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Tuberculosis(TB)

MedGen UID:
22513
Concept ID:
C0041296
Disease or Syndrome
Synonyms: Kochs disease; TB
SNOMED CT: Tuberculous (371569005); Infection caused by Mycobacterium tuberculosis (373576009); TB - Tuberculosis (56717001); Tuberculosis (56717001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018076
Orphanet: ORPHA3389

Definition

Tuberculosis (TB) is a contagious-infectious disease caused mainly by <i>Mycobacterium tuberculosis</i> that in most individuals is usually asymptomatic but that in at risk individuals (e.g. with diabetes or with HIV infection) can cause weakness, fever, weight loss, night sweat, and respiratory anomalies such as chronic cough, chest pain, hemoptysis or respiratory insufficiency. [from ORDO]

Professional guidelines

PubMed

Lamoth F, Calandra T
Eur Respir Rev 2022 Dec 31;31(166) Epub 2022 Nov 29 doi: 10.1183/16000617.0114-2022. PMID: 36450372Free PMC Article
Suárez I, Fünger SM, Kröger S, Rademacher J, Fätkenheuer G, Rybniker J
Dtsch Arztebl Int 2019 Oct 25;116(43):729-735. doi: 10.3238/arztebl.2019.0729. PMID: 31755407
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, Hayee B, Lomer MCE, Parkes GC, Selinger C, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop MG, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson J, Terry H; IBD guidelines eDelphi consensus group, Gaya DR, Iqbal TH, Taylor SA, Smith M, Brookes M, Hansen R, Hawthorne AB
Gut 2019 Dec;68(Suppl 3):s1-s106. Epub 2019 Sep 27 doi: 10.1136/gutjnl-2019-318484. PMID: 31562236Free PMC Article

Recent clinical studies

Etiology

Bates B, Crowell EL
Curr Opin Ophthalmol 2023 Nov 1;34(6):529-534. Epub 2023 Aug 18 doi: 10.1097/ICU.0000000000000991. PMID: 37593994
Schwoebel V
Indian J Tuberc 2020 Dec;67(4S):S33-S42. Epub 2020 Nov 15 doi: 10.1016/j.ijtb.2020.11.006. PMID: 33308670
Testi I, Agrawal R, Mehta S, Basu S, Nguyen Q, Pavesio C, Gupta V
Indian J Ophthalmol 2020 Sep;68(9):1808-1817. doi: 10.4103/ijo.IJO_1451_20. PMID: 32823397Free PMC Article
Carvalho I, Goletti D, Manga S, Silva DR, Manissero D, Migliori G
Pulmonology 2018 Mar-Apr;24(2):106-114. Epub 2018 Mar 2 doi: 10.1016/j.rppnen.2017.10.007. PMID: 29502937
Churchyard G, Kim P, Shah NS, Rustomjee R, Gandhi N, Mathema B, Dowdy D, Kasmar A, Cardenas V
J Infect Dis 2017 Nov 3;216(suppl_6):S629-S635. doi: 10.1093/infdis/jix362. PMID: 29112747Free PMC Article

Diagnosis

Pan J, Chang Z, Zhang X, Dong Q, Zhao H, Shi J, Wang G
Front Immunol 2023;14:1276194. Epub 2023 Oct 13 doi: 10.3389/fimmu.2023.1276194. PMID: 37901241Free PMC Article
The Lancet Microbe
Lancet Microbe 2023 Jun;4(6):e379. doi: 10.1016/S2666-5247(23)00153-2. PMID: 37269864Free PMC Article
Ismail N, Nathanson CM, Zignol M, Kasaeva T
BMJ Glob Health 2023 May;8(5) doi: 10.1136/bmjgh-2023-012666. PMID: 37230547Free PMC Article
Carpenter SM, Bold TD
NEJM Evid 2022 Nov;1(11):EVIDccon2200125. Epub 2022 Oct 25 doi: 10.1056/EVIDccon2200125. PMID: 38319857
Brodie D, Schluger NW
Clin Chest Med 2005 Jun;26(2):247-71, vi. doi: 10.1016/j.ccm.2005.02.012. PMID: 15837109

