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Ovarian hyperstimulation syndrome(OHSS)

MedGen UID:
38966
Concept ID:
C0085083
Disease or Syndrome
Synonyms: OHSS; OVARIAN HYPERSTIMULATION SYNDROME, FAMILIAL GESTATIONAL SPONTANEOUS
SNOMED CT: Secondary Meig's syndrome (129635004); Ovarian hyperstimulation syndrome (129635004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Gene (location): FSHR (2p16.3)
 
Monarch Initiative: MONDO:0011972
OMIM®: 608115
Orphanet: ORPHA64739

Definition

A rare non-malformative gynecological disease affecting pre-menopausal women usually following treatment with ovarian stimulating hormones, characterized by ovarian enlargement and, to varying degrees, shift of serum from the intravascular space to the third space, mainly into the peritoneal, pleural, and to a lesser extent to the pericardial cavities. Presenting symptoms include abdomen distention, pain, nausea, and vomiting. Severity ranges from mild to life-threatening and is complicated by increased risk of thrombosis, acute hepato-renal failure, acute respiratory distress syndrome, and ovarian torsion and rupture. [from ORDO]

Clinical features

From HPO
Abdominal pain
MedGen UID:
7803
Concept ID:
C0000737
Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the abdomen.
Abnormality of the genitourinary system
MedGen UID:
52948
Concept ID:
C0042063
Congenital Abnormality
The presence of any abnormality of the genitourinary system.
Ascites
MedGen UID:
416
Concept ID:
C0003962
Disease or Syndrome
Accumulation of fluid in the peritoneal cavity.
Nausea
MedGen UID:
10196
Concept ID:
C0027497
Sign or Symptom
A sensation of unease in the stomach together with an urge to vomit.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian hyperstimulation syndrome
Follow this link to review classifications for Ovarian hyperstimulation syndrome in Orphanet.

Professional guidelines

PubMed

Carson SA, Kallen AN
JAMA 2021 Jul 6;326(1):65-76. doi: 10.1001/jama.2021.4788. PMID: 34228062Free PMC Article
Siddall E, Khatri M, Radhakrishnan J
Kidney Int 2017 Jul;92(1):37-46. Epub 2017 Mar 17 doi: 10.1016/j.kint.2016.11.029. PMID: 28318633
Nelson SM
Thromb Res 2017 Mar;151 Suppl 1:S61-S64. doi: 10.1016/S0049-3848(17)30070-1. PMID: 28262238

Recent clinical studies

Etiology

Practice Committee of the American Society for Reproductive Medicine. Electronic address: asrm@asrm.org
Fertil Steril 2024 Feb;121(2):230-245. Epub 2023 Dec 13 doi: 10.1016/j.fertnstert.2023.11.013. PMID: 38099867
Palomba S, Costanzi F, Nelson SM, Besharat A, Caserta D, Humaidan P
Int J Mol Sci 2023 Sep 16;24(18) doi: 10.3390/ijms241814185. PMID: 37762488Free PMC Article
Timmons D, Montrief T, Koyfman A, Long B
Am J Emerg Med 2019 Aug;37(8):1577-1584. Epub 2019 May 7 doi: 10.1016/j.ajem.2019.05.018. PMID: 31097257
Nelson SM
Thromb Res 2017 Mar;151 Suppl 1:S61-S64. doi: 10.1016/S0049-3848(17)30070-1. PMID: 28262238
Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org; Practice Committee of the American Society for Reproductive Medicine
Fertil Steril 2016 Dec;106(7):1634-1647. Epub 2016 Sep 24 doi: 10.1016/j.fertnstert.2016.08.048. PMID: 27678032

Diagnosis

Practice Committee of the American Society for Reproductive Medicine. Electronic address: asrm@asrm.org
Fertil Steril 2024 Feb;121(2):230-245. Epub 2023 Dec 13 doi: 10.1016/j.fertnstert.2023.11.013. PMID: 38099867
Sun B, Ma Y, Li L, Hu L, Wang F, Zhang Y, Dai S, Sun Y
Front Endocrinol (Lausanne) 2020;11:615957. Epub 2021 Jan 19 doi: 10.3389/fendo.2020.615957. PMID: 33542709Free PMC Article
Timmons D, Montrief T, Koyfman A, Long B
Am J Emerg Med 2019 Aug;37(8):1577-1584. Epub 2019 May 7 doi: 10.1016/j.ajem.2019.05.018. PMID: 31097257
Blumenfeld Z
Vitam Horm 2018;107:423-451. Epub 2018 Feb 23 doi: 10.1016/bs.vh.2018.01.018. PMID: 29544639
Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org; Practice Committee of the American Society for Reproductive Medicine
Fertil Steril 2016 Dec;106(7):1634-1647. Epub 2016 Sep 24 doi: 10.1016/j.fertnstert.2016.08.048. PMID: 27678032

