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Resistant ovary syndrome

MedGen UID:
88557
•Concept ID:
C0086367
•
Disease or Syndrome
Synonyms: Gonadotropin Resistant Ovary Syndrome; Gonadotropin-Resistant Ovary Syndrome; Resistant Ovary Syndrome
SNOMED CT: Resistant ovary syndrome (80956002)

Definition

Ovarian dysfunction due to a defect at the receptor or post receptor level, or due to the presence of antibodies against gonadotropin receptors, resulting in deficient gonadotropin signaling that causes elevated concentrations of follicle stimulating hormone and/or luteinizing hormone. A distinguishing feature is the presence of normal numbers of ova. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResistant ovary syndrome

Professional guidelines

PubMed

The live birth in a woman with resistant ovary syndrome after in vitro oocyte maturation and preimplantation genetic testing for aneuploidy.
Kornilov NV, Pavlova MN, Yakovlev PP
J Assist Reprod Genet 2021 Jun;38(6):1303-1309. Epub 2021 Jan 26 doi: 10.1007/s10815-021-02085-5. PMID: 33495936Free PMC Article
Could transvaginal, ultrasound-guided ovarian interstitial laser treatment replace laparoscopic ovarian drilling in women with polycystic ovary syndrome resistant to clomiphene citrate?
Api M
Fertil Steril 2009 Dec;92(6):2039-40. Epub 2009 Jul 15 doi: 10.1016/j.fertnstert.2009.06.024. PMID: 19608164
Luteinizing hormone releasing hormone analogue in treatment of hypergonadotrophic amenorrhoea.
Menon V, Edwards RL, Lynch SS, Butt WR
Br J Obstet Gynaecol 1983 Jun;90(6):539-42. doi: 10.1111/j.1471-0528.1983.tb08964.x. PMID: 6407517

Recent clinical studies

Etiology

Application value of Early-Follicular Phase Long-Acting Gonadotropin-Releasing Hormone Agonist Long Protocol in patients with resistant ovary syndrome.
Zhang F, Zhang H, Du H, Li X, Jin H, Li G
BMC Pregnancy Childbirth 2023 Mar 15;23(1):178. doi: 10.1186/s12884-023-05477-w. PMID: 36922772Free PMC Article
Diagnostic role of inhibin B in resistant ovary syndrome associated with secondary amenorrhea.
Arici A, Matalliotakis IM, Koumantakis GE, Goumenou AG, Neonaki MA, Koumantakis EE
Fertil Steril 2002 Dec;78(6):1324-6. doi: 10.1016/s0015-0282(02)04239-5. PMID: 12477534
Characterization of idiopathic premature ovarian failure.
Conway GS, Kaltsas G, Patel A, Davies MC, Jacobs HS
Fertil Steril 1996 Feb;65(2):337-41. doi: 10.1016/s0015-0282(16)58095-9. PMID: 8566258
Noninvasive diagnosis of resistant ovary syndrome by ultrasonography.
Mehta AE, Matwijiw I, Lyons EA, Faiman C
Fertil Steril 1992 Jan;57(1):56-61. PMID: 1730331
Receptors, antibodies, and disease.
Blecher M
Clin Chem 1984 Jul;30(7):1137-56. PMID: 6329552

Diagnosis

Application value of Early-Follicular Phase Long-Acting Gonadotropin-Releasing Hormone Agonist Long Protocol in patients with resistant ovary syndrome.
Zhang F, Zhang H, Du H, Li X, Jin H, Li G
BMC Pregnancy Childbirth 2023 Mar 15;23(1):178. doi: 10.1186/s12884-023-05477-w. PMID: 36922772Free PMC Article
Effective ovarian stimulation in a patient with resistant ovary syndrome and antigonadotrophin antibodies.
Rogenhofer N, Pavlik R, Jeschke U, Wypior G, Ochsenkühn R, Thaler CJ
Am J Reprod Immunol 2015 Feb;73(2):185-91. Epub 2014 Aug 14 doi: 10.1111/aji.12306. PMID: 25123925
Diagnostic role of inhibin B in resistant ovary syndrome associated with secondary amenorrhea.
Arici A, Matalliotakis IM, Koumantakis GE, Goumenou AG, Neonaki MA, Koumantakis EE
Fertil Steril 2002 Dec;78(6):1324-6. doi: 10.1016/s0015-0282(02)04239-5. PMID: 12477534
Noninvasive diagnosis of resistant ovary syndrome by ultrasonography.
Mehta AE, Matwijiw I, Lyons EA, Faiman C
Fertil Steril 1992 Jan;57(1):56-61. PMID: 1730331
The resistant ovary syndrome.
Dewhurst CJ, de Koos EB, Ferreira HP
Br J Obstet Gynaecol 1975 Apr;82(4):341-5. doi: 10.1111/j.1471-0528.1975.tb00646.x. PMID: 1125157