Therapy

Motta I, Boeree M, Chesov D, Dheda K, Günther G, Horsburgh CR Jr, Kherabi Y, Lange C, Lienhardt C, McIlleron HM, Paton NI, Stagg HR, Thwaites G, Udwadia Z, Van Crevel R, Velásquez GE, Wilkinson RJ, Guglielmetti L; Study group on Mycobacteria (ESGMYC) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID)
Clin Microbiol Infect 2024 Sep;30(9):1107-1114. Epub 2023 Jul 22 doi: 10.1016/j.cmi.2023.07.013. PMID: 37482332
Berry C, du Cros P, Fielding K, Gajewski S, Kazounis E, McHugh TD, Merle C, Motta I, Moore DAJ, Nyang'wa BT
Trials 2022 Jun 13;23(1):484. doi: 10.1186/s13063-022-06331-8. PMID: 35698158Free PMC Article
Gils T, Lynen L, de Jong BC, Van Deun A, Decroo T
Clin Microbiol Infect 2022 Jan;28(1):31-42. Epub 2021 Aug 14 doi: 10.1016/j.cmi.2021.08.007. PMID: 34400340
Sterling TR, Njie G, Zenner D, Cohn DL, Reves R, Ahmed A, Menzies D, Horsburgh CR Jr, Crane CM, Burgos M, LoBue P, Winston CA, Belknap R
MMWR Recomm Rep 2020 Feb 14;69(1):1-11. doi: 10.15585/mmwr.rr6901a1. PMID: 32053584Free PMC Article
Schrager LK, Vekemens J, Drager N, Lewinsohn DM, Olesen OF
Lancet Infect Dis 2020 Mar;20(3):e28-e37. Epub 2020 Jan 31 doi: 10.1016/S1473-3099(19)30625-5. PMID: 32014117

Prognosis

Lei Y, Wang J, Wang Y, Xu C
BMC Public Health 2023 Apr 24;23(1):755. doi: 10.1186/s12889-023-15553-7. PMID: 37095497Free PMC Article
Kulchavenya E, Kholtobin D, Shevchenko S
World J Urol 2020 Jan;38(1):89-94. Epub 2019 Apr 17 doi: 10.1007/s00345-019-02767-x. PMID: 30997530
Fasanmade OA, Dagogo-Jack S
Ann Glob Health 2015 Nov-Dec;81(6):821-9. doi: 10.1016/j.aogh.2015.12.012. PMID: 27108149
Laibl VR, Sheffield JS
Clin Perinatol 2005 Sep;32(3):739-47. doi: 10.1016/j.clp.2005.04.010. PMID: 16085030
Hirsch CS, Johnson JL, Ellner JJ
Curr Opin Pulm Med 1999 May;5(3):143-50. doi: 10.1097/00063198-199905000-00004. PMID: 10228738

Clinical prediction guides

Allan-Blitz LT, Yarbrough C, Ndayizigiye M, Wade C, Goldsmith AJ, Duggan NM
Int J Tuberc Lung Dis 2024 May 1;28(5):217-224. doi: 10.5588/ijtld.23.0471. PMID: 38659144
Zheng M, Wang Y, Ying X, Zhang P, Liu F, Zheng Q
Diagn Microbiol Infect Dis 2023 Jun;106(2):115941. Epub 2023 Mar 14 doi: 10.1016/j.diagmicrobio.2023.115941. PMID: 37030282
Huang YT, Wei T, Huang YL, Wu YP, Chan KA
Pharmacoepidemiol Drug Saf 2023 Jul;32(7):795-811. Epub 2023 Mar 27 doi: 10.1002/pds.5608. PMID: 36890603
Fitzgibbons PL
Semin Diagn Pathol 2018 Nov;35(6):370-380. Epub 2018 Oct 16 doi: 10.1053/j.semdp.2018.10.002. PMID: 30366790
Maertzdorf J, Kaufmann SH, Weiner J 3rd
Cold Spring Harb Perspect Med 2014 Oct 23;5(1):a018531. doi: 10.1101/cshperspect.a018531. PMID: 25342061Free PMC Article

Recent systematic reviews

Salari N, Kanjoori AH, Hosseinian-Far A, Hasheminezhad R, Mansouri K, Mohammadi M
Infect Dis Poverty 2023 May 25;12(1):57. doi: 10.1186/s40249-023-01107-x. PMID: 37231463Free PMC Article
Sossen B, Richards AS, Heinsohn T, Frascella B, Balzarini F, Oradini-Alacreu A, Odone A, Rogozinska E, Häcker B, Cobelens F, Kranzer K, Houben RMGJ, Esmail H
Lancet Respir Med 2023 Apr;11(4):367-379. Epub 2023 Mar 23 doi: 10.1016/S2213-2600(23)00097-8. PMID: 36966795
Igbokwe V, Ruby LC, Sultanli A, Bélard S
Lancet Infect Dis 2023 Apr;23(4):e138-e150. doi: 10.1016/S1473-3099(23)00004-X. PMID: 36963920
Gils T, Lynen L, de Jong BC, Van Deun A, Decroo T
Clin Microbiol Infect 2022 Jan;28(1):31-42. Epub 2021 Aug 14 doi: 10.1016/j.cmi.2021.08.007. PMID: 34400340
Natarajan A, Beena PM, Devnikar AV, Mali S
Indian J Tuberc 2020 Jul;67(3):295-311. Epub 2020 Feb 28 doi: 10.1016/j.ijtb.2020.02.005. PMID: 32825856

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