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High Grade Squamous Intraepithelial Neoplasia

MedGen UID:
83093
•Concept ID:
C0333875
•
Neoplastic Process
Synonyms: High Grade Squamous Intraepithelial Lesion; High Grade Squamous Intraepithelial Lesions; High-Grade Squamous Intraepithelial Lesion; High-Grade Squamous Intraepithelial Lesions; HSIL, High Grade Squamous Intraepithelial Lesion; HSIL, High Grade Squamous Intraepithelial Lesions; HSIL, High-Grade Squamous Intraepithelial Lesions
SNOMED CT: High-grade squamous intraepithelial lesion (22725004); HSIL - high-grade squamous intraepithelial lesion (22725004); High grade SIL (squamous intraepithelial lesion) (22725004)

Definition

A precancerous neoplastic process characterized by the presence of moderate or severe dysplastic cytological changes which extend to the upper part of the squamous epithelium. Maturation at the surface of the squamous epithelium may or may not be present. Representative examples include the high grade esophageal squamous intraepithelial neoplasia, high grade cervical squamous intraepithelial neoplasia, high grade vaginal intraepithelial neoplasia, and high grade vulvar intraepithelial neoplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade Squamous Intraepithelial Neoplasia

Professional guidelines

PubMed

Risk of cervical high-grade squamous intraepithelial neoplasia in cytologic negative and persistently high-risk human papillomavirus positive patients according to genotypes: a retrospective single center analysis.
Kipp B, Ulrich E, van Meegen C, Schwenzer T
BMC Infect Dis 2024 Jun 4;24(1):558. doi: 10.1186/s12879-024-09449-z. PMID: 38834951Free PMC Article
Carcinogenic risk of human papillomavirus (HPV) genotypes and potential effects of HPV vaccines in Korea.
Park E, Kim JY, Choi S, Kim DS, Oh YL
Sci Rep 2019 Aug 29;9(1):12556. doi: 10.1038/s41598-019-49060-w. PMID: 31467383Free PMC Article
Clinical results of infrared coagulation as a treatment of high-grade anal dysplasia: a systematic review.
Corral J, Parés D, García-Cuyás F, Revollo B, Videla S, Chamorro A, Piñol M, Clotet B, Sirera G
Tech Coloproctol 2019 Aug;23(8):707-712. Epub 2019 Jul 23 doi: 10.1007/s10151-019-02041-7. PMID: 31338711

Recent clinical studies

Etiology

Risk of cervical high-grade squamous intraepithelial neoplasia in cytologic negative and persistently high-risk human papillomavirus positive patients according to genotypes: a retrospective single center analysis.
Kipp B, Ulrich E, van Meegen C, Schwenzer T
BMC Infect Dis 2024 Jun 4;24(1):558. doi: 10.1186/s12879-024-09449-z. PMID: 38834951Free PMC Article
Reflectance confocal microscopy as a non-invasive imaging tool in vulvar high-grade squamous intraepithelial lesions and lichen sclerosus: A descriptive morphological study in patients and healthy volunteers.
Huisman BW, Pagan L, Ulrich M, Rissmann R, Damman J, Piek JMJ, Niemeyer-van der Kolk T, van Poelgeest MIE
Exp Dermatol 2023 Oct;32(10):1734-1743. Epub 2023 Jul 24 doi: 10.1111/exd.14888. PMID: 37486173
The crossroads: divergent roles of virus-specific CD4(+) T lymphocytes in determining the outcome for human papillomavirus infection.
van Bockel D, Kelleher A
Immunol Cell Biol 2023 Jul;101(6):525-534. Epub 2023 May 9 doi: 10.1111/imcb.12650. PMID: 37159056
Lower accuracy of cytological screening for high-grade squamous intraepithelial neoplasia in women over 50 years of age in Japan.
Miki M, Imaeda Y, Takahashi H, Iwata A, Tsukamoto T, Nomura H, Kotani K, Mitani T, Ichikawa R, Fujii T
Int J Clin Oncol 2022 Feb;27(2):427-433. Epub 2021 Dec 6 doi: 10.1007/s10147-021-02065-w. PMID: 34873649Free PMC Article
Prevalence of high-grade squamous intraepithelial neoplasia (HiSIL) in symptomatic women referred to the colposcopy clinic with negative cytology.
Ray P, Kaul V
Arch Gynecol Obstet 2008 Jun;277(6):501-4. doi: 10.1007/s00404-007-0513-3. PMID: 18034351

