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Tonsillitis

MedGen UID:
11847
•Concept ID:
C0040425
•
Disease or Syndrome
Synonym: Tonsillitides
SNOMED CT: Tonsillitis (90176007)

Definition

Inflammation of the tonsillar tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTonsillitis

Professional guidelines

PubMed

Tonsillitis and Tonsilloliths: Diagnosis and Management.
Smith KL, Hughes R, Myrex P
Am Fam Physician 2023 Jan;107(1):35-41. PMID: 36689967
Clinical Practice Guideline: Tonsillectomy in Children (Update)-Executive Summary.
Mitchell RB, Archer SM, Ishman SL, Rosenfeld RM, Coles S, Finestone SA, Friedman NR, Giordano T, Hildrew DM, Kim TW, Lloyd RM, Parikh SR, Shulman ST, Walner DL, Walsh SA, Nnacheta LC
Otolaryngol Head Neck Surg 2019 Feb;160(2):187-205. doi: 10.1177/0194599818807917. PMID: 30921525
Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials.
Sadeghirad B, Siemieniuk RAC, Brignardello-Petersen R, Papola D, Lytvyn L, Vandvik PO, Merglen A, Guyatt GH, Agoritsas T
BMJ 2017 Sep 20;358:j3887. doi: 10.1136/bmj.j3887. PMID: 28931508Free PMC Article

Recent clinical studies

Etiology

Conservative management versus tonsillectomy in adults with recurrent acute tonsillitis in the UK (NATTINA): a multicentre, open-label, randomised controlled trial.
Wilson JA, O'Hara J, Fouweather T, Homer T, Stocken DD, Vale L, Haighton C, Rousseau N, Wilson R, McSweeney L, Wilkes S, Morrison J, MacKenzie K, Ah-See K, Carrie S, Hopkins C, Howe N, Hussain M, Mehanna H, Raine C, Sullivan F, von Wilamowitz-Moellendorff A, Teare MD
Lancet 2023 Jun 17;401(10393):2051-2059. Epub 2023 May 17 doi: 10.1016/S0140-6736(23)00519-6. PMID: 37209706
Healthcare aspects of peritonsillar infection before and during the COVID-19 pandemic.
García-Callejo FJ, Alba-García JR, Orozco-Núñez S, Martínez-Giménez L, Balaguer-García R, Ruescas-Gómez L
Acta Otorrinolaringol Esp (Engl Ed) 2023 Mar-Apr;74(2):108-115. Epub 2023 Mar 9 doi: 10.1016/j.otoeng.2022.04.003. PMID: 36906064Free PMC Article
Tonsillitis and Tonsilloliths: Diagnosis and Management.
Smith KL, Hughes R, Myrex P
Am Fam Physician 2023 Jan;107(1):35-41. PMID: 36689967
Current Indications for Tonsillectomy and Adenoidectomy.
Randall DA
J Am Board Fam Med 2020 Nov-Dec;33(6):1025-1030. doi: 10.3122/jabfm.2020.06.200038. PMID: 33219085
Hemorrhagic tonsillitis.
Levy S, Brodsky L, Stanievich J
Laryngoscope 1989 Jan;99(1):15-8. doi: 10.1288/00005537-198901000-00004. PMID: 2909817

Diagnosis

Tonsillitis and Tonsilloliths: Diagnosis and Management.
Smith KL, Hughes R, Myrex P
Am Fam Physician 2023 Jan;107(1):35-41. PMID: 36689967
Current Indications for Tonsillectomy and Adenoidectomy.
Randall DA
J Am Board Fam Med 2020 Nov-Dec;33(6):1025-1030. doi: 10.3122/jabfm.2020.06.200038. PMID: 33219085
Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management.
Windfuhr JP, Toepfner N, Steffen G, Waldfahrer F, Berner R
Eur Arch Otorhinolaryngol 2016 Apr;273(4):973-87. Epub 2016 Jan 11 doi: 10.1007/s00405-015-3872-6. PMID: 26755048Free PMC Article
Tonsillitis.
Georgalas CC, Tolley NS, Narula PA
BMJ Clin Evid 2014 Jul 22;2014 PMID: 25051184Free PMC Article
Acute tonsillitis.
Sidell D, Shapiro NL
Infect Disord Drug Targets 2012 Aug;12(4):271-6. doi: 10.2174/187152612801319230. PMID: 22338587

Therapy

Conservative management versus tonsillectomy in adults with recurrent acute tonsillitis in the UK (NATTINA): a multicentre, open-label, randomised controlled trial.
Wilson JA, O'Hara J, Fouweather T, Homer T, Stocken DD, Vale L, Haighton C, Rousseau N, Wilson R, McSweeney L, Wilkes S, Morrison J, MacKenzie K, Ah-See K, Carrie S, Hopkins C, Howe N, Hussain M, Mehanna H, Raine C, Sullivan F, von Wilamowitz-Moellendorff A, Teare MD
Lancet 2023 Jun 17;401(10393):2051-2059. Epub 2023 May 17 doi: 10.1016/S0140-6736(23)00519-6. PMID: 37209706
Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study.
Skoog Ståhlgren G, Tyrstrup M, Edlund C, Giske CG, Mölstad S, Norman C, Rystedt K, Sundvall PD, Hedin K
BMJ 2019 Oct 4;367:l5337. doi: 10.1136/bmj.l5337. PMID: 31585944Free PMC Article
Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials.
Sadeghirad B, Siemieniuk RAC, Brignardello-Petersen R, Papola D, Lytvyn L, Vandvik PO, Merglen A, Guyatt GH, Agoritsas T
BMJ 2017 Sep 20;358:j3887. doi: 10.1136/bmj.j3887. PMID: 28931508Free PMC Article
The role of tonsillectomy in IgA nephropathy.
Feriozzi S, Polci R
J Nephrol 2016 Feb;29(1):13-9. Epub 2015 Nov 18 doi: 10.1007/s40620-015-0247-4. PMID: 26582216
Telithromycin.
Balfour JA, Figgitt DP
Drugs 2001;61(6):815-29; discussion 830-1. doi: 10.2165/00003495-200161060-00016. PMID: 11398913

