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Anal Intraepithelial Neoplasia 3

MedGen UID:
509511
•Concept ID:
C0154064
•
Neoplastic Process
Synonyms: AIN III; Anal intraepithelial neoplasia grade III; Anal intraepithelial neoplasia, grade III; Anal Squamous Intraepithelial Neoplasia 3; Carcinoma in situ of anus
SNOMED CT: Carcinoma in situ of anus (92537005); Anal intraepithelial neoplasia grade III (92537005); Anal intraepithelial neoplasia, grade III (20365006); AIN III (20365006)

Definition

Anal canal or perianal skin intraepithelial neoplasia with severe dysplasia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnal Intraepithelial Neoplasia 3

Professional guidelines

PubMed

Recommendations on the use of quadrivalent human papillomavirus vaccine in males--Advisory Committee on Immunization Practices (ACIP), 2011.
Centers for Disease Control and Prevention (CDC)
MMWR Morb Mortal Wkly Rep 2011 Dec 23;60(50):1705-8. PMID: 22189893

Recent clinical studies

Etiology

The correlation Between anal pap cytology and histologic outcomes in HIV-Positive males.
McCutcheon T, Hawkins AT, Ford MM, Hopkins MB, Geiger T, Muldoon RL
Am J Surg 2022 Apr;223(4):759-763. Epub 2021 Jul 8 doi: 10.1016/j.amjsurg.2021.06.020. PMID: 34266659
Risk factors for anal high-grade squamous intraepithelial lesions in HIV-positive MSM: is targeted screening possible?
Siegenbeek van Heukelom ML, Marra E, de Vries HJC, Schim van der Loeff MF, Prins JM
AIDS 2017 Oct 23;31(16):2295-2301. doi: 10.1097/QAD.0000000000001639. PMID: 28991027Free PMC Article
Prevalence of abnormal anal cytology and high-grade squamous intraepithelial lesions among a cohort of HIV-infected men who have sex with men.
Sendagorta E, Herranz P, Guadalajara H, Bernardino JI, Viguer JM, Beato MJ, García-Olmo D, Peña JM
Dis Colon Rectum 2014 Apr;57(4):475-81. doi: 10.1097/DCR.0000000000000095. PMID: 24608304
Human papillomavirus-related tumors in HIV.
Palefsky J
Curr Opin Oncol 2006 Sep;18(5):463-8. doi: 10.1097/01.cco.0000239885.13537.36. PMID: 16894294

Diagnosis

The correlation Between anal pap cytology and histologic outcomes in HIV-Positive males.
McCutcheon T, Hawkins AT, Ford MM, Hopkins MB, Geiger T, Muldoon RL
Am J Surg 2022 Apr;223(4):759-763. Epub 2021 Jul 8 doi: 10.1016/j.amjsurg.2021.06.020. PMID: 34266659
Prevalence of abnormal anal cytology and high-grade squamous intraepithelial lesions among a cohort of HIV-infected men who have sex with men.
Sendagorta E, Herranz P, Guadalajara H, Bernardino JI, Viguer JM, Beato MJ, García-Olmo D, Peña JM
Dis Colon Rectum 2014 Apr;57(4):475-81. doi: 10.1097/DCR.0000000000000095. PMID: 24608304
Measurement characteristics of anal cytology, histopathology, and high-resolution anoscopic visual impression in an anal dysplasia screening program.
Mathews WC, Sitapati A, Caperna JC, Barber RE, Tugend A, Go U
J Acquir Immune Defic Syndr 2004 Dec 15;37(5):1610-5. doi: 10.1097/00126334-200412150-00014. PMID: 15577418

Therapy

Human papillomavirus-related tumors in HIV.
Palefsky J
Curr Opin Oncol 2006 Sep;18(5):463-8. doi: 10.1097/01.cco.0000239885.13537.36. PMID: 16894294

Clinical prediction guides

Prevalence of abnormal anal cytology and high-grade squamous intraepithelial lesions among a cohort of HIV-infected men who have sex with men.
Sendagorta E, Herranz P, Guadalajara H, Bernardino JI, Viguer JM, Beato MJ, García-Olmo D, Peña JM
Dis Colon Rectum 2014 Apr;57(4):475-81. doi: 10.1097/DCR.0000000000000095. PMID: 24608304

Supplemental Content

Table of contents

    Practice guidelines

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