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Breast fibrosis

MedGen UID:
57627
•Concept ID:
C0156318
•
Disease or Syndrome
Synonyms: breast fibrosclerosis; Breast Fibrosis; breast fibrosis; Fibrosclerosis of breast; Fibrosclerosis of Breast; fibrosclerosis of breast; fibrosclerosis of the breast; Fibrosis of Breast; fibrosis of breast; Fibrosis of the Breast; fibrosis of the breast
SNOMED CT: Fibrosclerosis of breast (29070004)
 
Monarch Initiative: MONDO:0006118

Definition

Breast fibrocystic change characterized by the prominence of fibrotic changes in the parenchyma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast fibrosis

Professional guidelines

PubMed

Guidelines and recommendations on the clinical use of shear wave elastography for evaluating thyroid nodule1.
Xu HX, Yan K, Liu BJ, Liu WY, Tang LN, Zhou Q, Wu JY, Xue ES, Shen B, Tang Q, Chen Q, Xue HY, Li YJ, Guo J, Wang B, Li F, Yan CY, Li QS, Wang YQ, Zhang W, Wu CJ, Yu WH, Zhou SJ
Clin Hemorheol Microcirc 2019;72(1):39-60. doi: 10.3233/CH-180452. PMID: 30320562
Diagnosis, treatment, and management of breast cancer in previously augmented women.
Tuli R, Flynn RA, Brill KL, Sabol JL, Usuki KY, Rosenberg AL
Breast J 2006 Jul-Aug;12(4):343-8. doi: 10.1111/j.1075-122X.2006.00273.x. PMID: 16848844
Breast cancer after augmentation mammaplasty: treatment by skin-sparing mastectomy and immediate reconstruction.
Carlson GW, Moore B, Thornton JF, Elliott M, Bolitho G
Plast Reconstr Surg 2001 Mar;107(3):687-92. doi: 10.1097/00006534-200103000-00006. PMID: 11304592

Recent clinical studies

Etiology

Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy.
Jaikuna T, Osorio EV, Azria D, Chang-Claude J, De Santis MC, Gutiérrez-Enríquez S, van Herk M, Hoskin P, Lambrecht M, Lingard Z, Seibold P, Seoane A, Sperk E, Symonds RP, Talbot CJ, Rancati T, Rattay T, Reyes V, Rosenstein BS, de Ruysscher D, Vega A, Veldeman L, Webb A, West CML, Aznar MC
Breast 2023 Dec;72:103578. Epub 2023 Sep 11 doi: 10.1016/j.breast.2023.103578. PMID: 37713940Free PMC Article
Cosmetic Outcome and Toxicity After Stereotactic Accelerated Partial Breast Irradiation in Early Breast Cancer: A Prospective Observational Cohort Study.
Byun HK, Chang JS, Kim H, Kim J, Han MC, Kim SY, Park RH, Kim CJ, Kim YB
Int J Radiat Oncol Biol Phys 2023 Nov 1;117(3):690-700. Epub 2023 May 17 doi: 10.1016/j.ijrobp.2023.05.018. PMID: 37201757
Long-Term Results of Postoperative Hypofractionated Accelerated Breast and Lymph Node Radiotherapy (HypoAR) with Hypofractionated Boost.
Koukourakis IM, Panteliadou M, Giakzidis AG, Nanos C, Abatzoglou I, Giatromanolaki A, Koukourakis MI
Curr Oncol 2021 Sep 7;28(5):3474-3487. doi: 10.3390/curroncol28050300. PMID: 34590607Free PMC Article
Analysis of breast cosmetic effects 3 years after breast-conserving surgery and intraoperative radiotherapy with and without adjuvant whole breast irradiation.
Falco M, Masojć B, Rolla M, Czekała A, Milchert-Leszczyńska M, Pietruszewska J, Lewocki M
Breast J 2020 May;26(5):882-887. Epub 2020 Jan 30 doi: 10.1111/tbj.13767. PMID: 31997527
Individualised target volume selection and dose prescription after conservative surgery, mastectomy and reconstruction.
Chua BH
Breast 2019 Nov;48 Suppl 1:S69-S75. doi: 10.1016/S0960-9776(19)31128-2. PMID: 31839165