Prognosis

Plain Language Summary for Patients: Tonsillectomy in Children.
Finestone SA, Giordano T, Mitchell RB, Walsh SA, O'Connor SS, Satterfield LM
Otolaryngol Head Neck Surg 2019 Feb;160(2):206-212. doi: 10.1177/0194599818817758. PMID: 30921526
Clinical Practice Guideline: Tonsillectomy in Children (Update)-Executive Summary.
Mitchell RB, Archer SM, Ishman SL, Rosenfeld RM, Coles S, Finestone SA, Friedman NR, Giordano T, Hildrew DM, Kim TW, Lloyd RM, Parikh SR, Shulman ST, Walner DL, Walsh SA, Nnacheta LC
Otolaryngol Head Neck Surg 2019 Feb;160(2):187-205. doi: 10.1177/0194599818807917. PMID: 30921525
Halitosis.
Scully Cbe C, Porter S
BMJ Clin Evid 2008 Jul 17;2008 PMID: 19445739Free PMC Article
Electrosurgery for tonsillectomy.
Maddern BR
Laryngoscope 2002 Aug;112(8 Pt 2 Suppl 100):11-3. doi: 10.1002/lary.5541121405. PMID: 12172230
Bacteremia during tonsillectomy.
Kaygusuz I, Gök U, Yalçin S, Keleş E, Kizirgil A, Demirbağ E
Int J Pediatr Otorhinolaryngol 2001 Apr 6;58(1):69-73. doi: 10.1016/s0165-5876(00)00471-7. PMID: 11249983

Clinical prediction guides

Conservative management versus tonsillectomy in adults with recurrent acute tonsillitis in the UK (NATTINA): a multicentre, open-label, randomised controlled trial.
Wilson JA, O'Hara J, Fouweather T, Homer T, Stocken DD, Vale L, Haighton C, Rousseau N, Wilson R, McSweeney L, Wilkes S, Morrison J, MacKenzie K, Ah-See K, Carrie S, Hopkins C, Howe N, Hussain M, Mehanna H, Raine C, Sullivan F, von Wilamowitz-Moellendorff A, Teare MD
Lancet 2023 Jun 17;401(10393):2051-2059. Epub 2023 May 17 doi: 10.1016/S0140-6736(23)00519-6. PMID: 37209706
Tonsillitis and Tonsilloliths: Diagnosis and Management.
Smith KL, Hughes R, Myrex P
Am Fam Physician 2023 Jan;107(1):35-41. PMID: 36689967
Infectious Mononucleosis: diagnosis and clinical interpretation.
Naughton P, Healy M, Enright F, Lucey B
Br J Biomed Sci 2021 Jul;78(3):107-116. Epub 2021 Apr 14 doi: 10.1080/09674845.2021.1903683. PMID: 33721513
Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management.
Windfuhr JP, Toepfner N, Steffen G, Waldfahrer F, Berner R
Eur Arch Otorhinolaryngol 2016 Apr;273(4):973-87. Epub 2016 Jan 11 doi: 10.1007/s00405-015-3872-6. PMID: 26755048Free PMC Article
Streptococcal acute pharyngitis.
Anjos LM, Marcondes MB, Lima MF, Mondelli AL, Okoshi MP
Rev Soc Bras Med Trop 2014 Jul;47(4):409-13. doi: 10.1590/0037-8682-0265-2013. PMID: 25229278

Recent systematic reviews

Complementary and alternative medicine in the (symptomatic) treatment of acute tonsillitis in children: A systematic review.
Büttner R, Schwermer M, Ostermann T, Längler A, Zuzak T
Complement Ther Med 2023 May;73:102940. Epub 2023 Mar 1 doi: 10.1016/j.ctim.2023.102940. PMID: 36868289
Immediate or interval abscess tonsillectomy? A systematic review and meta-analysis.
Tsikopoulos A, Fountarlis A, Tsikopoulos K, Dilmperis F, Garefis K, Tsikopoulos I, Skoulakis C, Karkos P, Triaridis S
Eur Arch Otorhinolaryngol 2022 May;279(5):2245-2257. Epub 2022 Feb 15 doi: 10.1007/s00405-022-07294-x. PMID: 35169892
Antibiotics for recurrent acute pharyngo-tonsillitis: systematic review.
Munck H, Jørgensen AW, Klug TE
Eur J Clin Microbiol Infect Dis 2018 Jul;37(7):1221-1230. Epub 2018 Apr 13 doi: 10.1007/s10096-018-3245-3. PMID: 29651614
Tonsillitis.
Georgalas CC, Tolley NS, Narula PA
BMJ Clin Evid 2014 Jul 22;2014 PMID: 25051184Free PMC Article
Tonsillitis.
Georgalas CC, Tolley NS, Narula A
BMJ Clin Evid 2009 Oct 26;2009 PMID: 21718574Free PMC Article

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