Diagnosis

Reflectance confocal microscopy as a non-invasive imaging tool in vulvar high-grade squamous intraepithelial lesions and lichen sclerosus: A descriptive morphological study in patients and healthy volunteers.
Huisman BW, Pagan L, Ulrich M, Rissmann R, Damman J, Piek JMJ, Niemeyer-van der Kolk T, van Poelgeest MIE
Exp Dermatol 2023 Oct;32(10):1734-1743. Epub 2023 Jul 24 doi: 10.1111/exd.14888. PMID: 37486173
Lower accuracy of cytological screening for high-grade squamous intraepithelial neoplasia in women over 50 years of age in Japan.
Miki M, Imaeda Y, Takahashi H, Iwata A, Tsukamoto T, Nomura H, Kotani K, Mitani T, Ichikawa R, Fujii T
Int J Clin Oncol 2022 Feb;27(2):427-433. Epub 2021 Dec 6 doi: 10.1007/s10147-021-02065-w. PMID: 34873649Free PMC Article
Performance of three colposcopic images for the identification of squamous and glandular cervical precursor neoplasias.
Fachetti-Machado G, Figueiredo-Alves RR, Moreira MAR
Arch Gynecol Obstet 2022 May;305(5):1319-1327. Epub 2021 Nov 2 doi: 10.1007/s00404-021-06284-4. PMID: 34727221Free PMC Article
Prevalence of high-grade squamous intraepithelial neoplasia (HiSIL) in symptomatic women referred to the colposcopy clinic with negative cytology.
Ray P, Kaul V
Arch Gynecol Obstet 2008 Jun;277(6):501-4. doi: 10.1007/s00404-007-0513-3. PMID: 18034351
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626

Therapy

Risk of cervical high-grade squamous intraepithelial neoplasia in cytologic negative and persistently high-risk human papillomavirus positive patients according to genotypes: a retrospective single center analysis.
Kipp B, Ulrich E, van Meegen C, Schwenzer T
BMC Infect Dis 2024 Jun 4;24(1):558. doi: 10.1186/s12879-024-09449-z. PMID: 38834951Free PMC Article
Reflectance confocal microscopy as a non-invasive imaging tool in vulvar high-grade squamous intraepithelial lesions and lichen sclerosus: A descriptive morphological study in patients and healthy volunteers.
Huisman BW, Pagan L, Ulrich M, Rissmann R, Damman J, Piek JMJ, Niemeyer-van der Kolk T, van Poelgeest MIE
Exp Dermatol 2023 Oct;32(10):1734-1743. Epub 2023 Jul 24 doi: 10.1111/exd.14888. PMID: 37486173
Efficacy of the AS04-Adjuvanted HPV16/18 Vaccine: Pooled Analysis of the Costa Rica Vaccine and PATRICIA Randomized Controlled Trials.
Tota JE, Struyf F, Sampson JN, Gonzalez P, Ryser M, Herrero R, Schussler J, Karkada N, Rodriguez AC, Folschweiller N, Porras C, Schiffman M, Schiller JT, Quint W, Kreimer AR, Wheeler CM, Hildesheim A; Costa Rica Vaccine Trial and PATRICIA Study
J Natl Cancer Inst 2020 Aug 1;112(8):818-828. doi: 10.1093/jnci/djz222. PMID: 31697384Free PMC Article
Clinical results of infrared coagulation as a treatment of high-grade anal dysplasia: a systematic review.
Corral J, Parés D, García-Cuyás F, Revollo B, Videla S, Chamorro A, Piñol M, Clotet B, Sirera G
Tech Coloproctol 2019 Aug;23(8):707-712. Epub 2019 Jul 23 doi: 10.1007/s10151-019-02041-7. PMID: 31338711
Incidence of squamous neoplasia of the cervix and vagina in women exposed prenatally to diethylstilbestrol (United States).
Hatch EE, Herbst AL, Hoover RN, Noller KL, Adam E, Kaufman RH, Palmer JR, Titus-Ernstoff L, Hyer M, Hartge P, Robboy SJ
Cancer Causes Control 2001 Nov;12(9):837-45. doi: 10.1023/a:1012229112696. PMID: 11714112

