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Erythema marginatum

MedGen UID:
39323
•Concept ID:
C0085659
•
Disease or Syndrome
HPO: HP:6001012

Definition

An erythematous (pink-red, depending on the skin color of the affected individual) macule that spreads peripherally and coalesces to form polycyclic or serpentine patches or plaques. Lesions occur in crops over days to weeks and are evanescent. The rate of migration is 2 to 12 mm over a period of a few hours. Erythema marginatum tends to affect the trunk more than the extremities and to not be accompanied by pruritus. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythema marginatum

Professional guidelines

PubMed

Diagnostic criteria of acute rheumatic fever.
Burke RJ, Chang C
Autoimmun Rev 2014 Apr-May;13(4-5):503-7. Epub 2014 Jan 11 doi: 10.1016/j.autrev.2014.01.036. PMID: 24424191
Diagnosis of rheumatic fever: current status of Jones Criteria and role of echocardiography.
Saxena A
Indian J Pediatr 2000 Mar;67(3 Suppl):S11-4. PMID: 11129913
Diagnosis of rheumatic fever: current status of Jones Criteria and role of echocardiography.
Saxena A
Indian J Pediatr 2000 Apr;67(4):283-6. doi: 10.1007/BF02758174. PMID: 10878870

Recent clinical studies

Etiology

Figurate erythemas - update and diagnostic approach.
Boehner A, Neuhauser R, Zink A, Ring J
J Dtsch Dermatol Ges 2021 Jul;19(7):963-972. Epub 2021 May 28 doi: 10.1111/ddg.14450. PMID: 34046996
Clinical presentation of hereditary angioedema.
Azmy V, Brooks JP, Hsu FI
Allergy Asthma Proc 2020 Nov 1;41(Suppl 1):S18-S21. doi: 10.2500/aap.2020.41.200065. PMID: 33109320
Diagnostic criteria of acute rheumatic fever.
Burke RJ, Chang C
Autoimmun Rev 2014 Apr-May;13(4-5):503-7. Epub 2014 Jan 11 doi: 10.1016/j.autrev.2014.01.036. PMID: 24424191
Rheumatic fever.
Rullan E, Sigal LH
Curr Rheumatol Rep 2001 Oct;3(5):445-52. doi: 10.1007/s11926-996-0016-4. PMID: 11564377
Gyrate erythema.
White JW Jr
Dermatol Clin 1985 Jan;3(1):129-39. PMID: 3912086

Diagnosis

Urticarial eruption.
Ajaaouani R, Hali F, Marnissi F, Chiheb S
Rev Med Interne 2023 Apr;44(4):199-200. Epub 2023 Feb 23 doi: 10.1016/j.revmed.2023.01.019. PMID: 36828694
Figurate erythemas - update and diagnostic approach.
Boehner A, Neuhauser R, Zink A, Ring J
J Dtsch Dermatol Ges 2021 Jul;19(7):963-972. Epub 2021 May 28 doi: 10.1111/ddg.14450. PMID: 34046996
Erythema Marginatum.
Sharma S, Biswal N
Indian Pediatr 2015 Dec;52(12):1100. PMID: 26714000
Rheumatic fever.
Rullan E, Sigal LH
Curr Rheumatol Rep 2001 Oct;3(5):445-52. doi: 10.1007/s11926-996-0016-4. PMID: 11564377
Gyrate erythema.
White JW Jr
Dermatol Clin 1985 Jan;3(1):129-39. PMID: 3912086

Therapy

Acute Rheumatic Fever: Case Report and Literature Review.
Noguchi K, Arain N, Galloway C
S D Med 2022 May;75(5):212-215. PMID: 35724350
Erythema Marginatum.
Sharma S, Biswal N
Indian Pediatr 2015 Dec;52(12):1100. PMID: 26714000
Rheumatic fever.
Rullan E, Sigal LH
Curr Rheumatol Rep 2001 Oct;3(5):445-52. doi: 10.1007/s11926-996-0016-4. PMID: 11564377
Gyrate erythema.
White JW Jr
Dermatol Clin 1985 Jan;3(1):129-39. PMID: 3912086
Erythema marginatum.
BURKE JB
Arch Dis Child 1955 Aug;30(152):359-65. doi: 10.1136/adc.30.152.359. PMID: 13249623Free PMC Article

Prognosis

Clinical Evaluation of Pediatric Patients with Hereditary Angioedema.
Kırmızıtaş Aydoğdu A, Ürel Demir G
Tohoku J Exp Med 2024 Jan 10;262(1):23-27. Epub 2023 Oct 5 doi: 10.1620/tjem.2023.J083. PMID: 37793880
Urticaria and Prodromal Symptoms Including Erythema Marginatum in Danish Patients with Hereditary Angioedema.
Rasmussen ER, de Freitas PV, Bygum A
Acta Derm Venereol 2016 Mar;96(3):373-6. doi: 10.2340/00015555-2233. PMID: 26336842
Diagnostic criteria of acute rheumatic fever.
Burke RJ, Chang C
Autoimmun Rev 2014 Apr-May;13(4-5):503-7. Epub 2014 Jan 11 doi: 10.1016/j.autrev.2014.01.036. PMID: 24424191
Rheumatic fever in children younger than 5 years: is the presentation different?
Tani LY, Veasy LG, Minich LL, Shaddy RE
Pediatrics 2003 Nov;112(5):1065-8. doi: 10.1542/peds.112.5.1065. PMID: 14595047
Rheumatic fever.
Rullan E, Sigal LH
Curr Rheumatol Rep 2001 Oct;3(5):445-52. doi: 10.1007/s11926-996-0016-4. PMID: 11564377

Clinical prediction guides

Hereditary angioedema with normal C1-inhibitor: Clinical and genetic characterization of 15 Portuguese unrelated families.
Dias de Castro E, Pinhal AL, Bragança M, Parente Freixo J, Martinho A
Ann Allergy Asthma Immunol 2024 Jun;132(6):730-736. Epub 2024 Feb 9 doi: 10.1016/j.anai.2024.01.027. PMID: 38342132
Clinical Evaluation of Pediatric Patients with Hereditary Angioedema.
Kırmızıtaş Aydoğdu A, Ürel Demir G
Tohoku J Exp Med 2024 Jan 10;262(1):23-27. Epub 2023 Oct 5 doi: 10.1620/tjem.2023.J083. PMID: 37793880
Acute rheumatic fever in adult patients.
Wang CR, Lee NY, Tsai HW, Yang CC, Lee CH
Medicine (Baltimore) 2022 Jul 1;101(26):e29833. doi: 10.1097/MD.0000000000029833. PMID: 35777053Free PMC Article
Pathways of Neutrophil Granulocyte Activation in Hereditary Angioedema with C1 Inhibitor Deficiency.
Kajdácsi E, Veszeli N, Mező B, Jandrasics Z, Kőhalmi KV, Ferrara AL, Cervenak L, Varga L, Farkas H
Clin Rev Allergy Immunol 2021 Jun;60(3):383-395. Epub 2021 Feb 19 doi: 10.1007/s12016-021-08847-4. PMID: 33606193Free PMC Article
Urticaria and Prodromal Symptoms Including Erythema Marginatum in Danish Patients with Hereditary Angioedema.
Rasmussen ER, de Freitas PV, Bygum A
Acta Derm Venereol 2016 Mar;96(3):373-6. doi: 10.2340/00015555-2233. PMID: 26336842

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