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Fungal meningitis

MedGen UID:
39285
•Concept ID:
C0085438
•
Disease or Syndrome
Synonyms: Fungal Meningitides; Fungal Meningitis; Meningitides, Fungal; Meningitis, Fungal
SNOMED CT: Fungal meningitis (24321005)
 
HPO: HP:0032159
Monarch Initiative: MONDO:0006764

Definition

An infection of the meninges caused by a fungus. Generally, only individuals with deficiencies of the immune system contract fungal meningitis. [from HPO]

Professional guidelines

PubMed

Microbiological diagnosis of tuberculous meningitis: Phenotype to genotype.
Garg RK
Indian J Med Res 2019 Nov;150(5):448-457. doi: 10.4103/ijmr.IJMR_1145_19. PMID: 31939388Free PMC Article
Systematic review of caudal epidural injections in the management of chronic back pain.
Friedman JH, Dighe G
R I Med J (2013) 2013 Jan 4;96(1):12-6. PMID: 23638452
Fungal infections and their management.
Graybill JR, Sharkey PK
Br J Clin Pract Suppl 1990 Sep;71:23-31. PMID: 1965416

Recent clinical studies

Etiology

Ventriculo - Gallbladder shunt.
Porto Junior S, Ramos JVB, da Cunha BLB, da Silva da Paz MG, de Oliveira Lima TV, Moreira LR, de Avellar LM
J Clin Neurosci 2024 Mar;121:83-88. Epub 2024 Feb 17 doi: 10.1016/j.jocn.2024.02.002. PMID: 38368659
Neuroinfections caused by fungi.
Góralska K, Blaszkowska J, Dzikowiec M
Infection 2018 Aug;46(4):443-459. Epub 2018 May 21 doi: 10.1007/s15010-018-1152-2. PMID: 29785613Free PMC Article
Sterile compounding: clinical, legal, and regulatory implications for patient safety.
Qureshi N, Wesolowicz L, Stievater T, Lin AT
J Manag Care Spec Pharm 2014 Dec;20(12):1183-91. doi: 10.18553/jmcp.2014.20.12.1183. PMID: 25443512Free PMC Article
Coccidioidomycosis.
Chiller TM, Galgiani JN, Stevens DA
Infect Dis Clin North Am 2003 Mar;17(1):41-57, viii. doi: 10.1016/s0891-5520(02)00040-5. PMID: 12751260
Fungal meningitis.
Gottfredsson M, Perfect JR
Semin Neurol 2000;20(3):307-22. doi: 10.1055/s-2000-9394. PMID: 11051295

Diagnosis

Connecting Cryptococcal Meningitis and Gut Microbiome.
Ma Y, Yang L, Jiang M, Zhao X, Xue P
Int J Mol Sci 2023 Aug 31;24(17) doi: 10.3390/ijms241713515. PMID: 37686320Free PMC Article
Burden of fungal meningitis.
Pagliano P, Esposito S, Ascione T, Spera AM
Future Microbiol 2020 May;15:469-472. Epub 2020 May 7 doi: 10.2217/fmb-2020-0006. PMID: 32378964
Methods for rapid diagnosis of meningitis etiology in adults.
Poplin V, Boulware DR, Bahr NC
Biomark Med 2020 Apr;14(6):459-479. Epub 2020 Apr 9 doi: 10.2217/bmm-2019-0333. PMID: 32270693Free PMC Article
Neuroinfections caused by fungi.
Góralska K, Blaszkowska J, Dzikowiec M
Infection 2018 Aug;46(4):443-459. Epub 2018 May 21 doi: 10.1007/s15010-018-1152-2. PMID: 29785613Free PMC Article
Fungal meningitis.
Gottfredsson M, Perfect JR
Semin Neurol 2000;20(3):307-22. doi: 10.1055/s-2000-9394. PMID: 11051295

Therapy

CNS fungal infections: A review.
Nathan CL, Emmert BE, Nelson E, Berger JR
J Neurol Sci 2021 Mar 15;422:117325. Epub 2021 Jan 22 doi: 10.1016/j.jns.2021.117325. PMID: 33516057
Iatrogenic meningitis.
Mutarelli EG, Adoni T
Arq Neuropsiquiatr 2013 Sep;71(9B):659-60. doi: 10.1590/0004-282X20130145. PMID: 24141499
Iatrogenic fungal meningitis: tragedy repeated.
Perfect JR
Ann Intern Med 2012 Dec 4;157(11):825-6. doi: 10.7326/0003-4819-157-11-201212040-00558. PMID: 23080380
Coccidioidal meningitis.
Williams PL
Ann N Y Acad Sci 2007 Sep;1111:377-84. Epub 2007 Mar 15 doi: 10.1196/annals.1406.037. PMID: 17363442
Therapy of fungal meningitis.
Slavoski LA, Tunkel AR
Clin Neuropharmacol 1995 Apr;18(2):95-112. doi: 10.1097/00002826-199504000-00001. PMID: 8635178

