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Tuberculoma

MedGen UID:
52881
•Concept ID:
C0041295
•
Disease or Syndrome
Synonym: Tuberculomas
SNOMED CT: Tuberculoma (15202009)
 
Monarch Initiative: MONDO:0021943

Definition

A tumor-like mass resulting from the enlargement of a tuberculous lesion. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTuberculoma

Professional guidelines

PubMed

Classification Criteria for Tubercular Uveitis.
Standardization of Uveitis Nomenclature (SUN) Working Group
Am J Ophthalmol 2021 Aug;228:142-151. Epub 2021 May 11 doi: 10.1016/j.ajo.2021.03.040. PMID: 33845014Free PMC Article
Dilemmas in the diagnosis and treatment of intracranial tuberculomas.
Ramachandran R, Muniyandi M, Iyer V, Sripriya T, Priya B, Govindarajan TG
J Neurol Sci 2017 Oct 15;381:256-264. Epub 2017 Sep 1 doi: 10.1016/j.jns.2017.08.3258. PMID: 28991694
British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children.
Thwaites G, Fisher M, Hemingway C, Scott G, Solomon T, Innes J; British Infection Society
J Infect 2009 Sep;59(3):167-87. Epub 2009 Jul 4 doi: 10.1016/j.jinf.2009.06.011. PMID: 19643501

Recent clinical studies

Etiology

Global morbidity and mortality of central nervous system tuberculosis: a systematic review and meta-analysis.
Navarro-Flores A, Fernandez-Chinguel JE, Pacheco-Barrios N, Soriano-Moreno DR, Pacheco-Barrios K
J Neurol 2022 Jul;269(7):3482-3494. Epub 2022 Mar 15 doi: 10.1007/s00415-022-11052-8. PMID: 35288778Free PMC Article
Neurotuberculosis: an update.
Cherian A, Ajitha KC, Iype T, Divya KP
Acta Neurol Belg 2021 Feb;121(1):11-21. Epub 2021 Jan 5 doi: 10.1007/s13760-020-01575-0. PMID: 33400226
Extrapulmonary Tuberculosis: Pathophysiology and Imaging Findings.
Rodriguez-Takeuchi SY, Renjifo ME, Medina FJ
Radiographics 2019 Nov-Dec;39(7):2023-2037. doi: 10.1148/rg.2019190109. PMID: 31697616
Tuberculosis.
Garcia-Monco JC
Handb Clin Neurol 2014;121:1485-99. doi: 10.1016/B978-0-7020-4088-7.00100-0. PMID: 24365432
Imaging of non-neoplastic intratesticular masses.
Bhatt S, Jafri SZ, Wasserman N, Dogra VS
Diagn Interv Radiol 2011 Mar;17(1):52-63. Epub 2010 Jun 30 doi: 10.4261/1305-3825.DIR.3116-09.0. PMID: 20677130

Diagnosis

Dilemmas in the diagnosis and treatment of intracranial tuberculomas.
Ramachandran R, Muniyandi M, Iyer V, Sripriya T, Priya B, Govindarajan TG
J Neurol Sci 2017 Oct 15;381:256-264. Epub 2017 Sep 1 doi: 10.1016/j.jns.2017.08.3258. PMID: 28991694
Tuberculoma-Induced Seizures.
Salway RJ, Sangani S, Parekh S, Bhatt S
West J Emerg Med 2015 Sep;16(5):625-8. Epub 2015 Oct 20 doi: 10.5811/westjem.2015.7.27758. PMID: 26587082Free PMC Article
Suprasellar tuberculoma.
Garg K, Gurjar HK, Chandra PS, Sharma BS
Br J Neurosurg 2014 Aug;28(4):562-3. Epub 2013 Nov 8 doi: 10.3109/02688697.2013.857009. PMID: 24199967
Cerebral tuberculoma.
Kenzaka T, Noda A
QJM 2014 Jan;107(1):81. Epub 2013 Jan 22 doi: 10.1093/qjmed/hct010. PMID: 23345463
Brainstem tuberculosis.
Demetriou GA
BMJ Case Rep 2013 Jul 18;2013 doi: 10.1136/bcr-2013-010359. PMID: 23868024Free PMC Article

Therapy

Central Nervous System Tuberculosis : Etiology, Clinical Manifestations and Neuroradiological Features.
Schaller MA, Wicke F, Foerch C, Weidauer S
Clin Neuroradiol 2019 Mar;29(1):3-18. Epub 2018 Sep 17 doi: 10.1007/s00062-018-0726-9. PMID: 30225516
Pituitary Tuberculoma.
Sohail AH, Bhatti UF, Islam N
J Coll Physicians Surg Pak 2018 Jun;28(6):S97-S98. doi: 10.29271/jcpsp.2018.06.S97. PMID: 29866234
Central Nervous System Tuberculosis.
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443
Suprasellar tuberculoma.
Garg K, Gurjar HK, Chandra PS, Sharma BS
Br J Neurosurg 2014 Aug;28(4):562-3. Epub 2013 Nov 8 doi: 10.3109/02688697.2013.857009. PMID: 24199967
CNS tuberculosis.
Sheller JR, Des Prez RM
Neurol Clin 1986 Feb;4(1):143-58. doi: 10.1016/S0733-8619(18)30992-7. PMID: 3523199Free PMC Article