Therapy

Resistant ovary syndrome: Two case reports and a literature review of effective controlled ovarian stimulation in IVF.
Zhao S, Zheng W, Gu X, Liang G, Long G
Medicine (Baltimore) 2024 May 3;103(18):e37886. doi: 10.1097/MD.0000000000037886. PMID: 38701292Free PMC Article
Case report: Birth achieved after effective ovarian stimulation combined with dexamethasone in a patient with resistant ovary syndrome.
Li H, Chang T, Mu H, Xiang W
J Ovarian Res 2022 Apr 7;15(1):42. doi: 10.1186/s13048-022-00976-4. PMID: 35392972Free PMC Article
Hippo signaling disruption and ovarian follicle activation in infertile patients.
Hsueh AJW, Kawamura K
Fertil Steril 2020 Sep;114(3):458-464. Epub 2020 Aug 8 doi: 10.1016/j.fertnstert.2020.07.031. PMID: 32782158
Successful live birth in a woman with resistant ovary syndrome treated with letrozole and HMG: A case report.
Mu Z, Song J, Yu Y, Sun Z
Medicine (Baltimore) 2020 May;99(20):e20199. doi: 10.1097/MD.0000000000020199. PMID: 32443342Free PMC Article
Chromosomally competent ovarian failure at adolescence.
Rauh JL, Waldrop CD, Burket RL
J Adolesc Health Care 1983 Dec;4(4):257-60. doi: 10.1016/s0197-0070(83)80007-2. PMID: 6315654

Prognosis

Identification and characterization of novel compound heterozygous variants in FSHR causing primary ovarian insufficiency with resistant ovary syndrome.
Chen X, Chen L, Wang Y, Shu C, Zhou Y, Wu R, Jin B, Yang L, Sun J, Qi M, Shu J
Front Endocrinol (Lausanne) 2022;13:1013894. Epub 2023 Jan 10 doi: 10.3389/fendo.2022.1013894. PMID: 36704038Free PMC Article
Live birth after in vitro maturation in women with gonadotropin resistance ovary syndrome: report of two cases.
Le HL, Ho VNA, Le TTN, Tran VTT, Ma MPQ, Le AH, Nguyen LK, Ho TM, Vuong LN
J Assist Reprod Genet 2021 Dec;38(12):3243-3249. Epub 2021 Nov 30 doi: 10.1007/s10815-021-02355-2. PMID: 34846627Free PMC Article
Novel inactivating mutations in the FSH receptor cause premature ovarian insufficiency with resistant ovary syndrome.
He WB, Du J, Yang XW, Li W, Tang WL, Dai C, Chen YZ, Zhang YX, Lu GX, Lin G, Gong F, Tan YQ
Reprod Biomed Online 2019 Mar;38(3):397-406. Epub 2018 Dec 8 doi: 10.1016/j.rbmo.2018.11.011. PMID: 30691934
A novel follicle-stimulating hormone receptor mutation causing primary ovarian failure: a fertility application of whole exome sequencing.
Bramble MS, Goldstein EH, Lipson A, Ngun T, Eskin A, Gosschalk JE, Roach L, Vashist N, Barseghyan H, Lee E, Arboleda VA, Vaiman D, Yuksel Z, Fellous M, Vilain E
Hum Reprod 2016 Apr;31(4):905-14. Epub 2016 Feb 23 doi: 10.1093/humrep/dew025. PMID: 26911863Free PMC Article
The resistant ovary syndrome in a patient with galactosemia: a clue to the natural history of ovarian failure.
Twigg S, Wallman L, McElduff A
J Clin Endocrinol Metab 1996 Apr;81(4):1329-31. doi: 10.1210/jcem.81.4.8636327. PMID: 8636327

Clinical prediction guides

Identification and characterization of novel compound heterozygous variants in FSHR causing primary ovarian insufficiency with resistant ovary syndrome.
Chen X, Chen L, Wang Y, Shu C, Zhou Y, Wu R, Jin B, Yang L, Sun J, Qi M, Shu J
Front Endocrinol (Lausanne) 2022;13:1013894. Epub 2023 Jan 10 doi: 10.3389/fendo.2022.1013894. PMID: 36704038Free PMC Article
Novel inactivating mutations in the FSH receptor cause premature ovarian insufficiency with resistant ovary syndrome.
He WB, Du J, Yang XW, Li W, Tang WL, Dai C, Chen YZ, Zhang YX, Lu GX, Lin G, Gong F, Tan YQ
Reprod Biomed Online 2019 Mar;38(3):397-406. Epub 2018 Dec 8 doi: 10.1016/j.rbmo.2018.11.011. PMID: 30691934
Minilaparoscopic ovarian biopsy performed under conscious sedation in women with premature ovarian failure.
Pellicano M, Zullo F, Cappiello F, Di Carlo C, Cirillo D, Nappi C
J Reprod Med 2000 Oct;45(10):817-22. PMID: 11077630
Recombinant human follicle-stimulating hormone and ovarian response in gonadotrophin-deficient women.
Schoot DC, Harlin J, Shoham Z, Mannaerts BM, Lahlou N, Bouchard P, Bennink HJ, Fauser BC
Hum Reprod 1994 Jul;9(7):1237-42. doi: 10.1093/oxfordjournals.humrep.a138685. PMID: 7962424
Hormonal and ultrastructural observations in a case of resistant ovary syndrome.
Starup J, Pedersen H
Acta Endocrinol (Copenh) 1978 Dec;89(4):744-52. doi: 10.1530/acta.0.0890744. PMID: 716779

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