Prognosis

Reflectance confocal microscopy as a non-invasive imaging tool in vulvar high-grade squamous intraepithelial lesions and lichen sclerosus: A descriptive morphological study in patients and healthy volunteers.
Huisman BW, Pagan L, Ulrich M, Rissmann R, Damman J, Piek JMJ, Niemeyer-van der Kolk T, van Poelgeest MIE
Exp Dermatol 2023 Oct;32(10):1734-1743. Epub 2023 Jul 24 doi: 10.1111/exd.14888. PMID: 37486173
Lower accuracy of cytological screening for high-grade squamous intraepithelial neoplasia in women over 50 years of age in Japan.
Miki M, Imaeda Y, Takahashi H, Iwata A, Tsukamoto T, Nomura H, Kotani K, Mitani T, Ichikawa R, Fujii T
Int J Clin Oncol 2022 Feb;27(2):427-433. Epub 2021 Dec 6 doi: 10.1007/s10147-021-02065-w. PMID: 34873649Free PMC Article
The Conundrum of an Accumulating Acuminatum.
Cimmino A, Walters E, Gubler A, Ibrahim A
Am J Case Rep 2020 Feb 23;21:e920516. doi: 10.12659/AJCR.920516. PMID: 32088723Free PMC Article
Combined detection of Twist1, Snail1 and squamous cell carcinoma antigen for the prognostic evaluation of invasion and metastasis in cervical squamous cell carcinoma.
Yang H, Hu H, Gou Y, Hu Y, Li H, Zhao H, Wang B, Li P, Zhang Z
Int J Clin Oncol 2018 Apr;23(2):321-328. Epub 2017 Nov 3 doi: 10.1007/s10147-017-1210-2. PMID: 29101499
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626

Clinical prediction guides

Reflectance confocal microscopy as a non-invasive imaging tool in vulvar high-grade squamous intraepithelial lesions and lichen sclerosus: A descriptive morphological study in patients and healthy volunteers.
Huisman BW, Pagan L, Ulrich M, Rissmann R, Damman J, Piek JMJ, Niemeyer-van der Kolk T, van Poelgeest MIE
Exp Dermatol 2023 Oct;32(10):1734-1743. Epub 2023 Jul 24 doi: 10.1111/exd.14888. PMID: 37486173
Lower accuracy of cytological screening for high-grade squamous intraepithelial neoplasia in women over 50 years of age in Japan.
Miki M, Imaeda Y, Takahashi H, Iwata A, Tsukamoto T, Nomura H, Kotani K, Mitani T, Ichikawa R, Fujii T
Int J Clin Oncol 2022 Feb;27(2):427-433. Epub 2021 Dec 6 doi: 10.1007/s10147-021-02065-w. PMID: 34873649Free PMC Article
p16INK4A and Ki-67 immunostaining on cell blocks from residual ThinPrep material is helpful in identifying significant preneoplastic cervical lesions.
Bao H, Wu Y
Pathol Res Pract 2011 Apr 15;207(4):216-9. Epub 2011 Mar 26 doi: 10.1016/j.prp.2010.12.011. PMID: 21440378
Disease persistence in patients with cervical intraepithelial neoplasia undergoing electrosurgical conization.
Costa S, De Nuzzo M, Infante FE, Bonavita B, Marinelli M, Rubino A, Rambelli V, Santini D, Cristiani P, Bucchi L
Gynecol Oncol 2002 Apr;85(1):119-24. doi: 10.1006/gyno.2001.6579. PMID: 11925130
Cytologic observations preceding high grade squamous intraepithelial lesions.
Troncone G, Gupta PK
Acta Cytol 1995 Jul-Aug;39(4):659-62. PMID: 7631539

Recent systematic reviews

Clinical results of infrared coagulation as a treatment of high-grade anal dysplasia: a systematic review.
Corral J, Parés D, García-Cuyás F, Revollo B, Videla S, Chamorro A, Piñol M, Clotet B, Sirera G
Tech Coloproctol 2019 Aug;23(8):707-712. Epub 2019 Jul 23 doi: 10.1007/s10151-019-02041-7. PMID: 31338711

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