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Angiodysplasia

MedGen UID:
88403
•Concept ID:
C0085411
•
Disease or Syndrome
Synonym: Angiodysplasias
 
Monarch Initiative: MONDO:0002322

Definition

Acquired degenerative dilation or expansion (ectasia) of normal blood vessels, often associated with aging. They are isolated, tortuous, thin-walled vessels and sources of bleeding. They occur most often in mucosal capillaries of the gastrointestinal tract leading to gastrointestinal hemorrhage and anemia. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAngiodysplasia

Professional guidelines

PubMed

Gastrointestinal Angiodysplasia before and after Treatment of Severe Aortic Stenosis.
Yashige M, Inoue K, Zen K, Kobayashi R, Nakamura S, Fujimoto T, Takamatsu K, Sugino S, Yamano M, Yamano T, Nakamura T, Doman T, Teramukai S, Horiuchi H, Itoh Y, Matoba S
N Engl J Med 2023 Oct 19;389(16):1530-1532. doi: 10.1056/NEJMc2306027. PMID: 37851881
Acute Lower Gastrointestinal Bleeding: Evaluation and Management.
Hawks MK, Svarverud JE
Am Fam Physician 2020 Feb 15;101(4):206-212. PMID: 32053333
Review article: gastrointestinal angiodysplasia - pathogenesis, diagnosis and management.
Sami SS, Al-Araji SA, Ragunath K
Aliment Pharmacol Ther 2014 Jan;39(1):15-34. Epub 2013 Oct 20 doi: 10.1111/apt.12527. PMID: 24138285

Recent clinical studies

Etiology

Standard of Care Versus Octreotide in Angiodysplasia-Related Bleeding (the OCEAN Study): A Multicenter Randomized Controlled Trial.
Goltstein LCMJ, Grooteman KV, Bernts LHP, Scheffer RCH, Laheij RJF, Gilissen LPL, Schrauwen RWM, Talstra NC, Zuur AT, Braat H, Hadithi M, Brouwer JT, Nagengast WB, Oort FA, Tenthof van Noorden J, Kievit W, van Geenen EJM, Drenth JPH
Gastroenterology 2024 Apr;166(4):690-703. Epub 2023 Dec 28 doi: 10.1053/j.gastro.2023.12.020. PMID: 38158089
Thalidomide for Recurrent Bleeding Due to Small-Intestinal Angiodysplasia.
Chen H, Wu S, Tang M, Zhao R, Zhang Q, Dai Z, Gao Y, Yang S, Li Z, Du Y, Yang A, Zhong L, Lu L, Xu L, Shen X, Liu S, Zhong J, Li X, Lu H, Xiong H, Shen Y, Chen H, Gong S, Xue H, Ge Z
N Engl J Med 2023 Nov 2;389(18):1649-1659. doi: 10.1056/NEJMoa2303706. PMID: 37913505
Review Article: Gastrointestinal Bleeding Risk with Direct Oral Anticoagulants.
Benamouzig R, Guenoun M, Deutsch D, Fauchier L
Cardiovasc Drugs Ther 2022 Oct;36(5):973-989. Epub 2021 Jun 18 doi: 10.1007/s10557-021-07211-0. PMID: 34143317
Diagnostic and therapeutic challenges of gastrointestinal angiodysplasias: A critical review and view points.
García-Compeán D, Del Cueto-Aguilera ÁN, Jiménez-Rodríguez AR, González-González JA, Maldonado-Garza HJ
World J Gastroenterol 2019 Jun 7;25(21):2549-2564. doi: 10.3748/wjg.v25.i21.2549. PMID: 31210709Free PMC Article
Hughes-Stovin syndrome.
Khalid U, Saleem T
Orphanet J Rare Dis 2011 Apr 13;6:15. doi: 10.1186/1750-1172-6-15. PMID: 21489283Free PMC Article

