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Penis carcinoma in situ

MedGen UID:
102309
•Concept ID:
C0154089
•
Neoplastic Process
Synonyms: Bowen disease of penis; Bowen Disease of the Penis; Bowen disease of the penis; Bowen's disease of glans penis; Bowen's disease of penis; Bowen's Disease of Penis; Bowen's Disease of the Penis; Bowen's disease of the penis; Cancer in situ of penis; Carcinoma in situ of penis; Carcinoma in situ of Penis; carcinoma in situ of penis; Carcinoma in situ of the Penis; carcinoma in situ of the penis; Erythroplasia of Queyrat; erythroplasia of Queyrat; Grade III Penile Intraepithelial Neoplasia; grade III penile intraepithelial neoplasia; Grade III Squamous Intraepithelial Lesion of Penis; grade III squamous intraepithelial lesion of penis; Grade III Squamous Intraepithelial Lesion of the Penis; grade III squamous intraepithelial lesion of the penis; Penile Carcinoma In Situ; penile carcinoma in situ; Penile Carcinoma In Situ AJCC v7; penile carcinoma in situ aJCC v7; Penile intraepithelial neoplasia grade III; penile intraepithelial neoplasia grade III; penis carcinoma in situ; penis in situ carcinoma; Queyrat erythroplasia; Queyrat Erythroplasia; Queyrat's erythroplasia; Queyrat's Erythroplasia; stage 0 penile carcinoma in situ; stage 0 penis carcinoma
SNOMED CT: Carcinoma in situ of penis (92679008); Queyrat's erythroplasia (398768004); Bowen's disease of penis (398831006); Penile intraepithelial neoplasia grade III (400092004); Erythroplasia of Queyrat (398768004); Bowen's disease of glans penis (398831006); Queyrat erythroplasia (18348002); Bowen disease of penis (398831006); Queyrat erythroplasia (398768004); Cancer in situ of penis (92679008); Queyrat's erythroplasia (18348002)
 
Monarch Initiative: MONDO:0004671

Definition

Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. cN0: No palpable or visibly enlarged inguinal lymph nodes. pN0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 7th ed.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPenis carcinoma in situ

Professional guidelines

PubMed

Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review.
Issa A, Sebro K, Kwok A, Janisch F, Grossmann NC, Lee E, Lucky M, Oliveira P, Lau M, Parnham A, Sangar V, Fankhauser CD
Eur Urol Focus 2022 May;8(3):829-832. Epub 2021 May 11 doi: 10.1016/j.euf.2021.04.026. PMID: 33994168
The management of penile intraepithelial neoplasia (PeIN): clinical and histological features and treatment of 345 patients and a review of the literature.
Kravvas G, Ge L, Ng J, Shim TN, Doiron PR, Watchorn R, Kentley J, Panou E, Dinneen M, Freeman A, Jameson C, Haider A, Francis N, Minhas S, Alnajjar H, Muneer A, Bunker CB
J Dermatolog Treat 2022 Mar;33(2):1047-1062. Epub 2020 Aug 6 doi: 10.1080/09546634.2020.1800574. PMID: 32705920
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article

Recent clinical studies

Etiology

Comorbidities in Male Patients With Lichen Sclerosus: A Case-Control Study.
Hieta NK, Haataja MAM, Tapana L
J Low Genit Tract Dis 2023 Oct 1;27(4):378-383. doi: 10.1097/LGT.0000000000000769. PMID: 37729047Free PMC Article
The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Carcinoma of the urethra.
Zhang M, Adeniran AJ, Vikram R, Tamboli P, Pettaway C, Bondaruk J, Liu J, Baggerly K, Czerniak B
Hum Pathol 2018 Feb;72:35-44. Epub 2017 Aug 18 doi: 10.1016/j.humpath.2017.08.006. PMID: 28827100Free PMC Article
Malignant tumors of the penis.
Brady KL, Mercurio MG, Brown MD
Dermatol Surg 2013 Apr;39(4):527-47. Epub 2012 Nov 16 doi: 10.1111/dsu.12029. PMID: 23164051
HPV infection in men.
Palefsky JM
Dis Markers 2007;23(4):261-72. doi: 10.1155/2007/159137. PMID: 17627061Free PMC Article

Diagnosis

The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Penoscrotal Paget's disease.
Dauendorffer JN, Herms F, Baroudjian B, Basset-Seguin N, Cavelier-Balloy B, Fouéré S, Bagot M, Lebbé C
Ann Dermatol Venereol 2021 Jun;148(2):71-76. Epub 2021 Jan 16 doi: 10.1016/j.annder.2020.08.051. PMID: 33461789
Noninfectious Penile Lesions.
Teichman JMH, Mannas M, Elston DM
Am Fam Physician 2018 Jan 15;97(2):102-110. PMID: 29365226
HPV infection in men.
Palefsky JM
Dis Markers 2007;23(4):261-72. doi: 10.1155/2007/159137. PMID: 17627061Free PMC Article

