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Vascular ectasia of gastric antrum(GAVE)

MedGen UID:
82753
•Concept ID:
C0267211
•
Acquired Abnormality
Synonyms: Gastric antral vascular ectasia; GAVE; Watermelon stomach
SNOMED CT: GAVE - Gastric antral vascular ectasia (43935004); Vascular ectasia of gastric antrum (43935004); Watermelon stomach (43935004)
 
Monarch Initiative: MONDO:0006767

Definition

Dilatation of the vessels in the antrum of the stomach. It is associated with portal hypertension, scleroderma, and chronic renal failure. It may cause gastric bleeding. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVascular ectasia of gastric antrum

Professional guidelines

PubMed

AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review.
DeLoughery TG, Jackson CS, Ko CW, Rockey DC
Clin Gastroenterol Hepatol 2024 Aug;22(8):1575-1583. Epub 2024 Jun 12 doi: 10.1016/j.cgh.2024.03.046. PMID: 38864796
Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review.
Peng M, Guo X, Yi F, Romeiro FG, Mancuso A, Qi X
Adv Ther 2021 Oct;38(10):5065-5077. Epub 2021 Sep 15 doi: 10.1007/s12325-021-01912-6. PMID: 34524644
Gastric vascular abnormalities: diagnosis and management.
Awadalla M, Mahmoud M, McNamara P, Wassef W
Curr Opin Gastroenterol 2020 Nov;36(6):538-546. doi: 10.1097/MOG.0000000000000675. PMID: 32925176

Recent clinical studies

Etiology

AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review.
DeLoughery TG, Jackson CS, Ko CW, Rockey DC
Clin Gastroenterol Hepatol 2024 Aug;22(8):1575-1583. Epub 2024 Jun 12 doi: 10.1016/j.cgh.2024.03.046. PMID: 38864796
Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers.
Cavazzana I, Vojinovic T, Airo' P, Fredi M, Ceribelli A, Pedretti E, Lazzaroni MG, Garrafa E, Franceschini F
Clin Rev Allergy Immunol 2023 Jun;64(3):412-430. Epub 2022 Jun 18 doi: 10.1007/s12016-022-08946-w. PMID: 35716254Free PMC Article
Prevalence of metabolic syndrome in cirrhotics with gastric antral vascular ectasia.
Aryan M, Jariwala R, Alkurdi B, Peter S, Shoreibah M
Diabetes Metab Syndr 2022 Jan;16(1):102377. Epub 2021 Dec 25 doi: 10.1016/j.dsx.2021.102377. PMID: 34974327
Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review.
Peng M, Guo X, Yi F, Romeiro FG, Mancuso A, Qi X
Adv Ther 2021 Oct;38(10):5065-5077. Epub 2021 Sep 15 doi: 10.1007/s12325-021-01912-6. PMID: 34524644
Unusual Causes of Upper Gastrointestinal Bleeding.
Parikh K, Ali MA, Wong RC
Gastrointest Endosc Clin N Am 2015 Jul;25(3):583-605. Epub 2015 Apr 18 doi: 10.1016/j.giec.2015.02.009. PMID: 26142040

Diagnosis

Endoscopic Advances in Hepatology.
Vanderschueren E, Trebicka J, Laleman W
Semin Liver Dis 2023 May;43(2):176-188. Epub 2023 May 16 doi: 10.1055/s-0043-1769009. PMID: 37192654
Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers.
Cavazzana I, Vojinovic T, Airo' P, Fredi M, Ceribelli A, Pedretti E, Lazzaroni MG, Garrafa E, Franceschini F
Clin Rev Allergy Immunol 2023 Jun;64(3):412-430. Epub 2022 Jun 18 doi: 10.1007/s12016-022-08946-w. PMID: 35716254Free PMC Article
Gastric vascular abnormalities: diagnosis and management.
Awadalla M, Mahmoud M, McNamara P, Wassef W
Curr Opin Gastroenterol 2020 Nov;36(6):538-546. doi: 10.1097/MOG.0000000000000675. PMID: 32925176
Portal hypertensive gastropathy and gastric antral vascular ectasia.
Garg H, Gupta S, Anand AC, Broor SL
Indian J Gastroenterol 2015 Sep;34(5):351-8. Epub 2015 Nov 13 doi: 10.1007/s12664-015-0605-0. PMID: 26564121
Watermelon stomach.
Abedi M, Haber GB
Gastroenterologist 1997 Sep;5(3):179-84. PMID: 9298372