Diagnosis

Standard of Care Versus Octreotide in Angiodysplasia-Related Bleeding (the OCEAN Study): A Multicenter Randomized Controlled Trial.
Goltstein LCMJ, Grooteman KV, Bernts LHP, Scheffer RCH, Laheij RJF, Gilissen LPL, Schrauwen RWM, Talstra NC, Zuur AT, Braat H, Hadithi M, Brouwer JT, Nagengast WB, Oort FA, Tenthof van Noorden J, Kievit W, van Geenen EJM, Drenth JPH
Gastroenterology 2024 Apr;166(4):690-703. Epub 2023 Dec 28 doi: 10.1053/j.gastro.2023.12.020. PMID: 38158089
Diagnosis and therapeutic strategies for small bowel vascular lesions.
Sakai E, Ohata K, Nakajima A, Matsuhashi N
World J Gastroenterol 2019 Jun 14;25(22):2720-2733. doi: 10.3748/wjg.v25.i22.2720. PMID: 31235995Free PMC Article
Diagnostic and therapeutic challenges of gastrointestinal angiodysplasias: A critical review and view points.
García-Compeán D, Del Cueto-Aguilera ÁN, Jiménez-Rodríguez AR, González-González JA, Maldonado-Garza HJ
World J Gastroenterol 2019 Jun 7;25(21):2549-2564. doi: 10.3748/wjg.v25.i21.2549. PMID: 31210709Free PMC Article
Review article: gastrointestinal angiodysplasia - pathogenesis, diagnosis and management.
Sami SS, Al-Araji SA, Ragunath K
Aliment Pharmacol Ther 2014 Jan;39(1):15-34. Epub 2013 Oct 20 doi: 10.1111/apt.12527. PMID: 24138285
Hughes-Stovin syndrome.
Khalid U, Saleem T
Orphanet J Rare Dis 2011 Apr 13;6:15. doi: 10.1186/1750-1172-6-15. PMID: 21489283Free PMC Article

Therapy

Thalidomide for Recurrent Bleeding Due to Small-Intestinal Angiodysplasia.
Chen H, Wu S, Tang M, Zhao R, Zhang Q, Dai Z, Gao Y, Yang S, Li Z, Du Y, Yang A, Zhong L, Lu L, Xu L, Shen X, Liu S, Zhong J, Li X, Lu H, Xiong H, Shen Y, Chen H, Gong S, Xue H, Ge Z
N Engl J Med 2023 Nov 2;389(18):1649-1659. doi: 10.1056/NEJMoa2303706. PMID: 37913505
Review Article: Gastrointestinal Bleeding Risk with Direct Oral Anticoagulants.
Benamouzig R, Guenoun M, Deutsch D, Fauchier L
Cardiovasc Drugs Ther 2022 Oct;36(5):973-989. Epub 2021 Jun 18 doi: 10.1007/s10557-021-07211-0. PMID: 34143317
Diagnosis and therapeutic strategies for small bowel vascular lesions.
Sakai E, Ohata K, Nakajima A, Matsuhashi N
World J Gastroenterol 2019 Jun 14;25(22):2720-2733. doi: 10.3748/wjg.v25.i22.2720. PMID: 31235995Free PMC Article
von Willebrand factor regulation of blood vessel formation.
Randi AM, Smith KE, Castaman G
Blood 2018 Jul 12;132(2):132-140. Epub 2018 Jun 4 doi: 10.1182/blood-2018-01-769018. PMID: 29866817Free PMC Article
Review article: gastrointestinal angiodysplasia - pathogenesis, diagnosis and management.
Sami SS, Al-Araji SA, Ragunath K
Aliment Pharmacol Ther 2014 Jan;39(1):15-34. Epub 2013 Oct 20 doi: 10.1111/apt.12527. PMID: 24138285

Prognosis

Effectiveness and predictors of response to somatostatin analogues in patients with gastrointestinal angiodysplasias: a systematic review and individual patient data meta-analysis.
Goltstein LCMJ, Grooteman KV, Rocco A, Holleran G, Frago S, Salgueiro PS, Aparicio T, Scaglione G, Chetcuti Zammit S, Prados-Manzano R, Benamouzig R, Nardone G, McNamara D, Benallaoua M, Michopoulos S, Sidhu R, Kievit W, Drenth JPH, van Geenen EJM
Lancet Gastroenterol Hepatol 2021 Nov;6(11):922-932. Epub 2021 Sep 9 doi: 10.1016/S2468-1253(21)00262-4. PMID: 34508668
An overview of angiodysplasia: management and patient prospects.
Holleran G, McNamara D
Expert Rev Gastroenterol Hepatol 2018 Sep;12(9):863-872. Epub 2018 Aug 3 doi: 10.1080/17474124.2018.1503532. PMID: 30028221
Hughes-Stovin syndrome.
Khalid U, Saleem T
Orphanet J Rare Dis 2011 Apr 13;6:15. doi: 10.1186/1750-1172-6-15. PMID: 21489283Free PMC Article
Colonic angiodysplasia.
Foutch PG
Gastroenterologist 1997 Jun;5(2):148-56. PMID: 9193932
Angiodysplasia of the colon in children.
de la Torre Mondragón L, Vargas Gómez MA, Mora Tiscarreño MA, Ramírez Mayans J
J Pediatr Surg 1995 Jan;30(1):72-5. doi: 10.1016/0022-3468(95)90614-2. PMID: 7722835