Therapy

Ingenol mebutate therapy in erythroplasia of Queyrat: a new approach.
Proietti I, Michelini S, Skroza N, Bernardini N, Tolino E, Anzalone A, Colapietra D, Mambrin A, DI Fraia M, Marchesiello A, Balduzzi V, Porta N, Petrozza V, Potenza C
Ital J Dermatol Venerol 2021 Jun;156(3):388-391. Epub 2019 Dec 4 doi: 10.23736/S2784-8671.19.06371-5. PMID: 31804047
Indication for early cystectomy in nonmuscle-invasive bladder cancer. Literature review.
Cogorno Wasylkowski L, Ríos-González E, Linares Espinós E, Leibar Tamayo A, Martínez-Piñeiro Lorenzo L
Actas Urol Esp (Engl Ed) 2018 Jan-Feb;42(1):17-24. Epub 2017 Feb 21 doi: 10.1016/j.acuro.2016.12.004. PMID: 28238343
Erythroplasia of Queyrat treated by laser and light modalities: a systematic review.
Maranda EL, Nguyen AH, Lim VM, Shah VV, Jimenez JJ
Lasers Med Sci 2016 Dec;31(9):1971-1976. Epub 2016 Jun 21 doi: 10.1007/s10103-016-2005-9. PMID: 27324019
The treatment of penile carcinoma in situ (CIS) within a UK supra-regional network.
Lucky M, Murthy KV, Rogers B, Jones S, Lau MW, Sangar VK, Parr NJ
BJU Int 2015 Apr;115(4):595-8. Epub 2014 Dec 15 doi: 10.1111/bju.12878. PMID: 25060513
Current strategies in the treatment of non-muscle-invasive bladder cancer.
Oosterlinck W, Decaestecker K
Expert Rev Anticancer Ther 2012 Aug;12(8):1097-106. doi: 10.1586/era.12.87. PMID: 23030228

Prognosis

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Review of in situ and invasive penile squamous cell carcinoma and associated non-neoplastic dermatological conditions.
Downes MR
J Clin Pathol 2015 May;68(5):333-40. doi: 10.1136/jclinpath-2015-202911. PMID: 25883161
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Carcinoma in situ of the penis.
Gerber GS
J Urol 1994 Apr;151(4):829-33. doi: 10.1016/s0022-5347(17)35099-1. PMID: 8126803
Dysplasia and carcinoma in situ of the cervix.
Kaufman RH
Clin Obstet Gynecol 1967 Dec;10(4):748-84. PMID: 4172733

Clinical prediction guides

Hospitalization burden associated with anus and penis neoplasm in Spain (2016-2020).
Fernandez-Alonso V, Gil-Prieto R, Amado-Anton-Pacheco M, Hernández-Barrera V, Gil-De-Miguel Á
Hum Vaccin Immunother 2024 Dec 31;20(1):2334001. Epub 2024 Apr 1 doi: 10.1080/21645515.2024.2334001. PMID: 38557433Free PMC Article
Noninfectious Penile Lesions.
Teichman JMH, Mannas M, Elston DM
Am Fam Physician 2018 Jan 15;97(2):102-110. PMID: 29365226
Carcinoma of the urethra.
Zhang M, Adeniran AJ, Vikram R, Tamboli P, Pettaway C, Bondaruk J, Liu J, Baggerly K, Czerniak B
Hum Pathol 2018 Feb;72:35-44. Epub 2017 Aug 18 doi: 10.1016/j.humpath.2017.08.006. PMID: 28827100Free PMC Article
Review of in situ and invasive penile squamous cell carcinoma and associated non-neoplastic dermatological conditions.
Downes MR
J Clin Pathol 2015 May;68(5):333-40. doi: 10.1136/jclinpath-2015-202911. PMID: 25883161
Noninfectious penile lesions.
Teichman JM, Sea J, Thompson IM, Elston DM
Am Fam Physician 2010 Jan 15;81(2):167-74. PMID: 20082512

Recent systematic reviews

Treatment Options and Outcomes for Men with Penile Intraepithelial Neoplasia: A Systematic Review.
Issa A, Sebro K, Kwok A, Janisch F, Grossmann NC, Lee E, Lucky M, Oliveira P, Lau M, Parnham A, Sangar V, Fankhauser CD
Eur Urol Focus 2022 May;8(3):829-832. Epub 2021 May 11 doi: 10.1016/j.euf.2021.04.026. PMID: 33994168
Urethral recurrence after radical cystectomy for urothelial carcinoma: A systematic review and meta-analysis.
Fahmy O, Khairul-Asri MG, Schubert T, Renninger M, Kübler H, Stenzl A, Gakis G
Urol Oncol 2018 Feb;36(2):54-59. Epub 2017 Nov 28 doi: 10.1016/j.urolonc.2017.11.007. PMID: 29196179
Erythroplasia of Queyrat treated by laser and light modalities: a systematic review.
Maranda EL, Nguyen AH, Lim VM, Shah VV, Jimenez JJ
Lasers Med Sci 2016 Dec;31(9):1971-1976. Epub 2016 Jun 21 doi: 10.1007/s10103-016-2005-9. PMID: 27324019

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