Therapy

AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review.
DeLoughery TG, Jackson CS, Ko CW, Rockey DC
Clin Gastroenterol Hepatol 2024 Aug;22(8):1575-1583. Epub 2024 Jun 12 doi: 10.1016/j.cgh.2024.03.046. PMID: 38864796
Gastric Antral Vascular Ectasia Pathogenesis and the Link to the Metabolic Syndrome.
Smith E, Davis J, Caldwell S
Curr Gastroenterol Rep 2018 Jul 2;20(8):36. doi: 10.1007/s11894-018-0644-7. PMID: 29961911
Portal hypertensive gastropathy and gastric antral vascular ectasia.
Garg H, Gupta S, Anand AC, Broor SL
Indian J Gastroenterol 2015 Sep;34(5):351-8. Epub 2015 Nov 13 doi: 10.1007/s12664-015-0605-0. PMID: 26564121
Portal hypertensive gastropathy and gastric antral vascular ectasia.
Han S, Chaudhary N, Wassef W
Curr Opin Gastroenterol 2015 Nov;31(6):506-12. doi: 10.1097/MOG.0000000000000214. PMID: 26376475
Gastrointestinal bleeding.
Dinis-Ribeiro M
Gastrointest Endosc 2013 Sep;78(3):434-8. doi: 10.1016/j.gie.2013.06.021. PMID: 23948192

Prognosis

Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers.
Cavazzana I, Vojinovic T, Airo' P, Fredi M, Ceribelli A, Pedretti E, Lazzaroni MG, Garrafa E, Franceschini F
Clin Rev Allergy Immunol 2023 Jun;64(3):412-430. Epub 2022 Jun 18 doi: 10.1007/s12016-022-08946-w. PMID: 35716254Free PMC Article
An update on biomarker discovery and use in systemic sclerosis.
Matsushita T, Takehara K
Expert Rev Mol Diagn 2017 Sep;17(9):823-833. Epub 2017 Jul 25 doi: 10.1080/14737159.2017.1356722. PMID: 28730919
Management of nonvariceal upper gastrointestinal bleeding.
Wee E
J Postgrad Med 2011 Apr-Jun;57(2):161-7. doi: 10.4103/0022-3859.81868. PMID: 21654147
Portal hypertensive gastropathy: a review.
Cubillas R, Rockey DC
Liver Int 2010 Sep;30(8):1094-102. Epub 2010 Jun 8 doi: 10.1111/j.1478-3231.2010.02286.x. PMID: 20536720
Watermelon stomach.
Chatterjee S
CMAJ 2008 Jul 15;179(2):162. doi: 10.1503/cmaj.080461. PMID: 18625989Free PMC Article

Clinical prediction guides

Systemic Sclerosis-Specific Antibodies: Novel and Classical Biomarkers.
Cavazzana I, Vojinovic T, Airo' P, Fredi M, Ceribelli A, Pedretti E, Lazzaroni MG, Garrafa E, Franceschini F
Clin Rev Allergy Immunol 2023 Jun;64(3):412-430. Epub 2022 Jun 18 doi: 10.1007/s12016-022-08946-w. PMID: 35716254Free PMC Article
An update on biomarker discovery and use in systemic sclerosis.
Matsushita T, Takehara K
Expert Rev Mol Diagn 2017 Sep;17(9):823-833. Epub 2017 Jul 25 doi: 10.1080/14737159.2017.1356722. PMID: 28730919
Portal hypertensive gastropathy and gastric antral vascular ectasia.
Garg H, Gupta S, Anand AC, Broor SL
Indian J Gastroenterol 2015 Sep;34(5):351-8. Epub 2015 Nov 13 doi: 10.1007/s12664-015-0605-0. PMID: 26564121
Portal hypertensive gastropathy.
Negreanu L, Buşegeanu C, Trandafir D, Dragomir P, Udeanu M, Fierbinţeanu-Braticevici C, Andronescu D
Rom J Intern Med 2005;43(1-2):3-8. PMID: 16739861
Watermelon stomach.
Abedi M, Haber GB
Gastroenterologist 1997 Sep;5(3):179-84. PMID: 9298372

Recent systematic reviews

Endoscopic band ligation in the treatment of gastric antral vascular ectasia: a systematic review and meta-analysis.
Mohan BP, Toy G, Kassab LL, Ponnada S, Chandan S, Parbhu S, Chandna S, Adler DG
Gastrointest Endosc 2021 Dec;94(6):1021-1029.e10. Epub 2021 Sep 1 doi: 10.1016/j.gie.2021.08.017. PMID: 34480922
Endoscopic band ligation compared to thermal therapy for gastric antral vascular ectasia: A systematic review and meta-analysis.
Chalhoub JM, Umar J, Groudan K, Hamadeh N, Desilets DJ, Greeff Y
United European Gastroenterol J 2021 Mar;9(2):150-158. Epub 2021 Feb 18 doi: 10.1177/2050640620975243. PMID: 33210983Free PMC Article
Comparative Effectiveness and Safety of Radiofrequency Ablation Versus Argon Plasma Coagulation for Treatment of Gastric Antral Vascular Ectasia: A Systematic Review and Meta-Analysis.
McCarty TR, Rustagi T
J Clin Gastroenterol 2019 Sep;53(8):599-606. doi: 10.1097/MCG.0000000000001088. PMID: 29952856
Medical and endoscopic therapies for angiodysplasia and gastric antral vascular ectasia: a systematic review.
Swanson E, Mahgoub A, MacDonald R, Shaukat A
Clin Gastroenterol Hepatol 2014 Apr;12(4):571-82. Epub 2013 Sep 5 doi: 10.1016/j.cgh.2013.08.038. PMID: 24013107

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