Diagnosis

Progressive breast fibrosis caused by extreme radiosensitivity: Oncocytogenetic diagnosis and treatment by reconstructive flap surgery.
Mészáros N, Farkas G, Székely G, Kocsis ZS, Kelemen PB, Fodor J, Polgár C, Jurányi Z
Cancer Rep (Hoboken) 2019 Feb;2(1):e1126. Epub 2018 Sep 24 doi: 10.1002/cnr2.1126. PMID: 32721122Free PMC Article
A Review of Radiation-Induced Lymphocyte Apoptosis as a Predictor of Late Toxicity After Breast Radiotherapy.
Fhoghlú MN, Barrett S
J Med Imaging Radiat Sci 2019 Jun;50(2):337-344. Epub 2019 Apr 15 doi: 10.1016/j.jmir.2019.02.004. PMID: 31176443
Randomized trial of pentoxifylline and vitamin E vs standard follow-up after breast irradiation to prevent breast fibrosis, evaluated by tissue compliance meter.
Jacobson G, Bhatia S, Smith BJ, Button AM, Bodeker K, Buatti J
Int J Radiat Oncol Biol Phys 2013 Mar 1;85(3):604-8. Epub 2012 Jul 28 doi: 10.1016/j.ijrobp.2012.06.042. PMID: 22846413
Diagnosis, treatment, and management of breast cancer in previously augmented women.
Tuli R, Flynn RA, Brill KL, Sabol JL, Usuki KY, Rosenberg AL
Breast J 2006 Jul-Aug;12(4):343-8. doi: 10.1111/j.1075-122X.2006.00273.x. PMID: 16848844
Imaging features of focal breast fibrosis: mammographic-pathologic correlation of noncalcified breast lesions.
Venta LA, Wiley EL, Gabriel H, Adler YT
AJR Am J Roentgenol 1999 Aug;173(2):309-16. doi: 10.2214/ajr.173.2.10430125. PMID: 10430125

Therapy

Factors Associated with Late Local Radiation Toxicity after Post-Operative Breast Irradiation.
Batenburg MCT, Bartels M, Maarse W, Witkamp A, Verkooijen HM, van den Bongard HJGD
Breast J 2022;2022:6745954. Epub 2022 Apr 16 doi: 10.1155/2022/6745954. PMID: 35711897Free PMC Article
Cost-effectiveness of endocrine therapy versus radiotherapy versus combined endocrine and radiotherapy for older women with early-stage breast cancer.
Wheeler SB, Rotter JS, Baggett CD, Zhou X, Zagar T, Reeder-Hayes KE
J Geriatr Oncol 2021 Jun;12(5):741-748. Epub 2021 Feb 6 doi: 10.1016/j.jgo.2021.01.004. PMID: 33558179
Five-Year Results of the Preoperative Accelerated Partial Breast Irradiation (PAPBI) Trial.
Bosma SCJ, Leij F, Vreeswijk S, Maaker M, Wesseling J, Vijver MV, Scholten A, Rivera S, Bourgier C, Auzac G, Foukakis T, Lekberg T, Bongard D, Loo C, Rutgers E, Bartelink H, Elkhuizen PHM
Int J Radiat Oncol Biol Phys 2020 Apr 1;106(5):958-967. Epub 2020 Jan 25 doi: 10.1016/j.ijrobp.2019.12.037. PMID: 31987957
Individualised target volume selection and dose prescription after conservative surgery, mastectomy and reconstruction.
Chua BH
Breast 2019 Nov;48 Suppl 1:S69-S75. doi: 10.1016/S0960-9776(19)31128-2. PMID: 31839165
Cosmetic outcome 1-5 years after breast conservative surgery, irradiation and systemic therapy.
Kelemen G, Varga Z, Lázár G, Thurzó L, Kahán Z
Pathol Oncol Res 2012 Apr;18(2):421-7. Epub 2011 Oct 8 doi: 10.1007/s12253-011-9462-z. PMID: 21984131

