, and have indented nuclei. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnaplastic large cell lymphoma

Professional guidelines

PubMed

T-Cell Lymphomas, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Horwitz SM, Ansell S, Ai WZ, Barnes J, Barta SK, Brammer J, Clemens MW, Dogan A, Foss F, Ghione P, Goodman AM, Guitart J, Halwani A, Haverkos BM, Hoppe RT, Jacobsen E, Jagadeesh D, Jones A, Kallam A, Kim YH, Kumar K, Mehta-Shah N, Olsen EA, Rajguru SA, Rozati S, Said J, Shaver A, Shea L, Shinohara MM, Sokol L, Torres-Cabala C, Wilcox R, Wu P, Zain J, Dwyer M, Sundar H
J Natl Compr Canc Netw 2022 Mar;20(3):285-308. doi: 10.6004/jnccn.2022.0015. PMID: 35276674
Epigenetic alterations and advancement of treatment in peripheral T-cell lymphoma.
Zhang P, Zhang M
Clin Epigenetics 2020 Nov 7;12(1):169. doi: 10.1186/s13148-020-00962-x. PMID: 33160401Free PMC Article
Management of Anaplastic Large Cell Lymphoma.
Chihara D, Fanale MA
Hematol Oncol Clin North Am 2017 Apr;31(2):209-222. doi: 10.1016/j.hoc.2016.11.001. PMID: 28340874

Recent clinical studies

Etiology

Cutaneous T-cell Lymphoma.
Weiner DM, Rook AH
Hematol Oncol Clin North Am 2024 Oct;38(5):1087-1110. Epub 2024 Jul 29 doi: 10.1016/j.hoc.2024.05.012. PMID: 39079789
T-Cell Lymphomas, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Horwitz SM, Ansell S, Ai WZ, Barnes J, Barta SK, Brammer J, Clemens MW, Dogan A, Foss F, Ghione P, Goodman AM, Guitart J, Halwani A, Haverkos BM, Hoppe RT, Jacobsen E, Jagadeesh D, Jones A, Kallam A, Kim YH, Kumar K, Mehta-Shah N, Olsen EA, Rajguru SA, Rozati S, Said J, Shaver A, Shea L, Shinohara MM, Sokol L, Torres-Cabala C, Wilcox R, Wu P, Zain J, Dwyer M, Sundar H
J Natl Compr Canc Netw 2022 Mar;20(3):285-308. doi: 10.6004/jnccn.2022.0015. PMID: 35276674
Primary cutaneous T-cell lymphomas other than mycosis fungoides and Sézary syndrome. Part I: Clinical and histologic features and diagnosis.
Stoll JR, Willner J, Oh Y, Pulitzer M, Moskowitz A, Horwitz S, Myskowski P, Noor SJ
J Am Acad Dermatol 2021 Nov;85(5):1073-1090. Epub 2021 Apr 30 doi: 10.1016/j.jaad.2021.04.080. PMID: 33940098
Breast implant-associated anaplastic large cell lymphoma: A comprehensive review.
Marra A, Viale G, Pileri SA, Pravettoni G, Viale G, De Lorenzi F, Nolè F, Veronesi P, Curigliano G
Cancer Treat Rev 2020 Mar;84:101963. Epub 2020 Jan 13 doi: 10.1016/j.ctrv.2020.101963. PMID: 31958739
Cutaneous T-cell Lymphoma.
Pulitzer M
Clin Lab Med 2017 Sep;37(3):527-546. doi: 10.1016/j.cll.2017.06.006. PMID: 28802499Free PMC Article

Diagnosis

Cutaneous T-cell Lymphoma.
Weiner DM, Rook AH
Hematol Oncol Clin North Am 2024 Oct;38(5):1087-1110. Epub 2024 Jul 29 doi: 10.1016/j.hoc.2024.05.012. PMID: 39079789
Breast implant-associated anaplastic large cell lymphoma: A comprehensive review.
Marra A, Viale G, Pileri SA, Pravettoni G, Viale G, De Lorenzi F, Nolè F, Veronesi P, Curigliano G
Cancer Treat Rev 2020 Mar;84:101963. Epub 2020 Jan 13 doi: 10.1016/j.ctrv.2020.101963. PMID: 31958739
Breast Implant-Associated Anaplastic Large Cell Lymphoma.
Ashar BS, Yoon SW, Nagel S
Am Fam Physician 2020 Jan 1;101(1):8-9. PMID: 31894932
Pediatric Extranodal Lymphoma.
Chung EM, Pavio M
Radiol Clin North Am 2016 Jul;54(4):727-46. doi: 10.1016/j.rcl.2016.03.004. PMID: 27265605
Anaplastic large-cell lymphoma.
Inghirami G, Pileri SA; European T-Cell Lymphoma Study Group
Semin Diagn Pathol 2011 Aug;28(3):190-201. doi: 10.1053/j.semdp.2011.03.002. PMID: 21850985