Prognosis

Central Nervous System Tuberculosis : Etiology, Clinical Manifestations and Neuroradiological Features.
Schaller MA, Wicke F, Foerch C, Weidauer S
Clin Neuroradiol 2019 Mar;29(1):3-18. Epub 2018 Sep 17 doi: 10.1007/s00062-018-0726-9. PMID: 30225516
Central Nervous System Tuberculosis.
Leonard JM
Microbiol Spectr 2017 Mar;5(2) doi: 10.1128/microbiolspec.TNMI7-0044-2017. PMID: 28281443
Tuberculous meningitis.
Schoeman JF, Donald PR
Handb Clin Neurol 2013;112:1135-8. doi: 10.1016/B978-0-444-52910-7.00033-7. PMID: 23622321
Geographical neurosurgery.
Ohaegbulam SC
Neurol Res 1999 Mar;21(2):161-70. doi: 10.1080/01616412.1999.11740912. PMID: 10100202
Tuberculous meningitis.
Leonard JM, Des Prez RM
Infect Dis Clin North Am 1990 Dec;4(4):769-87. PMID: 2277198

Clinical prediction guides

Global morbidity and mortality of central nervous system tuberculosis: a systematic review and meta-analysis.
Navarro-Flores A, Fernandez-Chinguel JE, Pacheco-Barrios N, Soriano-Moreno DR, Pacheco-Barrios K
J Neurol 2022 Jul;269(7):3482-3494. Epub 2022 Mar 15 doi: 10.1007/s00415-022-11052-8. PMID: 35288778Free PMC Article
Clinical and Multimodal Imaging Clues in Differentiating Between Tuberculomas and Sarcoid Choroidal Granulomas.
Agarwal A, Aggarwal K, Pichi F, Meng T, Munk MR, Bazgain K, Bansal R, Agrawal R, Gupta V
Am J Ophthalmol 2021 Jun;226:42-55. Epub 2021 Jan 30 doi: 10.1016/j.ajo.2021.01.025. PMID: 33529591
Central nervous system and spinal cord tuberculosis: Revisiting an important disease.
Salvador GLO, Basso ACN, Barbieri PP, Leitao CA, Teixeira BCA, Neto AC
Clin Imaging 2021 Jan;69:158-168. Epub 2020 Jul 29 doi: 10.1016/j.clinimag.2020.07.020. PMID: 32853843
Isolated brainstem tuberculomas.
Sadashiva N, Tiwari S, Shukla D, Bhat D, Saini J, Somanna S, Devi BI
Acta Neurochir (Wien) 2017 May;159(5):889-897. Epub 2017 Feb 11 doi: 10.1007/s00701-017-3108-1. PMID: 28190145
Geographical neurosurgery.
Ohaegbulam SC
Neurol Res 1999 Mar;21(2):161-70. doi: 10.1080/01616412.1999.11740912. PMID: 10100202

Recent systematic reviews

The etiological spectrum of miliary brain lesions: A systematic review of published cases and case series.
Garg RK, Paliwal V, Suvirya S, Malhotra HS, Verma A
Neuroradiol J 2024 Oct;37(5):556-563. Epub 2024 Mar 14 doi: 10.1177/19714009241240055. PMID: 38485688Free PMC Article
Intramedullary Spinal Cord Abscess Management: Case Series, Operative Video, and Systematic Review.
Satyadev N, Moore C, Khunkhun SK, Aggarwal K, Osman M, Protas M, Abi-Aad K, Goulart CR, Rai SS, Galgano MA
World Neurosurg 2023 Jun;174:205-212.e6. Epub 2023 Mar 9 doi: 10.1016/j.wneu.2023.03.013. PMID: 36898628
Global morbidity and mortality of central nervous system tuberculosis: a systematic review and meta-analysis.
Navarro-Flores A, Fernandez-Chinguel JE, Pacheco-Barrios N, Soriano-Moreno DR, Pacheco-Barrios K
J Neurol 2022 Jul;269(7):3482-3494. Epub 2022 Mar 15 doi: 10.1007/s00415-022-11052-8. PMID: 35288778Free PMC Article
Tuberculoma of the Peripheral Nerve: Illustrative Case and Systematic Review of the Literature.
Omar AT 2nd, Villaruel AR, Khu KJO
World Neurosurg 2020 May;137:e547-e553. Epub 2020 Feb 14 doi: 10.1016/j.wneu.2020.02.031. PMID: 32061957
Orbital tuberculosis: a review of the literature.
Madge SN, Prabhakaran VC, Shome D, Kim U, Honavar S, Selva D
Orbit 2008;27(4):267-77. doi: 10.1080/01676830802225152. PMID: 18716964

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