Clinical prediction guides

Effectiveness of aortic valve replacement in Heyde syndrome: a meta-analysis.
Goltstein LCMJ, Rooijakkers MJP, Hoeks M, Li WWL, van Wely MH, Rodwell L, van Royen N, Drenth JPH, van Geenen EM
Eur Heart J 2023 Sep 1;44(33):3168-3177. doi: 10.1093/eurheartj/ehad340. PMID: 37555393Free PMC Article
Effectiveness and predictors of response to somatostatin analogues in patients with gastrointestinal angiodysplasias: a systematic review and individual patient data meta-analysis.
Goltstein LCMJ, Grooteman KV, Rocco A, Holleran G, Frago S, Salgueiro PS, Aparicio T, Scaglione G, Chetcuti Zammit S, Prados-Manzano R, Benamouzig R, Nardone G, McNamara D, Benallaoua M, Michopoulos S, Sidhu R, Kievit W, Drenth JPH, van Geenen EJM
Lancet Gastroenterol Hepatol 2021 Nov;6(11):922-932. Epub 2021 Sep 9 doi: 10.1016/S2468-1253(21)00262-4. PMID: 34508668
Diagnostic and therapeutic challenges of gastrointestinal angiodysplasias: A critical review and view points.
García-Compeán D, Del Cueto-Aguilera ÁN, Jiménez-Rodríguez AR, González-González JA, Maldonado-Garza HJ
World J Gastroenterol 2019 Jun 7;25(21):2549-2564. doi: 10.3748/wjg.v25.i21.2549. PMID: 31210709Free PMC Article
Overview of small bowel angioectasias: clinical presentation and treatment options.
Chetcuti Zammit S, Koulaouzidis A, Sanders DS, McAlindon ME, Rondonotti E, Yung DE, Sidhu R
Expert Rev Gastroenterol Hepatol 2018 Feb;12(2):125-139. Epub 2017 Oct 18 doi: 10.1080/17474124.2018.1390429. PMID: 28994309
Risk of gastrointestinal bleeding during anticoagulant treatment.
Lanas-Gimeno A, Lanas A
Expert Opin Drug Saf 2017 Jun;16(6):673-685. Epub 2017 May 17 doi: 10.1080/14740338.2017.1325870. PMID: 28467190

Recent systematic reviews

Effectiveness of aortic valve replacement in Heyde syndrome: a meta-analysis.
Goltstein LCMJ, Rooijakkers MJP, Hoeks M, Li WWL, van Wely MH, Rodwell L, van Royen N, Drenth JPH, van Geenen EM
Eur Heart J 2023 Sep 1;44(33):3168-3177. doi: 10.1093/eurheartj/ehad340. PMID: 37555393Free PMC Article
Efficacy of pharmacologic treatment for treating gastrointestinal angiodysplasias-related bleeding: a systematic review and meta-analysis.
Gkolfakis P, Fostier R, Tziatzios G, Lazaridis N, Fernandez Y Viesca M, Facciorusso A, Despott E, Triantafyllou K, Devière J, Arvanitakis M
Eur J Gastroenterol Hepatol 2022 Oct 1;34(10):1021-1030. Epub 2022 Jul 19 doi: 10.1097/MEG.0000000000002414. PMID: 35913758
Effectiveness and predictors of response to somatostatin analogues in patients with gastrointestinal angiodysplasias: a systematic review and individual patient data meta-analysis.
Goltstein LCMJ, Grooteman KV, Rocco A, Holleran G, Frago S, Salgueiro PS, Aparicio T, Scaglione G, Chetcuti Zammit S, Prados-Manzano R, Benamouzig R, Nardone G, McNamara D, Benallaoua M, Michopoulos S, Sidhu R, Kievit W, Drenth JPH, van Geenen EJM
Lancet Gastroenterol Hepatol 2021 Nov;6(11):922-932. Epub 2021 Sep 9 doi: 10.1016/S2468-1253(21)00262-4. PMID: 34508668
Medical and endoscopic therapies for angiodysplasia and gastric antral vascular ectasia: a systematic review.
Swanson E, Mahgoub A, MacDonald R, Shaukat A
Clin Gastroenterol Hepatol 2014 Apr;12(4):571-82. Epub 2013 Sep 5 doi: 10.1016/j.cgh.2013.08.038. PMID: 24013107
Indications and detection, completion, and retention rates of small-bowel capsule endoscopy: a systematic review.
Liao Z, Gao R, Xu C, Li ZS
Gastrointest Endosc 2010 Feb;71(2):280-6. doi: 10.1016/j.gie.2009.09.031. PMID: 20152309

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