Therapy

The ECHELON-2 Trial: 5-year results of a randomized, phase III study of brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma.
Horwitz S, O'Connor OA, Pro B, Trümper L, Iyer S, Advani R, Bartlett NL, Christensen JH, Morschhauser F, Domingo-Domenech E, Rossi G, Kim WS, Feldman T, Menne T, Belada D, Illés Á, Tobinai K, Tsukasaki K, Yeh SP, Shustov A, Hüttmann A, Savage KJ, Yuen S, Zinzani PL, Miao H, Bunn V, Fenton K, Fanale M, Puhlmann M, Illidge T
Ann Oncol 2022 Mar;33(3):288-298. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.002. PMID: 34921960Free PMC Article
Breast Implant-Associated Anaplastic Large Cell Lymphoma.
Ashar BS, Yoon SW, Nagel S
Am Fam Physician 2020 Jan 1;101(1):8-9. PMID: 31894932
Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial.
Horwitz S, O'Connor OA, Pro B, Illidge T, Fanale M, Advani R, Bartlett NL, Christensen JH, Morschhauser F, Domingo-Domenech E, Rossi G, Kim WS, Feldman T, Lennard A, Belada D, Illés Á, Tobinai K, Tsukasaki K, Yeh SP, Shustov A, Hüttmann A, Savage KJ, Yuen S, Iyer S, Zinzani PL, Hua Z, Little M, Rao S, Woolery J, Manley T, Trümper L; ECHELON-2 Study Group
Lancet 2019 Jan 19;393(10168):229-240. Epub 2018 Dec 4 doi: 10.1016/S0140-6736(18)32984-2. PMID: 30522922Free PMC Article
Brentuximab vedotin.
Ansell SM
Blood 2014 Nov 20;124(22):3197-200. Epub 2014 Oct 7 doi: 10.1182/blood-2014-06-537514. PMID: 25293772
Brentuximab vedotin.
Deng C, Pan B, O'Connor OA
Clin Cancer Res 2013 Jan 1;19(1):22-7. Epub 2012 Nov 15 doi: 10.1158/1078-0432.CCR-12-0290. PMID: 23155186

Prognosis

Brentuximab vedotin in combination with chemotherapy for pediatric patients with ALK+ ALCL: results of COG trial ANHL12P1.
Lowe EJ, Reilly AF, Lim MS, Gross TG, Saguilig L, Barkauskas DA, Wu R, Alexander S, Bollard CM
Blood 2021 Jul 1;137(26):3595-3603. doi: 10.1182/blood.2020009806. PMID: 33684925Free PMC Article
Breast Implant-associated Anaplastic Large Cell Lymphoma.
Alotaibi S, Hamadani M, Al-Mansour M, Aljurf M
Clin Lymphoma Myeloma Leuk 2021 Mar;21(3):e272-e276. Epub 2020 Dec 13 doi: 10.1016/j.clml.2020.12.005. PMID: 33384263
Breast implant-associated anaplastic large cell lymphoma: A comprehensive review.
Marra A, Viale G, Pileri SA, Pravettoni G, Viale G, De Lorenzi F, Nolè F, Veronesi P, Curigliano G
Cancer Treat Rev 2020 Mar;84:101963. Epub 2020 Jan 13 doi: 10.1016/j.ctrv.2020.101963. PMID: 31958739
Breast Implant-Associated Lymphoma.
Kricheldorff J, Fallenberg EM, Solbach C, Gerber-Schäfer C, Rancsó C, Fritschen UV
Dtsch Arztebl Int 2018 Sep 21;115(38):628-635. doi: 10.3238/arztebl.2018.0628. PMID: 30373708Free PMC Article
Management of Anaplastic Large Cell Lymphoma.
Chihara D, Fanale MA
Hematol Oncol Clin North Am 2017 Apr;31(2):209-222. doi: 10.1016/j.hoc.2016.11.001. PMID: 28340874