Prognosis

Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy.
Jaikuna T, Osorio EV, Azria D, Chang-Claude J, De Santis MC, Gutiérrez-Enríquez S, van Herk M, Hoskin P, Lambrecht M, Lingard Z, Seibold P, Seoane A, Sperk E, Symonds RP, Talbot CJ, Rancati T, Rattay T, Reyes V, Rosenstein BS, de Ruysscher D, Vega A, Veldeman L, Webb A, West CML, Aznar MC
Breast 2023 Dec;72:103578. Epub 2023 Sep 11 doi: 10.1016/j.breast.2023.103578. PMID: 37713940Free PMC Article
Design, Synthesis and Antitumor Activity of Novel Dispiro[oxindole-cyclohexanone]- pyrrolidines.
Gouda M, Bawazeer M, Hegazy L, Azab M, Elagawany M, Rateb M, Yaseen M, Elgendy B
Curr Pharm Des 2022;28(3):198-207. doi: 10.2174/1381612827666210625160627. PMID: 34176458
Long-Term Results of Postoperative Hypofractionated Accelerated Breast and Lymph Node Radiotherapy (HypoAR) with Hypofractionated Boost.
Koukourakis IM, Panteliadou M, Giakzidis AG, Nanos C, Abatzoglou I, Giatromanolaki A, Koukourakis MI
Curr Oncol 2021 Sep 7;28(5):3474-3487. doi: 10.3390/curroncol28050300. PMID: 34590607Free PMC Article
Progressive breast fibrosis caused by extreme radiosensitivity: Oncocytogenetic diagnosis and treatment by reconstructive flap surgery.
Mészáros N, Farkas G, Székely G, Kocsis ZS, Kelemen PB, Fodor J, Polgár C, Jurányi Z
Cancer Rep (Hoboken) 2019 Feb;2(1):e1126. Epub 2018 Sep 24 doi: 10.1002/cnr2.1126. PMID: 32721122Free PMC Article
Similar Outcomes of Standard Radiotherapy and Hypofractionated Radiotherapy Following Breast-Conserving Surgery.
Hou HL, Song YC, Li RY, Zhu L, Zhao LJ, Yuan ZY, You JQ, Chen ZJ, Wang P
Med Sci Monit 2015 Aug 3;21:2251-6. doi: 10.12659/MSM.893585. PMID: 26235604Free PMC Article

Clinical prediction guides

Contouring variation affects estimates of normal tissue complication probability for breast fibrosis after radiotherapy.
Jaikuna T, Osorio EV, Azria D, Chang-Claude J, De Santis MC, Gutiérrez-Enríquez S, van Herk M, Hoskin P, Lambrecht M, Lingard Z, Seibold P, Seoane A, Sperk E, Symonds RP, Talbot CJ, Rancati T, Rattay T, Reyes V, Rosenstein BS, de Ruysscher D, Vega A, Veldeman L, Webb A, West CML, Aznar MC
Breast 2023 Dec;72:103578. Epub 2023 Sep 11 doi: 10.1016/j.breast.2023.103578. PMID: 37713940Free PMC Article
Cosmetic Outcome and Toxicity After Stereotactic Accelerated Partial Breast Irradiation in Early Breast Cancer: A Prospective Observational Cohort Study.
Byun HK, Chang JS, Kim H, Kim J, Han MC, Kim SY, Park RH, Kim CJ, Kim YB
Int J Radiat Oncol Biol Phys 2023 Nov 1;117(3):690-700. Epub 2023 May 17 doi: 10.1016/j.ijrobp.2023.05.018. PMID: 37201757
Design, Synthesis and Antitumor Activity of Novel Dispiro[oxindole-cyclohexanone]- pyrrolidines.
Gouda M, Bawazeer M, Hegazy L, Azab M, Elagawany M, Rateb M, Yaseen M, Elgendy B
Curr Pharm Des 2022;28(3):198-207. doi: 10.2174/1381612827666210625160627. PMID: 34176458
Five-Year Results of the Preoperative Accelerated Partial Breast Irradiation (PAPBI) Trial.
Bosma SCJ, Leij F, Vreeswijk S, Maaker M, Wesseling J, Vijver MV, Scholten A, Rivera S, Bourgier C, Auzac G, Foukakis T, Lekberg T, Bongard D, Loo C, Rutgers E, Bartelink H, Elkhuizen PHM
Int J Radiat Oncol Biol Phys 2020 Apr 1;106(5):958-967. Epub 2020 Jan 25 doi: 10.1016/j.ijrobp.2019.12.037. PMID: 31987957
Individualised target volume selection and dose prescription after conservative surgery, mastectomy and reconstruction.
Chua BH
Breast 2019 Nov;48 Suppl 1:S69-S75. doi: 10.1016/S0960-9776(19)31128-2. PMID: 31839165

Recent systematic reviews

Factors Associated with Late Local Radiation Toxicity after Post-Operative Breast Irradiation.
Batenburg MCT, Bartels M, Maarse W, Witkamp A, Verkooijen HM, van den Bongard HJGD
Breast J 2022;2022:6745954. Epub 2022 Apr 16 doi: 10.1155/2022/6745954. PMID: 35711897Free PMC Article
A Review of Radiation-Induced Lymphocyte Apoptosis as a Predictor of Late Toxicity After Breast Radiotherapy.
Fhoghlú MN, Barrett S
J Med Imaging Radiat Sci 2019 Jun;50(2):337-344. Epub 2019 Apr 15 doi: 10.1016/j.jmir.2019.02.004. PMID: 31176443

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