Prognosis

Rhino-orbital-cerebral-mucormycosis in COVID-19: A systematic review.
Bhattacharyya A, Sarma P, Sharma DJ, Das KK, Kaur H, Prajapat M, Kumar S, Bansal S, Prakash A, Avti P, Thota P, Reddy DH, Gautam BS, Medhi B
Indian J Pharmacol 2021 Jul-Aug;53(4):317-327. doi: 10.4103/ijp.ijp_419_21. PMID: 34414911Free PMC Article
Chronic and subacute meningitis.
Zunt JR, Baldwin KJ
Continuum (Minneap Minn) 2012 Dec;18(6 Infectious Disease):1290-318. doi: 10.1212/01.CON.0000423848.17276.21. PMID: 23221842
Cryptococcal meningitis.
Jones GA, Nathwani D
Br J Hosp Med 1995 Nov 1-14;54(9):439-45. PMID: 8564179
Viral meningitis. Tips to rapidly diagnose treatable causes.
Maxson S, Jacobs RF
Postgrad Med 1993 Jun;93(8):153-6, 159-60, 163-6. doi: 10.1080/00325481.1993.11701723. PMID: 8506174
Cerebral phaeohyphomycosis.
Palaoglu S, Sav A, Basak T, Yalcinlar Y, Scheithauer BW
Neurosurgery 1993 Nov;33(5):894-7. doi: 10.1227/00006123-199311000-00018. PMID: 8264889

Clinical prediction guides

Bird's Eye View of a Neonatologist: Clinical Approach to Emergency Neonatal Infection.
Huang FK, Chen HL, Yang PH, Lin HC
Pediatr Neonatol 2016 Jun;57(3):167-73. Epub 2015 Oct 23 doi: 10.1016/j.pedneo.2015.06.004. PMID: 26701838
Trends in bacterial, mycobacterial, and fungal meningitis in England and Wales 2004-11: an observational study.
Okike IO, Ribeiro S, Ramsay ME, Heath PT, Sharland M, Ladhani SN
Lancet Infect Dis 2014 Apr;14(4):301-7. Epub 2014 Feb 7 doi: 10.1016/S1473-3099(13)70332-3. PMID: 24508198
Fungal infections of the central nervous system.
Mathur M, Johnson CE, Sze G
Neuroimaging Clin N Am 2012 Nov;22(4):609-32. Epub 2012 Aug 17 doi: 10.1016/j.nic.2012.04.004. PMID: 23122259
Pharmacokinetic optimisation of oral antifungal therapy.
Schäfer-Korting M
Clin Pharmacokinet 1993 Oct;25(4):329-41. doi: 10.2165/00003088-199325040-00006. PMID: 8261715
Detection of fungi in cerebrospinal fluid.
McGinnis MR
Am J Med 1983 Jul 28;75(1B):129-38. doi: 10.1016/0002-9343(83)90084-0. PMID: 6349340

Recent systematic reviews

Ventriculo - Gallbladder shunt.
Porto Junior S, Ramos JVB, da Cunha BLB, da Silva da Paz MG, de Oliveira Lima TV, Moreira LR, de Avellar LM
J Clin Neurosci 2024 Mar;121:83-88. Epub 2024 Feb 17 doi: 10.1016/j.jocn.2024.02.002. PMID: 38368659
Efficacy of Cerebrospinal Fluid Beta-d-Glucan Diagnostic Testing for Fungal Meningitis: a Systematic Review.
Davis C, Wheat LJ, Myint T, Boulware DR, Bahr NC
J Clin Microbiol 2020 Mar 25;58(4) doi: 10.1128/JCM.02094-19. PMID: 31996446Free PMC Article
Clinical Response, Outbreak Investigation, and Epidemiology of the Fungal Meningitis Epidemic in the United States: Systematic Review.
Abbas KM, Dorratoltaj N, O'Dell ML, Bordwine P, Kerkering TM, Redican KJ
Disaster Med Public Health Prep 2016 Feb;10(1):145-51. Epub 2015 Dec 18 doi: 10.1017/dmp.2015.137. PMID: 26681583Free PMC Article
Antifungal therapy for newborn infants with invasive fungal infection.
Clerihew L, McGuire W
Cochrane Database Syst Rev 2012 Jun 13;2012(6):CD003953. doi: 10.1002/14651858.CD003953.pub3. PMID: 22696338Free PMC Article
Systemic antifungal drugs for invasive fungal infection in preterm infants.
Clerihew L, McGuire W
Cochrane Database Syst Rev 2004;(1):CD003953. doi: 10.1002/14651858.CD003953.pub2. PMID: 14974045

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