Clinical prediction guides

Brentuximab vedotin plus cyclophosphamide, doxorubicin, etoposide, and prednisone followed by brentuximab vedotin consolidation in CD30-positive peripheral T-cell lymphomas: a multicentre, single-arm, phase 2 study.
Herrera AF, Zain J, Savage KJ, Feldman T, Brammer JE, Chen L, Puverel S, Popplewell L, Budde LE, Mei M, Hosing C, Nair R, Leslie L, Daniels S, Peters L, Forman S, Rosen S, Kwak L, Iyer SP
Lancet Haematol 2024 Sep;11(9):e671-e681. Epub 2024 Jul 24 doi: 10.1016/S2352-3026(24)00171-6. PMID: 39067464
Anaplastic Large Cell Lymphoma: Contemporary Concepts and Optimal Management.
Shustov A, Soma L
Cancer Treat Res 2019;176:127-144. doi: 10.1007/978-3-319-99716-2_6. PMID: 30596216
CD30+ T-cell lymphoproliferative disorders.
Martin JM, Wu H, Barta SK
Chin Clin Oncol 2019 Feb;8(1):4. Epub 2018 Oct 11 doi: 10.21037/cco.2018.09.06. PMID: 30525751
Hematolymphoid lesions of the breast.
Hoffmann J, Ohgami RS
Semin Diagn Pathol 2017 Sep;34(5):462-469. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.007. PMID: 28662998
Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma.
Iqbal J, Wright G, Wang C, Rosenwald A, Gascoyne RD, Weisenburger DD, Greiner TC, Smith L, Guo S, Wilcox RA, Teh BT, Lim ST, Tan SY, Rimsza LM, Jaffe ES, Campo E, Martinez A, Delabie J, Braziel RM, Cook JR, Tubbs RR, Ott G, Geissinger E, Gaulard P, Piccaluga PP, Pileri SA, Au WY, Nakamura S, Seto M, Berger F, de Leval L, Connors JM, Armitage J, Vose J, Chan WC, Staudt LM; Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Blood 2014 May 8;123(19):2915-23. Epub 2014 Mar 14 doi: 10.1182/blood-2013-11-536359. PMID: 24632715Free PMC Article

Recent systematic reviews

Epidemiology of Breast Implant-Associated Anaplastic Large Cell Lymphoma in the United States: A Systematic Review.
Santanelli di Pompeo F, Clemens MW, Paolini G, Firmani G, Panagiotakos D, Sorotos M
Aesthet Surg J 2023 Dec 14;44(1):NP32-NP40. doi: 10.1093/asj/sjad279. PMID: 37616552
Pulmonary anaplastic large-cell lymphoma: A case-based systematic review of world literature.
Padhi S, Panigrahi MK, Mohapatra S, Mishra P, Patra S, Sable MN, Thakur B, Nayak M, Panigrahi A
J Cancer Res Ther 2021 Oct-Dec;17(6):1297-1306. doi: 10.4103/jcrt.JCRT_1089_19. PMID: 34916357
Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Systematic Review.
Leberfinger AN, Behar BJ, Williams NC, Rakszawski KL, Potochny JD, Mackay DR, Ravnic DJ
JAMA Surg 2017 Dec 1;152(12):1161-1168. doi: 10.1001/jamasurg.2017.4026. PMID: 29049466
Breast implant-associated anaplastic large cell lymphoma: a systematic review.
Gidengil CA, Predmore Z, Mattke S, van Busum K, Kim B
Plast Reconstr Surg 2015 Mar;135(3):713-720. doi: 10.1097/PRS.0000000000001037. PMID: 25490539
Anaplastic large cell lymphoma and breast implants: a systematic review.
Kim B, Roth C, Chung KC, Young VL, van Busum K, Schnyer C, Mattke S
Plast Reconstr Surg 2011 Jun;127(6):2141-2150. doi: 10.1097/PRS.0b013e3182172418. PMID: 21358562

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