Therapy

Rosenberg H, Rangwala S, Magee B
CMAJ 2024 Sep 9;196(29):E1012. doi: 10.1503/cmaj.240213. PMID: 39251242Free PMC Article
Palomba S, Costanzi F, Nelson SM, Besharat A, Caserta D, Humaidan P
Int J Mol Sci 2023 Sep 16;24(18) doi: 10.3390/ijms241814185. PMID: 37762488Free PMC Article
He Y, Lu Y, Zhu Q, Wang Y, Lindheim SR, Qi J, Li X, Ding Y, Shi Y, Wei D, Chen ZJ, Sun Y
Am J Obstet Gynecol 2019 Aug;221(2):138.e1-138.e12. Epub 2019 Mar 22 doi: 10.1016/j.ajog.2019.03.011. PMID: 30910544
Tanbo T, Mellembakken J, Bjercke S, Ring E, Åbyholm T, Fedorcsak P
Acta Obstet Gynecol Scand 2018 Oct;97(10):1162-1167. Epub 2018 Jul 24 doi: 10.1111/aogs.13395. PMID: 29889977
Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, Zhu Y, Deng X, Qi X, Li H, Ma X, Ren H, Wang Y, Zhang D, Wang B, Liu F, Wu Q, Wang Z, Bai H, Li Y, Zhou Y, Sun M, Liu H, Li J, Zhang L, Chen X, Zhang S, Sun X, Legro RS, Chen ZJ
N Engl J Med 2018 Jan 11;378(2):126-136. doi: 10.1056/NEJMoa1705334. PMID: 29320646

Prognosis

Palomba S, Costanzi F, Nelson SM, Besharat A, Caserta D, Humaidan P
Int J Mol Sci 2023 Sep 16;24(18) doi: 10.3390/ijms241814185. PMID: 37762488Free PMC Article
Kotlyar AM, Seifer DB
Reprod Biol Endocrinol 2023 Aug 1;21(1):70. doi: 10.1186/s12958-023-01120-7. PMID: 37528417Free PMC Article
Palomba S, Costanzi F, Nelson SM, Caserta D, Humaidan P
Reprod Biol Endocrinol 2023 Jul 21;21(1):67. doi: 10.1186/s12958-023-01113-6. PMID: 37480081Free PMC Article
Sun B, Ma Y, Li L, Hu L, Wang F, Zhang Y, Dai S, Sun Y
Front Endocrinol (Lausanne) 2020;11:615957. Epub 2021 Jan 19 doi: 10.3389/fendo.2020.615957. PMID: 33542709Free PMC Article
Moolhuijsen LME, Visser JA
J Clin Endocrinol Metab 2020 Nov 1;105(11):3361-73. doi: 10.1210/clinem/dgaa513. PMID: 32770239Free PMC Article

Clinical prediction guides

Sun B, Ma Y, Li L, Hu L, Wang F, Zhang Y, Dai S, Sun Y
Front Endocrinol (Lausanne) 2020;11:615957. Epub 2021 Jan 19 doi: 10.3389/fendo.2020.615957. PMID: 33542709Free PMC Article
Siddall E, Khatri M, Radhakrishnan J
Kidney Int 2017 Jul;92(1):37-46. Epub 2017 Mar 17 doi: 10.1016/j.kint.2016.11.029. PMID: 28318633
Nastri CO, Teixeira DM, Moroni RM, Leitão VM, Martins WP
Ultrasound Obstet Gynecol 2015 Apr;45(4):377-93. Epub 2015 Mar 1 doi: 10.1002/uog.14684. PMID: 25302750
Corbett S, Shmorgun D, Claman P; REPRODUCTIVE ENDOCRINOLOGY INFERTILITY COMMITTEE; SPECIAL CONTRIBUTOR
J Obstet Gynaecol Can 2014 Nov;36(11):1024-1033. doi: 10.1016/S1701-2163(15)30417-5. PMID: 25574681
McElhinney B, McClure N
Baillieres Best Pract Res Clin Obstet Gynaecol 2000 Feb;14(1):103-22. doi: 10.1053/beog.1999.0066. PMID: 10789263

Recent systematic reviews

Practice Committee of the American Society for Reproductive Medicine. Electronic address: asrm@asrm.org
Fertil Steril 2024 Feb;121(2):230-245. Epub 2023 Dec 13 doi: 10.1016/j.fertnstert.2023.11.013. PMID: 38099867
Al Wattar BH, Fisher M, Bevington L, Talaulikar V, Davies M, Conway G, Yasmin E
J Clin Endocrinol Metab 2021 Jul 13;106(8):2436-2446. doi: 10.1210/clinem/dgab232. PMID: 33839790Free PMC Article
Farquhar C, Marjoribanks J
Cochrane Database Syst Rev 2018 Aug 17;8(8):CD010537. doi: 10.1002/14651858.CD010537.pub5. PMID: 30117155Free PMC Article
Practice Committee of the American Society for Reproductive Medicine. Electronic address: ASRM@asrm.org; Practice Committee of the American Society for Reproductive Medicine
Fertil Steril 2016 Dec;106(7):1634-1647. Epub 2016 Sep 24 doi: 10.1016/j.fertnstert.2016.08.048. PMID: 27678032
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863

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